Efficacy of Risperidone Orally Disintegrating Tablets Combined with Oxazepam in the Treatment of Schizophrenia
CONCLUSION: Risperidone orally disintegrating tablets combined with oxazepam shows potential in the treatment of schizophrenia by relieving patients' mental symptoms, improving quality of life and activities of daily living, and minimizing the incidence of adverse reactions.PMID:35990853 | PMC:PMC9388236 | DOI:10.1155/2022/2344946 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - August 22, 2022 Category: Complementary Medicine Authors: Liang Fang Ying Xu Xuefei Tong Xue Wu Xiaomeng Zhou Source Type: research
Corrigendum: Pregnancy and Neonatal Outcomes After Exposure to Alprazolam in Pregnancy
(Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - August 5, 2022 Category: Drugs & Pharmacology Source Type: research
Prenatal effects of alprazolam treatment on the immature cerebellum of rats
Int J Dev Neurosci. 2022 Aug 2. doi: 10.1002/jdn.10222. Online ahead of print.ABSTRACTThe use of benzodiazepines (BZDs) during pregnancy, especially alprazolam, is common and its impact on the fetal neural tissue is not known. In this sense, the present study aimed to investigate the effects of prenatal treatment with alprazolam on the cerebellum of Wistar rat pups. Thirty animals (24 females and six males, CEUA protocol 014/17) were separated into pairs for copulation. Females were divided into three groups: Control (CT), treatment 1 (T1, 1.25 mg per animal), and treatment 2, which is an overdose (T2, 30 mg per animal). A...
Source: International Journal of Developmental Neuroscience - August 2, 2022 Category: Neuroscience Authors: Fernanda Naves Ara újo do Prado Mascarenhas Nat ália Ferreira Silva Lorena Tann ús Menezes-Reis Luc élia Gonçalves Vieira L íria Queiroz Luz Hirano Fran çoise Vasconcelos Botelho Daniele Lisboa Ribeiro Renata Graciele Zanon Source Type: research
Prenatal effects of alprazolam treatment on the immature cerebellum of rats
Int J Dev Neurosci. 2022 Aug 2. doi: 10.1002/jdn.10222. Online ahead of print.ABSTRACTThe use of benzodiazepines (BZDs) during pregnancy, especially alprazolam, is common and its impact on the fetal neural tissue is not known. In this sense, the present study aimed to investigate the effects of prenatal treatment with alprazolam on the cerebellum of Wistar rat pups. Thirty animals (24 females and 6 males, CEUA protocol 014/17) were separated into pairs for copulation. Females were divided into three groups: control (CT), treatment 1 (T1, 1.25 mg/animal) and treatment 2 is an overdose (T2, 30 mg/animal). Alprazolam was admi...
Source: International Journal of Developmental Neuroscience - August 2, 2022 Category: Neuroscience Authors: Mascarenhas Fernanda Naves Ara újo do Prado Silva Nat ália Ferreira Reis Lorena Tann ús Menezes Vieira Luc élia Gonçalves Hirano L íria Queiroz Luz Botelho Fran çoise Vasconcelos Ribeiro Daniele Lisboa Zanon Renata Graciele Source Type: research
Prenatal effects of alprazolam treatment on the immature cerebellum of rats
Int J Dev Neurosci. 2022 Aug 2. doi: 10.1002/jdn.10222. Online ahead of print.ABSTRACTThe use of benzodiazepines (BZDs) during pregnancy, especially alprazolam, is common and its impact on the fetal neural tissue is not known. In this sense, the present study aimed to investigate the effects of prenatal treatment with alprazolam on the cerebellum of Wistar rat pups. Thirty animals (24 females and 6 males, CEUA protocol 014/17) were separated into pairs for copulation. Females were divided into three groups: control (CT), treatment 1 (T1, 1.25 mg/animal) and treatment 2 is an overdose (T2, 30 mg/animal). Alprazolam was admi...
Source: International Journal of Developmental Neuroscience - August 2, 2022 Category: Neuroscience Authors: Mascarenhas Fernanda Naves Ara újo do Prado Silva Nat ália Ferreira Reis Lorena Tann ús Menezes Vieira Luc élia Gonçalves Hirano L íria Queiroz Luz Botelho Fran çoise Vasconcelos Ribeiro Daniele Lisboa Zanon Renata Graciele Source Type: research
Prenatal effects of alprazolam treatment on the immature cerebellum of rats
Int J Dev Neurosci. 2022 Aug 2. doi: 10.1002/jdn.10222. Online ahead of print.ABSTRACTThe use of benzodiazepines (BZDs) during pregnancy, especially alprazolam, is common and its impact on the fetal neural tissue is not known. In this sense, the present study aimed to investigate the effects of prenatal treatment with alprazolam on the cerebellum of Wistar rat pups. Thirty animals (24 females and six males, CEUA protocol 014/17) were separated into pairs for copulation. Females were divided into three groups: Control (CT), treatment 1 (T1, 1.25 mg per animal), and treatment 2, which is an overdose (T2, 30 mg per animal). A...
Source: International Journal of Developmental Neuroscience - August 2, 2022 Category: Neuroscience Authors: Fernanda Naves Ara újo do Prado Mascarenhas Nat ália Ferreira Silva Lorena Tann ús Menezes-Reis Luc élia Gonçalves Vieira L íria Queiroz Luz Hirano Fran çoise Vasconcelos Botelho Daniele Lisboa Ribeiro Renata Graciele Zanon Source Type: research
Prenatal effects of alprazolam treatment on the immature cerebellum of rats
Int J Dev Neurosci. 2022 Aug 2. doi: 10.1002/jdn.10222. Online ahead of print.ABSTRACTThe use of benzodiazepines (BZDs) during pregnancy, especially alprazolam, is common and its impact on the fetal neural tissue is not known. In this sense, the present study aimed to investigate the effects of prenatal treatment with alprazolam on the cerebellum of Wistar rat pups. Thirty animals (24 females and six males, CEUA protocol 014/17) were separated into pairs for copulation. Females were divided into three groups: Control (CT), treatment 1 (T1, 1.25 mg per animal), and treatment 2, which is an overdose (T2, 30 mg per animal). A...
Source: International Journal of Developmental Neuroscience - August 2, 2022 Category: Neuroscience Authors: Fernanda Naves Ara újo do Prado Mascarenhas Nat ália Ferreira Silva Lorena Tann ús Menezes-Reis Luc élia Gonçalves Vieira L íria Queiroz Luz Hirano Fran çoise Vasconcelos Botelho Daniele Lisboa Ribeiro Renata Graciele Zanon Source Type: research
Prenatal effects of alprazolam treatment on the immature cerebellum of rats
Int J Dev Neurosci. 2022 Aug 2. doi: 10.1002/jdn.10222. Online ahead of print.ABSTRACTThe use of benzodiazepines (BZDs) during pregnancy, especially alprazolam, is common and its impact on the fetal neural tissue is not known. In this sense, the present study aimed to investigate the effects of prenatal treatment with alprazolam on the cerebellum of Wistar rat pups. Thirty animals (24 females and six males, CEUA protocol 014/17) were separated into pairs for copulation. Females were divided into three groups: Control (CT), treatment 1 (T1, 1.25 mg per animal), and treatment 2, which is an overdose (T2, 30 mg per animal). A...
Source: International Journal of Developmental Neuroscience - August 2, 2022 Category: Neuroscience Authors: Fernanda Naves Ara újo do Prado Mascarenhas Nat ália Ferreira Silva Lorena Tann ús Menezes-Reis Luc élia Gonçalves Vieira L íria Queiroz Luz Hirano Fran çoise Vasconcelos Botelho Daniele Lisboa Ribeiro Renata Graciele Zanon Source Type: research
The alprazolam analogue 4 ′‐chloro deschloroalprazolam identified in seized capsules
A new alprazolam analogue has been identified in seized material and characterised by a range of techniques. The analogue has very similar mass spectral properties to alprazolam and could be misidentified. AbstractNew designer benzodiazepines continue to be identified in the illicit drug market. In December 2021, eight capsules were submitted to ChemCentre for analysis. The samples were analysed by a range of analytical techniques including gas chromatography –mass spectrometry (GC–MS), ultraviolet–visible spectrophotometry, liquid chromatography-mass spectrometry (LC–MS, low and high resolution), nuclear magnetic ...
Source: Drug Testing and Analysis - June 4, 2022 Category: Drugs & Pharmacology Authors: Sheena Trigg,
Jason M. Wells,
Jasmine McGann,
Soeren Bock,
Adam Holman,
Stephen M. Harrison,
Ching Yong Goh,
Stephen A. Moggach,
David H. Brown Tags: CASE REPORT Source Type: research
Evaluation of extraction parameters in authentic hair reference material using statistical design of experiments
J Forensic Sci. 2022 May 4. doi: 10.1111/1556-4029.15051. Online ahead of print.ABSTRACTOptimal methods for forensic hair analysis are often debated, especially regarding extraction parameters that include incubation time, temperature, and size of extracted hair particles. To assess hair pretreatment parameters for analysis of drugs of abuse, the statistical technique known as Design of Experiments (DoE) is useful. DoE evaluates both the individual roles and the combinatorial associations between multiple variables and overall drug extraction efficiency. Previous reports have focused on incorporated hair reference material...
Source: Journal of Forensic Sciences - May 4, 2022 Category: Forensic Medicine Authors: Brianna Spear Anthony P DeCaprio Source Type: research
Evaluation of extraction parameters in authentic hair reference material using statistical design of experiments
J Forensic Sci. 2022 May 4. doi: 10.1111/1556-4029.15051. Online ahead of print.ABSTRACTOptimal methods for forensic hair analysis are often debated, especially regarding extraction parameters that include incubation time, temperature, and size of extracted hair particles. To assess hair pretreatment parameters for analysis of drugs of abuse, the statistical technique known as Design of Experiments (DoE) is useful. DoE evaluates both the individual roles and the combinatorial associations between multiple variables and overall drug extraction efficiency. Previous reports have focused on incorporated hair reference material...
Source: Journal of Forensic Sciences - May 4, 2022 Category: Forensic Medicine Authors: Brianna Spear Anthony P DeCaprio Source Type: research
Can GABAkines Quiet the Noise? The GABA < sub > A < /sub > Receptor Neurobiology and Pharmacology of Tinnitus
Biochem Pharmacol. 2022 Apr 30:115067. doi: 10.1016/j.bcp.2022.115067. Online ahead of print.ABSTRACTTinnitus is a highly prevalent and disabling disorder in which sound is perceived in the absence of an external auditory energy source. The disorder is complex and can arise from multiple etiologies. Co-morbid symptoms of anxiety, depression, and sleep loss are prevalent. There are no approved medications and the treatments that have been studied produce marginal improvements in symptoms. A major hypothesis of the etiology and maintenance of tinnitus is that inhibitory input mechanisms become compromised where impairedγ-am...
Source: Biochemical Pharmacology - May 3, 2022 Category: Drugs & Pharmacology Authors: Jeffrey M Witkin Arnold Lippa Jodi L Smith James M Cook Rok Cerne Source Type: research
Can GABAkines Quiet the Noise? The GABA < sub > A < /sub > Receptor Neurobiology and Pharmacology of Tinnitus
Biochem Pharmacol. 2022 Apr 30:115067. doi: 10.1016/j.bcp.2022.115067. Online ahead of print.ABSTRACTTinnitus is a highly prevalent and disabling disorder in which sound is perceived in the absence of an external auditory energy source. The disorder is complex and can arise from multiple etiologies. Co-morbid symptoms of anxiety, depression, and sleep loss are prevalent. There are no approved medications and the treatments that have been studied produce marginal improvements in symptoms. A major hypothesis of the etiology and maintenance of tinnitus is that inhibitory input mechanisms become compromised where impairedγ-am...
Source: Biochemical Pharmacology - May 3, 2022 Category: Drugs & Pharmacology Authors: Jeffrey M Witkin Arnold Lippa Jodi L Smith James M Cook Rok Cerne Source Type: research
