Alprazolam Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Collaborative permeation of drug and excipients in transdermal formulations. In vitro scrutiny for ethanol:limonene combinations
Eur J Pharm Biopharm. 2022 Nov 13:S0939-6411(22)00261-2. doi: 10.1016/j.ejpb.2022.11.004. Online ahead of print.ABSTRACTEnhancement of skin permeation of drugs is affected by the simultaneous co-permeation of excipients that hinder the predictivity of in vitro tests. The collaborative effects of two permeation enhancers (ethanol and d-limonene) of a lipophilic drug (alprazolam) have been simultaneously assessed in human skin under different in vitro conditions: integrated setups of diffusion cell experiments with selective concentration gradients of permeants (asymmetric) or without (symmetric) have been combined with coad...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 17, 2022 Category: Drugs & Pharmacology Authors: A Boix-Monta ñés C Celma-Lezcano R Obach-Vidal C Peraire-Guitart Source Type: research

Occurrence and removal of psychiatric pharmaceuticals in the Tehran South Municipal Wastewater Treatment Plant
In this study, the occurrence of the two most common groups of psychiatric drugs (sedatives-hypnotics-anxiolytics and antidepressants) were evaluated in the Tehran South Municipal Wastewater Treatment Plant. All the target sedatives-hypnotics-anxiolytics (alprazolam, phenobarbital, and thioridazine) and antidepressants (fluoxetine, citalopram, sertraline, and venlafaxine) were observed in influent and secondary clarification (SC) effluent. Thioridazine (164.25 ± 218.74 ng/L) and citalopram (672.53 ± 938.56 ng/L) had the highest mean concentrations in the influent, while alprazolam (5.09 ± 2.33 ng/L) and citalopram (776....
Source: Environmental Science and Pollution Research International - November 14, 2022 Category: Environmental Health Authors: Somayeh Golbaz Mirzaman Zamanzadeh Kamyar Yaghmaeian Ramin Nabizadeh Nushin Rastkari Hadi Esfahani Source Type: research

IJERPH, Vol. 19, Pages 14879: Use of Alcohol, Cannabinoids, Psychostimulants, and Sedatives before and during the COVID-19 Pandemic among Students in 40 European Countries
i In March 2020, the WHO announced the COVID-19 pandemic, which has been ongoing for over 2 years. To stop the spread of the virus, the governments of many countries decided to introduce reasonable social restrictions that were suitable for pandemic waves. This led to radical changes in people&rsquo;s lives, especially among students, who are very active in society. Before COVID-19, being of student age was associated with the highest frequency of stimulants use. It is important to note that drugs are taken disparately in various areas. Therefore, using the Computer-Assisted Web Interview type of study, the imp...
Source: International Journal of Environmental Research and Public Health - November 12, 2022 Category: Environmental Health Authors: Mateusz Babicki Tags: Article Source Type: research

Use of central nervous system drugs in combination with selective serotonin reuptake inhibitor treatment: A Bayesian screening study for risk of suicidal behavior
ConclusionSeveral of the detected signals for reduced risk correspond to drugs where there is previous evidence of benefit for antidepressant augmentation (e.g., olanzapine, quetiapine, lithium, buspirone, and mirtazapine). Novel signals of reduced suicidal behavior risk, including for lamotrigine, valproic acid, risperidone, and melatonin, warrant further investigation. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - November 9, 2022 Category: Psychiatry Source Type: research

Feasibility of Emergency Department–based Fentanyl Test Strip Distribution
Conclusions This report demonstrates the feasibility and acceptability of ED fentanyl test strip distribution among patients with opioid-related ED visits. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - November 1, 2022 Category: Addiction Tags: Brief Reports Source Type: research

Effectiveness and safety of Jiuwei Zhenxin granules for treating generalized anxiety disorder: A randomized controlled trial
ConclusionJiuwei Zhenxin granules are an effective, safe, and well-tolerated treatment against GAD. Combining them with alprazolam may not significantly improve efficacy.Clinical trial registration[www.ClinicalTrials.gov], identifier [CHICTR1800020095]. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - October 4, 2022 Category: Psychiatry Source Type: research

Molecules, Vol. 27, Pages 6420: Detection and Quantification of Alprazolam Added to Long Drinks by Near Infrared Spectroscopy and Chemometrics
Marini In the present work, a fast, relatively cheap, and green analytical strategy to identify and quantify the fraudulent (or voluntary) addition of a drug (alprazolam, the API of Xanax&reg;) to an alcoholic drink of large consumption, namely gin and tonic, was developed using coupling near-infrared spectroscopy (NIR) and chemometrics. The approach used was both qualitative and quantitative as models were built that would allow for highlighting the presence of alprazolam with high accuracy, and to quantify its concentration with, in many cases, an acceptable error. Classification models built using partial l...
Source: Molecules - September 28, 2022 Category: Chemistry Authors: Claudia Scappaticci Stella Spera Alessandra Biancolillo Federico Marini Tags: Article Source Type: research

Phytochemicals That Interfere With Drug Metabolism and Transport, Modifying Plasma Concentration in Humans and Animals
Dose Response. 2022 Sep 21;20(3):15593258221120485. doi: 10.1177/15593258221120485. eCollection 2022 Jul-Sep.ABSTRACTPhytochemicals (Pch) present in fruits, vegetables and other foods, are known to inhibit or induce drug metabolism and transport. An exhaustive search was performed in five databases covering from 2000 to 2021. Twenty-one compounds from plants were found to modulate CYP3A and/or P-gp activities and modified the pharmacokinetics and the therapeutic effect of 27 different drugs. Flavonols, flavanones, flavones, stilbenes, diferuloylmethanes, tannins, protoalkaloids, flavans, hyperforin and terpenes, reduce pla...
Source: Dose Response - September 26, 2022 Category: Drugs & Pharmacology Authors: Josefina G ómez-Garduño Renato Le ón-Rodríguez Radam és Alemón-Medina Beatriz E P érez-Guillé Rosa E Soriano-Rosales Ailema Gonz ález-Ortiz Juan L Ch ávez-Pacheco Edelmira Solorio-L ópez Paola Fernandez-P érez Liliana Rivera-Espinosa Source Type: research

Benzodiazepine use disorder: A cross-sectional study at a tertiary care center in Lebanon
This study aims to assess the patient utilization patterns and benzodiazepine use disorder among Lebanese patients. A cross-sectional study was performed on Lebanese patients presenting to the Emergency Department of the American University of Beirut Medical Center (AUBMC), between November 11th, 2019, and May 30th, 2020. Institutional review board approved the study, and an informed consent was obtained from patients. A total of 244 patients were included in the final analysis. A total of 154 (63.1%) patients were found to have benzodiazepine use disorder as per the DSM-V criteria with the majority (64%) being females and...
Source: Medicine - September 23, 2022 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Voltage-clamp evidence of GABA < sub > A < /sub > receptor subunit-specific effects: pharmacodynamic fingerprint of chlornordiazepam, the major active metabolite of mexazolam, as compared to alprazolam, bromazepam, and zolpidem
CONCLUSIONS: This novel evidence demonstrates that mexazolam (through its main metabolite chlornordiazepam) has a "pharmacodynamic fingerprint" that correlates better with an anxiolytic profile and fewer sedative effects, when compared to alprazolam, bromazepam and zolpidem, explaining clinical trial outcomes with these drugs. This also highlights the relevance of the pharmacological selectivity over GABAA receptor subtypes in the selection of benzodiazepines, in addition to their clinical performance and pharmacokinetic characteristics.PMID:36097257 | DOI:10.1007/s43440-022-00411-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 13, 2022 Category: Drugs & Pharmacology Authors: H élder Fernandes V ânia Batalha Ellen Braksator Simon Hebeisen Maria Jo ão Bonifácio Maria Augusta Vieira-Coelho Patr ício Soares-da-Silva Source Type: research

meditation on dying
the xanax& the pot& the oxy not- withstanding, sleep is impossible for me. at least it is in the cold nod of that dark bedroom— i’ll tomb it soon enough, thank you. until i do, the lights stay on, albeit low, the tv too: law& order, the outer limits, jaws 2: chief brody back on beach patrol, every townie& tourist in line to be a meal. a dorsal fin fins the span of the far wall. �...
Source: JAMA - August 23, 2022 Category: General Medicine Source Type: research