Pilomyxoid xanthoastrocytoma (PXA) : MRI
History– A 14 yr female c/o headache since 2 months. 2 episodes of seizures in last one weekFindings- An ill-defined soild-cystic mass is seen in the left parietal lobe with surrounding mild to moderate edema. The cystic component shows restriction of diffusion and rim enhancement. The solid component shows avid postcontrast enhancementFinal Diagnosis- Pilomyxoid xanthoastrocytoma (PXA)Golden PointDDs of cyst with mural nodule-Pilocytic astrocytoma, PXA, ganglioglioma, hemangioblastoma, craniopharyngioma Famous Radiology Blog by Dr Sumer Sethi www.sumersethi.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - February 9, 2022 Category: Radiology Authors: Sumer Sethi Source Type: blogs
cIMPACT-NOW Update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAFV600E mutation
This cIMPACT-NOW update was published this month:Summary:cIMPACT (Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) has reviewed the status of WHO grade II IDH-wt/H3-wt diffuse gliomas, focusing on those with a BRAFV600E mutation, FGFR1 alteration, or a MYB or MYBL1 rearrangement, and recommends the use of an integrated diagnosis to combine their histologic and genetic features. The consortium ecommends the use of an integrated diagnosis to combine their histologic and genetic features, as suggested in the following:Diffuse glioma, MYB...
Source: neuropathology blog - April 16, 2019 Category: Radiology Tags: molecular studies neoplasms Source Type: blogs
The growing role of end-of-life activists
Brittany Maynard was diagnosed with grade 2 astrocytoma, a form of brain cancer on January 1, 2014, her cancer also returned in April 2014, where her diagnosis was elevated to grade 4 astrocytoma, also known as glioblastoma, with a prognosis of just six months to live. She decided to take lethal drugs prescribed by her physician to end […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 31, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/jennifer-lynn" rel="tag" > Jennifer Lynn < /a > < /span > Tags: Conditions Hospital-Based Medicine Palliative Care Source Type: blogs
Cauda equina mass: An Approach
- CLINICAL PRESENTATION&FINDINGS 57 yr male with h/o low back pain with no h/o trauma presents for MRI lumbar spine which shows – Large relatively well defined , regular, intradural, subtly& heterogeneously enhancing SOL, seen from lower L3 border to middle of body of L5 with compression of cauda equina fibers, displaying mostly soft tissue signals on all sequences / normal meningeal enhancement, with no significant hemorrhage / fat / cystic / necrosis/ MR demonstrable calcification components / sugarcoating / scalloping or enlargement of the posterior neural e...
Source: Sumer's Radiology Site - January 12, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Best Post of June 2018: Who was Rosenthal?
Of the ten posts from June 2018, my favorite was " Who was Rosenthal? " from June 22. So, here ' s the next in our " Best of the Month " series:A Rosenthal fiber in pilocytic astrocytoma" In 1898, the German pathologist Werner Rosenthal noted elongated inclusions within the gliotic edge of a syringeal cavity of an ependymoma. Assigned to write the case report by a senior mentor while serving as a “first assistant” at the University of Erlangen, Rosenthal colorfully described these inclusions as a “glossy formation of little bulbs or wavy sausages with one thick and one pointed end.”…. His supp...
Source: neuropathology blog - August 10, 2018 Category: Radiology Tags: Best of the Month series history Source Type: blogs
Best Post of May 2018: Moving beyond histologic grading of IDH-wildtype diffuse astrocytic gliomas
The next in our " Best of the Month " series comes fromMay, 30, 2018:Despite the fact that the most recent update of the World Health Organization (WHO) classification of central nervous system tumors was published only two years ago, the data is already showing that we are moving beyond that classification system when if comes to IDH-wildtype diffuse astrocytomas. The concept of an " integrated diagnosis " in the setting of IDH-wildtype histologic grade II and III tumors has already been eclipsed in the literature by the primacy of the genetic signature over histologic appearance in predicting outcome. In the near future,...
Source: neuropathology blog - July 12, 2018 Category: Radiology Tags: Best of the Month series molecular studies neoplasms Source Type: blogs
Who was Rosenthal?
A Rosenthal fiber in pilocytic astrocytoma" In 1898, the German pathologist Werner Rosenthal noted elongated inclusions within the gliotic edge of a syringeal cavity of an ependymoma. Assigned to write the case report by a senior mentor while serving as a “first assistant” at theUniversity of Erlangen, Rosenthal colorfully described these inclusions as a “glossy formation of little bulbs or wavy sausages with one thick and one pointed end.”…. His supposition that they were related to glial fibers would prove surprisingly insightful. Not until some 20 years later did Bielschowsky and Unger use the t...
Source: neuropathology blog - June 22, 2018 Category: Radiology Tags: neoplasms Source Type: blogs
Pennies-on-a-plate cell in a pilocytic astrocytoma
Multinucleated astrocytes with peripherally situated nuclei like this one in a pilocytic astrocytomaare referred to as having a " pennies-on-a-plate " configurationThis is a common " degenerative " change seen in long-standing pilocytic astrocytomas. I ' m not sure from where this " pennies-on-a-plate " designation derives, but please leave a comment if you know. (Source: neuropathology blog)
Source: neuropathology blog - June 21, 2018 Category: Radiology Tags: neoplasms Source Type: blogs
Moving beyond histologic grading of IDH-wildtype diffuse astrocytic gliomas
Despite the fact that the most recent update of the World Health Organization (WHO) classification of central nervous system tumors was published only two years ago, the data is already showing that we are moving beyond that classification system when if comes to IDH-wildtype diffuse astrocytomas. The concept of an " integrated diagnosis " in the setting of IDH-wildtype histologic grade II and III tumors has already been eclipsed in the literature by the primacy of the genetic signature over histologic appearance in predicting outcome. In the near future, diffuse IDH-wildtype astrocytic gliomas with (1) combined whole chro...
Source: neuropathology blog - May 30, 2018 Category: Radiology Tags: neoplasms Source Type: blogs
Pilomyxoid astrocytoma
Angiocentricity, a hallmark of pilomyxoid astroctyoma, is demonstrated hereAlthough thought to be related to pilocytic astrocytoma, full characterization of pilomyxoid astrocytoma has yet to yield a definitive WHO grade for these tumors (although the prior edition of the WHO book pegged this tumor as grade II). Pilomyxoid astrocytomas differ from pilocytic astrocytomas in that they tend not to be biphasic or harbor Rosenthal fibers. (Source: neuropathology blog)
Source: neuropathology blog - May 2, 2018 Category: Radiology Tags: neoplasms Source Type: blogs
Join the #hpm Tweet Chat This Week in a Research Initiative with the Brain Cancer Quality of Life Collaborative
The Pallimed community is invited to participate in the #hpm Tweet Chat this week which help inform and shape a comparative effectiveness research proposal being designed by the Brain Cancer Quality of Life Collaborative, an initiative led by a team of patients, care partners, advocates, neuro-oncologists, and palliative care professionals.The #hpm Tweet Chat is this Wednesday, April 25th, 6-7p PST/9-10p ET.Topics for the chatare available here, in the #hpm chat ’s blog post,How might we introduce palliative care to people with complex neurological conditions, by Liz Salmi and Bethany Kwan, PhD, ...
Source: Pallimed: A Hospice and Palliative Medicine Blog - April 22, 2018 Category: Palliative Care Tags: #hpm brain cancer btsm tweetchat twitter Source Type: blogs
Should McCain Fight or Fold?
ANISH KOKA, MD
There are 80,000 new cases of primary brain tumors diagnosed every year in the United States. About 26,000 of these cases are of the malignant variety – and John McCain unfortunately joined their ranks last week. In cancer, fate is defined by cell type, and the adage is of particular relevance here.
Cancer is akin to a mutiny arising within the body, formed of regular every day cells that have forgotten the purpose they were born with. In the case of brain tumors, the mutinous cell frequently happens to not be the brain cell, but rather the lowly astrocyte that normally forms a matrix of support f...
Source: The Health Care Blog - July 24, 2017 Category: Consumer Health News Authors: anish_koka Tags: Physicians Anish Koka John McCain Source Type: blogs
Giving Cancer Hell
ANISH KOKA, MD
There are 80,000 new cases of primary brain tumors diagnosed every year in the United States. About 26,000 of these cases are of the malignant variety – and John McCain unfortunately joined their ranks last week. In cancer, fate is defined by cell type, and the adage is of particular relevance here.
Cancer is akin to a mutiny arising within the body, formed of regular every day cells that have forgotten the purpose they were born with. In the case of brain tumors, the mutinous cell frequently happens to not be the brain cell, but rather the lowly astrocyte that normally forms a matrix of support f...
Source: The Health Care Blog - July 24, 2017 Category: Consumer Health News Authors: anish_koka Tags: Physicians Anish Koka John McCain Source Type: blogs
Neuropathology Maintenance of Certification Topics
For those taking the maintenance of certification (MOC) examination at some point in the next few years, the American Board of Pathology (ABP) has published topics that may be covered in the examination. The examination consists of 150 multiple-choice questions, 50 of which are required to be in the a category designated " general neuropathology I " . The remaining 100 questions can be from various categories which the examinee chooses (general neuropathology II, degenerative I& II, developmental/pediatric/congenital I& II, neoplastic I& II, and neuromuscular I& II). The ABP provides an MOC examination...
Source: neuropathology blog - November 2, 2016 Category: Radiology Tags: MOC Source Type: blogs
