Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs
Xenobiotica. 2023 May 11:1-9. doi: 10.1080/00498254.2023.2211673. Online ahead of print.ABSTRACTDrug oxidations are mediated mainly by cytochromes P450 (P450s or CYPs). CYP3As are an important P450 subfamily and include liver-specific CYP3A12 and intestine-specific CYP3A98 in dogs. Individual differences in drug oxidation activities were investigated, including correlations with immunoreactive CYP3A protein intensities and CYP3A mRNA expression levels in livers.Pooled and individual dog liver microsomes showed activities towards nifedipine, midazolam, alprazolam, and estradiol, but the levels of catalytic activities varied...
Source: Xenobiotica - May 5, 2023 Category: Research Authors: Yasuhiro Uno Yutaro Noda Saho Morikuni Norie Murayama Hiroshi Yamazaki Source Type: research
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs
Xenobiotica. 2023 May 5:1-21. doi: 10.1080/00498254.2023.2211673. Online ahead of print.ABSTRACTDrug oxidations are mediated mainly by cytochromes P450 (P450s or CYPs). CYP3As are an important P450 subfamily and include liver-specific CYP3A12 and intestine-specific CYP3A98 in dogs. Individual differences in drug oxidation activities were investigated, including correlations with immunoreactive CYP3A protein intensities and CYP3A mRNA expression levels in liver microsomes.Pooled and individual dog liver microsomes showed activities toward nifedipine, midazolam, alprazolam, and estradiol, but the levels of catalytic activiti...
Source: Xenobiotica - May 5, 2023 Category: Research Authors: Yasuhiro Uno Yutaro Noda Saho Morikuni Norie Murayama Hiroshi Yamazaki Source Type: research
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs
Xenobiotica. 2023 May 11:1-9. doi: 10.1080/00498254.2023.2211673. Online ahead of print.ABSTRACTDrug oxidations are mediated mainly by cytochromes P450 (P450s or CYPs). CYP3As are an important P450 subfamily and include liver-specific CYP3A12 and intestine-specific CYP3A98 in dogs. Individual differences in drug oxidation activities were investigated, including correlations with immunoreactive CYP3A protein intensities and CYP3A mRNA expression levels in livers.Pooled and individual dog liver microsomes showed activities towards nifedipine, midazolam, alprazolam, and estradiol, but the levels of catalytic activities varied...
Source: Xenobiotica - May 5, 2023 Category: Research Authors: Yasuhiro Uno Yutaro Noda Saho Morikuni Norie Murayama Hiroshi Yamazaki Source Type: research
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs
Xenobiotica. 2023 May 11:1-9. doi: 10.1080/00498254.2023.2211673. Online ahead of print.ABSTRACTDrug oxidations are mediated mainly by cytochromes P450 (P450s or CYPs). CYP3As are an important P450 subfamily and include liver-specific CYP3A12 and intestine-specific CYP3A98 in dogs. Individual differences in drug oxidation activities were investigated, including correlations with immunoreactive CYP3A protein intensities and CYP3A mRNA expression levels in livers.Pooled and individual dog liver microsomes showed activities towards nifedipine, midazolam, alprazolam, and estradiol, but the levels of catalytic activities varied...
Source: Xenobiotica - May 5, 2023 Category: Research Authors: Yasuhiro Uno Yutaro Noda Saho Morikuni Norie Murayama Hiroshi Yamazaki Source Type: research
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs
Xenobiotica. 2023 May 5:1-21. doi: 10.1080/00498254.2023.2211673. Online ahead of print.ABSTRACTDrug oxidations are mediated mainly by cytochromes P450 (P450s or CYPs). CYP3As are an important P450 subfamily and include liver-specific CYP3A12 and intestine-specific CYP3A98 in dogs. Individual differences in drug oxidation activities were investigated, including correlations with immunoreactive CYP3A protein intensities and CYP3A mRNA expression levels in liver microsomes.Pooled and individual dog liver microsomes showed activities toward nifedipine, midazolam, alprazolam, and estradiol, but the levels of catalytic activiti...
Source: Xenobiotica - May 5, 2023 Category: Research Authors: Yasuhiro Uno Yutaro Noda Saho Morikuni Norie Murayama Hiroshi Yamazaki Source Type: research
Detection, quantification and degradation kinetic for five benzodiazepines using VAUS-ME-SFO/LC-MS/MS method for water, alcoholic and non-alcoholic beverages
Talanta. 2023 Apr 26;260:124572. doi: 10.1016/j.talanta.2023.124572. Online ahead of print.ABSTRACTBenzodiazepines can make victims more docile, they are frequently used in drug-facilitated crimes, such as robberies and sexual assaults. Therefore, it is essential to develop techniques for determining whether these chemicals are present in relation with illegal activity is crucial. Therefore, to determine the presence of five benzodiazepines (alprazolam, clonazepam, diazepam, lorazepam, and oxazepam) in water, alcoholic beverages, and non-alcoholic beverages, a simple and direct, miniaturized, and effective vortex assisted ...
Source: Talanta - April 30, 2023 Category: Chemistry Authors: Neha Gupta Ravindra Singh Thakur Devendra Kumar Patel Source Type: research
Detection, quantification and degradation kinetic for five benzodiazepines using VAUS-ME-SFO/LC-MS/MS method for water, alcoholic and non-alcoholic beverages
Talanta. 2023 Apr 26;260:124572. doi: 10.1016/j.talanta.2023.124572. Online ahead of print.ABSTRACTBenzodiazepines can make victims more docile, they are frequently used in drug-facilitated crimes, such as robberies and sexual assaults. Therefore, it is essential to develop techniques for determining whether these chemicals are present in relation with illegal activity is crucial. Therefore, to determine the presence of five benzodiazepines (alprazolam, clonazepam, diazepam, lorazepam, and oxazepam) in water, alcoholic beverages, and non-alcoholic beverages, a simple and direct, miniaturized, and effective vortex assisted ...
Source: Talanta - April 30, 2023 Category: Chemistry Authors: Neha Gupta Ravindra Singh Thakur Devendra Kumar Patel Source Type: research
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines
CONCLUSION: These experimental data add to our knowledge of the nine benzodiazepine drugs and their metabolism study, which could provide useful information and evidence of their in vivo metabolic profile prediction and help promote their monitoring in both clinical use and social/illegal abuse.PMID:37114779 | DOI:10.2174/1389200224666230419090733 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 28, 2023 Category: Drugs & Pharmacology Authors: Shuhan Zhou Xiaoting Song Pengkai Fang Jingyi Xu Siqi Liu Tian Zheng Guoping Wu Liang Wu Source Type: research
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines
CONCLUSION: These experimental data add to our knowledge of the nine benzodiazepine drugs and their metabolism study, which could provide useful information and evidence of their in vivo metabolic profile prediction and help promote their monitoring in both clinical use and social/illegal abuse.PMID:37114779 | DOI:10.2174/1389200224666230419090733 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 28, 2023 Category: Drugs & Pharmacology Authors: Shuhan Zhou Xiaoting Song Pengkai Fang Jingyi Xu Siqi Liu Tian Zheng Guoping Wu Liang Wu Source Type: research
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines
CONCLUSION: These experimental data add to our knowledge of the nine benzodiazepine drugs and their metabolism study, which could provide useful information and evidence of their in vivo metabolic profile prediction and help promote their monitoring in both clinical use and social/illegal abuse.PMID:37114779 | DOI:10.2174/1389200224666230419090733 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 28, 2023 Category: Drugs & Pharmacology Authors: Shuhan Zhou Xiaoting Song Pengkai Fang Jingyi Xu Siqi Liu Tian Zheng Guoping Wu Liang Wu Source Type: research
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines
CONCLUSION: These experimental data add to our knowledge of the nine benzodiazepine drugs and their metabolism study, which could provide useful information and evidence of their in vivo metabolic profile prediction and help promote their monitoring in both clinical use and social/illegal abuse.PMID:37114779 | DOI:10.2174/1389200224666230419090733 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 28, 2023 Category: Drugs & Pharmacology Authors: Shuhan Zhou Xiaoting Song Pengkai Fang Jingyi Xu Siqi Liu Tian Zheng Guoping Wu Liang Wu Source Type: research
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines
CONCLUSION: These experimental data add to our knowledge of the nine benzodiazepine drugs and their metabolism study, which could provide useful information and evidence of their in vivo metabolic profile prediction and help promote their monitoring in both clinical use and social/illegal abuse.PMID:37114779 | DOI:10.2174/1389200224666230419090733 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 28, 2023 Category: Drugs & Pharmacology Authors: Shuhan Zhou Xiaoting Song Pengkai Fang Jingyi Xu Siqi Liu Tian Zheng Guoping Wu Liang Wu Source Type: research
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines
CONCLUSION: These experimental data add to our knowledge of the nine benzodiazepine drugs and their metabolism study, which could provide useful information and evidence of their in vivo metabolic profile prediction and help promote their monitoring in both clinical use and social/illegal abuse.PMID:37114779 | DOI:10.2174/1389200224666230419090733 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 28, 2023 Category: Drugs & Pharmacology Authors: Shuhan Zhou Xiaoting Song Pengkai Fang Jingyi Xu Siqi Liu Tian Zheng Guoping Wu Liang Wu Source Type: research
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines
CONCLUSION: These experimental data add to our knowledge of the nine benzodiazepine drugs and their metabolism study, which could provide useful information and evidence of their in vivo metabolic profile prediction and help promote their monitoring in both clinical use and social/illegal abuse.PMID:37114779 | DOI:10.2174/1389200224666230419090733 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 28, 2023 Category: Drugs & Pharmacology Authors: Shuhan Zhou Xiaoting Song Pengkai Fang Jingyi Xu Siqi Liu Tian Zheng Guoping Wu Liang Wu Source Type: research
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines
CONCLUSION: These experimental data add to our knowledge of the nine benzodiazepine drugs and their metabolism study, which could provide useful information and evidence of their in vivo metabolic profile prediction and help promote their monitoring in both clinical use and social/illegal abuse.PMID:37114779 | DOI:10.2174/1389200224666230419090733 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 28, 2023 Category: Drugs & Pharmacology Authors: Shuhan Zhou Xiaoting Song Pengkai Fang Jingyi Xu Siqi Liu Tian Zheng Guoping Wu Liang Wu Source Type: research
