207. Opioid Use Diminishes Placebo Antidepressant Response Independently of Pain in a Ketamine Depression Trial: A Post Hoc Analysis
The μ-opioid system is implicated in ketamine's antidepressant effects and placebo antidepressant responses, but the effect of opioid use has not been evaluated in depression trials with ketamine. Since chronic opioid exposure may disrupt the μ-opioid system, we examined the influence of pre-trial opi oid use on depression outcomes after administering ketamine or placebo in anesthetized patients. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Theresa Lii, Ashleigh Smith, Josephine Flohr, Robin Okada, Cynthia Nyongesa, Lisa Cianfichi, Laura Hack, Alan Schatzberg, Boris Heifets Source Type: research
464. Ketamine Disrupts Consciousness in Healthy Controls in Relation With Psychotic-Like Symptoms
In this study, we explore whether ketamine triggers psychotic-like symptoms in healthy controls through a disruption of conscious access. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Lucie Berkovitch, Alexandre Salvador, Thomas Andrillon, Stanislas Dehaene, Rapha ël Gaillard Source Type: research
182. Transcriptional Profiling of Antidepressant Ketamine Treatment
Sub-anesthetic ketamine prompts rapid antidepressant responses in patients with treatment resistant depression (TRD), however the driving biomechanisms remain unclear. We performed an exploratory investigation of transcriptional profile changes throughout serial ketamine treatment in patients with TRD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Artemis Zavaliangos-Petropulu, Toni Boltz, Lingyu Zhan, Noor Al-Sharif, Brandon Taraku, Eliza Congdon, Randall Espinoza, Katherine Narr, Roel Ophoff Source Type: research
243. Anesthesia as a Control for Blinding in Psychedelic Therapy
Blinding is difficult in psychedelic trials due to their profound subjective effects, leading to potential expectation bias. Our aim was to preclinically assess the utility of a general anesthetic drug as a method of masking psilocybin treatment. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Tuuli Hietamies, Austen Casey, Wesley Zhao, Daniel Rijsketic, Ben Deverett, Zahra Restagar, Boris Heifets Source Type: research
Neither Amphetamine nor Sub-Anesthetic Ketamine Treatment during Adolescence Impairs Devaluation in Rats Tested during Adulthood
CONCLUSIONS: We discuss possible reasons for this discrepancy with the prior literature, including (1) the age of exposure and (2) the pattern in the previous literature that most previous demonstrations of drug exposure impairing devaluation in laboratory animals may be attributed to either drug-associated cues present in the testing environment and/or accelerated habit learning in tasks that predispose laboratory animals towards habit formation with extended training (with training procedures that should resist the formation of habits in the current experiment). However, additional research is needed to examine the effec...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Ian R Davis Hayley Fisher Caitlin McLean Jackson Murray Charles L Pickens Source Type: research
Dexmedetomidine Pretreatment Confers Myocardial Protection and Reduces Mechanical Ventilation Duration for Patients Undergoing Cardiac Valve Replacement under Cardiopulmonary Bypass
CONCLUSION: The study suggests that 0.50 µg/kg Dex pretreatment could reduce propofol use and the duration of mechanical ventilation, and confer myocardial protection without increased adverse events during cardiac valve replacement.PMID:38684422 | DOI:10.5761/atcs.oa.23-00210 (Source: Annals of Thoracic and Cardiovascular Surgery)
Source: Annals of Thoracic and Cardiovascular Surgery - April 29, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Binglin Yuan Xiqiang Huang Junlin Wen Mengzhe Peng Source Type: research
Practice Guidelines for Central Venous Access 2020 - Time for German Guidelines
Anasthesiol Intensivmed Notfallmed Schmerzther. 2024 Apr;59(4):252-262. doi: 10.1055/a-1690-5730. Epub 2024 Apr 29.ABSTRACTThe American Society of Anesthesiologists released practice guidelines for central venous access in 2020, and the entire world literature was examined for evidence on how to perform the entire process with best practice and minimal risk and harm to the patient. These guidelines may serve as a gold standard for individual procedural steps, allowing practitioners and hospital departments to critically question the own standard and improve upon them.We interpreted the guidelines for individual procedural ...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - April 29, 2024 Category: Intensive Care Authors: Wolf Armbruster R üdiger Eichholz Thomas Notheisen Source Type: research
To Compare the Anesthetic Effect of Remimazolam and Propofol in Painless Hysteroscopic Minimally Invasive Surgery
CONCLUSION: Intravenous induction of remimazolam at 6 mg·kg-1·h-1 and maintenance of anesthesia at 1-2 mg·kg-1·h-1 have less effect on hemodynamics, faster recovery time and lower incidence of adverse reactions compared with propofol when used in minimally invasive hysteroscopic surgery. Remimazolam can be safely and effectively used in this kind of surgery.PMID:38684498 | DOI:10.62713/aic.3291 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Fei Gao Yanjun Xie Hengwei Zhu Chen Chen Hongyan Fu Source Type: research
Median Effective Dose of Ciprofol Combined With Sufentanil for Inhibiting the Upper Gastrointestinal Endoscopic Placement Reaction in Elderly Patients
CONCLUSION: The ED50 of ciprofol in combination with sufentanil (0.1 μg/kg) for upper gastrointestinal endoscopy in elderly patients: 0.23 mg/kg in group A and 0.18 mg/kg in group B.PMID:38680849 | PMC:PMC11055479 | DOI:10.1177/15593258241248931 (Source: Dose Response)
Source: Dose Response - April 29, 2024 Category: Drugs & Pharmacology Authors: Haojing Xiong Hechen Xu Yang Yang Bailong Hu Ke Jiang Xiaohua Zou Source Type: research
Neither Amphetamine nor Sub-Anesthetic Ketamine Treatment during Adolescence Impairs Devaluation in Rats Tested during Adulthood
CONCLUSIONS: We discuss possible reasons for this discrepancy with the prior literature, including (1) the age of exposure and (2) the pattern in the previous literature that most previous demonstrations of drug exposure impairing devaluation in laboratory animals may be attributed to either drug-associated cues present in the testing environment and/or accelerated habit learning in tasks that predispose laboratory animals towards habit formation with extended training (with training procedures that should resist the formation of habits in the current experiment). However, additional research is needed to examine the effec...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Ian R Davis Hayley Fisher Caitlin McLean Jackson Murray Charles L Pickens Source Type: research
Dexmedetomidine Pretreatment Confers Myocardial Protection and Reduces Mechanical Ventilation Duration for Patients Undergoing Cardiac Valve Replacement under Cardiopulmonary Bypass
CONCLUSION: The study suggests that 0.50 µg/kg Dex pretreatment could reduce propofol use and the duration of mechanical ventilation, and confer myocardial protection without increased adverse events during cardiac valve replacement.PMID:38684422 | DOI:10.5761/atcs.oa.23-00210 (Source: Annals of Thoracic and Cardiovascular Surgery)
Source: Annals of Thoracic and Cardiovascular Surgery - April 29, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Binglin Yuan Xiqiang Huang Junlin Wen Mengzhe Peng Source Type: research
Safety of tranexamic acid in surgically treated isolated spine trauma
CONCLUSION: Our study demonstrated that TXA is safe for isolated spine trauma. It is challenging to determine whether TXA effectively reduces blood loss because most surgeons prefer TXA for open or multilevel cases. Further, larger studies are necessary to explore the rate, dosage, and mode of administration of TXA.PMID:38680673 | PMC:PMC11045465 | DOI:10.5312/wjo.v15.i4.346 (Source: World Journal of Orthopaedics)
Source: World Journal of Orthopaedics - April 29, 2024 Category: Orthopaedics Authors: Wajiha Zahra Sandeep Krishan Nayar Ashwin Bhadresha Vinay Jasani Syed Aftab Source Type: research
Practice Guidelines for Central Venous Access 2020 - Time for German Guidelines
Anasthesiol Intensivmed Notfallmed Schmerzther. 2024 Apr;59(4):252-262. doi: 10.1055/a-1690-5730. Epub 2024 Apr 29.ABSTRACTThe American Society of Anesthesiologists released practice guidelines for central venous access in 2020, and the entire world literature was examined for evidence on how to perform the entire process with best practice and minimal risk and harm to the patient. These guidelines may serve as a gold standard for individual procedural steps, allowing practitioners and hospital departments to critically question the own standard and improve upon them.We interpreted the guidelines for individual procedural ...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - April 29, 2024 Category: Intensive Care Authors: Wolf Armbruster R üdiger Eichholz Thomas Notheisen Source Type: research
To Compare the Anesthetic Effect of Remimazolam and Propofol in Painless Hysteroscopic Minimally Invasive Surgery
CONCLUSION: Intravenous induction of remimazolam at 6 mg·kg-1·h-1 and maintenance of anesthesia at 1-2 mg·kg-1·h-1 have less effect on hemodynamics, faster recovery time and lower incidence of adverse reactions compared with propofol when used in minimally invasive hysteroscopic surgery. Remimazolam can be safely and effectively used in this kind of surgery.PMID:38684498 | DOI:10.62713/aic.3291 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Fei Gao Yanjun Xie Hengwei Zhu Chen Chen Hongyan Fu Source Type: research
Median Effective Dose of Ciprofol Combined With Sufentanil for Inhibiting the Upper Gastrointestinal Endoscopic Placement Reaction in Elderly Patients
CONCLUSION: The ED50 of ciprofol in combination with sufentanil (0.1 μg/kg) for upper gastrointestinal endoscopy in elderly patients: 0.23 mg/kg in group A and 0.18 mg/kg in group B.PMID:38680849 | PMC:PMC11055479 | DOI:10.1177/15593258241248931 (Source: Dose Response)
Source: Dose Response - April 29, 2024 Category: Drugs & Pharmacology Authors: Haojing Xiong Hechen Xu Yang Yang Bailong Hu Ke Jiang Xiaohua Zou Source Type: research
