Cancers, Vol. 16, Pages 1516: Proteomic Analysis of Spatial Heterogeneity Identifies HMGB2 as Putative Biomarker of Tumor Progression in Adult-Type Diffuse Astrocytomas
gia Grosu
Arnab Chakravarti
Although grading is defined by the highest histological grade observed in a glioma, most high-grade gliomas retain areas with histology reminiscent of their low-grade counterparts. We sought to achieve the following: (i) identify proteins and molecular pathways involved in glioma evolution; and (ii) validate the high mobility group protein B2 (HMGB2) as a key player in tumor progression and as a prognostic/predictive biomarker for diffuse astrocytomas. We performed liquid chromatography tandem mass spectrometry (LC-MS/MS) in multiple areas of adult-type astrocytomas and validated our findi...
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Aline P. Becker Valesio Becker Joseph McElroy Amy Webb Chunhua Han Yingshi Guo Erica H. Bell Jessica Fleming Ilinca Popp Ori Staszewski Marco Prinz Jose J. Otero Saikh Jaharul Haque Anca-Ligia Grosu Arnab Chakravarti Tags: Article Source Type: research
Pilocytic Astrocytoma of the fourth ventricle: A case report
Asian J Surg. 2024 Apr 11:S1015-9584(24)00619-5. doi: 10.1016/j.asjsur.2024.03.192. Online ahead of print.NO ABSTRACTPMID:38609825 | DOI:10.1016/j.asjsur.2024.03.192 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 12, 2024 Category: Surgery Authors: Ting Zhao Li Guo Yan-Yu Qian Hao Guo Source Type: research
Cancers, Vol. 16, Pages 1474: Human-Level Differentiation of Medulloblastoma from Pilocytic Astrocytoma: A Real-World Multicenter Pilot Study
Johann
Hau
Frühwald
Medulloblastoma and pilocytic astrocytoma are the two most common pediatric brain tumors with overlapping imaging features. In this proof-of-concept study, we investigated using a deep learning classifier trained on a multicenter data set to differentiate these tumor types. We developed a patch-based 3D-DenseNet classifier, utilizing automated tumor segmentation. Given the heterogeneity of imaging data (and available sequences), we used all individually available preoperative imaging sequences to make the model robust to varying input. We compared the classifier to diagnostic assessments by f...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Wiestler Bison Behrens T üchert Metz Griessmair Jakob Schlegel Binder von Luettichau Metzler Johann Hau Fr ühwald Tags: Article Source Type: research
Intratumoral heterogeneity of CDKN2A deletions in IDH-mutant astrocytoma
(Source: Brain Tumor Pathology)
Source: Brain Tumor Pathology - April 10, 2024 Category: Neurology Source Type: research
Pediatric-Like Brain Tumors in Adults
Adv Tech Stand Neurosurg. 2024;50:147-183. doi: 10.1007/978-3-031-53578-9_5.ABSTRACTPediatric brain tumors are different to those found in adults in pathological type, anatomical site, molecular signature, and probable tumor drivers. Although these tumors usually occur in childhood, they also rarely present in adult patients, either as a de novo diagnosis or as a delayed recurrence of a pediatric tumor in the setting of a patient that has transitioned into adult services.Due to the rarity of pediatric-like tumors in adults, the literature on these tumor types in adults is often limited to small case series, and treatment d...
Source: Advances and Technical Standards in Neurosurgery - April 9, 2024 Category: Neurosurgery Authors: Sandra Fernandes Dias Oliver Richards Martin Elliot Paul Chumas Source Type: research
