Expression of KCNN4 in adult-type diffuse gliomas and its correlations with clinicopathological features and patient prognosis
CONCLUSIONS: KCNN4 was identified to be overexpressed in glioma cells and its expression level is positively related to tumor malignancy. It potentially participates in glioma biology by affecting extracellular regulation, subcellular trafficking, and immune escape. Additionally, high KCNN4 expression was correlated with poor survival outcomes of patients. The results can shed new light on the mechanisms of glioma progression, and provide a potential therapeutic target for treating gliomas.PMID:38555740 | DOI:10.1016/j.tranon.2024.101947 (Source: Translational Oncology)
Source: Translational Oncology - March 31, 2024 Category: Cancer & Oncology Authors: Jun Yang Zhuonan Pu Xiaorong Tao Jiajia Liu Ke Li Jiawei Shi Hui Qiao Xing Fan Source Type: research

Volumetric Response and Survival of Patients With Bulky IDH-Mutated Grade 3 Glioma Managed With FET-FDG-Guided Integrated Boost IMRT
CONCLUSION: Patients with large volume IDH-mutant Grade 3 glioma demonstrated significant tumour reduction post-IMRT, and good long-term outcomes with respect to survival and functional status. Although larger IMRT volumes were associated with poorer RFS, this was also associated with the initial volume of non-enhancing tumour.PMID:38553362 | DOI:10.1016/j.clon.2024.03.002 (Source: Cancer Control)
Source: Cancer Control - March 29, 2024 Category: Cancer & Oncology Authors: D Mills P Horsley V Venkatasha M Back Source Type: research

Agonists or positive allosteric modulators of α7 nicotinic acetylcholine receptor prevent interaction of SARS-Cov-2 receptor-binding domain with astrocytoma cells
Biochem Biophys Res Commun. 2024 Mar 25;709:149825. doi: 10.1016/j.bbrc.2024.149825. Online ahead of print.ABSTRACTSARS-Cov-2, the virus causing COVID-19, penetrates host target cells via the receptor of angiotensin-converting enzyme 2 (ACE2). Disrupting the virus interaction with ACE2 affords a plausible mechanism for prevention of cell penetration and inhibiting dissemination of the virus. Our studies demonstrate that ACE2 interaction with the receptor binding domain of SARS-Cov-2 spike protein (RBD) can be impaired by modulating the α7 nicotinic acetylcholine receptor (α7 nAChR) contiguous with ACE2. U373 cells of hum...
Source: Biochemical and Biophysical Research communications - March 27, 2024 Category: Biochemistry Authors: Olena Kalashnyk Olena Lykhmus Raymond Sullivan Serhiy Komisarenko Maryna Skok Source Type: research

Novel hybrid compounds of sclareol and doxorubicin as potential anticancer nanotherapy for glioblastoma
Biomed Pharmacother. 2024 Mar 26;174:116496. doi: 10.1016/j.biopha.2024.116496. Online ahead of print.ABSTRACTTwo novel hybrid compounds, CON1 and CON2, have been developed by combining sclareol (SC) and doxorubicin (DOX) into a single molecular entity. These hybrid compounds have a 1:1 molar ratio of covalently linked SC and DOX. They have demonstrated promising anticancer properties, especially in glioblastoma cells, and have also shown potential in treating multidrug-resistant (MDR) cancer cells that express the P-glycoprotein (P-gp) membrane transporter. CON1 and CON2 form nanoparticles, as confirmed by Zetasizer, tran...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 27, 2024 Category: Drugs & Pharmacology Authors: Ana Stepanovi ć Nata ša Terzić Jovanović Aleksandra Kora ć Mario Zlatovi ć Igor Nikoli ć Igor Opsenica Milica Pe šić Source Type: research

Agonists or positive allosteric modulators of α7 nicotinic acetylcholine receptor prevent interaction of SARS-Cov-2 receptor-binding domain with astrocytoma cells
Biochem Biophys Res Commun. 2024 Mar 25;709:149825. doi: 10.1016/j.bbrc.2024.149825. Online ahead of print.ABSTRACTSARS-Cov-2, the virus causing COVID-19, penetrates host target cells via the receptor of angiotensin-converting enzyme 2 (ACE2). Disrupting the virus interaction with ACE2 affords a plausible mechanism for prevention of cell penetration and inhibiting dissemination of the virus. Our studies demonstrate that ACE2 interaction with the receptor binding domain of SARS-Cov-2 spike protein (RBD) can be impaired by modulating the α7 nicotinic acetylcholine receptor (α7 nAChR) contiguous with ACE2. U373 cells of hum...
Source: Biochemical and Biophysical Research communications - March 27, 2024 Category: Biochemistry Authors: Olena Kalashnyk Olena Lykhmus Raymond Sullivan Serhiy Komisarenko Maryna Skok Source Type: research

Primary central nervous system tumors survival in children in ten Colombian cities: a VIGICANCER report
CONCLUSION: We found that half of Colombia's children and adolescents with primary CNS tumors survive five years, compared to 70% to 80% in high-income countries. In addition to tumor biology and location, gross total resection was crucial for improved survival in this cohort. Systematic monitoring of survival and its determinants provides empirical data for guiding cancer control policies.PMID:38505512 | PMC:PMC10949889 | DOI:10.3389/fonc.2023.1326788 (Source: Cancer Control)
Source: Cancer Control - March 20, 2024 Category: Cancer & Oncology Authors: Oscar Ramirez Vivian Piedrahita Jesus Ardila Carlos Pardo Edgar Cabrera-Bernal John Lopera Amaranto Suarez Carlos Andr és Portilla Carlos Narv áez Pamela Rodriguez Ximena Castro Ángel Castro Diego Ivan Estupinan-Perico Diana Valencia Mar ía Del Rosari Source Type: research

High costs, low quality of life, reduced survival, and room for improving treatment: an analysis of burden and unmet needs in glioma
Gliomas are a group of heterogeneous tumors that account for substantial morbidity, mortality, and costs to patients and healthcare systems globally. Survival varies considerably by grade, histology, biomarkers, and genetic alterations such as IDH mutations and MGMT promoter methylation, and treatment, but is poor for some grades and histologies, with many patients with glioblastoma surviving less than a year from diagnosis. The present review provides an introduction to glioma, including its classification, epidemiology, economic and humanistic burden, as well as treatment options. Another focus is on treatment recommenda...
Source: Frontiers in Oncology - March 20, 2024 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 16, Pages 1223: Proteomic Profiling of Cerebrospinal Fluid and Its Extracellular Vesicles from Extraventricular Drainage in Pediatric Pilocytic Astrocytoma, towards Precision Oncology
Maurizio Bruschi Pediatric pilocytic astrocytoma (PA) is the most common brain tumor in children. Complete resection provides a favorable prognosis, except for unresectable PA forms. There is an incomplete understanding of the molecular and cellular pathogenesis of PA. Potential biomarkers for PA patients, especially the non-BRAF-mutated ones are needed. Cerebrospinal fluid (CSF) is a valuable source of brain tumor biomarkers. Extracellular vesicles (EVs), circulating in CSF, express valuable disease targets. These can be isolated from CSF from waste extraventricular drainage (EVD). We analyzed the proteome of EVD C...
Source: Cancers - March 20, 2024 Category: Cancer & Oncology Authors: Sonia Spinelli Xhuliana Kajana Andrea Garbarino Martina Bartolucci Andrea Petretto Marco Pavanello Enrico Verrina Giovanni Candiano Isabella Panfoli Maurizio Bruschi Tags: Article Source Type: research

How does deep learning/ machine learning perform in comparison to radiologists in distinguishing Glioblastomas (or grade IV Astrocytomas) from Primary CNS Lymphomas?: A meta-analysis and systematic review
Several studies have been published comparing deep learning (DL)/machine learning (ML) to radiologists in differentiating PCNSLs from GBMs with equivocal results. We aimed to perform this meta-analysis to evaluate the diagnostic accuracy of ML/DL versus radiologists in classifying PCNSL versus GBM using MRI. (Source: Clinical Radiology)
Source: Clinical Radiology - March 19, 2024 Category: Radiology Authors: Amrita Guha, Soutik Halder, Shubham H. Shinde, Jitendra Gawde, Satish Munnolli, Sanjay Talole, Jayant S. Goda Source Type: research

How does deep learning/machine learning perform in comparison to radiologists in distinguishing glioblastomas (or grade IV astrocytomas) from primary CNS lymphomas?: a meta-analysis and systematic review
Several studies have been published comparing deep learning (DL)/machine learning (ML) to radiologists in differentiating PCNSLs from GBMs with equivocal results. We aimed to perform this meta-analysis to evaluate the diagnostic accuracy of ML/DL versus radiologists in classifying PCNSL versus GBM using MRI. (Source: Clinical Radiology)
Source: Clinical Radiology - March 19, 2024 Category: Radiology Authors: A. Guha, S. Halder, S.H. Shinde, J. Gawde, S. Munnolli, S. Talole, J.S. Goda Source Type: research

Intratumoral histological and molecular heterogeneity in an adult diffuse glioma
Clin Neuropathol. 2024 Mar 15. doi: 10.5414/NP301598. Online ahead of print.ABSTRACTAdult-type diffuse gliomas are the most prevalent type of malignant adult brain tumors. Intratumoral heterogeneity can hinder accurate diagnosis and subsequent treatment. This case report documents a tumor with intratumoral heterogeneity, both histologically and by methylation analysis, located within the left cerebral hemisphere of a 29-year-old female. She presented after a witnessed generalized tonic clonic seizure at home. Two years prior she had a witnessed seizure; however, no brain imaging was done at the time. Magnetic resonance ima...
Source: Clinical Neuropathology - March 18, 2024 Category: Pathology Authors: Trishhani Yogaretnam Josephine Heffernan Rosa Leung Ciara Heeney Andrea Walsh Seamus Looby John Caird Francesca M Brett Source Type: research

Intratumoral histological and molecular heterogeneity in an adult diffuse glioma
Clin Neuropathol. 2024 Mar 15. doi: 10.5414/NP301598. Online ahead of print.ABSTRACTAdult-type diffuse gliomas are the most prevalent type of malignant adult brain tumors. Intratumoral heterogeneity can hinder accurate diagnosis and subsequent treatment. This case report documents a tumor with intratumoral heterogeneity, both histologically and by methylation analysis, located within the left cerebral hemisphere of a 29-year-old female. She presented after a witnessed generalized tonic clonic seizure at home. Two years prior she had a witnessed seizure; however, no brain imaging was done at the time. Magnetic resonance ima...
Source: Clinical Neuropathology - March 18, 2024 Category: Pathology Authors: Trishhani Yogaretnam Josephine Heffernan Rosa Leung Ciara Heeney Andrea Walsh Seamus Looby John Caird Francesca M Brett Source Type: research

Intratumoral histological and molecular heterogeneity in an adult diffuse glioma
Clin Neuropathol. 2024 Mar 15. doi: 10.5414/NP301598. Online ahead of print.ABSTRACTAdult-type diffuse gliomas are the most prevalent type of malignant adult brain tumors. Intratumoral heterogeneity can hinder accurate diagnosis and subsequent treatment. This case report documents a tumor with intratumoral heterogeneity, both histologically and by methylation analysis, located within the left cerebral hemisphere of a 29-year-old female. She presented after a witnessed generalized tonic clonic seizure at home. Two years prior she had a witnessed seizure; however, no brain imaging was done at the time. Magnetic resonance ima...
Source: Clinical Neuropathology - March 18, 2024 Category: Pathology Authors: Trishhani Yogaretnam Josephine Heffernan Rosa Leung Ciara Heeney Andrea Walsh Seamus Looby John Caird Francesca M Brett Source Type: research

Effects of cognitive-motor intervention for pediatric posterior fossa tumor survivors: results of a pilot study
AbstractThe purpose of this prospective pilot study was to evaluate the feasibility and effects of cognitive-motor intervention on the cognitive and motor abilities of pediatric survivors of posterior fossa tumors. The study involved patients aged 7 to 18 years with cognitive deficits who had completed primary treatment for posterior fossa tumors. 25 participants (Mage=11.3  ± 2.93, 64% male; 17 medulloblastoma, 1 ependymoma, 1 desmoplastic medulloblastoma, 6 piloid astrocytoma; 22 in remission (Mmonths =45), 3 in stabilization (Mmonths=49)) were recruited from the Research Institute for Brain Development and Peak Per...
Source: Journal of Neuro-Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research

Regulation of astrocyte metabolism by mitochondrial translocator protein 18  kDa
Astrocytes are key players in maintaining central nervous system (CNS) homeostasis. Proper control of cellular bioenergetics is essential for this, and poor control of astrocyte bioenergetics may underlie many CNS conditions. We hypothesized that translocator protein 18  kDa (TSPO) regulates the metabolism of astrocytes and thus serves as a therapeutic target. In two models, TSPO deficiency reduced bioenergetic rates and lactate release, while promoting bioenergetic resistance to glucose withdrawal and fatty acid oxidation (FAO). Following lipopolysaccharide (LPS ) stimulation, TSPO deficient astrocytes showed no change ...
Source: Journal of Neurochemistry - March 14, 2024 Category: Neuroscience Authors: Wyn Firth, Josephine L. Robb, Daisy Stewart, Katherine R. Pye, Rosemary Bamford, Asami Oguro ‐Ando, Craig Beall, Kate L. J. Ellacott Tags: ORIGINAL ARTICLE Source Type: research