International Journal of Developmental Neuroscience This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Mutation in the β-tubulin gene TUBB4A results in epileptic encephalopathy associated with hypomyelinated leucodystrophy: Unexpected findings reveal genetic mosaicism
CONCLUSIONS: Our study is the first to report a disease-causing variant in the TUBB4A gene in a patient with EE associated with hypomyelinated leucodystrophy. In addition, we expanded the phenotypic spectrum associated with the TUBB4A gene.PMID:37529938 | DOI:10.1002/jdn.10284 (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - August 2, 2023 Category: Neuroscience Authors: Marwa Ben Jdila Fatma Kammoun Rania Abdelmaksoud-Dammak Chahnez Triki Faiza Fakhfakh Source Type: research

Serum trimethylamine N-oxide and lipopolysaccharide binding protein levels among children diagnosed with autism spectrum disorder
In this study, it is aimed to examine the relationship between the levels of trimethylamine N-oxide (TMAO), which is a parameter associated with intestinal permeability, and lipopolysaccharide binding protein (LBP), which is a marker associated with bacterial translocation from the intestine, in patients with autism spectrum disorder (ASD) and healthy controls. Fifty-three children with ASD as the patient group and 30 healthy children as the control group have been included in the study. The diagnostic evaluation has been made according to DSM-5 criteria. According to the obtained results, there has been no significant dif...
Source: International Journal of Developmental Neuroscience - August 1, 2023 Category: Neuroscience Authors: Sadettin Burak A çıkel Aziz Kara Zafer Ba ğcı Ümmügülsüm Can Source Type: research

Effect of sex differences and time of oxytocin administration on treatment of rat model of autism spectrum disorder: Focused on necroptosis markers
This study aimed to evaluate the necroptosis pathway for the neuroprotective effects of oxytocin in the valproic acid-induced autism spectrum disorder model. The autism spectrum disorder was induced by valproic acid on gestational day 12.5 (600 mg/kg, intraperitoneally). Offspring received intranasal oxytocin (1 μg/μL) on the 21st and 40th days after birth. The offspring behaviors were scrutinized by self-grooming, marble-burying, three-chamber, and Morris water maze tests. Western blot was performed on the hippocampus and amygdala tissues to investigate the expression of RIP3 and MLKL markers. The valproic acid group de...
Source: International Journal of Developmental Neuroscience - July 28, 2023 Category: Neuroscience Authors: Marjan Shariatpanahi Zahra Sojoudi Fariba Khodagholi Hiva Rahmati Seyed Behnamedin Jameie Mina Eftekharzadeh Maryam Soleimani Karizmeh Mostafa Shabani Ehsan Zamani Source Type: research

Lipopolysaccharide impairs neurodevelopment and induces changes in astroglial reactivity, antioxidant defenses and bioenergetics in the cerebral cortex of neonatal rats
Int J Dev Neurosci. 2023 Jul 21. doi: 10.1002/jdn.10288. Online ahead of print.ABSTRACTNeonates have an immature immune system, which increases their vulnerability to infectious agents and inflammatory insults. The administration of the immunostimulatory agent lipopolysaccharide (LPS) has been shown to induce the expression of pro-inflammatory cytokines and cause behavior alterations in rodents at different ages. However, the effects of LPS administration during the neonatal period and its consequences during immune system maturation remain to be elucidated. We showed here that a single intraperitoneal administration of LP...
Source: International Journal of Developmental Neuroscience - July 21, 2023 Category: Neuroscience Authors: Denise Bertin Rojas Adriana Fernanda K Vizuete Vivian Strassburger de Andrade Rodrigo Binkowski de Andrade Tanise Gemelli Tomas Duk Hwa Kim Carlos Alberto Gon çalves Guilhian Leipnitz Clovis Milton Duval Wannmacher Source Type: research

Maternal music exposure during pregnancy influences reflexive motor behaviors in mice offspring
This study aims to determine the effects of prenatal exposure to music on reflexive motor behaviors in mice offspring. Six pregnant female NMRI mice (8-10 weeks old) were randomly and equally allocated into two groups. Group 1 as control was placed in a normal housing area (average room noise 35 dB), and Group 2 was exposed to music pitched at 432 Hz for 2 h a day played at constant volume (75/80 dB) during pregnancy. Following delivery, four pups from each pregnant mouse were selected, and reflexive motor behaviors including ambulation, hind-limb foot angle, surface righting, grip strength, front- and hind-limb suspension...
Source: International Journal of Developmental Neuroscience - July 6, 2023 Category: Neuroscience Authors: Sara Bidari Morteza Zendehdel Shahin Hassanpour Behrooz Rahmani Source Type: research