Complex genotypes in family with metachromatic leukodystrophy: Effect of trans and cis mutations distribution on the phenotype variability
In conclusion, we identified a complex genotype of ARSA variants within two MLD siblings with a variable severity due to a de novo variant present in one of them. Our results allowed the establishment of an adult MLD diagnosis and highlighted the importance of an assessment of the trans/cis distribution in the cases of complex genotypes.PMID:37848385 | DOI:10.1002/jdn.10306 (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - October 17, 2023 Category: Neuroscience Authors: Abir Ben Issa Fatma Kamoun Wafa Bouchaala Chahnez Charfi Triki Faiza Fakhfakh Source Type: research

Long-term effect of indomethacin on a rat model of neonatal hypoxia ischemic encephalopathy through behavioral tests
CONCLUSIONS: In this study, we have shown for the first time that indomethacin treatment can reduce levels of anxiety-like behavior and enhance levels of exploratory behavior in a neonatal rat model with HIE. It is necessary to determine whether nonsteroidal anti-inflammatory agents, such as indomethacin, should be used for adjuvant therapy in newborns with HIE.PMID:37842754 | DOI:10.1002/jdn.10305 (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - October 16, 2023 Category: Neuroscience Authors: Tugay Tepe Mehmet Satar Mustafa Ozdemir Hacer Yapicioglu Yildizdas Ferda Ozl ü Seyda Erdogan Tugba Toyran K übra Akillioglu Seda K öse Cagri Avci Source Type: research

Long-term effect of indomethacin on a rat model of neonatal hypoxia ischemic encephalopathy through behavioral tests
CONCLUSIONS: In this study, we have shown for the first time that indomethacin treatment can reduce levels of anxiety-like behavior and enhance levels of exploratory behavior in a neonatal rat model with HIE. It is necessary to determine whether nonsteroidal anti-inflammatory agents, such as indomethacin, should be used for adjuvant therapy in newborns with HIE.PMID:37842754 | DOI:10.1002/jdn.10305 (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - October 16, 2023 Category: Neuroscience Authors: Tugay Tepe Mehmet Satar Mustafa Ozdemir Hacer Yapicioglu Yildizdas Ferda Ozl ü Seyda Erdogan Tugba Toyran K übra Akillioglu Seda K öse Cagri Avci Source Type: research

The effect of the home environment on children with autism spectrum disorder
Int J Dev Neurosci. 2023 Sep 29. doi: 10.1002/jdn.10304. Online ahead of print.ABSTRACTThe estimated prevalence of autism spectrum disorders (ASD) is 1% worldwide. Autistic individuals typically have a high level of sensitivity to the various environmental stimuli (smell, noise, light). These stimuli have a positive or negative influence on the person-environment interaction, and an excess of stimuli may create inappropriate or unanticipated behavioral responses (such as a crisis) effecting their well-being. The Model of Competence, which provides an explanation of the interaction between the individual and the environment...
Source: International Journal of Developmental Neuroscience - September 30, 2023 Category: Neuroscience Authors: Gul Kahveci Emrah Caylak Donay Nisa Kara Source Type: research

The effect of the home environment on children with autism spectrum disorder
Int J Dev Neurosci. 2023 Sep 29. doi: 10.1002/jdn.10304. Online ahead of print.ABSTRACTThe estimated prevalence of autism spectrum disorders (ASD) is 1% worldwide. Autistic individuals typically have a high level of sensitivity to the various environmental stimuli (smell, noise, light). These stimuli have a positive or negative influence on the person-environment interaction, and an excess of stimuli may create inappropriate or unanticipated behavioral responses (such as a crisis) effecting their well-being. The Model of Competence, which provides an explanation of the interaction between the individual and the environment...
Source: International Journal of Developmental Neuroscience - September 30, 2023 Category: Neuroscience Authors: Gul Kahveci Emrah Caylak Donay Nisa Kara Source Type: research

The effect of the home environment on children with autism spectrum disorder
Int J Dev Neurosci. 2023 Sep 29. doi: 10.1002/jdn.10304. Online ahead of print.ABSTRACTThe estimated prevalence of autism spectrum disorders (ASD) is 1% worldwide. Autistic individuals typically have a high level of sensitivity to the various environmental stimuli (smell, noise, light). These stimuli have a positive or negative influence on the person-environment interaction, and an excess of stimuli may create inappropriate or unanticipated behavioral responses (such as a crisis) effecting their well-being. The Model of Competence, which provides an explanation of the interaction between the individual and the environment...
Source: International Journal of Developmental Neuroscience - September 30, 2023 Category: Neuroscience Authors: Gul Kahveci Emrah Caylak Donay Nisa Kara Source Type: research

The effect of the home environment on children with autism spectrum disorder
Int J Dev Neurosci. 2023 Sep 29. doi: 10.1002/jdn.10304. Online ahead of print.ABSTRACTThe estimated prevalence of autism spectrum disorders (ASD) is 1% worldwide. Autistic individuals typically have a high level of sensitivity to the various environmental stimuli (smell, noise, light). These stimuli have a positive or negative influence on the person-environment interaction, and an excess of stimuli may create inappropriate or unanticipated behavioral responses (such as a crisis) effecting their well-being. The Model of Competence, which provides an explanation of the interaction between the individual and the environment...
Source: International Journal of Developmental Neuroscience - September 30, 2023 Category: Neuroscience Authors: Gul Kahveci Emrah Caylak Donay Nisa Kara Source Type: research

The effect of the home environment on children with autism spectrum disorder
Int J Dev Neurosci. 2023 Sep 29. doi: 10.1002/jdn.10304. Online ahead of print.ABSTRACTThe estimated prevalence of autism spectrum disorders (ASD) is 1% worldwide. Autistic individuals typically have a high level of sensitivity to the various environmental stimuli (smell, noise, light). These stimuli have a positive or negative influence on the person-environment interaction, and an excess of stimuli may create inappropriate or unanticipated behavioral responses (such as a crisis) effecting their well-being. The Model of Competence, which provides an explanation of the interaction between the individual and the environment...
Source: International Journal of Developmental Neuroscience - September 30, 2023 Category: Neuroscience Authors: Gul Kahveci Emrah Caylak Donay Nisa Kara Source Type: research

The effect of the home environment on children with autism spectrum disorder
Int J Dev Neurosci. 2023 Sep 29. doi: 10.1002/jdn.10304. Online ahead of print.ABSTRACTThe estimated prevalence of autism spectrum disorders (ASD) is 1% worldwide. Autistic individuals typically have a high level of sensitivity to the various environmental stimuli (smell, noise, light). These stimuli have a positive or negative influence on the person-environment interaction, and an excess of stimuli may create inappropriate or unanticipated behavioral responses (such as a crisis) effecting their well-being. The Model of Competence, which provides an explanation of the interaction between the individual and the environment...
Source: International Journal of Developmental Neuroscience - September 30, 2023 Category: Neuroscience Authors: Gul Kahveci Emrah Caylak Donay Nisa Kara Source Type: research

The effect of the home environment on children with autism spectrum disorder
Int J Dev Neurosci. 2023 Sep 29. doi: 10.1002/jdn.10304. Online ahead of print.ABSTRACTThe estimated prevalence of autism spectrum disorders (ASD) is 1% worldwide. Autistic individuals typically have a high level of sensitivity to the various environmental stimuli (smell, noise, light). These stimuli have a positive or negative influence on the person-environment interaction, and an excess of stimuli may create inappropriate or unanticipated behavioral responses (such as a crisis) effecting their well-being. The Model of Competence, which provides an explanation of the interaction between the individual and the environment...
Source: International Journal of Developmental Neuroscience - September 30, 2023 Category: Neuroscience Authors: Gul Kahveci Emrah Caylak Donay Nisa Kara Source Type: research

The effect of the home environment on children with autism spectrum disorder
Int J Dev Neurosci. 2023 Sep 29. doi: 10.1002/jdn.10304. Online ahead of print.ABSTRACTThe estimated prevalence of autism spectrum disorders (ASD) is 1% worldwide. Autistic individuals typically have a high level of sensitivity to the various environmental stimuli (smell, noise, light). These stimuli have a positive or negative influence on the person-environment interaction, and an excess of stimuli may create inappropriate or unanticipated behavioral responses (such as a crisis) effecting their well-being. The Model of Competence, which provides an explanation of the interaction between the individual and the environment...
Source: International Journal of Developmental Neuroscience - September 30, 2023 Category: Neuroscience Authors: Gul Kahveci Emrah Caylak Donay Nisa Kara Source Type: research

The effect of the home environment on children with autism spectrum disorder
Int J Dev Neurosci. 2023 Sep 29. doi: 10.1002/jdn.10304. Online ahead of print.ABSTRACTThe estimated prevalence of autism spectrum disorders (ASD) is 1% worldwide. Autistic individuals typically have a high level of sensitivity to the various environmental stimuli (smell, noise, light). These stimuli have a positive or negative influence on the person-environment interaction, and an excess of stimuli may create inappropriate or unanticipated behavioral responses (such as a crisis) effecting their well-being. The Model of Competence, which provides an explanation of the interaction between the individual and the environment...
Source: International Journal of Developmental Neuroscience - September 30, 2023 Category: Neuroscience Authors: Gul Kahveci Emrah Caylak Donay Nisa Kara Source Type: research

The effect of the home environment on children with autism spectrum disorder
Int J Dev Neurosci. 2023 Sep 29. doi: 10.1002/jdn.10304. Online ahead of print.ABSTRACTThe estimated prevalence of autism spectrum disorders (ASD) is 1% worldwide. Autistic individuals typically have a high level of sensitivity to the various environmental stimuli (smell, noise, light). These stimuli have a positive or negative influence on the person-environment interaction, and an excess of stimuli may create inappropriate or unanticipated behavioral responses (such as a crisis) effecting their well-being. The Model of Competence, which provides an explanation of the interaction between the individual and the environment...
Source: International Journal of Developmental Neuroscience - September 30, 2023 Category: Neuroscience Authors: Gul Kahveci Emrah Caylak Donay Nisa Kara Source Type: research

The effect of the home environment on children with autism spectrum disorder
Int J Dev Neurosci. 2023 Sep 29. doi: 10.1002/jdn.10304. Online ahead of print.ABSTRACTThe estimated prevalence of autism spectrum disorders (ASD) is 1% worldwide. Autistic individuals typically have a high level of sensitivity to the various environmental stimuli (smell, noise, light). These stimuli have a positive or negative influence on the person-environment interaction, and an excess of stimuli may create inappropriate or unanticipated behavioral responses (such as a crisis) effecting their well-being. The Model of Competence, which provides an explanation of the interaction between the individual and the environment...
Source: International Journal of Developmental Neuroscience - September 30, 2023 Category: Neuroscience Authors: Gul Kahveci Emrah Caylak Donay Nisa Kara Source Type: research

The effect of the home environment on children with autism spectrum disorder
Int J Dev Neurosci. 2023 Sep 29. doi: 10.1002/jdn.10304. Online ahead of print.ABSTRACTThe estimated prevalence of autism spectrum disorders (ASD) is 1% worldwide. Autistic individuals typically have a high level of sensitivity to the various environmental stimuli (smell, noise, light). These stimuli have a positive or negative influence on the person-environment interaction, and an excess of stimuli may create inappropriate or unanticipated behavioral responses (such as a crisis) effecting their well-being. The Model of Competence, which provides an explanation of the interaction between the individual and the environment...
Source: International Journal of Developmental Neuroscience - September 30, 2023 Category: Neuroscience Authors: Gul Kahveci Emrah Caylak Donay Nisa Kara Source Type: research