Effective bolus dose of remimazolam for i-gel < sup > ® < /sup > insertion in nonparalyzed patients: a dose-finding study

CONCLUSION: Based on the ED95 of remimazolam bolus dose determined in our study, we recommend using 0.182 mg·kg-1 of remimazolam in combination with remifentanil TCI at a Ce of 3.0 ng·mL-1 for successful i-gel insertion without NMBAs in adult patients. This regimen seems effective with a low risk of hemodynamic instability during anesthesia induction.STUDY REGISTRATION: ClinicalTrials.gov ( NCT05298228 ); first submitted 6 March 2022.PMID:38671251 | DOI:10.1007/s12630-024-02762-w
Source: Canadian Journal of Anaesthesia - Category: Anesthesiology Authors: Source Type: research