Cancers, Vol. 16, Pages 1637: Pentraxin 3: A Main Driver of Inflammation and Immune System Dysfunction in the Tumor Microenvironment of Glioblastoma
Paola Capra
Brain tumors are a heterogeneous group of brain neoplasms that are highly prevalent in individuals of all ages worldwide. Within this pathological framework, the most prevalent and aggressive type of primary brain tumor is glioblastoma (GB), a subtype of glioma that falls within the IV-grade astrocytoma group. The death rate for patients with GB remains high, occurring within a few months after diagnosis, even with the gold-standard therapies now available, such as surgery, radiation, or a pharmaceutical approach with Temozolomide. For this reason, it is crucial to continue looking for cutting-edge therape...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Sarah Adriana Scuderi Alessio Ardizzone Ayomide Eniola Salako Giuseppe Pant ò Fabiola De Luca Emanuela Esposito Anna Paola Capra Tags: Review Source Type: research
The role of apparent diffusion coefficient in the grading of adult isocitrate dehydrogenase-mutant astrocytomas: relationship with the Ki-67 proliferation index
CONCLUSION: Conventional MRI features and ADC are valuable to predict pathological grading of adult IDH-mutant astrocytomas.PMID:38644751 | DOI:10.1177/02841851241242653 (Source: Acta Radiologica)
Source: Acta Radiologica - April 22, 2024 Category: Radiology Authors: Yingxia She Xianwang Liu Jian Jiang Xuwen Wang Qian Niu Junlin Zhou Source Type: research
Single is not combined: the role of Co and Ni bioavailability on toxicity mechanisms in liver and brain cells
In this study, we focused on the treatment of liver carcinoma (HepG2) and astrocytoma (CCF-STTG1) cells as a model for the target sites of these two metals. We investigated their effects in single and combined exposure on cell survival, cell death mechanisms, bioavailability, and the induction of oxidative stress. The combination of CoCl2 and NiCl2 resulted in higher Co levels with subsequent decreased amount of Ni compared to the individual treatment. Only CoCl2 and the combination of both metals led to RONS induction and increased GSSG formation, while apoptosis and necrosis seem to be involved in the cell death mechanis...
Source: Chemosphere - April 22, 2024 Category: Chemistry Authors: Alicia Thiel Vivien Michaelis Marco Restle Sabrina Figge Martin Simon Tanja Schwerdtle Julia Bornhorst Source Type: research
Single is not combined: the role of Co and Ni bioavailability on toxicity mechanisms in liver and brain cells
In this study, we focused on the treatment of liver carcinoma (HepG2) and astrocytoma (CCF-STTG1) cells as a model for the target sites of these two metals. We investigated their effects in single and combined exposure on cell survival, cell death mechanisms, bioavailability, and the induction of oxidative stress. The combination of CoCl2 and NiCl2 resulted in higher Co levels with subsequent decreased amount of Ni compared to the individual treatment. Only CoCl2 and the combination of both metals led to RONS induction and increased GSSG formation, while apoptosis and necrosis seem to be involved in the cell death mechanis...
Source: Chemosphere - April 22, 2024 Category: Chemistry Authors: Alicia Thiel Vivien Michaelis Marco Restle Sabrina Figge Martin Simon Tanja Schwerdtle Julia Bornhorst Source Type: research
Multi-omics technologies and molecular biomarkers in brain tumor-related epilepsy
CONCLUSIONS: Based on the synthesized information, this review provided new research perspectives and insights into the early diagnosis, etiological factors, and personalized treatment of BTRE.PMID:38641945 | PMC:PMC11031674 | DOI:10.1111/cns.14717 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 20, 2024 Category: Neuroscience Authors: Yaoqiang Du Rusong Li Danqing Fu Biqin Zhang Ailin Cui Yutian Shao Zeyu Lai Rongrong Chen Bingyu Chen Zhen Wang Wei Zhang Lisheng Chu Source Type: research
Cancers, Vol. 16, Pages 1543: Predicting Isocitrate Dehydrogenase Status in Non-Contrast-Enhanced Adult-Type Astrocytic Tumors Using Diffusion Tensor Imaging and 11C-Methionine, 11C-Choline, and 18F-Fluorodeoxyglucose PET
da
Tsuyoshi Izumo
We aimed to differentiate the isocitrate dehydrogenase (IDH) status among non-enhanced astrocytic tumors using preoperative MRI and PET. We analyzed 82 patients with non-contrast-enhanced, diffuse, supratentorial astrocytic tumors (IDH mutant [IDH-mut], 55 patients; IDH-wildtype [IDH-wt], 27 patients) who underwent MRI and PET between May 2012 and December 2022. We calculated the fractional anisotropy (FA) and mean diffusivity (MD) values using diffusion tensor imaging. We evaluated the tumor/normal brain uptake (T/N) ratios using 11C-methionine, 11C-choline, and 18F-fluorodeoxyglucose PET; extracte...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Shoji Yasuda Hirohito Yano Yuka Ikegame Soko Ikuta Takashi Maruyama Morio Kumagai Yoshihiro Muragaki Toru Iwama Jun Shinoda Tsuyoshi Izumo Tags: Article Source Type: research
Rare vermian pilocytic astrocytoma with recurrent spontaneous hemorrhage in the elderly: A case report and review of literature
CONCLUSION: PA in the elderly is a rare disease with distinct histologic and genetic peculiarities. This case review showed one of the oldest cases of cerebellar vermian PA presenting with recurrent spontaneous intratumoral hemorrhage, an extremely rare occurrence in benign glioma. Although complete surgical excision is recommended, partial resection is advocated for morbidly adherent tumors. Overall prognosis is worse in elderly PA.PMID:38628526 | PMC:PMC11021065 | DOI:10.25259/SNI_978_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Campbell Chukwuebuka Francis Kohei Kanaya Kohei Nagamine Tetsuya Goto Tetsuyoshi Horiuchi Samuel Chukwunonyerem Ohaegbulam Source Type: research
A cohort study of CNS tumors in Multiple Endocrine Neoplasia Type 1
CONCLUSIONS: Incidence of each CNS tumor was higher in the MEN1 population than in the French general population. Meningiomas and ependymomas should be considered part of the MEN1 syndrome, but somatic molecular data are missing to conclude for astrocytomas and schwannomas.PMID:38630553 | DOI:10.1158/1078-0432.CCR-23-3308 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 17, 2024 Category: Cancer & Oncology Authors: Thomas Graillon Pauline Romanet Clara Camilla Camille Gelin Romain Appay Catherine Roche Arnaud Lagarde Gr égory Mougel Kaissar Farah Ma ëlle Le Bras Julien Engelhardt Michel Kalamarides Matthieu Peyre Aymeric Amelot Evelyne Emery Elsa Magro Helene Cebu Source Type: research
Rare vermian pilocytic astrocytoma with recurrent spontaneous hemorrhage in the elderly: A case report and review of literature
CONCLUSION: PA in the elderly is a rare disease with distinct histologic and genetic peculiarities. This case review showed one of the oldest cases of cerebellar vermian PA presenting with recurrent spontaneous intratumoral hemorrhage, an extremely rare occurrence in benign glioma. Although complete surgical excision is recommended, partial resection is advocated for morbidly adherent tumors. Overall prognosis is worse in elderly PA.PMID:38628526 | PMC:PMC11021065 | DOI:10.25259/SNI_978_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Campbell Chukwuebuka Francis Kohei Kanaya Kohei Nagamine Tetsuya Goto Tetsuyoshi Horiuchi Samuel Chukwunonyerem Ohaegbulam Source Type: research
A cohort study of CNS tumors in Multiple Endocrine Neoplasia Type 1
CONCLUSIONS: Incidence of each CNS tumor was higher in the MEN1 population than in the French general population. Meningiomas and ependymomas should be considered part of the MEN1 syndrome, but somatic molecular data are missing to conclude for astrocytomas and schwannomas.PMID:38630553 | DOI:10.1158/1078-0432.CCR-23-3308 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 17, 2024 Category: Cancer & Oncology Authors: Thomas Graillon Pauline Romanet Clara Camilla Camille Gelin Romain Appay Catherine Roche Arnaud Lagarde Gr égory Mougel Kaissar Farah Ma ëlle Le Bras Julien Engelhardt Michel Kalamarides Matthieu Peyre Aymeric Amelot Evelyne Emery Elsa Magro Helene Cebu Source Type: research
Rare vermian pilocytic astrocytoma with recurrent spontaneous hemorrhage in the elderly: A case report and review of literature
CONCLUSION: PA in the elderly is a rare disease with distinct histologic and genetic peculiarities. This case review showed one of the oldest cases of cerebellar vermian PA presenting with recurrent spontaneous intratumoral hemorrhage, an extremely rare occurrence in benign glioma. Although complete surgical excision is recommended, partial resection is advocated for morbidly adherent tumors. Overall prognosis is worse in elderly PA.PMID:38628526 | PMC:PMC11021065 | DOI:10.25259/SNI_978_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Campbell Chukwuebuka Francis Kohei Kanaya Kohei Nagamine Tetsuya Goto Tetsuyoshi Horiuchi Samuel Chukwunonyerem Ohaegbulam Source Type: research
Cancers, Vol. 16, Pages 1516: Proteomic Analysis of Spatial Heterogeneity Identifies HMGB2 as Putative Biomarker of Tumor Progression in Adult-Type Diffuse Astrocytomas
gia Grosu
Arnab Chakravarti
Although grading is defined by the highest histological grade observed in a glioma, most high-grade gliomas retain areas with histology reminiscent of their low-grade counterparts. We sought to achieve the following: (i) identify proteins and molecular pathways involved in glioma evolution; and (ii) validate the high mobility group protein B2 (HMGB2) as a key player in tumor progression and as a prognostic/predictive biomarker for diffuse astrocytomas. We performed liquid chromatography tandem mass spectrometry (LC-MS/MS) in multiple areas of adult-type astrocytomas and validated our findi...
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Aline P. Becker Valesio Becker Joseph McElroy Amy Webb Chunhua Han Yingshi Guo Erica H. Bell Jessica Fleming Ilinca Popp Ori Staszewski Marco Prinz Jose J. Otero Saikh Jaharul Haque Anca-Ligia Grosu Arnab Chakravarti Tags: Article Source Type: research
Pilocytic Astrocytoma of the fourth ventricle: A case report
Asian J Surg. 2024 Apr 11:S1015-9584(24)00619-5. doi: 10.1016/j.asjsur.2024.03.192. Online ahead of print.NO ABSTRACTPMID:38609825 | DOI:10.1016/j.asjsur.2024.03.192 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 12, 2024 Category: Surgery Authors: Ting Zhao Li Guo Yan-Yu Qian Hao Guo Source Type: research
Cancers, Vol. 16, Pages 1474: Human-Level Differentiation of Medulloblastoma from Pilocytic Astrocytoma: A Real-World Multicenter Pilot Study
Johann
Hau
Frühwald
Medulloblastoma and pilocytic astrocytoma are the two most common pediatric brain tumors with overlapping imaging features. In this proof-of-concept study, we investigated using a deep learning classifier trained on a multicenter data set to differentiate these tumor types. We developed a patch-based 3D-DenseNet classifier, utilizing automated tumor segmentation. Given the heterogeneity of imaging data (and available sequences), we used all individually available preoperative imaging sequences to make the model robust to varying input. We compared the classifier to diagnostic assessments by f...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Wiestler Bison Behrens T üchert Metz Griessmair Jakob Schlegel Binder von Luettichau Metzler Johann Hau Fr ühwald Tags: Article Source Type: research
