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Maternal separation stress through triggering of the neuro-immune response in the hippocampus induces autistic-like behaviors in male mice
In this study, we aimed to focus on the possible role of neuroinflammatory response in the hippocampus in development of the autistic-like behaviors following maternal separation (MS) stress in mice. To do this, mice neonates daily separated from their mothers from postnatal day (PND) 2 to PND 14 for 3 h. During PND45-60, behavioral tests related to autistic-like behaviors including three-chamber sociability, Morris water maze (MWM), shuttle box, resident-intruder, and marble burying tests were performed. Then, hippocampi were dissected out, and the gene expression of inflammatory mediators including TNF-α, IL-1β, TLR4, ...
Source: International Journal of Developmental Neuroscience - December 18, 2023 Category: Neuroscience Authors: Vahid Reisi-Vanani Zahra Lorigooini Elham Bijad Hossein Amini-Khoei Source Type: research

Maternal separation stress through triggering of the neuro-immune response in the hippocampus induces autistic-like behaviors in male mice
In this study, we aimed to focus on the possible role of neuroinflammatory response in the hippocampus in development of the autistic-like behaviors following maternal separation (MS) stress in mice. To do this, mice neonates daily separated from their mothers from postnatal day (PND) 2 to PND 14 for 3 h. During PND45-60, behavioral tests related to autistic-like behaviors including three-chamber sociability, Morris water maze (MWM), shuttle box, resident-intruder, and marble burying tests were performed. Then, hippocampi were dissected out, and the gene expression of inflammatory mediators including TNF-α, IL-1β, TLR4, ...
Source: International Journal of Developmental Neuroscience - December 18, 2023 Category: Neuroscience Authors: Vahid Reisi-Vanani Zahra Lorigooini Elham Bijad Hossein Amini-Khoei Source Type: research

Maternal separation stress through triggering of the neuro-immune response in the hippocampus induces autistic-like behaviors in male mice
In this study, we aimed to focus on the possible role of neuroinflammatory response in the hippocampus in development of the autistic-like behaviors following maternal separation (MS) stress in mice. To do this, mice neonates daily separated from their mothers from postnatal day (PND) 2 to PND 14 for 3 h. During PND45-60, behavioral tests related to autistic-like behaviors including three-chamber sociability, Morris water maze (MWM), shuttle box, resident-intruder, and marble burying tests were performed. Then, hippocampi were dissected out, and the gene expression of inflammatory mediators including TNF-α, IL-1β, TLR4, ...
Source: International Journal of Developmental Neuroscience - December 18, 2023 Category: Neuroscience Authors: Vahid Reisi-Vanani Zahra Lorigooini Elham Bijad Hossein Amini-Khoei Source Type: research

Maternal separation stress through triggering of the neuro-immune response in the hippocampus induces autistic-like behaviors in male mice
In this study, we aimed to focus on the possible role of neuroinflammatory response in the hippocampus in development of the autistic-like behaviors following maternal separation (MS) stress in mice. To do this, mice neonates daily separated from their mothers from postnatal day (PND) 2 to PND 14 for 3 h. During PND45-60, behavioral tests related to autistic-like behaviors including three-chamber sociability, Morris water maze (MWM), shuttle box, resident-intruder, and marble burying tests were performed. Then, hippocampi were dissected out, and the gene expression of inflammatory mediators including TNF-α, IL-1β, TLR4, ...
Source: International Journal of Developmental Neuroscience - December 18, 2023 Category: Neuroscience Authors: Vahid Reisi-Vanani Zahra Lorigooini Elham Bijad Hossein Amini-Khoei Source Type: research

Maternal separation stress through triggering of the neuro-immune response in the hippocampus induces autistic-like behaviors in male mice
In this study, we aimed to focus on the possible role of neuroinflammatory response in the hippocampus in development of the autistic-like behaviors following maternal separation (MS) stress in mice. To do this, mice neonates daily separated from their mothers from postnatal day (PND) 2 to PND 14 for 3 h. During PND45-60, behavioral tests related to autistic-like behaviors including three-chamber sociability, Morris water maze (MWM), shuttle box, resident-intruder, and marble burying tests were performed. Then, hippocampi were dissected out, and the gene expression of inflammatory mediators including TNF-α, IL-1β, TLR4, ...
Source: International Journal of Developmental Neuroscience - December 18, 2023 Category: Neuroscience Authors: Vahid Reisi-Vanani Zahra Lorigooini Elham Bijad Hossein Amini-Khoei Source Type: research

Maternal separation stress through triggering of the neuro-immune response in the hippocampus induces autistic-like behaviors in male mice
In this study, we aimed to focus on the possible role of neuroinflammatory response in the hippocampus in development of the autistic-like behaviors following maternal separation (MS) stress in mice. To do this, mice neonates daily separated from their mothers from postnatal day (PND) 2 to PND 14 for 3 h. During PND45-60, behavioral tests related to autistic-like behaviors including three-chamber sociability, Morris water maze (MWM), shuttle box, resident-intruder, and marble burying tests were performed. Then, hippocampi were dissected out, and the gene expression of inflammatory mediators including TNF-α, IL-1β, TLR4, ...
Source: International Journal of Developmental Neuroscience - December 18, 2023 Category: Neuroscience Authors: Vahid Reisi-Vanani Zahra Lorigooini Elham Bijad Hossein Amini-Khoei Source Type: research

Maternal separation stress through triggering of the neuro-immune response in the hippocampus induces autistic-like behaviors in male mice
In this study, we aimed to focus on the possible role of neuroinflammatory response in the hippocampus in development of the autistic-like behaviors following maternal separation (MS) stress in mice. To do this, mice neonates daily separated from their mothers from postnatal day (PND) 2 to PND 14 for 3 h. During PND45-60, behavioral tests related to autistic-like behaviors including three-chamber sociability, Morris water maze (MWM), shuttle box, resident-intruder, and marble burying tests were performed. Then, hippocampi were dissected out, and the gene expression of inflammatory mediators including TNF-α, IL-1β, TLR4, ...
Source: International Journal of Developmental Neuroscience - December 18, 2023 Category: Neuroscience Authors: Vahid Reisi-Vanani Zahra Lorigooini Elham Bijad Hossein Amini-Khoei Source Type: research

Maternal separation stress through triggering of the neuro-immune response in the hippocampus induces autistic-like behaviors in male mice
In this study, we aimed to focus on the possible role of neuroinflammatory response in the hippocampus in development of the autistic-like behaviors following maternal separation (MS) stress in mice. To do this, mice neonates daily separated from their mothers from postnatal day (PND) 2 to PND 14 for 3 h. During PND45-60, behavioral tests related to autistic-like behaviors including three-chamber sociability, Morris water maze (MWM), shuttle box, resident-intruder, and marble burying tests were performed. Then, hippocampi were dissected out, and the gene expression of inflammatory mediators including TNF-α, IL-1β, TLR4, ...
Source: International Journal of Developmental Neuroscience - December 18, 2023 Category: Neuroscience Authors: Vahid Reisi-Vanani Zahra Lorigooini Elham Bijad Hossein Amini-Khoei Source Type: research

Infantile epileptic spasm syndrome as a new NR2F1 gene phenotype
CONCLUSIONS: Our findings indicate that new missense NR2F1 pathogenetic variants may lead to IESS with abnormal visual evoked potentials. Thus, clinicians should be aware of the Bosch-Boonstra-Schaaf optic atrophy syndrome and regular monitoring of the fundus, and the optic nerve is necessary during follow-up.PMID:38010976 | DOI:10.1002/jdn.10309 (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - November 27, 2023 Category: Neuroscience Authors: Yan Liang Lin Wan Xinting Liu Jing Zhang Gang Zhu Guang Yang Source Type: research

Infantile epileptic spasm syndrome as a new NR2F1 gene phenotype
CONCLUSIONS: Our findings indicate that new missense NR2F1 pathogenetic variants may lead to IESS with abnormal visual evoked potentials. Thus, clinicians should be aware of the Bosch-Boonstra-Schaaf optic atrophy syndrome and regular monitoring of the fundus, and the optic nerve is necessary during follow-up.PMID:38010976 | DOI:10.1002/jdn.10309 (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - November 27, 2023 Category: Neuroscience Authors: Yan Liang Lin Wan Xinting Liu Jing Zhang Gang Zhu Guang Yang Source Type: research

Infantile epileptic spasm syndrome as a new NR2F1 gene phenotype
CONCLUSIONS: Our findings indicate that new missense NR2F1 pathogenetic variants may lead to IESS with abnormal visual evoked potentials. Thus, clinicians should be aware of the Bosch-Boonstra-Schaaf optic atrophy syndrome and regular monitoring of the fundus, and the optic nerve is necessary during follow-up.PMID:38010976 | DOI:10.1002/jdn.10309 (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - November 27, 2023 Category: Neuroscience Authors: Yan Liang Lin Wan Xinting Liu Jing Zhang Gang Zhu Guang Yang Source Type: research

Infantile epileptic spasm syndrome as a new NR2F1 gene phenotype
CONCLUSIONS: Our findings indicate that new missense NR2F1 pathogenetic variants may lead to IESS with abnormal visual evoked potentials. Thus, clinicians should be aware of the Bosch-Boonstra-Schaaf optic atrophy syndrome and regular monitoring of the fundus, and the optic nerve is necessary during follow-up.PMID:38010976 | DOI:10.1002/jdn.10309 (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - November 27, 2023 Category: Neuroscience Authors: Yan Liang Lin Wan Xinting Liu Jing Zhang Gang Zhu Guang Yang Source Type: research

Infantile epileptic spasm syndrome as a new NR2F1 gene phenotype
CONCLUSIONS: Our findings indicate that new missense NR2F1 pathogenetic variants may lead to IESS with abnormal visual evoked potentials. Thus, clinicians should be aware of the Bosch-Boonstra-Schaaf optic atrophy syndrome and regular monitoring of the fundus, and the optic nerve is necessary during follow-up.PMID:38010976 | DOI:10.1002/jdn.10309 (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - November 27, 2023 Category: Neuroscience Authors: Yan Liang Lin Wan Xinting Liu Jing Zhang Gang Zhu Guang Yang Source Type: research

Infantile epileptic spasm syndrome as a new NR2F1 gene phenotype
CONCLUSIONS: Our findings indicate that new missense NR2F1 pathogenetic variants may lead to IESS with abnormal visual evoked potentials. Thus, clinicians should be aware of the Bosch-Boonstra-Schaaf optic atrophy syndrome and regular monitoring of the fundus, and the optic nerve is necessary during follow-up.PMID:38010976 | DOI:10.1002/jdn.10309 (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - November 27, 2023 Category: Neuroscience Authors: Yan Liang Lin Wan Xinting Liu Jing Zhang Gang Zhu Guang Yang Source Type: research

Infantile epileptic spasm syndrome as a new NR2F1 gene phenotype
CONCLUSIONS: Our findings indicate that new missense NR2F1 pathogenetic variants may lead to IESS with abnormal visual evoked potentials. Thus, clinicians should be aware of the Bosch-Boonstra-Schaaf optic atrophy syndrome and regular monitoring of the fundus, and the optic nerve is necessary during follow-up.PMID:38010976 | DOI:10.1002/jdn.10309 (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - November 27, 2023 Category: Neuroscience Authors: Yan Liang Lin Wan Xinting Liu Jing Zhang Gang Zhu Guang Yang Source Type: research