Crosstalk between purinergic receptor P2Y < sub > 11 < /sub > and chemokine receptor CXCR7 is regulated by CXCR4 in human macrophages
Cell Mol Life Sci. 2024 Mar 13;81(1):132. doi: 10.1007/s00018-024-05158-7.ABSTRACTP2Y11 is a G protein-coupled ATP receptor that activates IL-1 receptor (IL-1R) in a cyclic AMP dependent manner. In human macrophages, P2Y11/IL-1R crosstalk with CCL20 as a prime target is controlled by phosphodiesterase 4 (PDE4), which mediates breakdown of cyclic AMP. Here, we used gene expression analysis to identify activation of CXCR4 and CXCR7 as a hallmark of P2Y11 signaling. We found that PDE4 inhibition with rolipram boosts P2Y11/IL-1R-induced upregulation of CXCR7 expression and CCL20 production in an epidermal growth factor recepto...
Source: Molecular Medicine - March 13, 2024 Category: Molecular Biology Authors: Dominik Klaver Hubert Gander Beatrice Frena Marco Amato Martin Thurnher Source Type: research

Crosstalk between purinergic receptor P2Y < sub > 11 < /sub > and chemokine receptor CXCR7 is regulated by CXCR4 in human macrophages
Cell Mol Life Sci. 2024 Mar 13;81(1):132. doi: 10.1007/s00018-024-05158-7.ABSTRACTP2Y11 is a G protein-coupled ATP receptor that activates IL-1 receptor (IL-1R) in a cyclic AMP dependent manner. In human macrophages, P2Y11/IL-1R crosstalk with CCL20 as a prime target is controlled by phosphodiesterase 4 (PDE4), which mediates breakdown of cyclic AMP. Here, we used gene expression analysis to identify activation of CXCR4 and CXCR7 as a hallmark of P2Y11 signaling. We found that PDE4 inhibition with rolipram boosts P2Y11/IL-1R-induced upregulation of CXCR7 expression and CCL20 production in an epidermal growth factor recepto...
Source: Cellular and Molecular Life Sciences : CMLS - March 13, 2024 Category: Cytology Authors: Dominik Klaver Hubert Gander Beatrice Frena Marco Amato Martin Thurnher Source Type: research

Cancers, Vol. 16, Pages 1069: CA9, CYFIP2 and LGALS3BP & mdash;A Novel Biomarker Panel to Aid Prognostication in Glioma
Cancers, Vol. 16, Pages 1069: CA9, CYFIP2 and LGALS3BP&mdash;A Novel Biomarker Panel to Aid Prognostication in Glioma Cancers doi: 10.3390/cancers16051069 Authors: Amanda L. Hudson Angela Cho Emily K. Colvin Sarah A. Hayes Helen R. Wheeler Viive M. Howell Brain cancer is a devastating and life-changing disease. Biomarkers are becoming increasingly important in addressing clinical issues, including in monitoring tumour progression and assessing survival and treatment response. The goal of this study was to identify prognostic biomarkers associated with glioma progression. Discovery proteomic analysis w...
Source: Cancers - March 6, 2024 Category: Cancer & Oncology Authors: Amanda L. Hudson Angela Cho Emily K. Colvin Sarah A. Hayes Helen R. Wheeler Viive M. Howell Tags: Article Source Type: research

Methylation class oligosarcoma, IDH-mutant could exhibit astrocytoma-like molecular features
(Source: Acta Neuropathologica)
Source: Acta Neuropathologica - March 5, 2024 Category: Neurology Source Type: research

A multi-institutional phase I study of acetazolamide with temozolomide in adults with newly diagnosed < em > MGMT < /em > -methylated malignant glioma
CONCLUSIONS: The addition of acetazolamide is safe and tolerable in GBM patients receiving standard TMZ. Survival results compare favorably to historical data from randomized trials in patients with MGMT promoter-methylated GBM and support examination of acetazolamide in a randomized trial. BCL-3 expression is a potential biomarker for prognosis in GBM or for patients more likely to benefit from TMZ.PMID:38420615 | PMC:PMC10901541 | DOI:10.1093/noajnl/vdae014 (Source: Adv Data)
Source: Adv Data - February 29, 2024 Category: Epidemiology Authors: Riley K Driscoll Sean B Lyne David J Voce Stefania Maraka Vinai Gondi Steven J Chmura Karan S Dixit Priya U Kumthekar Theodore G Karrison Peter Pytel John M Collins Roger Stupp Ryan T Merrell Rimas V Lukas Bakhtiar Yamini Source Type: research

Primary central nervous system tumors survival in children in ten Colombian cities: a VIGICANCER report
ConclusionWe found that half of Colombia’s children and adolescents with primary CNS tumors survive five years, compared to 70% to 80% in high-income countries. In addition to tumor biology and location, gross total resection was crucial for improved survival in this cohort. Systematic monitoring of survival and its determinants provides empirical data for guiding cancer control policies. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - February 27, 2024 Category: Cancer & Oncology Source Type: research

The impact of wound-healing assay, phorbol myristate acetate (PMA) stimulation and siRNA-mediated FURIN gene silencing on endogenous retroviral ERVW-1 expression level in U87-MG astrocytoma cells
CONCLUSION: Results showed that mechanical impact affects the expression of endogenous retroviruses in U-87 MG astrocytoma cells by scratch assay. Regulation of FURIN, a crucial enzyme in ERVW-1 turnover may support the therapy of some neurological conditions.PMID:38403160 | DOI:10.1016/j.advms.2024.02.007 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 25, 2024 Category: Biomedical Science Authors: Grzegorz Machnik Łukasz Bułdak Karolina Zapletal-Pude łko Beniamin Oskar Grabarek Rafa ł Staszkiewicz Dawid Soba ński Bogus ław Okopień Source Type: research

The impact of wound-healing assay, phorbol myristate acetate (PMA) stimulation and siRNA-mediated FURIN gene silencing on endogenous retroviral ERVW-1 expression level in U87-MG astrocytoma cells
CONCLUSION: Results showed that mechanical impact affects the expression of endogenous retroviruses in U-87 MG astrocytoma cells by scratch assay. Regulation of FURIN, a crucial enzyme in ERVW-1 turnover may support the therapy of some neurological conditions.PMID:38403160 | DOI:10.1016/j.advms.2024.02.007 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 25, 2024 Category: Biomedical Science Authors: Grzegorz Machnik Łukasz Bułdak Karolina Zapletal-Pude łko Beniamin Oskar Grabarek Rafa ł Staszkiewicz Dawid Soba ński Bogus ław Okopień Source Type: research

The impact of wound-healing assay, phorbol myristate acetate (PMA) stimulation and siRNA-mediated FURIN gene silencing on endogenous retroviral ERVW-1 expression level in U87-MG astrocytoma cells
CONCLUSION: Results showed that mechanical impact affects the expression of endogenous retroviruses in U-87 MG astrocytoma cells by scratch assay. Regulation of FURIN, a crucial enzyme in ERVW-1 turnover may support the therapy of some neurological conditions.PMID:38403160 | DOI:10.1016/j.advms.2024.02.007 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 25, 2024 Category: Biomedical Science Authors: Grzegorz Machnik Łukasz Bułdak Karolina Zapletal-Pude łko Beniamin Oskar Grabarek Rafa ł Staszkiewicz Dawid Soba ński Bogus ław Okopień Source Type: research

The impact of wound-healing assay, phorbol myristate acetate (PMA) stimulation and siRNA-mediated FURIN gene silencing on endogenous retroviral ERVW-1 expression level in U87-MG astrocytoma cells
CONCLUSION: Results showed that mechanical impact affects the expression of endogenous retroviruses in U-87 MG astrocytoma cells by scratch assay. Regulation of FURIN, a crucial enzyme in ERVW-1 turnover may support the therapy of some neurological conditions.PMID:38403160 | DOI:10.1016/j.advms.2024.02.007 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 25, 2024 Category: Biomedical Science Authors: Grzegorz Machnik Łukasz Bułdak Karolina Zapletal-Pude łko Beniamin Oskar Grabarek Rafa ł Staszkiewicz Dawid Soba ński Bogus ław Okopień Source Type: research

The impact of wound-healing assay, phorbol myristate acetate (PMA) stimulation and siRNA-mediated FURIN gene silencing on endogenous retroviral ERVW-1 expression level in U87-MG astrocytoma cells
CONCLUSION: Results showed that mechanical impact affects the expression of endogenous retroviruses in U-87 MG astrocytoma cells by scratch assay. Regulation of FURIN, a crucial enzyme in ERVW-1 turnover may support the therapy of some neurological conditions.PMID:38403160 | DOI:10.1016/j.advms.2024.02.007 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 25, 2024 Category: Biomedical Science Authors: Grzegorz Machnik Łukasz Bułdak Karolina Zapletal-Pude łko Beniamin Oskar Grabarek Rafa ł Staszkiewicz Dawid Soba ński Bogus ław Okopień Source Type: research

Pilocytic astrocytoma: The paradigmatic entity in low ‑grade gliomas (Review)
Oncol Lett. 2024 Feb 8;27(4):146. doi: 10.3892/ol.2024.14279. eCollection 2024 Apr.ABSTRACTAmong low-grade gliomas, representing 10-20% of all primary brain tumours, the paradigmatic entity is constituted by pilocytic astrocytoma (PA), considered a grade 1 tumour by the World Health Organization. Generally, this tumour requires surgical treatment with an infrequent progression towards malignant gliomas. The present review focuses on clinicopathological characteristics, and reports imaging, neurosurgical and molecular features using a multidisciplinary approach. Macroscopically, PA is a slow-growing soft grey tissue, charac...
Source: Oncology Letters - February 22, 2024 Category: Cancer & Oncology Authors: Cristina Pizzimenti Vincenzo Fiorentino Antonino German ò Maurizio Martini Antonio Ieni Giovanni Tuccari Source Type: research