Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma
Conditions: Astrocytoma; Glioma; Recurrent Glioblastoma Interventions: Radiation: Radiation Therapy Sponsors: National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 3, 2024 Category: Research Source Type: clinical trials

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion
Conditions: High Grade Glioma; Diffuse Intrinsic Pontine Glioma; Anaplastic Astrocytoma; Infant Type Hemispheric Glioma; Glioblastoma; Glioblastoma Multiforme; WHO Grade III Glioma; WHO Grade IV Glioma; Diffuse Midline Glioma, H3K27-altered Interventions: Drug: Lorlatinib; Drug: Lorlatinib with chemotherapy1; Drug: Lorlatinib with chemotherapy 2; Drug: Lorlatinib post Radiation Sponsors: Nationwide Children ' s Hospital; Pfizer Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 27, 2024 Category: Research Source Type: clinical trials

The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)
Conditions: Glioblastoma; Glioblastoma Multiforme; Glioblastoma, IDH-wildtype; Glioblastoma Multiforme of Brain; Glioblastoma Multiforme, Adult; Recurrent Glioblastoma; Astrocytoma, Malignant; Astrocytoma of Brain Interventions: Procedure: Re-resection; Drug: Temozolomide; Drug: Lomustine; Radiation: Re-irradiation; Procedure: Experimental therapy; Other: Best supportive care Sponsors: Jasper Gerritsen; Haaglanden Medical Centre; Universitaire Ziekenhuizen KU Leuven; University Hospital Heidelberg; Technical University of Munich; Insel Gruppe AG, University Hospital Bern; Massachusetts General Hospital; University of Calif...
Source: ClinicalTrials.gov - February 28, 2024 Category: Research Source Type: clinical trials

The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma
Conditions: Glioblastoma, IDH-wildtype; Glioblastoma; Glioblastoma Multiforme of Brain; Astrocytoma, Malignant; Brain Neoplasms; Brain Neoplasms, Adult, Malignant; Brain Neoplasms, Adult; Recurrent Adult Brain Tumor; Recurrent Glioblastoma Interventions: Procedure: Awake mapping under local anesthesia; Procedure: Asleep mapping under general anesthesia; Procedure: Resection under general anesthesia without mapping Sponsors: Erasmus Medical Center; Haaglanden Medical Centre; Universitaire Ziekenhuizen KU Leuven; University Hospital Heidelberg; Technical University of Munich; Insel Gruppe AG, University Hospital Bern; Massac...
Source: ClinicalTrials.gov - February 22, 2024 Category: Research Source Type: clinical trials

A Biomarker-Guided Phase 2 Study of DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) Extended-Release Tablets
Conditions: High Grade Glioma; Anaplastic Astrocytoma Interventions: Drug: DB107-RRV; Drug: DB107-FC Sponsors: Ashish Shah; Denovo Biopharma LLC; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 19, 2024 Category: Research Source Type: clinical trials

Ga-68 Prostate Specific Membrane Antigen PET/CT in Gliomas
Conditions: Glioma; Astrocytoma; Anaplastic Astrocytoma; Oligodendroglioma; Glioblastoma Multiforme Interventions: Diagnostic Test: PSMA PET-CT Sponsors: All India Institute of Medical Sciences, Bhubaneswar Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 5, 2024 Category: Research Source Type: clinical trials

IDH1 and OCT4 in High Grade Astrocytoma
Conditions: High Grade Astrocytoma Interventions: Other: biomarkers analysis Sponsors: Assiut University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 19, 2024 Category: Research Source Type: clinical trials

Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1)
Conditions: Recurrent Malignant Glioma; Glioblastoma Multiforme of Brain; Gliosarcoma of Brain; Anaplastic Astrocytoma of Brain Interventions: Drug: C134 Re-Administration Sponsors: University of Alabama at Birmingham Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 5, 2024 Category: Research Source Type: clinical trials

Study of Olutasidenib and Temozolomide in HGG
Conditions: High Grade Glioma; Astrocytoma; Astrocytoma, Grade III; Astrocytoma, Grade IV; Diffuse Intrinsic Pontine Glioma; WHO Grade III Glioma; WHO Grade IV Glioma; Metastatic Brain Tumor; Diffuse Midline Glioma, H3 K27M-Mutant; Thalamus Tumor; Spinal Tumor; IDH1 Mutation; IDH1 R132; IDH1 R132C; IDH1 R132H; IDH1 R132S; IDH1 R132G; IDH1 R132L; Oligodendroglioma Interventions: Drug: Olutasidenib + TMZ Sponsors: Nationwide Children ' s Hospital; Rigel Pharmaceuticals Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 8, 2023 Category: Research Source Type: clinical trials

T Cells and Pembrolizumab for Recurrent and Newly Diagnosed Glioblastoma
Conditions: Glioblastoma Multiforme; Astrocytoma, Grade IV Interventions: Biological: Allogeneic cytomegalovirus-specific T cells; Drug: Pembrolizumab Sponsors: Queensland Institute of Medical Research; CUREator; Merck Sharp& Dohme LLC; The Newro Foundation; Royal Brisbane and Women ' s Hospital; Princess Alexandra Hospital, Brisbane, Australia; Austin Hospital, Melbourne Australia Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 6, 2023 Category: Research Source Type: clinical trials

The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients
Conditions: Glioblastoma; High-grade Glioma; Glioblastoma, IDH-wildtype; Glioblastoma, IDH-mutant; Glioblastoma Multiforme, Adult; Astrocytoma, Grade IV; Astrocytoma, Grade III; Astrocytoma, Malignant; Brain Neoplasms; Brain Neoplasm, Primary; Brain Neoplasms, Adult; Brain Neoplasm, Malignant Interventions: Procedure: Supramaximal resection; Procedure: Maximal safe resection Sponsors: Jasper Gerritsen; Haaglanden Medical Centre; Universitaire Ziekenhuizen KU Leuven; University Hospital Heidelberg; Technical University of Munich; Insel Gruppe AG, University Hospital Bern; Massachusetts General Hospital; University of Califo...
Source: ClinicalTrials.gov - November 6, 2023 Category: Research Source Type: clinical trials

Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma
Conditions: Glioblastoma; Anaplastic Astrocytoma; Astrocytoma; Anaplastic Oligodendroglioma Interventions: Other: Adaptive Radiotherapy Sponsors: Columbia University; Varian Medical Systems Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 30, 2023 Category: Research Source Type: clinical trials

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Conditions:   Diffuse Astrocytoma, IDH-Mutant;   Glioblastoma, IDH-wildtype;   Brain Metastases, Adult;   Cervical Cancer;   Colorectal Cancer;   Esophageal Cancer;   Esophageal Squamous Cell Carcinoma;   Gastric Cancer;   Gastroesophageal Junction Adenocarcinoma;   Head and Neck Squ amous Cell Carcinoma;   Melanoma;   Merkel Cell Carcinoma;   Microsatellite Instability-High Solid Malignant Tumor;   Mismatch Repair Deficient Solid Malignant Tumor;   Microsatellite Instability-High Colorectal Cancer;   Mismatch Repair Deficient Colorectal Cancer;   Non-smal l Cell Lung Ca...
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials