Astrocytoma Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Naringenin Nanoformulations for Neurodegenerative Diseases
Curr Pharm Biotechnol. 2024 Feb 12. doi: 10.2174/0113892010281459240118091137. Online ahead of print.ABSTRACTGlioblastoma (GBM) is a grade-IV astrocytoma, which is the most common and aggressive type of brain tumor, spreads rapidly and has a life-threatening catastrophic effect. GBM mostly occurs in adults with an average survival time of 15 to 18 months, and the overall mortality rate is 5%. Significant invasion and drug resistance activity cause the poor diagnosis of GBM. Naringenin (NRG) is a plant secondary metabolite byproduct of the flavanone subgroup. NRG can cross the blood-brain barrier and deliver drugs into the ...
Source: Current Pharmaceutical Biotechnology - February 13, 2024 Category: Biotechnology Authors: Liza Sahoo Nigam Sekhar Tripathy Fahima Dilnawaz Source Type: research

Patterns of T2-FLAIR discordance across a cohort of adult-type diffuse gliomas and deviations from the classic T2-FLAIR mismatch sign
ConclusionT2-FLAIR discordance patterns in adult-type diffuse LrGGs exist on a diverging but distinct spectrum of classic mismatch to T2-FLAIR matched patterns. Specific molecular markers may play a role in deviations from classic mismatch sign. (Source: Neuroradiology)
Source: Neuroradiology - February 13, 2024 Category: Radiology Source Type: research

MGMT unmethylation and high levels of CD47 and TIGIT indicate a poor prognosis in adult diffuse gliomas
This study reclassified the adult diffuse glioma (ADG) into astrocytoma, oligodendroglioma, and glioblastoma (GBM) according to the new tumor classification.MethodsThe association of TERT promoter (pTERT) mutation, MGMT methylation, and CD47/TIGIT expression with patient prognosis was investigated.ResultsImmunohistochemical analysis showed that the expression levels of CD47 and TIGIT in tumor tissues were significantly higher than those in normal brain tissues. CD47 levels were higher in GBM and grade 4 astrocytoma tissues. TIGIT expression was also higher in patients with GBM. The high expressions of CD47, TIGIT, and CD47...
Source: Frontiers in Immunology - February 9, 2024 Category: Allergy & Immunology Source Type: research

Repeat surgery of recurrent glioma for molecularly informed treatment in the age of precision oncology: A risk –benefit analysis
ConclusionSurgery for recurrent glioma provides relevant molecular diagnostic information with a direct consequence for targeted therapy under a reasonable risk of postoperative complications. With satisfactory postoperative survival it can therefore complement a multi-modal glioma therapy approach. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 9, 2024 Category: Cancer & Oncology Source Type: research

Algorithmic approach utilizing histology and immunohistochemistry for the current classification of diffuse glioma
CONCLUSION: Implementation of combined phenotypic-genotypic diagnosis with the use of histomorphology and immunohistochemical surrogates for molecular genetic alterations will yield more homogeneous and narrowly defined diagnostic entities which will provide better prognostication and definitive treatment. It also is cost-effective in a resource-limited setup.PMID:38322173 | PMC:PMC10839248 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 7, 2024 Category: Pathology Authors: Chandni Bhandary Panambur Subhashini Ramamoorthy Bheemanathi Hanuman Srinivas Sree Rekha Jinkala Surendar Kumar Verma Gopalakrishnan Madhavan Sasidharan Source Type: research