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Notes from the Field: Seizures, Hyperthermia, and Myocardial Injury in Three Young Adults Who Consumed Bromazolam Disguised as Alprazolam - Chicago, Illinois, February 2023
MMWR Morb Mortal Wkly Rep. 2024 Jan 5;72(5253):1392-1393. doi: 10.15585/mmwr.mm725253a5.NO ABSTRACTPMID:38175814 | DOI:10.15585/mmwr.mm725253a5 (Source: MMWR Morb Mortal Wkl...)
Source: MMWR Morb Mortal Wkl... - January 4, 2024 Category: Epidemiology Authors: Paul F Ehlers Amy Deitche Leslie M Wise Sarah L Patrick Alfreda Holloway-Beth Ross Ellison Jordan Trecki Roy Gerona Michael S Wahl Source Type: research

Benzodiazepine Use During Pregnancy May Be Associated With Miscarriage
Women who use benzodiazepines during pregnancy may be more likely to experience miscarriage, according to areport inJAMA Psychiatry.This finding underscores “the necessity for health care professionals to meticulously balance the risk-benefit ratio when considering the use of benzodiazepines to treat psychiatric and sleep disorders during pregnancy,” wrote lead author Fei-Yuan Hsiao, Ph.D., M.S., of the National Taiwan University College of Medicine and colleagues.The population-based study in Taiwan used two national data sources to investigate the association between benzodiazepine use during pregnancy and the risk o...
Source: Psychiatr News - January 2, 2024 Category: Psychiatry Tags: alprazolam benzodiazepines Fei-Yuan Hsiao fludiazepam long-acting benzodiazepines miscarriage National Taiwan University College of Medicine pregnancy short-acting benzodiazepines Source Type: research

Alprazolam/Bupropion
(Source: Reactions Weekly)
Source: Reactions Weekly - January 1, 2024 Category: Drugs & Pharmacology Source Type: research

Treatment of Concurrent Depression and Its Effect on Outcomes After Total Joint Arthroplasty: A Systematic Review of Comparative Studies
CONCLUSION: Interventions targeted at PDDs may improve short-term pain and functional outcomes, and there may be an association between selective serotonin reuptake inhibitor use and implant survival. The current literature is limited and inconclusive, with important gaps in understanding regarding the optimization and treatment of this modifiable risk factor. Surgeons should consider depression treatment as a method to improve outcomes in this cohort.PMID:38154094 | DOI:10.5435/JAAOS-D-23-00459 (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - December 28, 2023 Category: Orthopaedics Authors: Samuel B Morgan Ali Shahabi Colin Kruse Michael Zywiel Jesse Wolfstadt Seper Ekhtiari Source Type: research

A brain-tumor neural circuit controls breast cancer progression in mice
Tumor burden, considered a common chronic stressor, can cause widespread anxiety. Evidence suggests that cancer-induced anxiety can promote tumor progression, but the underlying neural mechanism remains unclear. Here, we used neuroscience and cancer tools to investigate how the brain contributes to tumor progression via nerve-tumor crosstalk in a mouse model of breast cancer. We show that tumor-bearing mice exhibited significant anxiety-like behaviors and that corticotropin-releasing hormone (CRH) neurons in the central medial amygdala (CeM) were activated. Moreover, we detected newly formed sympathetic nerves in tumors, w...
Source: Journal of Clinical Investigation - December 15, 2023 Category: Biomedical Science Authors: Si-Yi Xiong, Hui-Zhong Wen, Li-Meng Dai, Yun-Xiao Lou, Zhao-Qun Wang, Yi-Lun Yi, Xiao-Jing Yan, Ya-Ran Wu, Wei Sun, Peng-Hui Chen, Si-Zhe Yang, Xiao-Wei Qi, Yi Zhang, Guang-Yan Wu Source Type: research

Detection of drugs and hepatitis C virus in used syringes from a needle exchange in Gothenburg, Sweden
This study aimed to determine which substances are injected in Gothenburg, Sweden, and estimate the risk of HCV transmission. A total of 150 syringes handed in at the needle and syringe exchange program (NEP) in Gothenburg over a week in November 2021 were analysed for drug content using liquid chromatography coupled with high-resolution mass spectrometry. Using a dose-adjusted comparison, the main drug(s) injected was distinguished from the impurities in the syringes containing several drugs. HCV RNA was quantified by real-time PCR in an additional set of 150 syringes. Drugs were detected in>99% of analysed syringes, a...
Source: Drug Testing and Analysis - December 4, 2023 Category: Drugs & Pharmacology Authors: Moa Andresen Bergstr öm, Maria E. Andersson, Simon B. Larsson Tags: RESEARCH ARTICLE Source Type: research