Compounds identified in an illicit generic Xanax tablet are the result of a failed synthesis of alprazolam
J Forensic Sci. 2023 Jun 16. doi: 10.1111/1556-4029.15315. Online ahead of print.ABSTRACTUnintended compounds produced by inexperienced clandestine chemists may present a challenge in laboratories tasked with their identification. In March 2020, an anonymously submitted tablet purchased as a generic form of Xanax was analyzed by Erowid's DrugsData.org. The gas chromatography-mass spectrometry (GC-MS) results publicly released online indicated several unidentified compounds due to a lack of database references at that time. Elucidation by our group indicated the presence of several structurally related compounds that were l...
Source: Journal of Forensic Sciences - June 16, 2023 Category: Forensic Medicine Authors: Koby L Kizzire Emily Langlois Savannah Brown Source Type: research
Prescription drug dependence with and without concurrent illicit drug use: a multicenter cross-sectional survey among an addiction treatment seeking population
CONCLUSION: The study found benzodiazepine and opioid dependence in sub sample of addiction treatment seekers. The results have implications for drug policy and intervention strategies for preventing and treating drug use disorders.PMID:37324815 | PMC:PMC10267420 | DOI:10.3389/fpsyt.2023.1133606 (Source: Pain Physician)
Source: Pain Physician - June 16, 2023 Category: Anesthesiology Authors: Asma Nawaz Suzanne Nielsen Tahir Mehmood Abdullah Abdullah Ali Ahmed Waseem Ullah Ahmad Khan Source Type: research
COVID-19-Related Shifts in Polysubstance Use
Conclusions: The COVID-19 pandemic disproportionately affected those who are young adults, LGBPQ, and use drugs. Their unique needs during the pandemic warrant attention. The swap from leisure (e.g. MDMA) to anti-anxiety (e.g. Xanax) drugs is not surprising. Yet, the rise in novel benzodiazepines (Laing et al., 2021) is a point of concern that suggests drug checking and educational efforts can best reduce potential risks.PMID:37317983 | DOI:10.1080/10826084.2023.2181034 (Source: Substance Use and Misuse)
Source: Substance Use and Misuse - June 15, 2023 Category: Addiction Authors: Dina Perrone Ryan Fischer Jianna Florek Source Type: research
Fatal intoxication involving 2-methyl AP-237
J Forensic Sci. 2023 Jun 1. doi: 10.1111/1556-4029.15295. Online ahead of print.ABSTRACTNovel synthetic opioids contribute considerably to the opioid epidemic, especially with the frequent emergence of structurally similar compounds. This case report describes a fatal intoxication involving 2-methyl AP-237. A 54-year-old Caucasian male was found deceased from an apparent drug overdose. A plastic container labeled "2MAP" and a cut straw were found in the decedent's backpack at the scene. A white substance found in the container tested positive for fentanyl by field testing. According to his medical history, the decedent was...
Source: Journal of Forensic Sciences - June 2, 2023 Category: Forensic Medicine Authors: Michael T Truver Michele M Crosby Alex T Gillette Sara C Brogan Jennifer L Hoyer Chris W Chronister Wilson A Broussard Russell S Vega Bruce A Goldberger Source Type: research
Fatal intoxication involving 2-methyl AP-237
J Forensic Sci. 2023 Jun 1. doi: 10.1111/1556-4029.15295. Online ahead of print.ABSTRACTNovel synthetic opioids contribute considerably to the opioid epidemic, especially with the frequent emergence of structurally similar compounds. This case report describes a fatal intoxication involving 2-methyl AP-237. A 54-year-old Caucasian male was found deceased from an apparent drug overdose. A plastic container labeled "2MAP" and a cut straw were found in the decedent's backpack at the scene. A white substance found in the container tested positive for fentanyl by field testing. According to his medical history, the decedent was...
Source: Journal of Forensic Sciences - June 2, 2023 Category: Forensic Medicine Authors: Michael T Truver Michele M Crosby Alex T Gillette Sara C Brogan Jennifer L Hoyer Chris W Chronister Wilson A Broussard Russell S Vega Bruce A Goldberger Source Type: research
Fatal intoxication involving 2-methyl AP-237
J Forensic Sci. 2023 Jun 1. doi: 10.1111/1556-4029.15295. Online ahead of print.ABSTRACTNovel synthetic opioids contribute considerably to the opioid epidemic, especially with the frequent emergence of structurally similar compounds. This case report describes a fatal intoxication involving 2-methyl AP-237. A 54-year-old Caucasian male was found deceased from an apparent drug overdose. A plastic container labeled "2MAP" and a cut straw were found in the decedent's backpack at the scene. A white substance found in the container tested positive for fentanyl by field testing. According to his medical history, the decedent was...
Source: Journal of Forensic Sciences - June 2, 2023 Category: Forensic Medicine Authors: Michael T Truver Michele M Crosby Alex T Gillette Sara C Brogan Jennifer L Hoyer Chris W Chronister Wilson A Broussard Russell S Vega Bruce A Goldberger Source Type: research
Fatal intoxication involving 2-methyl AP-237
J Forensic Sci. 2023 Jun 1. doi: 10.1111/1556-4029.15295. Online ahead of print.ABSTRACTNovel synthetic opioids contribute considerably to the opioid epidemic, especially with the frequent emergence of structurally similar compounds. This case report describes a fatal intoxication involving 2-methyl AP-237. A 54-year-old Caucasian male was found deceased from an apparent drug overdose. A plastic container labeled "2MAP" and a cut straw were found in the decedent's backpack at the scene. A white substance found in the container tested positive for fentanyl by field testing. According to his medical history, the decedent was...
Source: Journal of Forensic Sciences - June 2, 2023 Category: Forensic Medicine Authors: Michael T Truver Michele M Crosby Alex T Gillette Sara C Brogan Jennifer L Hoyer Chris W Chronister Wilson A Broussard Russell S Vega Bruce A Goldberger Source Type: research
Prescription drug dependence with and without concurrent illicit drug use: a multicenter cross-sectional survey among an addiction treatment seeking population
Discussion and conclusionThe study found benzodiazepine and opioid dependence in sub sample of addiction treatment seekers. The results have implications for drug policy and intervention strategies for preventing and treating drug use disorders. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - June 1, 2023 Category: Psychiatry Source Type: research
Comprehensive analysis of the diagnostic and therapeutic value of the hypoxia-related gene PLAUR in the progression of atherosclerosis
In this study, Plasminogen activator, urokinase receptor (PLAUR) was identified as an effective diagnostic marker for AS lesion progression by combining WGCNA and random forest algorithm. We validated the stability of the diagnostic value on multiple external datasets including humans and mice. We identified a significant correlation between PLAUR expression and lesion progression. We mined multiple single cell-RNA sequencing (sc-RNA seq) data to nominate macrophage as the key cell cluster for PLAUR mediated lesion progression. We combined cross-validation results from multiple databases to predict that HCG17-hsa-miR-424-5...
Source: Atherosclerosis - May 26, 2023 Category: Cardiology Authors: Chengyi Dai Yuhang Lin Source Type: research
GABAergic Effects of Etifoxine and Alprazolam Assessed by Double
Pulse TMS
This study indicated a favorable side effect profile of
etifoxine in healthy volunteers. Moreover, it revealed differential GABA-related
effects on neuromuscular function by means of TMS. The side effects and TMS
profile of etifoxine are compatible with the involvement of neurosteroidogenesis
and a predominant α3 subunit modulation compared to alprazolam. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 23, 2023 Category: Psychiatry Authors: Riebel, Marco von Pappenheim, Benedikt Kanig, Carolina Nothdurfter, Caroline Wetter, Thomas C. Rupprecht, Rainer Schwarzbach, Jens Tags: Original Paper Source Type: research
Emergence of fentanyl-related deaths in Travis County, Texas and surrounding areas: A retrospective review of postmortem fentanyl-related drug toxicities from 2020 to 2022
J Forensic Sci. 2023 May 16. doi: 10.1111/1556-4029.15283. Online ahead of print.ABSTRACTThe opioid epidemic has affected the United States (US) for decades with fentanyl and its analogs accounting for a recent surge in morbidity and mortality. Currently, there is a relative lack of information characterizing fentanyl-related fatalities specifically in the Southern US. A retrospective study was conducted to examine all postmortem fentanyl-related drug toxicities in Travis County, Texas, encompassing Austin (one of the fastest-growing cities in the US), from 2020 to 2022. Fentanyl contributed to 2.6% and 12.2% of deaths sub...
Source: Journal of Forensic Sciences - May 17, 2023 Category: Forensic Medicine Authors: Kayla N Ellefsen Christina R Smith Elizabeth A Taylor Brad J Hall Source Type: research
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs
Xenobiotica. 2023 May 5:1-21. doi: 10.1080/00498254.2023.2211673. Online ahead of print.ABSTRACTDrug oxidations are mediated mainly by cytochromes P450 (P450s or CYPs). CYP3As are an important P450 subfamily and include liver-specific CYP3A12 and intestine-specific CYP3A98 in dogs. Individual differences in drug oxidation activities were investigated, including correlations with immunoreactive CYP3A protein intensities and CYP3A mRNA expression levels in liver microsomes.Pooled and individual dog liver microsomes showed activities toward nifedipine, midazolam, alprazolam, and estradiol, but the levels of catalytic activiti...
Source: Xenobiotica - May 5, 2023 Category: Research Authors: Yasuhiro Uno Yutaro Noda Saho Morikuni Norie Murayama Hiroshi Yamazaki Source Type: research
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs
Xenobiotica. 2023 May 11:1-9. doi: 10.1080/00498254.2023.2211673. Online ahead of print.ABSTRACTDrug oxidations are mediated mainly by cytochromes P450 (P450s or CYPs). CYP3As are an important P450 subfamily and include liver-specific CYP3A12 and intestine-specific CYP3A98 in dogs. Individual differences in drug oxidation activities were investigated, including correlations with immunoreactive CYP3A protein intensities and CYP3A mRNA expression levels in livers.Pooled and individual dog liver microsomes showed activities towards nifedipine, midazolam, alprazolam, and estradiol, but the levels of catalytic activities varied...
Source: Xenobiotica - May 5, 2023 Category: Research Authors: Yasuhiro Uno Yutaro Noda Saho Morikuni Norie Murayama Hiroshi Yamazaki Source Type: research
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs
Xenobiotica. 2023 May 11:1-9. doi: 10.1080/00498254.2023.2211673. Online ahead of print.ABSTRACTDrug oxidations are mediated mainly by cytochromes P450 (P450s or CYPs). CYP3As are an important P450 subfamily and include liver-specific CYP3A12 and intestine-specific CYP3A98 in dogs. Individual differences in drug oxidation activities were investigated, including correlations with immunoreactive CYP3A protein intensities and CYP3A mRNA expression levels in livers.Pooled and individual dog liver microsomes showed activities towards nifedipine, midazolam, alprazolam, and estradiol, but the levels of catalytic activities varied...
Source: Xenobiotica - May 5, 2023 Category: Research Authors: Yasuhiro Uno Yutaro Noda Saho Morikuni Norie Murayama Hiroshi Yamazaki Source Type: research
