The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma

ConclusionsTOP2-RNA is a highly sensitive assay for detecting fusion genes, exon skipping, and aberrant gene expression. Alterations in targetable driver genes were identified in more than 50% of glioblastoma. Molecular profiling by TOP2-RNA provides ample predictive, prognostic, and diagnostic biomarkers that may not be identified by conventional assays and, therefore, is expected to increase treatment options for individual patients with glioma.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research