Neither Amphetamine nor Sub-Anesthetic Ketamine Treatment during Adolescence Impairs Devaluation in Rats Tested during Adulthood
CONCLUSIONS: We discuss possible reasons for this discrepancy with the prior literature, including (1) the age of exposure and (2) the pattern in the previous literature that most previous demonstrations of drug exposure impairing devaluation in laboratory animals may be attributed to either drug-associated cues present in the testing environment and/or accelerated habit learning in tasks that predispose laboratory animals towards habit formation with extended training (with training procedures that should resist the formation of habits in the current experiment). However, additional research is needed to examine the effec...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Ian R Davis Hayley Fisher Caitlin McLean Jackson Murray Charles L Pickens Source Type: research
Dexmedetomidine Pretreatment Confers Myocardial Protection and Reduces Mechanical Ventilation Duration for Patients Undergoing Cardiac Valve Replacement under Cardiopulmonary Bypass
CONCLUSION: The study suggests that 0.50 µg/kg Dex pretreatment could reduce propofol use and the duration of mechanical ventilation, and confer myocardial protection without increased adverse events during cardiac valve replacement.PMID:38684422 | DOI:10.5761/atcs.oa.23-00210 (Source: Annals of Thoracic and Cardiovascular Surgery)
Source: Annals of Thoracic and Cardiovascular Surgery - April 29, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Binglin Yuan Xiqiang Huang Junlin Wen Mengzhe Peng Source Type: research
Safety of tranexamic acid in surgically treated isolated spine trauma
CONCLUSION: Our study demonstrated that TXA is safe for isolated spine trauma. It is challenging to determine whether TXA effectively reduces blood loss because most surgeons prefer TXA for open or multilevel cases. Further, larger studies are necessary to explore the rate, dosage, and mode of administration of TXA.PMID:38680673 | PMC:PMC11045465 | DOI:10.5312/wjo.v15.i4.346 (Source: World Journal of Orthopaedics)
Source: World Journal of Orthopaedics - April 29, 2024 Category: Orthopaedics Authors: Wajiha Zahra Sandeep Krishan Nayar Ashwin Bhadresha Vinay Jasani Syed Aftab Source Type: research
Tissue oxygen saturation is positively correlated with oxygen delivery and cardiac output in a canine hemorrhagic shock and resuscitation model
Am J Vet Res. 2024 May 1:1-6. doi: 10.2460/ajvr.23.12.0297. Online ahead of print.ABSTRACTOBJECTIVE: To determine if tissue oxygen saturation (StO2) correlates with oxygen delivery (DO2) and/or cardiac output (CO) in a canine hemorrhagic shock model.ANIMALS: 8 healthy purpose-bred dogs.METHODS: Dogs were anesthetized, and hemorrhagic shock was induced by withdrawing up to 60% of total blood volume, targeting a mean arterial pressure (MAP) of 40 mm Hg. The withdrawn blood was returned to the patient in 2 equal aliquots. Data was collected at 4 time points: 10 minutes after MAP was stabilized under anesthesia (time point [TP...
Source: American Journal of Veterinary Research - April 29, 2024 Category: Veterinary Research Authors: Taylor N Baird Charles T Talbot Kelly E Hall Ann M Hess Kristin M Zersen Source Type: research
Practice Guidelines for Central Venous Access 2020 - Time for German Guidelines
Anasthesiol Intensivmed Notfallmed Schmerzther. 2024 Apr;59(4):252-262. doi: 10.1055/a-1690-5730. Epub 2024 Apr 29.ABSTRACTThe American Society of Anesthesiologists released practice guidelines for central venous access in 2020, and the entire world literature was examined for evidence on how to perform the entire process with best practice and minimal risk and harm to the patient. These guidelines may serve as a gold standard for individual procedural steps, allowing practitioners and hospital departments to critically question the own standard and improve upon them.We interpreted the guidelines for individual procedural ...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - April 29, 2024 Category: Intensive Care Authors: Wolf Armbruster R üdiger Eichholz Thomas Notheisen Source Type: research
Median Effective Dose of Ciprofol Combined With Sufentanil for Inhibiting the Upper Gastrointestinal Endoscopic Placement Reaction in Elderly Patients
CONCLUSION: The ED50 of ciprofol in combination with sufentanil (0.1 μg/kg) for upper gastrointestinal endoscopy in elderly patients: 0.23 mg/kg in group A and 0.18 mg/kg in group B.PMID:38680849 | PMC:PMC11055479 | DOI:10.1177/15593258241248931 (Source: Dose Response)
Source: Dose Response - April 29, 2024 Category: Drugs & Pharmacology Authors: Haojing Xiong Hechen Xu Yang Yang Bailong Hu Ke Jiang Xiaohua Zou Source Type: research
A piezoelectric-driven microneedle platform for skin disease therapy
Innovation (Camb). 2024 Apr 5;5(3):100621. doi: 10.1016/j.xinn.2024.100621. eCollection 2024 May 6.ABSTRACTWith over a million cases detected each year, skin disease is a global public health problem that diminishes the quality of life due to its difficulty to eradicate, propensity for recurrence, and potential for post-treatment scarring. Photodynamic therapy (PDT) is a treatment with minimal invasiveness or scarring and few side effects, making it well tolerated by patients. However, this treatment requires further research and development to improve its effective clinical use. Here, a piezoelectric-driven microneedle (P...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Ziyan Chen Xin Liu Zixi Jiang Huayi Wu Tao Yang Lanyuan Peng Lisha Wu Zhongling Luo Mi Zhang Juan Su Yan Tang Jinmao Li Yang Xie Han Shan Qibo Lin Xiuli Wang Xiang Chen Hanmin Peng Shuang Zhao Zeyu Chen Source Type: research
A prospective randomized comparative trial of pediatric C-MAC D-blade video laryngoscope with McCoy direct laryngoscope for intubation in children posted for elective surgical procedures under general anesthesia
CONCLUSION: The C-MAC video laryngoscope size 2 D-blade provided faster and better glottic visualization but similar intubation difficulty compared to McCoy size 2 laryngoscope in children. The shorter time to achieve glottic view demonstrated with the C-MAC failed to translate into a shorter total duration of intubation when compared to the McCoy laryngoscope attributable to a pronounced curvature of the D-blade.PMID:38682461 | DOI:10.1111/pan.14911 (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - April 29, 2024 Category: Anesthesiology Authors: Geeta Kamal Divyamedha Agarwal Shilpa Agarwal Anju Gupta Aikta Gupta Bhumika Kalra Nishkarsh Gupta Source Type: research
Neither Amphetamine nor Sub-Anesthetic Ketamine Treatment during Adolescence Impairs Devaluation in Rats Tested during Adulthood
CONCLUSIONS: We discuss possible reasons for this discrepancy with the prior literature, including (1) the age of exposure and (2) the pattern in the previous literature that most previous demonstrations of drug exposure impairing devaluation in laboratory animals may be attributed to either drug-associated cues present in the testing environment and/or accelerated habit learning in tasks that predispose laboratory animals towards habit formation with extended training (with training procedures that should resist the formation of habits in the current experiment). However, additional research is needed to examine the effec...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Ian R Davis Hayley Fisher Caitlin McLean Jackson Murray Charles L Pickens Source Type: research
Assessment of the Occupational Radiation Exposure of Anesthesia Staff in Interventional Cardiology
(Source: Risk Management and Healthcare Policy)
Source: Risk Management and Healthcare Policy - April 29, 2024 Category: Health Management Tags: Risk Management and Healthcare Policy Source Type: research
Short ‐term outcomes after liver resection with vascular reconstruction: Results from a study with the National Clinical Database of Japan
ConclusionsThe NCD revealed the detailed status of liver resection combined with vascular reconstruction in Japan. Based on the results of this analysis, understanding the factors that influence the outcome and postoperative course of each procedure will provide patients with accurate information and opportunities to improve future outcomes. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - April 29, 2024 Category: Gastroenterology Authors: Akihiko Soyama,
Hiroyuki Yamamoto,
Susumu Eguchi,
Atsushi Nanashima,
Yoshihiro Kakeji,
Yuko Kitagawa,
Masafumi Nakamura,
Itaru Endo Tags: ORIGINAL ARTICLE Source Type: research
Total spinal anaesthesia following obstetric neuraxial blockade: a narrative review
Total spinal anaesthesia (TSA) is a recognised complication of all neuraxial local anaesthetic (LA) techniques. It refers to a high neuraxial block causing respiratory failure and/or loss of consciousness, usually requiring airway intervention.1 –7 In contrast to other emergencies, there are few evidence-based guidelines for its prevention and treatment. We have performed a narrative review which aims to describe the epidemiology, pathophysiology and management of TSA. (Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - April 29, 2024 Category: Anesthesiology Authors: M. Radwan, L. O'Carroll, C.L. McCaul Tags: Review Article Source Type: research
Prognostic significance of preoperative osteosarcopenia on patient ’ outcomes after emergency surgery for gastrointestinal perforation
ConclusionPreoperative osteosarcopenia is a risk factor of in-hospital mortality in patients with gastrointestinal perforation after emergency surgery. (Source: Surgery Today)
Source: Surgery Today - April 29, 2024 Category: Surgery Source Type: research
Use of sugammadex in prevention of post-operative urinary retention in minimally invasive hernia surgery
ConclusionThe results of this study reflect the protective role of sugammadex against POUR in minimally invasive IHR cases. (Source: Hernia)
Source: Hernia - April 29, 2024 Category: Sports Medicine Source Type: research
Effect of a national infection control programme in Sweden on prosthetic joint infection incidence following primary total hip arthroplasty: a cohort study
Conclusions
Despite the comprehensive nationwide PRISS Project, Swedish PJI incidence was higher after the project and time to diagnosis remained unchanged. Factors contributing to PJI, such as increasing obesity, higher American Society of Anesthesiology class and more fractures as indications, explain the PJI increase among primary THA patients. (Source: BMJ Open)
Source: BMJ Open - April 29, 2024 Category: General Medicine Authors: Wildeman, P., Rolfson, O., Wretenberg, P., Natman, J., Gordon, M., Söderquist, B., Lindgren, V. Tags: Open access, Infectious diseases Source Type: research
