International Journal of Developmental Neuroscience This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

An analysis of POMC gene methylation and expression in patients with schizophrenia
In this study, we evaluated three fragments of the POMC promoter region, including 51 CpG sites, in the peripheral blood of schizophrenia patients and healthy controls. The POMC protein level was measured via enzyme-linked immunosorbent assay (ELISA). The schizophrenia group exhibited significantly greater levels of methylation of the POMC gene than those in the control group. The methylation level of the POMC-2 fragment was significantly greater in the patient group than in the control group. There were 17 significantly hypermethylated CpG sites in the patient group. After stratification by sex, POMC methylation levels we...
Source: International Journal of Developmental Neuroscience - February 12, 2024 Category: Neuroscience Authors: Xuanyu Chen Lili Qing Tiantian Zou Jia Wang Wensa Yin Zhiyong Wang Tiantian Cheng Yumei Lu Liping Hu Linlin Liu Shengjie Nie Source Type: research

Adolescent intermittent ethanol use in male rats do not change cerebellar cell numbers but initiate astroglial reaction
In this study, we investigated the effects of adolescent intermittent ethanol (AIE) exposure on the cellular composition of the cerebellum in male rats, particularly when alcohol consumption begins early. The male rats received eight doses of intermittent intraperitoneal injection of 25% (v/v) ethanol (3 g/kg) or saline from postnatal days (PND) 25 to PND 38. In rats, 28-42 days old corresponds to 10-18 years old in humans. Two hours after the last injection, the cells, neurons, and non-neuronal cells in the cerebellum were immunocytochemically labeled and the total numbers of related cells were calculated using the Isotro...
Source: International Journal of Developmental Neuroscience - February 8, 2024 Category: Neuroscience Authors: Nurhan Çon Sevcan Mercan Asuman K üçüköner N üket Çalişkan Source Type: research

Using varied technological agents-assisted simultaneous prompting for teaching discrete skills to children with developmental disabilities
This study examines the effectiveness of combining simultaneous prompting method with small group teaching through computer projection, SMART board, tablet computer and humanoid robot to teach discrete skills to children with developmental disabilities (CDD). The study included 14 CDD aged 10-15. It utilizes a multiple probe design across behaviors and probe conditions and replicates them across subjects. Each participant is taught discrete skills within a small group teaching arrangement. The study includes daily probes, full probes, teaching sessions, generalization, and follow-up sessions. It also collects interobserver...
Source: International Journal of Developmental Neuroscience - February 7, 2024 Category: Neuroscience Authors: Ayten Ozkirac Kirsal Gul Kahveci Source Type: research

Comparison and discussion of behavior and pathology of four kinds of cerebral palsy disease models
Conclusion: except for the absence of data of bilateral common carotid artery ligation rats, the other three methods could all achieve a successful cerebral palsy disease model for both behavioral and pathological. For researchers, the selection of intraperitoneal infection model in pregnant rats or unilateral ischemia and hypoxia model in infant rats is sufficient to meet the experimental needs, whereas the selection of the combined method for modeling does not show enough advantages, which not only causes the waste of financial and human resources but also increases the possibility of experimental error made by intervent...
Source: International Journal of Developmental Neuroscience - February 7, 2024 Category: Neuroscience Authors: Jinyan Xu Siyang Yan Chen Xia Jianyi Xue Wentao Yu Yuanjie Yan Zhenjin Yin Source Type: research

The effects of choline supplementation in mothers with hypothyroidism on the alteration of cognitive-behavioral, long-term potentiation, morphology, and apoptosis in the hippocampus of pre-pubertal offspring rats
Int J Dev Neurosci. 2024 Feb 4. doi: 10.1002/jdn.10312. Online ahead of print.ABSTRACTThe mother's thyroid hormone status during gestation and the first few months after delivery can play a crucial role in maturation during the brain development of the child. Transient abnormalities in thyroid function at birth indicate developmental and cognitive disorders in adulthood. Choline supplementation during gestation and the perinatal period in rats causes long-lasting memory improvement in the offspring. However, it remains unclear whether choline is able to restore the deficits in rats with maternal hypothyroidism. The aim of ...
Source: International Journal of Developmental Neuroscience - February 4, 2024 Category: Neuroscience Authors: Siamak Sheikhi Razieh Aghazadeh Hojjat Sayyadi Bagher Pourheydar Ehsan Saboory Morteza Bagheri Leila Derafshpour Source Type: research

Agmatine ameliorates valproic acid-induced depletion of parvalbumin-positive neuron
Int J Dev Neurosci. 2024 Feb 2. doi: 10.1002/jdn.10314. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is a widespread neurodevelopmental disorder with unknown etiology. Dysfunction of several brain areas including the prefrontal cortex (PFC), hippocampus, and cerebellum is involved in cognitive and behavioral deficits associated with ASD. Several studies have reported a reduction in the number of parvalbumin-immunoreactive (PV+ ) neurons in brain areas of ASD patients and animal models such as a shank mutant mouse model and rodents receiving fetal valproic acid (VPA) administration. Developing therapeutic in...
Source: International Journal of Developmental Neuroscience - February 2, 2024 Category: Neuroscience Authors: Khadijeh Mirzaee Khoram-Abadi Mohsen Basiri Mozhdeh Nemati Masoumeh Nozari Source Type: research

The interaction of RELN-DNMT genes involving in neurotrophin signaling pathway contributes to schizophrenia susceptibility
CONCLUSION: The interaction between the RELN (rs2073559, rs2229864)-DNMT3B (rs2424908) may be related to schizophrenia, and large sample sizes should be verified in different population.PMID:38296839 | DOI:10.1002/jdn.10316 (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - January 31, 2024 Category: Neuroscience Authors: Junjiao Ping Jing Wan Jiali Luo Baoguo Du Xinxia Liu Tingyun Jiang Jie Zhang Source Type: research

Late pregnancy maternal naringin supplementation affects the mitochondria in the cerebellum of Wistar rat offspring via sirtuin 3 and AKT
Int J Dev Neurosci. 2024 Jan 18. doi: 10.1002/jdn.10313. Online ahead of print.ABSTRACTDietary polyphenol consumption is associated with a wide range of neuroprotective effects by improving mitochondrial function and signaling. Consequently, the use of polyphenol supplementation has been investigated as an approach to prevent neurodevelopmental diseases during gestation; however, the data obtained are still very inconclusive, mostly because of the difficulty of choosing the correct doses and period of administration to properly prevent neurodegenerative diseases without undermining normal brain development. Thus, we aimed ...
Source: International Journal of Developmental Neuroscience - January 19, 2024 Category: Neuroscience Authors: Bernardo Gindri Dos Santos Pauline Maciel August D ébora Santos Rocha Ismael Mesquita Manuela Menegotto Vin ícius Stone Cristiane Matt é Source Type: research

Feeding metformin during pregnancy and lactation periods improved learning and memory impairment in the rat offspring exposed to febrile seizure: Role of oxidative stress and inflammatory response
CONCLUSION: Considering the present research and related study in relation to metformin in ameliorating the epilepsy symptoms, there are numerous evidences on positive effect of metformin on seizure. Although the exact mechanism is unclear, the anti-oxidant effect of metformin is strongly supported.PMID:38178780 | DOI:10.1002/jdn.10311 (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - January 5, 2024 Category: Neuroscience Authors: Niloofar Khoshroo Ali Rahimi Samaneh Kakhki Fatemeh Kaffashan Maha Masoudi Soheil Baharlou Farimah Beheshti Source Type: research

Maternal separation stress through triggering of the neuro-immune response in the hippocampus induces autistic-like behaviors in male mice
In this study, we aimed to focus on the possible role of neuroinflammatory response in the hippocampus in development of the autistic-like behaviors following maternal separation (MS) stress in mice. To do this, mice neonates daily separated from their mothers from postnatal day (PND) 2 to PND 14 for 3 h. During PND45-60, behavioral tests related to autistic-like behaviors including three-chamber sociability, Morris water maze (MWM), shuttle box, resident-intruder, and marble burying tests were performed. Then, hippocampi were dissected out, and the gene expression of inflammatory mediators including TNF-α, IL-1β, TLR4, ...
Source: International Journal of Developmental Neuroscience - December 18, 2023 Category: Neuroscience Authors: Vahid Reisi-Vanani Zahra Lorigooini Elham Bijad Hossein Amini-Khoei Source Type: research