Effective bolus dose of remimazolam for i-gel < sup > ® < /sup > insertion in nonparalyzed patients: a dose-finding study
CONCLUSION: Based on the ED95 of remimazolam bolus dose determined in our study, we recommend using 0.182 mg·kg-1 of remimazolam in combination with remifentanil TCI at a Ce of 3.0 ng·mL-1 for successful i-gel insertion without NMBAs in adult patients. This regimen seems effective with a low risk of hemodynamic instability during anesthesia induction.STUDY REGISTRATION: ClinicalTrials.gov ( NCT05298228 ); first submitted 6 March 2022.PMID:38671251 | DOI:10.1007/s12630-024-02762-w (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 26, 2024 Category: Anesthesiology Authors: Eunah Cho Yun Ho Roh Jisu Moon Yangjin Kim Seokyung Shin Source Type: research
Motor, somatosensory, and executive cortical areas elicit monosynaptic and polysynaptic neuronal activity in the auditory midbrain
Hear Res. 2024 Apr 16;447:109009. doi: 10.1016/j.heares.2024.109009. Online ahead of print.ABSTRACTWe recently reported that the central nucleus of the inferior colliculus (the auditory midbrain) is innervated by glutamatergic pyramidal cells originating not only in auditory cortex (AC), but also in multiple 'non-auditory' regions of the cerebral cortex. Here, in anaesthetised rats, we used optogenetics and electrical stimulation, combined with recording in the inferior colliculus to determine the functional influence of these descending connections. Specifically, we determined the extent of monosynaptic excitation and the...
Source: Hearing Research - April 26, 2024 Category: Audiology Authors: Sarah E Gartside Bas Mj Olthof Adrian Rees Source Type: research
Cubital tunnel release with Wide Awake Local Anaesthesia No Tourniquet (WALANT) technique in an outpatient setting is safe and effective
This study aims to evaluate clinical outcomes after ulnar nerve release under WALANT 27 patients with ulnar nerve release for cubital tunnel syndrome were included. The primary outcome was the presence of (remaining) symptoms after ulnar nerve release. Data was extracted from medical records. 13 out of 27 patients had (mild) remaining symptoms after ulnar nerve release, and 1 complication (superficial wound infection) was seen. Ulnar nerve release under WALANT is safe and effective in patients with primary ulnar nerve entrapment that have failed conservative therapy.PMID:38669651 | DOI:10.52628/90.1.12681 (Source: Acta Orthopaedica Belgica)
Source: Acta Orthopaedica Belgica - April 26, 2024 Category: Orthopaedics Authors: C Bruggink I Koenraadt-VAN Oost A Beumer B The Source Type: research
Efficacy of local infiltration analgesia on recovery after total hip arthroplasty using direct anterior approach under spinal anaesthesia: a randomized, double-blind, placebo-controlled trial
Acta Orthop Belg. 2024 Mar;90(1):11-15. doi: 10.52628/90.1.12345.ABSTRACTThe utilization of local infiltration analgesia (LIA) is a common practice in total hip arthroplasty (THA) procedures to mitigate postoperative pain and diminish the necessity for opioids. However, contemporary literature reports conflicting results. Our working hypothesis was that LIA renders better postoperative VAS-scores and reduces the need for oral analgetics. We performed a randomized, double-blind, placebo-controlled trial aimed at examining the effectiveness of LIA in THA. A total of 90 patients were included for statistical analysis. Our pri...
Source: Acta Orthopaedica Belgica - April 26, 2024 Category: Orthopaedics Authors: S Biesemans B Schuermans E Voets H Feyen Source Type: research
Cubital tunnel release with Wide Awake Local Anaesthesia No Tourniquet (WALANT) technique in an outpatient setting is safe and effective
This study aims to evaluate clinical outcomes after ulnar nerve release under WALANT 27 patients with ulnar nerve release for cubital tunnel syndrome were included. The primary outcome was the presence of (remaining) symptoms after ulnar nerve release. Data was extracted from medical records. 13 out of 27 patients had (mild) remaining symptoms after ulnar nerve release, and 1 complication (superficial wound infection) was seen. Ulnar nerve release under WALANT is safe and effective in patients with primary ulnar nerve entrapment that have failed conservative therapy.PMID:38669651 | DOI:10.52628/90.1.12681 (Source: Acta Orthopaedica)
Source: Acta Orthopaedica - April 26, 2024 Category: Orthopaedics Authors: C Bruggink I Koenraadt-VAN Oost A Beumer B The Source Type: research
Efficacy of local infiltration analgesia on recovery after total hip arthroplasty using direct anterior approach under spinal anaesthesia: a randomized, double-blind, placebo-controlled trial
Acta Orthop Belg. 2024 Mar;90(1):11-15. doi: 10.52628/90.1.12345.ABSTRACTThe utilization of local infiltration analgesia (LIA) is a common practice in total hip arthroplasty (THA) procedures to mitigate postoperative pain and diminish the necessity for opioids. However, contemporary literature reports conflicting results. Our working hypothesis was that LIA renders better postoperative VAS-scores and reduces the need for oral analgetics. We performed a randomized, double-blind, placebo-controlled trial aimed at examining the effectiveness of LIA in THA. A total of 90 patients were included for statistical analysis. Our pri...
Source: Acta Orthopaedica - April 26, 2024 Category: Orthopaedics Authors: S Biesemans B Schuermans E Voets H Feyen Source Type: research
Renal implications of pneumoperitoneum in laparoscopic surgery: mechanisms, risk factors, and preventive strategies
Korean J Anesthesiol. 2024 Apr 26. doi: 10.4097/kja.24011. Online ahead of print.ABSTRACTPneumoperitoneum, which is established for laparoscopic surgery, has systemic implications on the renal system and may contribute to acute kidney injury or postoperative renal dysfunction. Specifically, when the pressure exceeds 10 mmHg, pneumoperitoneum decreases renal blood flow, leading to renal dysfunction and temporary oliguria. The renal effects of pneumoperitoneum stem from both the direct effects of increased intra-abdominal pressure and indirect factors such as carbon dioxide absorption, neuroendocrine influences, and tissue d...
Source: Korean Journal of Anesthesiology - April 26, 2024 Category: Anesthesiology Authors: Gianluca Villa Marco Fiorentino Eleonora Cappellini Sergio Lassola Silvia De Rosa Source Type: research
Effective bolus dose of remimazolam for i-gel < sup > ® < /sup > insertion in nonparalyzed patients: a dose-finding study
CONCLUSION: Based on the ED95 of remimazolam bolus dose determined in our study, we recommend using 0.182 mg·kg-1 of remimazolam in combination with remifentanil TCI at a Ce of 3.0 ng·mL-1 for successful i-gel insertion without NMBAs in adult patients. This regimen seems effective with a low risk of hemodynamic instability during anesthesia induction.STUDY REGISTRATION: ClinicalTrials.gov ( NCT05298228 ); first submitted 6 March 2022.PMID:38671251 | DOI:10.1007/s12630-024-02762-w (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 26, 2024 Category: Anesthesiology Authors: Eunah Cho Yun Ho Roh Jisu Moon Yangjin Kim Seokyung Shin Source Type: research
Motor, somatosensory, and executive cortical areas elicit monosynaptic and polysynaptic neuronal activity in the auditory midbrain
Hear Res. 2024 Apr 16;447:109009. doi: 10.1016/j.heares.2024.109009. Online ahead of print.ABSTRACTWe recently reported that the central nucleus of the inferior colliculus (the auditory midbrain) is innervated by glutamatergic pyramidal cells originating not only in auditory cortex (AC), but also in multiple 'non-auditory' regions of the cerebral cortex. Here, in anaesthetised rats, we used optogenetics and electrical stimulation, combined with recording in the inferior colliculus to determine the functional influence of these descending connections. Specifically, we determined the extent of monosynaptic excitation and the...
Source: Hearing Research - April 26, 2024 Category: Audiology Authors: Sarah E Gartside Bas Mj Olthof Adrian Rees Source Type: research
Cubital tunnel release with Wide Awake Local Anaesthesia No Tourniquet (WALANT) technique in an outpatient setting is safe and effective
This study aims to evaluate clinical outcomes after ulnar nerve release under WALANT 27 patients with ulnar nerve release for cubital tunnel syndrome were included. The primary outcome was the presence of (remaining) symptoms after ulnar nerve release. Data was extracted from medical records. 13 out of 27 patients had (mild) remaining symptoms after ulnar nerve release, and 1 complication (superficial wound infection) was seen. Ulnar nerve release under WALANT is safe and effective in patients with primary ulnar nerve entrapment that have failed conservative therapy.PMID:38669651 | DOI:10.52628/90.1.12681 (Source: Acta Orthopaedica Belgica)
Source: Acta Orthopaedica Belgica - April 26, 2024 Category: Orthopaedics Authors: C Bruggink I Koenraadt-VAN Oost A Beumer B The Source Type: research
Efficacy of local infiltration analgesia on recovery after total hip arthroplasty using direct anterior approach under spinal anaesthesia: a randomized, double-blind, placebo-controlled trial
Acta Orthop Belg. 2024 Mar;90(1):11-15. doi: 10.52628/90.1.12345.ABSTRACTThe utilization of local infiltration analgesia (LIA) is a common practice in total hip arthroplasty (THA) procedures to mitigate postoperative pain and diminish the necessity for opioids. However, contemporary literature reports conflicting results. Our working hypothesis was that LIA renders better postoperative VAS-scores and reduces the need for oral analgetics. We performed a randomized, double-blind, placebo-controlled trial aimed at examining the effectiveness of LIA in THA. A total of 90 patients were included for statistical analysis. Our pri...
Source: Acta Orthopaedica Belgica - April 26, 2024 Category: Orthopaedics Authors: S Biesemans B Schuermans E Voets H Feyen Source Type: research
Cubital tunnel release with Wide Awake Local Anaesthesia No Tourniquet (WALANT) technique in an outpatient setting is safe and effective
This study aims to evaluate clinical outcomes after ulnar nerve release under WALANT 27 patients with ulnar nerve release for cubital tunnel syndrome were included. The primary outcome was the presence of (remaining) symptoms after ulnar nerve release. Data was extracted from medical records. 13 out of 27 patients had (mild) remaining symptoms after ulnar nerve release, and 1 complication (superficial wound infection) was seen. Ulnar nerve release under WALANT is safe and effective in patients with primary ulnar nerve entrapment that have failed conservative therapy.PMID:38669651 | DOI:10.52628/90.1.12681 (Source: Acta Orthopaedica)
Source: Acta Orthopaedica - April 26, 2024 Category: Orthopaedics Authors: C Bruggink I Koenraadt-VAN Oost A Beumer B The Source Type: research
Efficacy of local infiltration analgesia on recovery after total hip arthroplasty using direct anterior approach under spinal anaesthesia: a randomized, double-blind, placebo-controlled trial
Acta Orthop Belg. 2024 Mar;90(1):11-15. doi: 10.52628/90.1.12345.ABSTRACTThe utilization of local infiltration analgesia (LIA) is a common practice in total hip arthroplasty (THA) procedures to mitigate postoperative pain and diminish the necessity for opioids. However, contemporary literature reports conflicting results. Our working hypothesis was that LIA renders better postoperative VAS-scores and reduces the need for oral analgetics. We performed a randomized, double-blind, placebo-controlled trial aimed at examining the effectiveness of LIA in THA. A total of 90 patients were included for statistical analysis. Our pri...
Source: Acta Orthopaedica - April 26, 2024 Category: Orthopaedics Authors: S Biesemans B Schuermans E Voets H Feyen Source Type: research
Renal implications of pneumoperitoneum in laparoscopic surgery: mechanisms, risk factors, and preventive strategies
Korean J Anesthesiol. 2024 Apr 26. doi: 10.4097/kja.24011. Online ahead of print.ABSTRACTPneumoperitoneum, which is established for laparoscopic surgery, has systemic implications on the renal system and may contribute to acute kidney injury or postoperative renal dysfunction. Specifically, when the pressure exceeds 10 mmHg, pneumoperitoneum decreases renal blood flow, leading to renal dysfunction and temporary oliguria. The renal effects of pneumoperitoneum stem from both the direct effects of increased intra-abdominal pressure and indirect factors such as carbon dioxide absorption, neuroendocrine influences, and tissue d...
Source: Korean Journal of Anesthesiology - April 26, 2024 Category: Anesthesiology Authors: Gianluca Villa Marco Fiorentino Eleonora Cappellini Sergio Lassola Silvia De Rosa Source Type: research
Effective bolus dose of remimazolam for i-gel < sup > ® < /sup > insertion in nonparalyzed patients: a dose-finding study
CONCLUSION: Based on the ED95 of remimazolam bolus dose determined in our study, we recommend using 0.182 mg·kg-1 of remimazolam in combination with remifentanil TCI at a Ce of 3.0 ng·mL-1 for successful i-gel insertion without NMBAs in adult patients. This regimen seems effective with a low risk of hemodynamic instability during anesthesia induction.STUDY REGISTRATION: ClinicalTrials.gov ( NCT05298228 ); first submitted 6 March 2022.PMID:38671251 | DOI:10.1007/s12630-024-02762-w (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 26, 2024 Category: Anesthesiology Authors: Eunah Cho Yun Ho Roh Jisu Moon Yangjin Kim Seokyung Shin Source Type: research
