The potential of liquid biopsy for detection of the KIAA1549-BRAF fusion in circulating tumor DNA from children with pilocytic astrocytoma
CONCLUSIONS: While CNV analysis of CSF samples from LGGs still has some limitations, it has the potential to serve as a valuable complementary tool. Furthermore, it can also be multiplexed with other aberrations, for example, to the BRAF V600 test, to provide important insights into the molecular characteristics of LGGs.PMID:38371226 | PMC:PMC10874216 | DOI:10.1093/noajnl/vdae008 (Source: Adv Data)
Source: Adv Data - February 19, 2024 Category: Epidemiology Authors: Olha Krynina Teresita D íaz de Ståhl Cecilia Jylh ä Cecilia Arthur Geraldine Giraud Per Nyman Anders Fritzberg Johanna Sandgren Emma Tham Ulrika Sandvik Source Type: research

The potential of liquid biopsy for detection of the KIAA1549-BRAF fusion in circulating tumor DNA from children with pilocytic astrocytoma
CONCLUSIONS: While CNV analysis of CSF samples from LGGs still has some limitations, it has the potential to serve as a valuable complementary tool. Furthermore, it can also be multiplexed with other aberrations, for example, to the BRAF V600 test, to provide important insights into the molecular characteristics of LGGs.PMID:38371226 | PMC:PMC10874216 | DOI:10.1093/noajnl/vdae008 (Source: Adv Data)
Source: Adv Data - February 19, 2024 Category: Epidemiology Authors: Olha Krynina Teresita D íaz de Ståhl Cecilia Jylh ä Cecilia Arthur Geraldine Giraud Per Nyman Anders Fritzberg Johanna Sandgren Emma Tham Ulrika Sandvik Source Type: research

Radio-pathomic maps of glioblastoma identify phenotypes of non-enhancing tumor infiltration associated with bevacizumab treatment response
ConclusionPatients with a hypocellular tumor front identified by radio-pathomic maps showed improved treatment efficacy when treated with bevacizumab, and reducing hypocellular volumes over the course of treatment may indicate treatment response. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 19, 2024 Category: Cancer & Oncology Source Type: research

The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma
ConclusionsTOP2-RNA is a highly sensitive assay for detecting fusion genes, exon skipping, and aberrant gene expression. Alterations in targetable driver genes were identified in more than 50% of glioblastoma. Molecular profiling by TOP2-RNA provides ample predictive, prognostic, and diagnostic biomarkers that may not be identified by conventional assays and, therefore, is expected to increase treatment options for individual patients with glioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 16, 2024 Category: Cancer & Oncology Source Type: research

Correction to: CDKN2A/B deletion in IDH-mutant astrocytomas: An evaluation by Fluorescence in-situ hybridization
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 15, 2024 Category: Cancer & Oncology Source Type: research

Distant recurrence in the cerebellar dentate nucleus through the dentato-rubro-thalamo-cortical pathway in supratentorial glioma cases
ConclusionDistant recurrence along the DRTC pathway is not rare in astrocytomas, GB, or DMG at the frontal lobe or thalamus. Recurrence in the DN developed as a result of the infiltration of tumor cells through the DRTC pathway, not dissemination through the CSF. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - February 14, 2024 Category: Neurosurgery Source Type: research

Naringenin Nanoformulations for Neurodegenerative Diseases
Curr Pharm Biotechnol. 2024 Feb 12. doi: 10.2174/0113892010281459240118091137. Online ahead of print.ABSTRACTGlioblastoma (GBM) is a grade-IV astrocytoma, which is the most common and aggressive type of brain tumor, spreads rapidly and has a life-threatening catastrophic effect. GBM mostly occurs in adults with an average survival time of 15 to 18 months, and the overall mortality rate is 5%. Significant invasion and drug resistance activity cause the poor diagnosis of GBM. Naringenin (NRG) is a plant secondary metabolite byproduct of the flavanone subgroup. NRG can cross the blood-brain barrier and deliver drugs into the ...
Source: Current Pharmaceutical Biotechnology - February 13, 2024 Category: Biotechnology Authors: Liza Sahoo Nigam Sekhar Tripathy Fahima Dilnawaz Source Type: research

Patterns of T2-FLAIR discordance across a cohort of adult-type diffuse gliomas and deviations from the classic T2-FLAIR mismatch sign
ConclusionT2-FLAIR discordance patterns in adult-type diffuse LrGGs exist on a diverging but distinct spectrum of classic mismatch to T2-FLAIR  matched patterns. Specific molecular markers may play a role in deviations from classic mismatch sign. (Source: Neuroradiology)
Source: Neuroradiology - February 13, 2024 Category: Radiology Source Type: research

MGMT unmethylation and high levels of CD47 and TIGIT indicate a poor prognosis in adult diffuse gliomas
This study reclassified the adult diffuse glioma (ADG) into astrocytoma, oligodendroglioma, and glioblastoma (GBM) according to the new tumor classification.MethodsThe association of TERT promoter (pTERT) mutation, MGMT methylation, and CD47/TIGIT expression with patient prognosis was investigated.ResultsImmunohistochemical analysis showed that the expression levels of CD47 and TIGIT in tumor tissues were significantly higher than those in normal brain tissues. CD47 levels were higher in GBM and grade 4 astrocytoma tissues. TIGIT expression was also higher in patients with GBM. The high expressions of CD47, TIGIT, and CD47...
Source: Frontiers in Immunology - February 9, 2024 Category: Allergy & Immunology Source Type: research

Repeat surgery of recurrent glioma for molecularly informed treatment in the age of precision oncology: A risk –benefit analysis
ConclusionSurgery for recurrent glioma provides relevant molecular diagnostic information with a direct consequence for targeted therapy under a reasonable risk of postoperative complications. With satisfactory postoperative survival it can therefore complement a multi-modal glioma therapy approach. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 9, 2024 Category: Cancer & Oncology Source Type: research

Algorithmic approach utilizing histology and immunohistochemistry for the current classification of diffuse glioma
CONCLUSION: Implementation of combined phenotypic-genotypic diagnosis with the use of histomorphology and immunohistochemical surrogates for molecular genetic alterations will yield more homogeneous and narrowly defined diagnostic entities which will provide better prognostication and definitive treatment. It also is cost-effective in a resource-limited setup.PMID:38322173 | PMC:PMC10839248 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 7, 2024 Category: Pathology Authors: Chandni Bhandary Panambur Subhashini Ramamoorthy Bheemanathi Hanuman Srinivas Sree Rekha Jinkala Surendar Kumar Verma Gopalakrishnan Madhavan Sasidharan Source Type: research

Algorithmic approach utilizing histology and immunohistochemistry for the current classification of diffuse glioma
CONCLUSION: Implementation of combined phenotypic-genotypic diagnosis with the use of histomorphology and immunohistochemical surrogates for molecular genetic alterations will yield more homogeneous and narrowly defined diagnostic entities which will provide better prognostication and definitive treatment. It also is cost-effective in a resource-limited setup.PMID:38322173 | PMC:PMC10839248 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 7, 2024 Category: Pathology Authors: Chandni Bhandary Panambur Subhashini Ramamoorthy Bheemanathi Hanuman Srinivas Sree Rekha Jinkala Surendar Kumar Verma Gopalakrishnan Madhavan Sasidharan Source Type: research

Algorithmic approach utilizing histology and immunohistochemistry for the current classification of diffuse glioma
CONCLUSION: Implementation of combined phenotypic-genotypic diagnosis with the use of histomorphology and immunohistochemical surrogates for molecular genetic alterations will yield more homogeneous and narrowly defined diagnostic entities which will provide better prognostication and definitive treatment. It also is cost-effective in a resource-limited setup.PMID:38322173 | PMC:PMC10839248 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 7, 2024 Category: Pathology Authors: Chandni Bhandary Panambur Subhashini Ramamoorthy Bheemanathi Hanuman Srinivas Sree Rekha Jinkala Surendar Kumar Verma Gopalakrishnan Madhavan Sasidharan Source Type: research

Algorithmic approach utilizing histology and immunohistochemistry for the current classification of diffuse glioma
CONCLUSION: Implementation of combined phenotypic-genotypic diagnosis with the use of histomorphology and immunohistochemical surrogates for molecular genetic alterations will yield more homogeneous and narrowly defined diagnostic entities which will provide better prognostication and definitive treatment. It also is cost-effective in a resource-limited setup.PMID:38322173 | PMC:PMC10839248 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 7, 2024 Category: Pathology Authors: Chandni Bhandary Panambur Subhashini Ramamoorthy Bheemanathi Hanuman Srinivas Sree Rekha Jinkala Surendar Kumar Verma Gopalakrishnan Madhavan Sasidharan Source Type: research