A subregion-based RadioFusionOmics model discriminates between grade 4 astrocytoma and glioblastoma on multisequence MRI
ConclusionThe performance of subregions defined by clustering was comparable to that of subregions that were manually defined. Fusion of features from the edematous subregions of multiple MRI sequences by the RFO model resulted in differentiation between grade 4 astrocytoma and glioblastoma. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 2, 2024 Category: Cancer & Oncology Source Type: research

Suppression of antitumor immune signatures and upregulation of VEGFA as IDH-mutant gliomas progress to higher grade
CONCLUSIONS: Here, the authors have provided a transcriptomic analysis of a progression cohort for IDH-mutant glioma. Compared with lower-grade tumors, grade 4 astrocytomas displayed alterations that may inform the timing of antiangiogenic and immune-based therapy as these tumors progress.PMID:38301244 | DOI:10.3171/2023.11.FOCUS23694 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - February 1, 2024 Category: Neurosurgery Authors: Eric P Grewal Leland G K Richardson Jing Sun Rishab Ramapriyan Maria Martinez-Lage Julie J Miller Daniel P Cahill Bryan D Choi William T Curry Source Type: research

Radiographic growth rate as a predictor of aggressiveness of diffuse gliomas without 1p19q codeletion
CONCLUSIONS: The spontaneous radiographic tumor growth rates could be used as an additional tool to preoperatively screen tumor aggressiveness of adult-type diffuse gliomas without 1p19q codeletion.PMID:38301236 | DOI:10.3171/2023.11.FOCUS23648 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - February 1, 2024 Category: Neurosurgery Authors: Arthur Leclerc Alexandre Roux Angela Elia Sophie Peeters Oumaima Aboubakr Aziz Bedioui Martin Planet Joseph Benzakoun Giorgia Antonia Simboli Arnault Tauziede-Espariat Alessandro Moiraghi Pascale Varlet Fabrice Chr étien Catherine Oppenheim Marc Zanello Source Type: research

From molecular signatures to radiomics: tailoring neurooncological strategies through forecasting of glioma growth
CONCLUSIONS: The authors developed an advanced statistical model to predict tumor volumes both pre- and postoperatively, using comprehensive data prior to the initiation of adjuvant therapy. Using radiomics enhanced the precision of the prediction models. Whereas tumor extent of resection and topology emerged as influential factors in tumor growth, the IDH status did not. This study emphasizes the imperative of advanced computational methods in refining personalized low-grade glioma treatment, advocating a move beyond traditional paradigms.PMID:38301234 | DOI:10.3171/2023.11.FOCUS23685 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - February 1, 2024 Category: Neurosurgery Authors: Philip Rauch Martin Aichholzer Carlo Serra Olivier Zanier Victor E Staartjes Petra B öhm Gregor Seyer Helga Wagner Ilja Manakov Michael Sonnberger Nico Stroh Stefan Aspalter Kathrin Aufschnaiter-Hiessb öck Tobias Rossmann Annette Leibetseder Stefan Katl Source Type: research

Suppression of antitumor immune signatures and upregulation of VEGFA as IDH-mutant gliomas progress to higher grade
CONCLUSIONS: Here, the authors have provided a transcriptomic analysis of a progression cohort for IDH-mutant glioma. Compared with lower-grade tumors, grade 4 astrocytomas displayed alterations that may inform the timing of antiangiogenic and immune-based therapy as these tumors progress.PMID:38301244 | DOI:10.3171/2023.11.FOCUS23694 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - February 1, 2024 Category: Neurosurgery Authors: Eric P Grewal Leland G K Richardson Jing Sun Rishab Ramapriyan Maria Martinez-Lage Julie J Miller Daniel P Cahill Bryan D Choi William T Curry Source Type: research

Radiographic growth rate as a predictor of aggressiveness of diffuse gliomas without 1p19q codeletion
CONCLUSIONS: The spontaneous radiographic tumor growth rates could be used as an additional tool to preoperatively screen tumor aggressiveness of adult-type diffuse gliomas without 1p19q codeletion.PMID:38301236 | DOI:10.3171/2023.11.FOCUS23648 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - February 1, 2024 Category: Neurosurgery Authors: Arthur Leclerc Alexandre Roux Angela Elia Sophie Peeters Oumaima Aboubakr Aziz Bedioui Martin Planet Joseph Benzakoun Giorgia Antonia Simboli Arnault Tauziede-Espariat Alessandro Moiraghi Pascale Varlet Fabrice Chr étien Catherine Oppenheim Marc Zanello Source Type: research

From molecular signatures to radiomics: tailoring neurooncological strategies through forecasting of glioma growth
CONCLUSIONS: The authors developed an advanced statistical model to predict tumor volumes both pre- and postoperatively, using comprehensive data prior to the initiation of adjuvant therapy. Using radiomics enhanced the precision of the prediction models. Whereas tumor extent of resection and topology emerged as influential factors in tumor growth, the IDH status did not. This study emphasizes the imperative of advanced computational methods in refining personalized low-grade glioma treatment, advocating a move beyond traditional paradigms.PMID:38301234 | DOI:10.3171/2023.11.FOCUS23685 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - February 1, 2024 Category: Neurosurgery Authors: Philip Rauch Martin Aichholzer Carlo Serra Olivier Zanier Victor E Staartjes Petra B öhm Gregor Seyer Helga Wagner Ilja Manakov Michael Sonnberger Nico Stroh Stefan Aspalter Kathrin Aufschnaiter-Hiessb öck Tobias Rossmann Annette Leibetseder Stefan Katl Source Type: research

Suppression of antitumor immune signatures and upregulation of VEGFA as IDH-mutant gliomas progress to higher grade
CONCLUSIONS: Here, the authors have provided a transcriptomic analysis of a progression cohort for IDH-mutant glioma. Compared with lower-grade tumors, grade 4 astrocytomas displayed alterations that may inform the timing of antiangiogenic and immune-based therapy as these tumors progress.PMID:38301244 | DOI:10.3171/2023.11.FOCUS23694 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - February 1, 2024 Category: Neurosurgery Authors: Eric P Grewal Leland G K Richardson Jing Sun Rishab Ramapriyan Maria Martinez-Lage Julie J Miller Daniel P Cahill Bryan D Choi William T Curry Source Type: research

Radiographic growth rate as a predictor of aggressiveness of diffuse gliomas without 1p19q codeletion
CONCLUSIONS: The spontaneous radiographic tumor growth rates could be used as an additional tool to preoperatively screen tumor aggressiveness of adult-type diffuse gliomas without 1p19q codeletion.PMID:38301236 | DOI:10.3171/2023.11.FOCUS23648 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - February 1, 2024 Category: Neurosurgery Authors: Arthur Leclerc Alexandre Roux Angela Elia Sophie Peeters Oumaima Aboubakr Aziz Bedioui Martin Planet Joseph Benzakoun Giorgia Antonia Simboli Arnault Tauziede-Espariat Alessandro Moiraghi Pascale Varlet Fabrice Chr étien Catherine Oppenheim Marc Zanello Source Type: research

From molecular signatures to radiomics: tailoring neurooncological strategies through forecasting of glioma growth
CONCLUSIONS: The authors developed an advanced statistical model to predict tumor volumes both pre- and postoperatively, using comprehensive data prior to the initiation of adjuvant therapy. Using radiomics enhanced the precision of the prediction models. Whereas tumor extent of resection and topology emerged as influential factors in tumor growth, the IDH status did not. This study emphasizes the imperative of advanced computational methods in refining personalized low-grade glioma treatment, advocating a move beyond traditional paradigms.PMID:38301234 | DOI:10.3171/2023.11.FOCUS23685 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - February 1, 2024 Category: Neurosurgery Authors: Philip Rauch Martin Aichholzer Carlo Serra Olivier Zanier Victor E Staartjes Petra B öhm Gregor Seyer Helga Wagner Ilja Manakov Michael Sonnberger Nico Stroh Stefan Aspalter Kathrin Aufschnaiter-Hiessb öck Tobias Rossmann Annette Leibetseder Stefan Katl Source Type: research

Suppression of antitumor immune signatures and upregulation of VEGFA as IDH-mutant gliomas progress to higher grade
CONCLUSIONS: Here, the authors have provided a transcriptomic analysis of a progression cohort for IDH-mutant glioma. Compared with lower-grade tumors, grade 4 astrocytomas displayed alterations that may inform the timing of antiangiogenic and immune-based therapy as these tumors progress.PMID:38301244 | DOI:10.3171/2023.11.FOCUS23694 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - February 1, 2024 Category: Neurosurgery Authors: Eric P Grewal Leland G K Richardson Jing Sun Rishab Ramapriyan Maria Martinez-Lage Julie J Miller Daniel P Cahill Bryan D Choi William T Curry Source Type: research

Radiographic growth rate as a predictor of aggressiveness of diffuse gliomas without 1p19q codeletion
CONCLUSIONS: The spontaneous radiographic tumor growth rates could be used as an additional tool to preoperatively screen tumor aggressiveness of adult-type diffuse gliomas without 1p19q codeletion.PMID:38301236 | DOI:10.3171/2023.11.FOCUS23648 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - February 1, 2024 Category: Neurosurgery Authors: Arthur Leclerc Alexandre Roux Angela Elia Sophie Peeters Oumaima Aboubakr Aziz Bedioui Martin Planet Joseph Benzakoun Giorgia Antonia Simboli Arnault Tauziede-Espariat Alessandro Moiraghi Pascale Varlet Fabrice Chr étien Catherine Oppenheim Marc Zanello Source Type: research

From molecular signatures to radiomics: tailoring neurooncological strategies through forecasting of glioma growth
CONCLUSIONS: The authors developed an advanced statistical model to predict tumor volumes both pre- and postoperatively, using comprehensive data prior to the initiation of adjuvant therapy. Using radiomics enhanced the precision of the prediction models. Whereas tumor extent of resection and topology emerged as influential factors in tumor growth, the IDH status did not. This study emphasizes the imperative of advanced computational methods in refining personalized low-grade glioma treatment, advocating a move beyond traditional paradigms.PMID:38301234 | DOI:10.3171/2023.11.FOCUS23685 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - February 1, 2024 Category: Neurosurgery Authors: Philip Rauch Martin Aichholzer Carlo Serra Olivier Zanier Victor E Staartjes Petra B öhm Gregor Seyer Helga Wagner Ilja Manakov Michael Sonnberger Nico Stroh Stefan Aspalter Kathrin Aufschnaiter-Hiessb öck Tobias Rossmann Annette Leibetseder Stefan Katl Source Type: research

Suppression of antitumor immune signatures and upregulation of VEGFA as IDH-mutant gliomas progress to higher grade
CONCLUSIONS: Here, the authors have provided a transcriptomic analysis of a progression cohort for IDH-mutant glioma. Compared with lower-grade tumors, grade 4 astrocytomas displayed alterations that may inform the timing of antiangiogenic and immune-based therapy as these tumors progress.PMID:38301244 | DOI:10.3171/2023.11.FOCUS23694 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - February 1, 2024 Category: Neurosurgery Authors: Eric P Grewal Leland G K Richardson Jing Sun Rishab Ramapriyan Maria Martinez-Lage Julie J Miller Daniel P Cahill Bryan D Choi William T Curry Source Type: research

Radiographic growth rate as a predictor of aggressiveness of diffuse gliomas without 1p19q codeletion
CONCLUSIONS: The spontaneous radiographic tumor growth rates could be used as an additional tool to preoperatively screen tumor aggressiveness of adult-type diffuse gliomas without 1p19q codeletion.PMID:38301236 | DOI:10.3171/2023.11.FOCUS23648 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - February 1, 2024 Category: Neurosurgery Authors: Arthur Leclerc Alexandre Roux Angela Elia Sophie Peeters Oumaima Aboubakr Aziz Bedioui Martin Planet Joseph Benzakoun Giorgia Antonia Simboli Arnault Tauziede-Espariat Alessandro Moiraghi Pascale Varlet Fabrice Chr étien Catherine Oppenheim Marc Zanello Source Type: research