International Journal of Developmental Neuroscience This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Music alleviates cognitive impairments in an animal model of autism
Int J Dev Neurosci. 2023 May 28. doi: 10.1002/jdn.10260. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by core symptoms including impairment in social communication and restrictive and repetitive behaviors and interests. Music has emerged in the past decade as an intervention therapy for children with ASD. The aim of the present study was to evaluate the effects of music on cognition impairments in the valproic acid (VPA) rat model of autism. The VPA was administered for animal modeling of autism on embryonic day 12.5 (E12.5) (600 mg/kg). Male and female pups we...
Source: International Journal of Developmental Neuroscience - May 29, 2023 Category: Neuroscience Authors: Farahnaz Taheri Sara Joushi Khadijeh Esmaeilpour Vahid Sheibani Mohammad Navid Ebrahimi Zahra Taheri Zadeh Source Type: research

Inhibition functions can be improved in children with autism spectrum disorders: An eye-tracking study
Int J Dev Neurosci. 2023 May 23. doi: 10.1002/jdn.10276. Online ahead of print.ABSTRACTCognitive remediation therapy interventions could improve cognitive functioning in subjects with autism. To investigate the benefit of a short cognitive training rehabilitation in children with autism spectrum disorder (ASD) on pursuit and fixation performances. We recruited two groups (G1 and G2) of 30 children with ASD, sex-, IQ- and age-matched (mean 11.6 ± 0.5 years), and pursuit and fixation eye movements were recorded twice at T1 and T2. Between T1 and T2, a 10-min cognitive training was performed by the G1 group only, whereas the...
Source: International Journal of Developmental Neuroscience - May 23, 2023 Category: Neuroscience Authors: Simona Caldani Elise Humeau Richard Delorme Maria Pia Bucci Source Type: research

Wuzi Yanzong Pill protects neural tube defects by activating PI3K/Akt signaling pathway
In this study, the neuroprotective effect and mechanism of WYP on NTDs were investigated in vivo using an atRA-induced mouse model and in vitro using cell injury model induced by atRA in Chinese hamster ovary (CHO) cells and Chinese hamster dihydrofolate reductase-deficient (CHO/dhFr) cells. Our findings suggest that WYP has an excellent preventive effect on atRA-induced NTDs in mouse embryos, which may be related to the activation of the PI3K/Akt signaling pathway, improved embryonic antioxidant capacity, and anti-apoptotic effects, and this effect is not dependent on folic acid (FA). Our results demonstrated that WYP sig...
Source: International Journal of Developmental Neuroscience - May 22, 2023 Category: Neuroscience Authors: Xinliang Wang Chanjuan Yang Yanrong Li Qiang Gong Yi Ru Liangqi Xie Baoguo Xiao Xiaoming Jin Cungen Ma Zhi Chai Huijie Fan Source Type: research

Novel KCNC2 variant associated with developmental and epileptic encephalopathy
Int J Dev Neurosci. 2023 May 18. doi: 10.1002/jdn.10263. Online ahead of print.ABSTRACTThe KCNC2 gene encodes Kv3.2, which is a member of the voltage-gated potassium channel subfamily. It is crucial for the generation of fast-spiking properties in cortical GABAergic interneurons. Recently, KCNC2 variations were found to be associated with epileptic encephalopathy in unrelated individuals. Here, we report a Chinese patient with developmental and epileptic encephalopathy (DEE) and motor development delay. Whole-exome sequencing (WES) revealed a novel heterozygous variant in the KCNC2 gene NM_139137.4:c.1163T>C (p.Phe388Se...
Source: International Journal of Developmental Neuroscience - May 19, 2023 Category: Neuroscience Authors: Liang Huo Qiong Wu Fan Yang Xueyan Liu Zuozhen Yang Hua Wang Source Type: research

A new case with the recurrent PURA p.(Phe233del) pathogenic variant: Expansion of the phenotype and review of the literature
Int J Dev Neurosci. 2023 May 19. doi: 10.1002/jdn.10266. Online ahead of print.ABSTRACTIn the process of neuronal development, the protein Purα (encoded by the PURA gene) is essential for neuronal proliferation, dendritic maturation, and the transportation of mRNA to translation sites. Mutations in the PURA gene may alter normal brain development and impair neuronal function, contributing to developmental delays and seizures. Recently, PURA syndrome is described as developmental encephalopathy with or without epilepsy, neonatal hypotonia, feeding difficulties, global developmental delay, and severe intellectual disability...
Source: International Journal of Developmental Neuroscience - May 19, 2023 Category: Neuroscience Authors: Abir Ben Issa Ikhlas Ben Ayed Olfa Jallouli Amal Souissi Wafa Bouchaalla Mariem Ben Said Salma Mallouli Saber Masmoudi Chahnez Charfi Triki Hassen Hadj Kacem Fatma Kammoun Source Type: research