The effect of preoperative TSH levels on perioperative complications in patients undergoing pituitary surgery
ConclusionsThe risk of perioperative mortality is higher in patients with TSH levels above normal. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 30, 2024 Category: Research Source Type: research
The effect of dexmedetomidine on the postoperative recovery of patients with severe traumatic brain injury undergoing craniotomy treatment: a retrospective study
ConclusionThe use of DEX in the ICU can effectively reduce the incidence of delirium in patients who return to the general ward after craniotomy. DEX had no adverse effect on the prognosis of patients other than causing bradycardia. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 30, 2024 Category: Research Source Type: research
The efficacy of articaine in pain management during endodontic procedures in pediatric patients
ConclusionIn the treatment of dental pulp diseases in children, the use of articaine can achieve better anesthesia effect and rapid onset of anesthesia and has less impact on the patient ’s blood pressure and heart rate, but it also can relieve pain and has good safety after the use of medication. It is worthy of clinical application. (Source: Perioperative Medicine)
Source: Perioperative Medicine - April 30, 2024 Category: Surgery Source Type: research
Effectiveness of trans-nasal humidified rapid insufflation ventilatory exchange compared with standard facemask oxygenation for pre- and apneic oxygenation during anesthesia induction: A meta-analysis based on randomized controlled trials
by Delai Zheng, Yi Yao, Chuan Luo, Yanhui Yang, Bogang Chen, Nana Li, Yi Wang
PurposeTo further identify the effectiveness of trans-nasal humidified rapid insufflation ventilatory exchange (THRIVE) for pre- and apneic oxygenation during the anesthesia induction by comparison to facemask ventilation (FMV) based on current available evidence. MethodsMedline, EMBASE, Web of Science, Cochrane Library and CNKI databases were searched from inception to December 22, 2023 for available randomized controlled trials (RCTs). Primary outcomes were PaO2 and PaCO2 after intubation and safe apnoea time. Secondary outcomes included the O2...
Source: PLoS One - April 30, 2024 Category: Biomedical Science Authors: Delai Zheng Source Type: research
Endobronchial Ultrasound Guided Transbronchial Needle Aspiration and Next Generation Sequencing Yields
ConclusionWhen a protocol of three to five dedicated needle rinses for NGS was followed, we nearly doubled our sample adequacy rate for NSG as compared to standard care. Studies are needed to determine the ideal collection and processing modality to preserve tissue samples for genetic sequencing. (Source: Lung)
Source: Lung - April 30, 2024 Category: Respiratory Medicine Source Type: research
Outcomes with General Anesthesia Compared to Conscious Sedation for Endovascular Treatment of Medium Vessel Occlusions: Results of an International Multicentric Study
ConclusionAnaesthetic strategy in MeVOs does not influence favorable outcomes or final successful recanalization rates, however, GA may be associated with an increased risk of sICH and mortality. (Source: Klinische Neuroradiologie)
Source: Klinische Neuroradiologie - April 30, 2024 Category: Radiology Source Type: research
The Role of Videolaryngoscopy in Cleft Surgery: A Single Centre Comparative Study Before and During the Covid-19 Pandemic
Cleft lip and palate (CLCP) surgeries necessitate precise airway management, especially in pediatric cases with anatomical variations. The Covid-19 pandemic has posed unprecedented challenges on anesthesiology practices, requiring adaptations to ensure patient safety and minimize viral transmission. Videolaryngoscopy (VL) has emerged as a valuable tool in airway management during the pandemic, offering improved intubation success rates and reduced aerosol generation risks. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - April 30, 2024 Category: Cosmetic Surgery Authors: Murat T ümer, Eser Şimşek, Aysun Ankay Yılbaş, Özgür Canbay Source Type: research
Agreement between three noninvasive temperature monitoring devices during spinal anaesthesia for caesarean delivery: a prospective observational study
This study aimed to compare a noninvasive core temperature monitor with two readily available peripheral temperature monitors during obstetric spinal anaesthesia. We undertook a prospective observational study including elective and emergency caesarean deliveries, to determine the agreement between affordable reusable surface temperature monitors (Welch Allyn SureTemp ® Plus oral thermometer and the Braun 3-in-1 No Touch infrared thermometer) and the Dräger T-core© (using dual-sensor heat flux technology), in detecting thermoregulatory changes during obstetric spinal anaesthesia. Predetermined clinically relevant limits...
Source: Journal of Clinical Monitoring and Computing - April 30, 2024 Category: Information Technology Source Type: research
The Development of Ketamine for Depression: A Long and Winding Road From Inception to Implementation
Serendipity and astute clinical observation drove the development of antidepressants for the past 60 years. This talk will chart the path of a very different antidepressant—ketamine—from its synthesis in 1962, to its widespread use as an anesthetic, to the animal and human studies that established its antidepressant properties, to its eventual FDA approval and use worldwide as the first antidepressant with a novel mechanism of action brought to market in decades. Unlike conventional antidepressants that are associated with a significant lag of onset of antidepressant effects, ketamine acts within hours. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Carlos Zarate Tags: Plenary and Symposium Abstracts 3 Source Type: research
Clinical Outcomes and Biomarkers From a Randomized Trial of Ketamine Masked by Surgical Anesthesia in Depressed Patients
We present a single-center, parallel-arm, triple-masked, randomized, placebo-controlled trial assessing the antidepressant efficacy and biomarkers associated with intravenous ketamine masked by surgical anesthesia (ClinicalTrials.gov, NCT03861988). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Boris Heifets, Theresa LII, Ashleigh Smith, Josephine Flohr, Cynthia Nyongesa, Lisa Cianfichi, Laura Hack, Alan Schatzberg Tags: SYMPOSIUM Source Type: research
207. Opioid Use Diminishes Placebo Antidepressant Response Independently of Pain in a Ketamine Depression Trial: A Post Hoc Analysis
The μ-opioid system is implicated in ketamine's antidepressant effects and placebo antidepressant responses, but the effect of opioid use has not been evaluated in depression trials with ketamine. Since chronic opioid exposure may disrupt the μ-opioid system, we examined the influence of pre-trial opi oid use on depression outcomes after administering ketamine or placebo in anesthetized patients. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Theresa Lii, Ashleigh Smith, Josephine Flohr, Robin Okada, Cynthia Nyongesa, Lisa Cianfichi, Laura Hack, Alan Schatzberg, Boris Heifets Source Type: research
464. Ketamine Disrupts Consciousness in Healthy Controls in Relation With Psychotic-Like Symptoms
In this study, we explore whether ketamine triggers psychotic-like symptoms in healthy controls through a disruption of conscious access. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Lucie Berkovitch, Alexandre Salvador, Thomas Andrillon, Stanislas Dehaene, Rapha ël Gaillard Source Type: research
182. Transcriptional Profiling of Antidepressant Ketamine Treatment
Sub-anesthetic ketamine prompts rapid antidepressant responses in patients with treatment resistant depression (TRD), however the driving biomechanisms remain unclear. We performed an exploratory investigation of transcriptional profile changes throughout serial ketamine treatment in patients with TRD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Artemis Zavaliangos-Petropulu, Toni Boltz, Lingyu Zhan, Noor Al-Sharif, Brandon Taraku, Eliza Congdon, Randall Espinoza, Katherine Narr, Roel Ophoff Source Type: research
243. Anesthesia as a Control for Blinding in Psychedelic Therapy
Blinding is difficult in psychedelic trials due to their profound subjective effects, leading to potential expectation bias. Our aim was to preclinically assess the utility of a general anesthetic drug as a method of masking psilocybin treatment. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Tuuli Hietamies, Austen Casey, Wesley Zhao, Daniel Rijsketic, Ben Deverett, Zahra Restagar, Boris Heifets Source Type: research
Neither Amphetamine nor Sub-Anesthetic Ketamine Treatment during Adolescence Impairs Devaluation in Rats Tested during Adulthood
CONCLUSIONS: We discuss possible reasons for this discrepancy with the prior literature, including (1) the age of exposure and (2) the pattern in the previous literature that most previous demonstrations of drug exposure impairing devaluation in laboratory animals may be attributed to either drug-associated cues present in the testing environment and/or accelerated habit learning in tasks that predispose laboratory animals towards habit formation with extended training (with training procedures that should resist the formation of habits in the current experiment). However, additional research is needed to examine the effec...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Ian R Davis Hayley Fisher Caitlin McLean Jackson Murray Charles L Pickens Source Type: research
