Experimental laboratory models as tools for understanding modifiable dementia risk
Alzheimers Dement. 2024 Apr 30. doi: 10.1002/alz.13834. Online ahead of print.ABSTRACTExperimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for dementia are promising targets for dementia prevention but are difficult to investigate in human populations due to technological constraints and confounds. Therefore, controlled laboratory experiments in models such as transgenic rodents, invertebrates and in vitro cultured cells are increasingly used to investigate dementia risk factors and test strategies which target them to prevent dementia. This re...
Source: The Journal of Alzheimers Association - April 30, 2024 Category: Psychiatry Authors: Duncan Sinclair Alison J Canty Jenna M Ziebell Adele Woodhouse Jessica M Collins Sharn Perry Eddy Roccati Maneesh Kuruvilla Jacqueline Leung Rachel Atkinson James C Vickers Anthony L Cook Anna E King Source Type: research
Development of rabbit models of ventilator-associated bacterial pneumonia produced by carbapenem-resistant < em > Pseudomonas aeruginosa < /em >
Antimicrob Agents Chemother. 2024 Apr 30:e0020524. doi: 10.1128/aac.00205-24. Online ahead of print.ABSTRACTVentilator-associated bacterial pneumonia (VABP) is among the most intractable of carbapenem-resistant Gram-negative bacterial infections. New antimicrobial agents are critically needed for the treatment of VABP. However, current conventionally used animal model systems are inadequate to meet this challenge. We, therefore, developed rabbit models of VABP caused by carbapenem-resistant Pseudomonas aeruginosa. Persistently neutropenic New Zealand White rabbits were used throughout the study. The early-phase intubated m...
Source: Antimicrobial Agents and Chemotherapy - April 30, 2024 Category: Microbiology Authors: Vidmantas Petraitis Ruta Petraitiene Povilas Kavaliauskas Ethan Naing Andrew Garcia Vilma Zigmantaite Ramune Grigaleviciute Audrius Kucinskas Alius Pockevicius Rimantas Stakauskas Thomas J Walsh Source Type: research
Perineal Squamous Cell Carcinoma Arising in an Epidermal Cyst
Acta Med Okayama. 2024 Apr;78(2):197-200. doi: 10.18926/AMO/66930.ABSTRACTA 90-year-old Japanese woman who had been aware of a subcutaneous mass on the right perineal region for 5 years was referred to our hospital for further examination and treatment because of the rapid growth of the mass and bleeding that began 3 months earlier. A biopsy of the mass revealed a diagnosis of well-differentiated squamous cell carcinoma. On preoperative examination, the tumor was 90×40 mm in size and was suspected to have partially invaded the levator ani muscle and external sphincter. Since a preoperative cardiac evaluation indicated sev...
Source: Acta Medica Okayama - April 30, 2024 Category: General Medicine Authors: Fuminori Teraishi Yuki Matsumi Kota Tachibana Toshiyuki Watanabe Toshiyoshi Fujiwara Source Type: research
Perineal Squamous Cell Carcinoma Arising in an Epidermal Cyst
Acta Med Okayama. 2024 Apr;78(2):197-200. doi: 10.18926/AMO/66930.ABSTRACTA 90-year-old Japanese woman who had been aware of a subcutaneous mass on the right perineal region for 5 years was referred to our hospital for further examination and treatment because of the rapid growth of the mass and bleeding that began 3 months earlier. A biopsy of the mass revealed a diagnosis of well-differentiated squamous cell carcinoma. On preoperative examination, the tumor was 90×40 mm in size and was suspected to have partially invaded the levator ani muscle and external sphincter. Since a preoperative cardiac evaluation indicated sev...
Source: Acta Med Okayama - April 30, 2024 Category: Universities & Medical Training Authors: Fuminori Teraishi Yuki Matsumi Kota Tachibana Toshiyuki Watanabe Toshiyoshi Fujiwara Source Type: research
Effect of isoflurane anaesthetic time on ocular a-scan ultrasonography measures and their relationship to age and OCT measures in the guinea pig
This study shows that the depth of ocular components can change dramatically with anaesthesia. Researchers should therefore be wary of these concomitant effects and should employ adjustments to better render 'true' values.PMID:38685338 | DOI:10.1016/j.exer.2024.109914 (Source: Experimental Eye Research)
Source: Experimental Eye Research - April 30, 2024 Category: Opthalmology Authors: William E Myles Yusupjan Abdulla Sally Anne McFadden Source Type: research
Dexmedetomidine hydrochloride plus sufentanil citrate inhibits glucose metabolism and epithelial ‑mesenchymal transition in human esophageal squamous carcinoma KYSE30 cells by modulating the JAK/STAT3/HIF‑1α axis
Oncol Lett. 2024 Apr 18;27(6):273. doi: 10.3892/ol.2024.14406. eCollection 2024 Jun.ABSTRACTDexmedetomidine hydrochloride (DEX-HCl) and sufentanil citrate (SFC) are commonly used anesthetic drugs for esophageal cancer (EC) surgery. The present study was performed to investigate the effect of DEX-HCl and SFC treatment on glucose metabolism and epithelial-mesenchymal transition in EC. Cell counting kit-8 (CCK8), clonogenic, wound healing and Transwell migration assays were performed to assess the effects of the DEX-HCl and SFC on KYSE30 cell proliferation, invasion and migration. Changes in lactate and glucose levels in KYSE...
Source: Oncology Letters - April 30, 2024 Category: Cancer & Oncology Authors: Weijing Li Yong Wang Xiaolin Li Han Wu Li Jia Source Type: research
Cystectomy for bladder cancer in Sweden - short-term outcomes after centralization
CONCLUSION: After the centralization of the cystectomy-care in Sweden, older patients and individuals with more extensive comorbidity were offered RC whereas 90-day mortality and the proportion of patients subjected to reoperations within 90 days of surgery decreased without increasing waiting times.PMID:38685576 | DOI:10.2340/sju.v59.40120 (Source: Scandinavian Journal of Urology)
Source: Scandinavian Journal of Urology - April 30, 2024 Category: Urology & Nephrology Authors: Fredrik Liedberg Oskar Hagberg Firas Aljabery Ove Andr én Victor Falini Truls G årdmark Viveka Str öck Tomas Jerlstr öm Source Type: research
Delta-SVV as a Predictor for Circulating Blood Volume Evaluation during Intraoperative Period: A Prospective Cohort Study
CONCLUSION: In conclusion, SVV measured by FloTrac / Vigileo could guile fluid therapy precisely by predicting the blood volume of patients during the intraoperative period, as it has a strong linear correlation with the blood volume of patients who underwent general anesthesia, meaning anesthesiologist could calculate the exact fluid volume for patients' infusion. Further studies with large cohorts and centers would be needed to validate its efficiency.PMID:38687861 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Bei Wang Yiqi Wu Zhiyong He Jianghui Xu Source Type: research
Comprehensive analysis of perioperative hypotension in photodynamic diagnosis-assisted transurethral resection of bladder tumor with 5-aminolevulinic acid
CONCLUSIONS: Renal function impairment and the other adverse effects of 5-aminolevulinic acid may be risk factors for severe hypotension. Mild or moderate hypotension may be caused by general anesthesia and severe hypotension may be caused by spinal anesthesia. To elucidate specific risk factors, further case-control studies are warranted.PMID:38687138 | DOI:10.1111/iju.15477 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Takahiro Nohara Atsuya Takimoto Rei Shinzawa Daimon Kurauchi Ren Toriumi Ryunosuke Nakagawa Shuhei Aoyama Taiki Kamijima Hiroshi Kano Renato Naito Suguru Kadomoto Hiroaki Iwamoto Hiroshi Yaegashi Shohei Kawaguchi Kazuyoshi Shigehara Kouji Izumi Atsushi Mi Source Type: research
A retrospective study on the delay in three different timescales of CT simulation among patients with pediatric cancer in a tertiary hospital
In conclusion, outpatients may experience CT sim delays. Machine availability, conditions of patients and IMRT treatment were the major reasons to cause the delay in CT sim. Strategies should be employed to prevent CT sim delays and improve patient experience.PMID:38686353 | PMC:PMC11056923 | DOI:10.3892/ol.2024.14405 (Source: Oncology Letters)
Source: Oncology Letters - April 30, 2024 Category: Cancer & Oncology Authors: Alshaimaa D Al-Mahnabi Rolina K Al-Wassia Source Type: research
Experimental laboratory models as tools for understanding modifiable dementia risk
Alzheimers Dement. 2024 Apr 30. doi: 10.1002/alz.13834. Online ahead of print.ABSTRACTExperimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for dementia are promising targets for dementia prevention but are difficult to investigate in human populations due to technological constraints and confounds. Therefore, controlled laboratory experiments in models such as transgenic rodents, invertebrates and in vitro cultured cells are increasingly used to investigate dementia risk factors and test strategies which target them to prevent dementia. This re...
Source: The Journal of Alzheimers Association - April 30, 2024 Category: Psychiatry Authors: Duncan Sinclair Alison J Canty Jenna M Ziebell Adele Woodhouse Jessica M Collins Sharn Perry Eddy Roccati Maneesh Kuruvilla Jacqueline Leung Rachel Atkinson James C Vickers Anthony L Cook Anna E King Source Type: research
The efficacy and safety of snare traction-assisted endoscopic submucosal dissection for circumferential superficial esophageal cancer
ConclusionSnare traction-assisted ESD is a safe and efficient approach for the treatment of circumferential superficial esophageal cancer. Its advantages includes shorter procedure so the anesthesia requirement, clear operative filed view, improved mucosal dissection efficiency, simple, and easily accessible equipment.Graphical abstract (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 30, 2024 Category: Surgery Source Type: research
Unrecognized Esophageal Intubation: Prevention, Recognition & amp; Management
This article reviews why UEI deaths happen and how the new guideline approaches this issue which will be of interest to all airway practitioners, independent of specialty or seniority. (Source: Current Anesthesiology Reports)
Source: Current Anesthesiology Reports - April 30, 2024 Category: Anesthesiology Source Type: research
A retrospective case series of the surgical management of thirty-one penile fibropapilloma cases presented to University College Dublin Veterinary Hospital (UCDVH) between 2017 and 2023
ConclusionThis case series summarises the history and presenting findings of 31 bovine penile fibropapilloma cases and describes a regional anaesthetic and standing surgical approach for successful case management. (Source: Irish Veterinary Journal)
Source: Irish Veterinary Journal - April 30, 2024 Category: Veterinary Research Source Type: research
How severity and classification of pulmonary hypertension affect pregnancy outcomes: a systematic review and timeline
Current consensus guidelines recommend that pregnancy is contraindicated in patients with pulmonary hypertension (PH) due to high maternal and fetal morbidity and mortality.1 In this systematic review we evaluated the data behind these recommendations to determine if all forms and severity of PH should be considered an absolute contraindication to pregnancy. Pulmonary hypertension is a complex disease involving multiple etiologies2 which increase pulmonary blood pressure. It is classified by the WHO (World Health Organization) according to the underlying pathology into five groups: 1. (Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - April 30, 2024 Category: Anesthesiology Authors: N.C. Cruz, E. Pham, H. Ali, J Nanavati, D Steppan, TM Kolb, AJ Thomas, J Murphy, S Nyhan, MC Grant, J Steppan Tags: Review Article Source Type: research
