PR-domain containing protein 12 (prdm12) is a downstream target of transcription factor zic1 during cellular differentiation in central nervous system.
Abstract Transcription factor, zic1 is an important regulator of neural plate patterning, formation of neural crest and cerebellar development, where its main function is neuronal cell differentiation. Among the genes identified, PR domain-containing 12 (prdm12) is a member of the prdm family and is expressed in the placode domain in the neurula stage. prdm12 is distinctly expressed in the dorsal part of the midbrain, trigeminal ganglion and the motor neuron in the spinal cord. prdm12 knockdown results ventralization of neural tube. zic1 knockdown results in a reduction of prdm12 expression in the midbrain, motor ...
Source: International Journal of Developmental Neuroscience - July 8, 2020 Category: Neuroscience Authors: Rahman MM, Kim IS, Ahn D, Tae HJ, Park BY Tags: Int J Dev Neurosci Source Type: research

Early weaning alters redox status in the hippocampus and hypothalamus of rat pups.
eacute; C Abstract Exposure to environmental factors can program the metabolism, conferring resistance or increasing the risk to chronic diseases development in childhood and adulthood. In this sense, lactation is an important period in this window of development. Herein, we investigated the effect of early weaning on neurochemical and behavioral changes in offspring at weaning and adulthood. Female and male pups were divided into 4 groups: 1. Control weaning (weaning on the PND21, pups were kept with the biological mother); 2. Early Weaning Bromocriptine group (EWB) (pharmacological weaning on PND16); 3. Early We...
Source: International Journal of Developmental Neuroscience - July 3, 2020 Category: Neuroscience Authors: Rodrigues KDS, Klein CP, August PM, Dos Santos BG, Hözer RM, Maurmann RM, Crestani MS, Hoppe JB, Matté C Tags: Int J Dev Neurosci Source Type: research

Prenatal pregabalin is associated with sex-dependent alterations in some behavioral parameters in valproic acid- induced autism in rat offspring.
In conclusion, prenatal exposure to VPA increased the risk of autism like behaviors in the offspring rats, and PGB treatment during the gestational period was associated with some beneficial effects, including anxiety reduction and motor impairment in autism like symptoms in rat offspring. PMID: 32588482 [PubMed - as supplied by publisher] (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - June 25, 2020 Category: Neuroscience Authors: Shamsi Meymandi M, Sepehri G, Moslemizadeh A, Vakili Shahrbabaki S, Bashiri H Tags: Int J Dev Neurosci Source Type: research

What are the consequences of Methylphenidate exposure for maternally separated rats?
Abstract Methylphenidate (MPH) abuse is prevalent among youth. Drug abuse results in pain perception. We sought to investigate whether Maternal separation (MS) prone to MPH addiction. The next question was whether MPH abusers with MS differ in pain perception. We investigated the impact of MS on addiction and drug reward as well as pain perception following 5 days of MPH injection in males and females rats. Initially, rats underwent MS protocol of 3 hours daily for 21 days. Conditioned place preference (CPP) test was an attempt to investigate whether MS rats experience more reward with MPH. The protocol consisted ...
Source: International Journal of Developmental Neuroscience - June 8, 2020 Category: Neuroscience Authors: Mohtashami Borzadaran F, Esmaeilpour K, Joushi S, Rajizadeh MA, Sheibani V, Ur Rehman N Tags: Int J Dev Neurosci Source Type: research

Prenatal exposure to methadone or buprenorphine alters µ-opioid receptor binding and downstream signaling in the rat brain.
In conclusion, our findings suggest that prenatal exposure to exogenous opioids such as methadone or buprenorphine may disturb the endogenous opioid system during development, with long-term effects on proteins important for cognitive functioning. PMID: 32484968 [PubMed - as supplied by publisher] (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - June 2, 2020 Category: Neuroscience Authors: Kongstorp M, Bogen IL, Steinsland S, Nerem E, Salih TW, Stiris T, Andersen JM Tags: Int J Dev Neurosci Source Type: research

The effects of gastrointestinal symptoms on structural gray matter volume in youth.
In conclusion, the structural differences found in participants with GIS support the need for further research into the neurophysiological impact of these symptoms. PMID: 32479685 [PubMed - as supplied by publisher] (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - June 1, 2020 Category: Neuroscience Authors: Pirwani AF, Fang Z, Li B, Smith A, Northoff G, Ismail N Tags: Int J Dev Neurosci Source Type: research

Inducible nitric oxide synthase inhibitor, aminoguanidine improved Ki67 as a marker of neurogenesis and learning and memory in juvenile hypothyroid rats.
CONCLUSION: These results revealed that AG improved neurogenesis, learning and memory impairments and oxidative imbalance in the brain juvenile Hypo rats. PMID: 32479691 [PubMed - as supplied by publisher] (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - June 1, 2020 Category: Neuroscience Authors: Alikhani V, Beheshti F, Rahbardar Ghasemzadeh M, Marefati N, Mansouritorghabeh F, Hosseini M Tags: Int J Dev Neurosci Source Type: research

Protective effects of Coenzyme Q10 against sevoflurane-induced cognitive impairment through regulating apolipoprotein E and phosphorylated Tau expression in young mice.
Abstract Children with multiple exposures to anesthesia and surgery may be more likely to develop learning disability. Coenzyme Q10 (CoQ10) was reported to reduce the multiple sevoflurane treatment induced cognitive deficiency in 6-day old young mice. However, its specific mechanisms have not yet been found. This research aimed to reveal the role of ApoE in the pathogenesis of cognitive deficiency caused by sevoflurane anesthesia and the protective mechanism of CoQ10 in a multiple sevoflurane treatment model of young mice. The mice were randomly divided into 4 groups: Control + corn oil, Sevoflurane + corn oil, Co...
Source: International Journal of Developmental Neuroscience - May 30, 2020 Category: Neuroscience Authors: Yang M, Tan H, Zhang K, Lian N, Yu Y, Yu Y Tags: Int J Dev Neurosci Source Type: research

Brain Tissue Volumes at Term-Equivalent Age Are Associated with Early Motor Behavior in Very Preterm Infants.
ron;asegi I Abstract Preterm birth is associated with a wide range of adverse developmental outcomes, including sensory, motor, cognitive and language impairments, and behavioral or attention problems. Subtle motor deficits that might emerge in premature infants with no evident or with mild brain injury encompass qualitative and quantitative aspects of motor behavior. This prospective cohort study provided evaluation of the relationship between brain tissue volumes revealed by magnetic resonance imaging (MRI) at term-equivalent age (TEA) and motor behavior in infancy in very preterm infants (total number=40; mean ...
Source: International Journal of Developmental Neuroscience - May 20, 2020 Category: Neuroscience Authors: Katušić A, Raguž M, Žunić Išasegi I Tags: Int J Dev Neurosci Source Type: research

Cortical Motor Areas Show Different Reorganizational Changes in Adult Patients with Brachial Plexus Birth Injury (BPBI).
In this study, adult patients with BPBI and age-matched healthy controls were compared for the cortical activity during action observation by functional magnetic resonance imaging (fMRI). RESULTS: The cortical activity in patients was significantly weaker than in the control group (p
Source: International Journal of Developmental Neuroscience - May 16, 2020 Category: Neuroscience Authors: Tuna Z, Oskay D, Algin O, Koçak OM Tags: Int J Dev Neurosci Source Type: research

Sex-dependent effects of post-weaning exposure to an enriched environment on novel objective recognition memory and anxiety-like behaviors: the role of hippocampal BDNF level.
In conclusion, adolescent exposure to EE has sex-dependent effects on cognitive functions and anxiety-like behaviors and increases BDNF mRNA expression in the hippocampus of both male and female rats; thus, BDNF is an important factor that can mediate the beneficial effects of EE and running exercise on cognitive functions and psychiatric traits. PMID: 32416621 [PubMed - as supplied by publisher] (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - May 16, 2020 Category: Neuroscience Authors: Sakhaie N, Sadegzadeh F, Mohammadnia A, Dadkhah M, Saadati H Tags: Int J Dev Neurosci Source Type: research

Sequence Variants in Three Genes Underlying Leukodystrophy in Pakistani Families.
This study was aimed to search for the causative variants in three unrelated consanguineous families presented with LD. Detailed clinical investigations were carried out on probands in three unrelated consanguineous families of Pakistani origin. Targeted gene sequencing and Whole Exome Sequencing (WES) were performed for variant identification. Candidate variants were checked for co-segregation with the phenotype using Sanger sequencing. Public databases including ExAC, gnomAD, dbSNP and the 1,000 Genome Project were searched to determine frequencies of the alleles. Conservation of the missense variants was ensured by alig...
Source: International Journal of Developmental Neuroscience - May 13, 2020 Category: Neuroscience Authors: Bibi F, Haider N, Din SU, Shah M, Krishin J, Qayyum N, Raja GK, Houlden H, Ahmad W, Khaliq T, Ullah A Tags: Int J Dev Neurosci Source Type: research

Ibuprofen during gestation prevents some changes in physical and reflex development in offspring in a model of hyperleucinemia and maternal inflammation.
Abstract Maple Syrup Urine Disease (MSUD) is caused by a severe deficiency in the branched-chain keto acid dehydrogenase complex activity. Patients MSUD accumulate the branched-chain amino acids leucine (Leu), isoleucine, valine in blood, and other tissues. Leu and/or their branched-chain α-keto acids are linked to neurological damage in MSUD. When immediately diagnosed and treated, patients develop normally. Inflammation in MSUD can elicit a metabolic decompensation crisis. There are few cases of pregnancy in MSUD women, and little is known about the effect of maternal hyperleucinemia on the neurodevelopmen...
Source: International Journal of Developmental Neuroscience - May 7, 2020 Category: Neuroscience Authors: de Franceschi ID, da Silva JD, Minuzzi BN, de Barros KC, Fernandes EK, Bortoluzzi VT, Rieger E, Preissler T, Feksa LR, Hahn RZ, Linden R, Rech VC, Casalli EA, Wannmacher CMD Tags: Int J Dev Neurosci Source Type: research

Sex-dependent aberrant PFC development in the adolescent offspring rats exposed to variable prenatal stress.
In conclusion, we found that PNS lead to Sex-dependent aberrant PFC development, and might accelerate the development of the adolescent PFC, and so that lessened the age difference (between adolescence and adulthood) and the sex difference. PMID: 32358823 [PubMed - as supplied by publisher] (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - May 1, 2020 Category: Neuroscience Authors: Niu Y, Wang T, Liang S, Li W, Hu X, Wu X, Jin F Tags: Int J Dev Neurosci Source Type: research

Consumption of a palatable diet rich in simple sugars during development impairs memory of different degrees of emotionality and changes hippocampal plasticity according to the age of the rats.
C, Krolow R Abstract We investigated the effect of a chronic palatable diet rich in simple sugars on memory of different degrees of emotionality in male adult rats, and on hippocampal plasticity markers in different stages of development. On postnatal day (PND) 21, forty-five male Wistar rats were divided in 2 groups, according to their diet: (1-Control) receiving standard lab chow or (2-Palatable Diet) receiving both standard chow plus palatable diet ad libitum. At PND 60, behavioral tests were performed to investigate memory in distinct tasks. Hippocampal plasticity markers were investigated at PND 28 in half of...
Source: International Journal of Developmental Neuroscience - April 16, 2020 Category: Neuroscience Authors: Altermann Torre V, Gonçalves Machado A, de Sá Couto-Pereira N, Mar Arcego D, Dos Santos Vieira A, Salerno PSV, Dos Santos Garcia E, Lazzaretti C, Toniazzo AP, Nedel F, Noschang C, Schmitz F, Wyse ATS, Dalmaz C, Krolow R Tags: Int J Dev Neurosci Source Type: research

Environmental Enrichment and Pain Sensitivity; a study in Maternally Separated Rats.
Abstract Rodents are highly dependent on maternal care after birth. Maternal separation (MS) is an animal model for studying neglect and abuse. Depriving the pup of such care renders the animal with Hypothalamic-Pituitary-adrenal (HPA) dysfunction and these animals are more susceptible to anxiety and stress as well as poor cognition. These effects are due to abnormal brain development in these animals. We have tried to investigate how maternal separation can affect pain sensation and whether a non-pharmacological intervention such as enriched environment (EE) can restore an abnormal pain sensation. Animals were pu...
Source: International Journal of Developmental Neuroscience - April 4, 2020 Category: Neuroscience Authors: Mohtashami Borzadaran F, Joushi S, Taheri Zadeh Z, Sheibani V, Esmaeilpour K Tags: Int J Dev Neurosci Source Type: research

Four novel compound heterozygous mutations in C5orf42 gene in patients with pure and mild Joubert syndrome.
Abstract Joubert syndrome (JS) is a rare clinically and genetically heterogeneous disease. Using whole or targeted exome sequencing, we identified four novel compound heterozygous mutations in chromosome 5 open reading frame 42 gene (C5orf42), including c.2876C>T (missense mutation) and c.3921+1G>A (splicing mutation), c.2292 -2delA (splicing mutation) and c.4067C>T (missense mutation), c.6997_6998insT (frameshift mutation) and c.8710C>T (nonsense mutation), c.3981G>C (nonsense mutation) and c.230 _233del (frameshift mutation), in four Chinese JS families. They were all inherited from their heterozy...
Source: International Journal of Developmental Neuroscience - March 31, 2020 Category: Neuroscience Authors: Liu Q, Wang H, Zhao J, Liu Z, Sun D, Yuan A, Luo G, Wei W, Hou M Tags: Int J Dev Neurosci Source Type: research

Adolescent cb1 receptor antagonism influences subsequent social interactions and neural activity in female rats.
Abstract We previously demonstrated that repeated exposure to the CB1 receptor antagonist/inverse agonist AM251 in adolescence (PND 30-44) increased social interactions in female rats when tested 48 h after the final exposure to the antagonist. Here, we investigated whether the increased sociality would be present after a longer drug washout period (5 days) in both male and female rats (experiment 1), and sought to identify candidate brain regions that may explain the observed differences in social behaviours between AM251 and vehicle-treated female rats (experiment 2). While drug-free, adolescent AM251 treatment ...
Source: International Journal of Developmental Neuroscience - March 27, 2020 Category: Neuroscience Authors: Simone JJ, Baumbach JL, McPherson J, McCormick CM Tags: Int J Dev Neurosci Source Type: research

Neonatal excitotoxicity modifies blood-brain barrier properties increasing its susceptibility to hypertonic shock in adulthood.
ilde;a-Guerrero M Abstract Early responses to a neurological excitotoxic process include blood-brain barrier (BBB) impairment and overexpression of vascular endothelial growth factor (VEGF), but the long-term effects of excitotoxicity on the BBB properties remain unknown. To assess this, we induced an excitotoxic process on male rats by neonatal monosodium glutamate (MSG) treatment. At postnatal day 60, we measured the expression level of structural proteins of the BBB and the VEGF type-2 receptor (VEGFR-2) protein in the cerebral motor cortex (CMC), striatum, hippocampus, entorhinal cortex, and hypothalamus. We a...
Source: International Journal of Developmental Neuroscience - March 21, 2020 Category: Neuroscience Authors: Fabiola Fajardo-Fregoso B, Luis Castañeda-Cabral J, Beas-Zárate C, Elisa Ureña-Guerrero M Tags: Int J Dev Neurosci Source Type: research

Developmental regulation and lateralization of the α7 and α4 Subunits of Nicotinic Acetylcholine Receptors (nAChRs) in Developing Rat Hippocampus.
Developmental regulation and lateralization of the α7 and α4 Subunits of Nicotinic Acetylcholine Receptors (nAChRs) in Developing Rat Hippocampus. Int J Dev Neurosci. 2020 Mar 21;: Authors: Baradaran R, Khoshdel-Sarkarizi H, Kargozar S, Hami J, Mohammadipour A, Sadr-Nabavi A, Peyvandi Karizbodagh M, Kheradmand H, Haghir H Abstract The purpose of this study was to describe distinct regional distribution patterns of expression of the α7 and α4 subunits of nicotinic acetylcholine receptors (nAChRs) and their left-right lateralization in the rat hippocampus during the first two wee...
Source: International Journal of Developmental Neuroscience - March 21, 2020 Category: Neuroscience Authors: Baradaran R, Khoshdel-Sarkarizi H, Kargozar S, Hami J, Mohammadipour A, Sadr-Nabavi A, Peyvandi Karizbodagh M, Kheradmand H, Haghir H Tags: Int J Dev Neurosci Source Type: research

Quercetin prevents alterations of behavioral parameters, delta-aminolevulinic dehydratase activity and oxidative damage in brain of rats in a prenatal model of autism.
Abstract Autism is a neuropathology characterized by behavioral disorders. Considering that oxidative stress is involved in the pathophysiology of this disease, we evaluated the effects of quercetin, a flavonoid with antioxidant and neuroprotective properties, in an experimental model of autism induced by valproic acid (VPA). Twelve pregnant female rats were divided into four groups (control, quercetin, VPA, VPA+quercetin). Quercetin (50 mg/kg) was administered orally to the animals from gestational days 6.5 to 18.5, and VPA (800 mg/kg) was administered orally in a single dosage on gestational day 12.5. Behavioral...
Source: International Journal of Developmental Neuroscience - March 17, 2020 Category: Neuroscience Authors: da Silveira de Mattos B, Soares MSP, Spohr L, Pedra NS, Teixeira FC, de Souza AA, Stefanello FM, Baldissarelli J, Gamaro GD, Spanevello RM Tags: Int J Dev Neurosci Source Type: research

Clinical correlates in children with autism spectrum disorder and CNVs: systematic investigation in a clinical setting.
This study documents the importance of measuring the physical and neurobehavioural correlates of ASD phenotypes to unravel the underlying molecular mechanisms in patient subgroups. PMID: 32159884 [PubMed - as supplied by publisher] (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - March 11, 2020 Category: Neuroscience Authors: Barone R, Gulisano M, Amore R, Domini C, Milana MC, Giglio S, Madia F, Mattina T, Casabona A, Fichera M, Rizzo R Tags: Int J Dev Neurosci Source Type: research

Altered morphology and function of the peripheral nociceptive system in the offspring of diabetic rats.
Abstract The aim of this study was to determine whether maternal diabetes induced by alloxan injection in the first gestational day of female Wistar rats interfere with the development of the nociceptive peripheral system of the offspring. Behavioral and histologic analysis was performed using the adult offspring of diabetic and control rats. It was found that the offspring of diabetic rats were more sensitive to thermal stimulation, and showed an altered response to carrageenan induced inflammatory hyperalgesia. The histological analysis showed an increased proportion of nociceptive neurons while the population o...
Source: International Journal of Developmental Neuroscience - March 6, 2020 Category: Neuroscience Authors: Lima TC, Paes Lemes JB, Capop TFPA, de Lima LB, da Cruz Lotufo CM Tags: Int J Dev Neurosci Source Type: research

Benefits of hypothermia in neonatal arterial ischemic strokes: a preclinical study.
CONCLUSION: Through combining anatomical, metabolic imaging and behavioral studies, our study provides evidence of neuroprotective effects of HT in NAIS. These results are potentially translational to human NAIS. PMID: 32115740 [PubMed - as supplied by publisher] (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - March 1, 2020 Category: Neuroscience Authors: Chevin M, Chabrier S, Dinomais M, Bedell BJ, Sébire G Tags: Int J Dev Neurosci Source Type: research

Elevation of stromal cell-derived factor 1 and C-X-C chemokine receptor type 4 in white matter damage treatment with recombinant human erythropoietin and human umbilical cord mesenchymal stem cells in a rat model of preterm birth.
CONCLUSIONS: The rhEPO and hUC-MSCs intervention reduced injury area, increased body weight at P7, and improved neurobehavioral scores at P28. Furthermore, their combined use proved even more beneficial. SDF-1 levels in the rhEPO group were higher than those in the other groups and highest in the hUC-MSCs + rhEPO group (all p 
Source: International Journal of Developmental Neuroscience - February 28, 2020 Category: Neuroscience Authors: Yin L, Wang S, Zhang N, Bai X, Xie J, Wen Q, Huang L, Qian L, Jiang L Tags: Int J Dev Neurosci Source Type: research

Amplitude of low-frequency fluctuation of resting-state fMRI in primary nocturnal enuresis and attention deficit hyperactivity disorder.
This study reveals the brain mechanism of cognitive changes on ADHD and NE which provides neuroimaging basis for behavioral differences among different diseases. PMID: 32092172 [PubMed - as supplied by publisher] (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - February 24, 2020 Category: Neuroscience Authors: Jiang K, Wang J, Zheng A, Li L, Yi Y, Ding L, Li H, Dong X, Zang Y Tags: Int J Dev Neurosci Source Type: research

Integrated analysis of miRNA and mRNA expression profiles in the brains of BTBR mice.
In this study, we analyzed microRNA (miRNA) and mRNA expression profiles in the cortical brain tissue from BTBR mice, using RNA sequencing. As compared to C57BL/6J (B6) mice, 1271 differentially expressed genes (DEGs) and 36 known differentially expressed miRNAs (DEMs) were found in the brain from BTBR mice. The functional annotation and categories of DEGs and DEMs were analyzed. Integration analysis identified 103 known miRNA-mRNA interaction pairs. We further verified selected several genes and miRNAs which may be associated with brain development using quantitative RT-PCR (qRT-PCR). Finally, we speculate that reduced MO...
Source: International Journal of Developmental Neuroscience - February 21, 2020 Category: Neuroscience Authors: Wang M, He J, Zhou Y, Lv N, Zhao M, Wei H, Li R Tags: Int J Dev Neurosci Source Type: research

Early weaning modulates eating behavior and promotes hypofunction of the serotonergic (5HT) system in juvenile male rats.
de Souza S Abstract Early life stress (ELS) has been associated with developmental impairments. Early weaning is a postnatal stress model consisting of interruption of lactation and maternal care. The 5HT-system has been associated with neurobehavioral modulations promoted by ELS. Thus, the present work aims to investigate the effects of early weaning on feeding behavior and serotonergic system of juvenile male rats. For this, rats were submitted to early (PND15) or natural (PND30) weaning and had the body weight, food intake in circadian phases and food intake in response to fenfluramine assessed. mRNA expressio...
Source: International Journal of Developmental Neuroscience - February 21, 2020 Category: Neuroscience Authors: Tavares GA, Cavalcanti do Amaral Almeida L, Araújo de Souza J, Leitão de Souza F, Feitosa Braz GR, Times Silva B, Mayara da Silva Santos A, Jacques Lagranha C, Lopes de Souza S Tags: Int J Dev Neurosci Source Type: research

Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice.
ibeiro-Carvalho A Abstract The brain is particularly vulnerable to ethanol effects during its growth spurt. Outcomes of early ethanol exposure such as hyperactivity have been extensively investigated; however, persons with fetal alcohol spectrum disorder frequently have social impairments and are heavy drinkers. Despite that, scant information is available regarding the neurobiological basis of these latter behavioral issues. Here, Swiss mice exposed to ethanol (Etoh, 5 g/Kg i.p., alternate days) or saline during the brain growth spurt [postnatal day (PN) 2 to 8] were used to assess social behavior after an e...
Source: International Journal of Developmental Neuroscience - February 19, 2020 Category: Neuroscience Authors: Demarque KC, Dutra-Tavares AC, Nunes-Freitas AL, Araújo UC, Manhães AC, Abreu-Villaça Y, Filgueiras CC, Ribeiro-Carvalho A Tags: Int J Dev Neurosci Source Type: research

Brain abnormalities on neuroimaging in Children with Congenital Zika Syndrome in Salvador, Brazil and its possible implications on neuropsychological development.
Abstract OBJECTIVE: to characterize the spectrum of brain damages presented in children affected by Congenital Zika Syndrome (CZS), verify the existence of a co-occurrence pattern of these damages and discuss possible implications for the neuropsychological development. METHODS: descriptive, quantitative, individualized and cross-sectional study using secondary sources. We selected 136 children with CZS from the database of the Center of Strategic Information on Health Vigilance of the Municipal Office of Salvador, Brazil. We conducted descriptive and multiple correspondence analyses. RESULTS: Among the ...
Source: International Journal of Developmental Neuroscience - February 17, 2020 Category: Neuroscience Authors: Sanders Pereira Pinto P, de Almeida TM, Monteiro L, da Silva Souza MM, Dos Santos GAA, Cardoso CW, Dos Santos LM, Ribeiro GS, Dos Santos DN Tags: Int J Dev Neurosci Source Type: research

Ketamine treatment affects hippocampal but not cortical mitochondrial function in prepubertal rats.
Abstract Previous reports have shown that ketamine triggered apoptosis in immature developing brain involving mitochondrial mediated pathways. However, no data for ketamine effects on hippocampal and cortical mitochondrial function are available in pre-pubertal rats. Twenty-one days-old Sprague-Dawley rats received ketamine (40 mg/Kg i.p.) for 3 days and were sacrificed 24 hours after last injection. Hippocampal mitochondria from ketamine-treated rats showed decreased malate-glutamate state 4 and 3 respiratory rates and an inhibition in Complex I and IV activities. Hippocampal mitochondrial membrane depolarization...
Source: International Journal of Developmental Neuroscience - February 13, 2020 Category: Neuroscience Authors: Czerniczyniec A, Karadayian AG, Bustamante J, Lores-Arnaiz S Tags: Int J Dev Neurosci Source Type: research

Prolonged methamphetamine exposure during a critical period in neonatal Sprague-Dawley rats does not exacerbate egocentric and allocentric learning deficits but increases reference memory impairments.
Abstract Children exposed to methamphetamine (MA) in utero have cognitive deficits. MA administration in rats for 5-10 days between postnatal day (P)6-20 produces cognitive deficits. The purpose of this study was to determine if extending MA administration by 5 days within P6-20 would exacerbate allocentric (Morris water maze) and egocentric (Cincinnati water maze) learning deficits. Sprague-Dawley female and male offspring (split-litter design) were administered saline (SAL) or MA (10 mg/kg) four times daily from P6-20 to create four groups: (1) SAL from P6-20, (2) MA from P6-20 (MA6-20), (3) MA from P6-15 (MA6-1...
Source: International Journal of Developmental Neuroscience - February 11, 2020 Category: Neuroscience Authors: Williams MT, Amos-Kroohs RM, Vorhees CV Tags: Int J Dev Neurosci Source Type: research

Early onset epileptic encephalopathy caused by novel compound heterozygous mutation of WWOX Gene.
Abstract The human WW Domain Containing Oxidoreductase (WWOX) gene has been identified as a tumor suppressor gene. However, recent reports have demonstrated its dominant role in autosomal recessive disorders of the central nervous system, especially in early onset epileptic encephalopathy (EOEE). Here, we report a Chinese case with novel compound heterozygous mutation of WWOX gene( c.229_230+2del mutation originated from her mother and c.1065dup (p.Ala356Serfs*173) variation from her father ),and compare them to previously reported 59 WWOX-related epileptic encephalopathy (WOREE). Early-onset and frequent epilepti...
Source: International Journal of Developmental Neuroscience - February 9, 2020 Category: Neuroscience Authors: Su T, Yan Y, Xu S, Zhang K, Xu S Tags: Int J Dev Neurosci Source Type: research

Behavioral and Brain Ultrastructural Changes Following Systemic Administration of Propionic Acid in Adolescent Male Rats. Further Development of a Rodent Model of Autism.
We examined behavior (Morris water and radial arm mazes) and the ultrastructure of the hippocampus and medial prefrontal cortex (electron microscopy) following a single intraperitoneal (i.p.) injection of PPA (175 mg/kg) in male adolescent rats. PPA treatment showed altered social and locomotor behavior without changes in learning and memory. Both transient and enduring ultrastructural alterations in synapses, astro- and microglia were detected in the CA1 hippocampal area. Electron microscopic analysis showed, PPA treatment significantly decreased total number of synaptic vesicles, presynaptic mitochondria and synapses wit...
Source: International Journal of Developmental Neuroscience - January 30, 2020 Category: Neuroscience Authors: Lobzhanidze G, Japaridze N, Lordkipandize T, Rzayev F, MacFabe D, Zhvania M Tags: Int J Dev Neurosci Source Type: research

Maternal lithium chloride exposure alters the neuroendocrine-cytokine axis in neonatal albino rats.
Abstract The aim of this work was to clarify whether maternal lithium chloride (LiCl) exposure disrupts the neonatal neuroendocrine-cytokine axis. Pregnant Wistar rats were orally administrated 50 mg LiCl/kg b.wt. from gestational day (GD) 1 to postpartum day 28. Maternal administration of LiCl-induced a hypothyroid state in both dams and their neonates compared to the control dams and neonates at lactation days (LDs) 14, 21 and 28, where the levels of serum free triiodothyronine (FT3) and free thyroxin (FT4) were decreased and the level of serum thyrotropin (TSH) level was increased. A noticeable depression in ma...
Source: International Journal of Developmental Neuroscience - January 28, 2020 Category: Neuroscience Authors: Dena AM, Ahmed RR, Ahmed RG Tags: Int J Dev Neurosci Source Type: research

Impairment of motor but not anxiety-like behavior caused by the increase of dopamine during development is sustained in zebrafish larvae at later stages.
In this study, we set out to determine whether these behavioral alterations were sustained in larvae at older stages (7 and 14 dpf). To test this hypothesis, we chronically treated zebrafish larvae from 3 to 5 dpf with DA. After washing the drug, we recorded and analyzed the first 5 minutes and 30 minutes of the motor behavior of 5 dpf, 7 dpf and 14 dpf subjects. We analyzed mobile episodes, distance travelled, time mobile, distance travelled per mobile episode, time in movement per mobile episode and distance travelled per time mobile. We showed, once again, that an increase of DA during the 3 to 5 dpf developmental windo...
Source: International Journal of Developmental Neuroscience - January 28, 2020 Category: Neuroscience Authors: de Souza Lima ACM, de Alvarenga KAF, Codo BC, Sacramento EK, Rosa DVF, Souza RP, Romano-Silva MA, Souza BR Tags: Int J Dev Neurosci Source Type: research

Morphine consumption during pregnancy exacerbates neonatal Hypoxia-Ischemia injury in rats.
CONCLUSION: Based on the results, morphine consumption during pregnancy and lactation enhanced deleterious effects of HI injury in pups. PMID: 31981237 [PubMed - as supplied by publisher] (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - January 24, 2020 Category: Neuroscience Authors: Bornavard M, Fanaei H, Mirshekar MA, Farajian Mashhadi F, Atashpanjeh A Tags: Int J Dev Neurosci Source Type: research

Recent advances in the pathophysiology of inherited metabolic diseases.
Abstract Inborn errors of metabolism (IEM) are a group of rare genetic diseases caused by defects in different types of proteins, including enzymes, structural proteins or transporters. The blockage of a metabolic pathway leads to an accumulation of precursors to the detriment of the products of this pathway (Fukao and Nakamura, 2019). The central nervous system is commonly affected in several of these disorders. PMID: 31951034 [PubMed - as supplied by publisher] (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - January 17, 2020 Category: Neuroscience Authors: Schuck PF, Ferreira GC, McKenna MC Tags: Int J Dev Neurosci Source Type: research

The role of GABAergic Neural Circuits in the Pathogenesis of Autism Spectrum Disorder.
Abstract Autism Spectrum Disorder (ASD) comprises a heterogeneous range of neurodevelopmental conditions represented by symptoms including, communication and language deficits, repetitive and restricted patterns of behavior and inadequate social interactions. Gamma-aminobutyric acid (GABA) is known to mediate inhibitory responses in the Central Nervous System (CNS) by interacting with GABA signaling receptors. In this context, several recent investigations suggest that imbalances in the GABAergic neurotransmission system may be implicated in the development of ASD as well as several other neurodevelopmental disord...
Source: International Journal of Developmental Neuroscience - January 7, 2020 Category: Neuroscience Authors: Di J, Li J, O'Hara B, Alberts I, Xiong L, Li J, Li X Tags: Int J Dev Neurosci Source Type: research

Elevated levels of BDNF and cathepsin-D as possible peripheral markers of neurodegeneration in plasma of patients with glutaric acidemia type I.
Abstract Glutaric acidemia type I (GA1) is caused by severe deficiency of glutaryl-CoA dehydrogenase activity, resulting in an accumulation of glutaric acid and glutarylcarnitine (C5DC) in the organism. Patients affected by GA1 are asymptomatic in the neonate period but usually manifest chronically progressive neurodegeneration apart from severe encephalopathic crises associated with acute striatum necrosis. Neurological manifestations like dyskinesia, dystonia, hypotonia, muscle stiffness and spasticity are present. Treatment is based on protein/lysine restriction and L-carnitine supplementation. In this work we ...
Source: International Journal of Developmental Neuroscience - January 7, 2020 Category: Neuroscience Authors: Guerreiro G, Diaz-Jaques CE, Wajner M, Vargas CR Tags: Int J Dev Neurosci Source Type: research

Vulnerable and Resilient Cognitive Performance Related to Early Life Stress: The Potential Mediating Role of Dopaminergic Receptors in the Medial Prefrontal Cortex of Adult Mice.
CONCLUSIONS: Our findings suggest a potential role of the dopaminergic system in the programming mechanisms of cognitive vulnerability and resilience related to ELS. PMID: 31907967 [PubMed - as supplied by publisher] (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - January 6, 2020 Category: Neuroscience Authors: Tractenberg SG, Orso R, Creutzberg KC, Malcon LM, Lumertz FS, Wearick-Silva LE, Viola TW, Riva MA, Grassi-Oliveira R Tags: Int J Dev Neurosci Source Type: research

Exercise before pregnancy attenuates the effects of prenatal stress in adult mice in a sex-dependent manner.
In conclusion, pregestational exercise may attenuate developmental changes induced by prenatal stress in a sex-dependent manner. PMID: 31909492 [PubMed - as supplied by publisher] (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - January 2, 2020 Category: Neuroscience Authors: Luft C, Levices IP, Costa MSD, Haute GV, Grassi-Oliveira R, de Oliveira JR, Donadio MVF Tags: Int J Dev Neurosci Source Type: research

Hyperthermia-induced seizures produce long-term effects on the functionality of adenosine A1 receptor in rat cerebral cortex.
acute;, Martín M Abstract Febrile seizures are one of the most frequent childhood neurological disorders; they are classified into simple and prolonged, depending on their duration. Prolonged FS lasts more than 15 min and may evoke neurological sequelae in a process in which molecular alterations seem to play an important role. Adenosine is a purine nucleoside that exerts anticonvulsant effects through binding to adenosine A1 receptor (A1R). This receptor belongs to the GPCR superfamily and is negatively coupled to adenylyl cyclase (AC) activity through Gi proteins. In the present study, we analyzed th...
Source: International Journal of Developmental Neuroscience - January 2, 2020 Category: Neuroscience Authors: Crespo M, León-Navarro DA, Ruíz MÁ, Martín M Tags: Int J Dev Neurosci Source Type: research

X-linked Adrenoleukodystrophy: Pathology, Pathophysiology, Diagnostic Testing, Newborn Screening, and Therapies.
Abstract Adrenoleukodystrophy (ALD) is a rare X-linked disease caused by a mutation of the peroxisomal ABCD1 gene. This review summarizes our current understanding of the pathogenic cell- and tissue-specific role of lipid species in the context of experimental therapeutic strategies and provides an overview of critical historical developments, therapeutic trials, and the advent of newborn screening in the United States. In ALD, very long chain fatty acid (VLCFA) chain-length-dependent dysregulation of endoplasmic reticulum stress and mitochondrial radical generating systems inducing cell death pathways has been sh...
Source: International Journal of Developmental Neuroscience - January 2, 2020 Category: Neuroscience Authors: Turk BR, Theda C, Fatemi A, Moser AB Tags: Int J Dev Neurosci Source Type: research

Intimate partner violence indirectly dysregulates child diurnal adrenocortical functioning through positive parenting.
Abstract Data were drawn from an ongoing study of preschoolers (N = 221). Mothers self-reported experiences of intimate partner violence (IPV) and parenting practices, and collected three saliva samples (waking, midday, and bedtime) on themselves and their child on two consecutive days. Saliva samples were later assayed for cortisol. Bootstrapped mediation analyses revealed IPV to indirectly impact child diurnal cortisol through positive parenting. Specifically, greater exposure to IPV was associated with reduced positive parenting and subsequently heightened child waking cortisol levels. IPV did not indirectly im...
Source: International Journal of Developmental Neuroscience - January 2, 2020 Category: Neuroscience Authors: Hibel LC, Nuttall AK, Valentino K Tags: Int J Dev Neurosci Source Type: research

X-linked Adrenoleukodystrophy: Pathology, Pathophysiology, Diagnostic Testing, Newborn Screening, and Therapies.
Abstract Adrenoleukodystrophy (ALD) is a rare X-linked disease caused by a mutation of the peroxisomal ABCD1 gene. This review summarizes our current understanding of the pathogenic cell- and tissue-specific role of lipid species in the context of experimental therapeutic strategies and provides an overview of critical historical developments, therapeutic trials, and the advent of newborn screening in the United States. In ALD, very long chain fatty acid (VLCFA) chain-length-dependent dysregulation of endoplasmic reticulum stress and mitochondrial radical generating systems inducing cell death pathways has been sh...
Source: International Journal of Developmental Neuroscience - November 25, 2019 Category: Neuroscience Authors: Turk BR, Theda C, Fatemi A, Moser AB Tags: Int J Dev Neurosci Source Type: research

Intimate partner violence indirectly dysregulates child diurnal adrenocortical functioning through positive parenting.
Abstract Data were drawn from an ongoing study of preschoolers (N = 221). Mothers self-reported experiences of intimate partner violence (IPV) and parenting practices, and collected three saliva samples (waking, midday, and bedtime) on themselves and their child on two consecutive days. Saliva samples were later assayed for cortisol. Bootstrapped mediation analyses revealed IPV to indirectly impact child diurnal cortisol through positive parenting. Specifically, greater exposure to IPV was associated with reduced positive parenting and subsequently heightened child waking cortisol levels. IPV did not...
Source: International Journal of Developmental Neuroscience - November 23, 2019 Category: Neuroscience Authors: Hibel LC, Nuttall AK, Valentino K Tags: Int J Dev Neurosci Source Type: research

Changes in vascular density in resected tissue of 97 patients with mild malformation of cortical development, focal cortical dysplasia or TSC-related cortical tubers.
In this study we aimed to further elucidate the relation between microvascular density and cortical developmental abnormalities in a cohort of 97 patients with epilepsy and histologically proven mild malformation of cortical development (mMCD), focal cortical dysplasia (FCD) or tuberous sclerosis complex (TSC). Surgical tissue samples were analyzed with quantitative measures of vessel density, T-cell response, microglial activation and myelin content. Subsequently, the results were compared to an age- and localization matched control group. We observed an increase in microvasculature in white matter of TSC cortical tubers,...
Source: International Journal of Developmental Neuroscience - November 23, 2019 Category: Neuroscience Authors: Veersema TJ, de Neef A, van Scheppingen J, Ferrier CH, van Eijsden P, Gosselaar PH, van Rijen PC, Spliet WGM, Braun KP, Mühlebner A, Aronica EMA Tags: Int J Dev Neurosci Source Type: research

Effects of dual tasking on postural and gait performances in children with cerebral palsy and healthy children.
Abstract Simultaneous execution of motor and cognitive tasks is embedded in the daily life of children. 53 children of 7-12 years and 22 adults (study 1), 20 healthy children and 20 children of 7-12 years with cerebral palsy (study 2) performed a Stroop-animal task simultaneously with a standing or a walking task in order to determine the attentional demand of postural control and locomotion. Dual-task cost decreased with advancing age in healthy children during balance. CP and healthy children were similarly affected by dual-task constraints during standing and walking. Children with diplegia were more affected b...
Source: International Journal of Developmental Neuroscience - November 10, 2019 Category: Neuroscience Authors: Palluel E, Chauvel G, Bourg V, Commare MC, Prado C, Farigoule V, Nougier V, Olivier I Tags: Int J Dev Neurosci Source Type: research

Neonatal anoxia impairs long-term energy metabolism and somatic development of Wistar rats.
CONCLUSION: Neonatal anoxia impairs long-term energy metabolism and somatic development in Wistar rats, with differences related to sex and age. PMID: 31715265 [PubMed - as supplied by publisher] (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - November 9, 2019 Category: Neuroscience Authors: Cruz-Ochoa NA, Ochoa-Amaya JE, Pulecio SL, Xavier GF, Nogueira MI Tags: Int J Dev Neurosci Source Type: research