Chinese herbal medicines for the treatment of depression: a systematic review and network meta-analysis
Conclusion: Our findings elucidate the promising therapeutic potential of Chinese herbal medicines as viable alternatives in the treatment of depression, with certain herbs demonstrating enhanced efficacy and safety profiles. The outcomes of this study advocate for the integration of these alternative modalities into contemporary depression management paradigms. However, it underscores the necessity for larger, methodologically robust trials to further validate and refine these preliminary findings.Systematic review registration:https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023452109. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Motor and non-motor symptoms, drugs, and their mode of action in Parkinson ’s disease (PD): a review
AbstractParkinson ’s disease is second most common neurodegenerative disorder neurological illness that primarily affects patients in their later years of life. Specific neurons in the brain begin to malfunction resulting in a loss of a substance called dopamine which is characterized by the accumulation of α-synu clein aggregates within cells, forming structures known as Lewy bodies and Lewy neurites. It is affecting more than 1% of people worldwide (aged 65 and above) and is expected to increase in prevalence by 2030. Muscle rigidity, tremor, and unresponsiveness of motion are some of the motor signs of thi s conditio...
Source: Medicinal Chemistry Research - March 7, 2024 Category: Chemistry Source Type: research
Leptin, Nesfatin-1, Orexin-A, and Total Ghrelin Levels in Drug-Naive Panic Disorder
CONCLUSION: This study reports that PD, like other anxiety disorders, may affect serum nesfatin-1, leptin, orexin-A, and total ghrelin levels, and there may be a relationship between PD treatment and the levels of these neuropeptides. The variability of this relationship among the neuropeptides examined indicates that various factors other than treatment play a role in this process.PMID:38433413 | PMC:PMC10910167 | DOI:10.30773/pi.2023.0309 (Source: Psychiatry Investigation)
Source: Psychiatry Investigation - March 4, 2024 Category: Psychiatry Authors: Dilek Örüm Sevda Korkmaz Nevin İlhan Mehmet Hamdi Örüm Murad Atmaca Source Type: research
Leptin, Nesfatin-1, Orexin-A, and Total Ghrelin Levels in Drug-Naive Panic Disorder
CONCLUSION: This study reports that PD, like other anxiety disorders, may affect serum nesfatin-1, leptin, orexin-A, and total ghrelin levels, and there may be a relationship between PD treatment and the levels of these neuropeptides. The variability of this relationship among the neuropeptides examined indicates that various factors other than treatment play a role in this process.PMID:38433413 | DOI:10.30773/pi.2023.0309 (Source: Psychiatry Investigation)
Source: Psychiatry Investigation - March 4, 2024 Category: Psychiatry Authors: Dilek Örüm Sevda Korkmaz Nevin İlhan Mehmet Hamdi Örüm Murad Atmaca Source Type: research
Leptin, Nesfatin-1, Orexin-A, and Total Ghrelin Levels in Drug-Naive Panic Disorder
CONCLUSION: This study reports that PD, like other anxiety disorders, may affect serum nesfatin-1, leptin, orexin-A, and total ghrelin levels, and there may be a relationship between PD treatment and the levels of these neuropeptides. The variability of this relationship among the neuropeptides examined indicates that various factors other than treatment play a role in this process.PMID:38433413 | PMC:PMC10910167 | DOI:10.30773/pi.2023.0309 (Source: Psychiatry Investigation)
Source: Psychiatry Investigation - March 4, 2024 Category: Psychiatry Authors: Dilek Örüm Sevda Korkmaz Nevin İlhan Mehmet Hamdi Örüm Murad Atmaca Source Type: research
