The impact of wound-healing assay, phorbol myristate acetate (PMA) stimulation and siRNA-mediated FURIN gene silencing on endogenous retroviral ERVW-1 expression level in U87-MG astrocytoma cells
CONCLUSION: Results showed that mechanical impact affects the expression of endogenous retroviruses in U-87 MG astrocytoma cells by scratch assay. Regulation of FURIN, a crucial enzyme in ERVW-1 turnover may support the therapy of some neurological conditions.PMID:38403160 | DOI:10.1016/j.advms.2024.02.007 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 25, 2024 Category: Biomedical Science Authors: Grzegorz Machnik Łukasz Bułdak Karolina Zapletal-Pude łko Beniamin Oskar Grabarek Rafa ł Staszkiewicz Dawid Soba ński Bogus ław Okopień Source Type: research
The impact of wound-healing assay, phorbol myristate acetate (PMA) stimulation and siRNA-mediated FURIN gene silencing on endogenous retroviral ERVW-1 expression level in U87-MG astrocytoma cells
CONCLUSION: Results showed that mechanical impact affects the expression of endogenous retroviruses in U-87 MG astrocytoma cells by scratch assay. Regulation of FURIN, a crucial enzyme in ERVW-1 turnover may support the therapy of some neurological conditions.PMID:38403160 | DOI:10.1016/j.advms.2024.02.007 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 25, 2024 Category: Biomedical Science Authors: Grzegorz Machnik Łukasz Bułdak Karolina Zapletal-Pude łko Beniamin Oskar Grabarek Rafa ł Staszkiewicz Dawid Soba ński Bogus ław Okopień Source Type: research
The impact of wound-healing assay, phorbol myristate acetate (PMA) stimulation and siRNA-mediated FURIN gene silencing on endogenous retroviral ERVW-1 expression level in U87-MG astrocytoma cells
CONCLUSION: Results showed that mechanical impact affects the expression of endogenous retroviruses in U-87 MG astrocytoma cells by scratch assay. Regulation of FURIN, a crucial enzyme in ERVW-1 turnover may support the therapy of some neurological conditions.PMID:38403160 | DOI:10.1016/j.advms.2024.02.007 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 25, 2024 Category: Biomedical Science Authors: Grzegorz Machnik Łukasz Bułdak Karolina Zapletal-Pude łko Beniamin Oskar Grabarek Rafa ł Staszkiewicz Dawid Soba ński Bogus ław Okopień Source Type: research
The impact of wound-healing assay, phorbol myristate acetate (PMA) stimulation and siRNA-mediated FURIN gene silencing on endogenous retroviral ERVW-1 expression level in U87-MG astrocytoma cells
CONCLUSION: Results showed that mechanical impact affects the expression of endogenous retroviruses in U-87 MG astrocytoma cells by scratch assay. Regulation of FURIN, a crucial enzyme in ERVW-1 turnover may support the therapy of some neurological conditions.PMID:38403160 | DOI:10.1016/j.advms.2024.02.007 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 25, 2024 Category: Biomedical Science Authors: Grzegorz Machnik Łukasz Bułdak Karolina Zapletal-Pude łko Beniamin Oskar Grabarek Rafa ł Staszkiewicz Dawid Soba ński Bogus ław Okopień Source Type: research
Pilocytic astrocytoma: The paradigmatic entity in low ‑grade gliomas (Review)
Oncol Lett. 2024 Feb 8;27(4):146. doi: 10.3892/ol.2024.14279. eCollection 2024 Apr.ABSTRACTAmong low-grade gliomas, representing 10-20% of all primary brain tumours, the paradigmatic entity is constituted by pilocytic astrocytoma (PA), considered a grade 1 tumour by the World Health Organization. Generally, this tumour requires surgical treatment with an infrequent progression towards malignant gliomas. The present review focuses on clinicopathological characteristics, and reports imaging, neurosurgical and molecular features using a multidisciplinary approach. Macroscopically, PA is a slow-growing soft grey tissue, charac...
Source: Oncology Letters - February 22, 2024 Category: Cancer & Oncology Authors: Cristina Pizzimenti Vincenzo Fiorentino Antonino German ò Maurizio Martini Antonio Ieni Giovanni Tuccari Source Type: research
The potential of liquid biopsy for detection of the KIAA1549-BRAF fusion in circulating tumor DNA from children with pilocytic astrocytoma
CONCLUSIONS: While CNV analysis of CSF samples from LGGs still has some limitations, it has the potential to serve as a valuable complementary tool. Furthermore, it can also be multiplexed with other aberrations, for example, to the BRAF V600 test, to provide important insights into the molecular characteristics of LGGs.PMID:38371226 | PMC:PMC10874216 | DOI:10.1093/noajnl/vdae008 (Source: Adv Data)
Source: Adv Data - February 19, 2024 Category: Epidemiology Authors: Olha Krynina Teresita D íaz de Ståhl Cecilia Jylh ä Cecilia Arthur Geraldine Giraud Per Nyman Anders Fritzberg Johanna Sandgren Emma Tham Ulrika Sandvik Source Type: research
The potential of liquid biopsy for detection of the KIAA1549-BRAF fusion in circulating tumor DNA from children with pilocytic astrocytoma
CONCLUSIONS: While CNV analysis of CSF samples from LGGs still has some limitations, it has the potential to serve as a valuable complementary tool. Furthermore, it can also be multiplexed with other aberrations, for example, to the BRAF V600 test, to provide important insights into the molecular characteristics of LGGs.PMID:38371226 | PMC:PMC10874216 | DOI:10.1093/noajnl/vdae008 (Source: Adv Data)
Source: Adv Data - February 19, 2024 Category: Epidemiology Authors: Olha Krynina Teresita D íaz de Ståhl Cecilia Jylh ä Cecilia Arthur Geraldine Giraud Per Nyman Anders Fritzberg Johanna Sandgren Emma Tham Ulrika Sandvik Source Type: research
Radio-pathomic maps of glioblastoma identify phenotypes of non-enhancing tumor infiltration associated with bevacizumab treatment response
ConclusionPatients with a hypocellular tumor front identified by radio-pathomic maps showed improved treatment efficacy when treated with bevacizumab, and reducing hypocellular volumes over the course of treatment may indicate treatment response. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 19, 2024 Category: Cancer & Oncology Source Type: research
The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma
ConclusionsTOP2-RNA is a highly sensitive assay for detecting fusion genes, exon skipping, and aberrant gene expression. Alterations in targetable driver genes were identified in more than 50% of glioblastoma. Molecular profiling by TOP2-RNA provides ample predictive, prognostic, and diagnostic biomarkers that may not be identified by conventional assays and, therefore, is expected to increase treatment options for individual patients with glioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 16, 2024 Category: Cancer & Oncology Source Type: research
Correction to: CDKN2A/B deletion in IDH-mutant astrocytomas: An evaluation by Fluorescence in-situ hybridization
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 15, 2024 Category: Cancer & Oncology Source Type: research
Distant recurrence in the cerebellar dentate nucleus through the dentato-rubro-thalamo-cortical pathway in supratentorial glioma cases
ConclusionDistant recurrence along the DRTC pathway is not rare in astrocytomas, GB, or DMG at the frontal lobe or thalamus. Recurrence in the DN developed as a result of the infiltration of tumor cells through the DRTC pathway, not dissemination through the CSF. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - February 14, 2024 Category: Neurosurgery Source Type: research
