Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer
CONCLUSIONS: We demonstrate that LOR stimulates fibrosis and inflammatory signaling, promotes desmoplasia and ischemic necrosis, and is associated with decreased pancreatic cancer patient survival.PMID:37587561 | DOI:10.1158/1078-0432.CCR-23-0547 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - August 17, 2023 Category: Cancer & Oncology Authors: Abigail C Cornwell Arwen A Tisdale Swati Venkat Kathryn E Maraszek Abdulrahman A Alahmari Anthony George Kristopher Attwood Madison George Donald Rempinski Janusz Franco-Barraza Mukund Seshadri Mark D Parker Eduardo Cortes Gomez Christos Fountzilas Edna C Source Type: research
Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer
CONCLUSIONS: We demonstrate that LOR stimulates fibrosis and inflammatory signaling, promotes desmoplasia and ischemic necrosis, and is associated with decreased pancreatic cancer patient survival.PMID:37587561 | DOI:10.1158/1078-0432.CCR-23-0547 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - August 17, 2023 Category: Cancer & Oncology Authors: Abigail C Cornwell Arwen A Tisdale Swati Venkat Kathryn E Maraszek Abdulrahman A Alahmari Anthony George Kristopher Attwood Madison George Donald Rempinski Janusz Franco-Barraza Mukund Seshadri Mark D Parker Eduardo Cortes Gomez Christos Fountzilas Edna C Source Type: research
The diagnostic dilemma in a patient with neuroleptic malignant syndrome during the COVID ‐19 pandemic: A significant increase in acute phase reactants
This article describes a woman treated with haloperidol, perphenazine, escitalopram, and alprazolam because she developed catatonic symptoms after psychological stress. She suffered from NMS symptoms and had elevated CRP and ESR levels, among other signs and symptoms. Given the COVID-19 pandemic and reports of co-occurrence of catatonia and NMS and COVID-19 and elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), this patient was a diagnostic dilemma. After consultation with the consultation-liaison psychiatry units, she was managed adequately with electroconvulsive therapy and lorazepam. (Source: Clinical Case Reports)
Source: Clinical Case Reports - August 3, 2023 Category: General Medicine Authors: Forouzan Elyasi,
Mehran Zarghami,
Arghavan Fariborzifar,
Hamed Cheraghmakani,
Mahboobeh Shirzad,
Feteme Kazempour Tags: CASE REPORT Source Type: research
Safety of Alprazolam Use in Pregnancy in Western Australia: A Retrospective Cohort Study Using Linked Health Data
. (Source: Journal of Psychoactive Drugs)
Source: Journal of Psychoactive Drugs - July 28, 2023 Category: Psychiatry & Psychology Authors: Erin KeltyKate ChittyDavid B Preena School of Population & Global Health, The University of Western Australia, Crawley, Western Australia, Australiab School of Medical Sciences, The University of Sydney, Camperdown, New South Wales, Australia Source Type: research
The impact of fentanyl on DUIDs and traffic fatalities: Blood and oral fluid data
This study aimed to evaluate fentanyl prevalence and concentrations in blood and oral fluid in driving under the influence of drugs (DUID) cases in three different regions (i.e., Alabama, Orange County, CA, and Houston, TX) from 2017 to 2022. Furthermore, traffic fatalities were evaluated for Alabama and Orange County, CA. Fentanyl positivity in DUID and traffic fatalities increased for most years in this study. In Alabama, the prevalence of fentanyl DUID cases increased 4-fold in 2022 compared to 2017. Orange County's increase from 2017 to 2022 was 14-fold. In Houston, the increase was approximately 2-fold from 2019 to 20...
Source: Journal of Forensic Sciences - July 21, 2023 Category: Forensic Medicine Authors: Curt E Harper Dani C Mata Dayong Lee Source Type: research
The impact of fentanyl on DUIDs and traffic fatalities: Blood and oral fluid data
This study aimed to evaluate fentanyl prevalence and concentrations in blood and oral fluid in driving under the influence of drugs (DUID) cases in three different regions (i.e., Alabama, Orange County, CA, and Houston, TX) from 2017 to 2022. Furthermore, traffic fatalities were evaluated for Alabama and Orange County, CA. Fentanyl positivity in DUID and traffic fatalities increased for most years in this study. In Alabama, the prevalence of fentanyl DUID cases increased 4-fold in 2022 compared to 2017. Orange County's increase from 2017 to 2022 was 14-fold. In Houston, the increase was approximately 2-fold from 2019 to 20...
Source: Journal of Forensic Sciences - July 21, 2023 Category: Forensic Medicine Authors: Curt E Harper Dani C Mata Dayong Lee Source Type: research
The impact of fentanyl on DUIDs and traffic fatalities: Blood and oral fluid data
This study aimed to evaluate fentanyl prevalence and concentrations in blood and oral fluid in driving under the influence of drugs (DUID) cases in three different regions (i.e., Alabama, Orange County, CA, and Houston, TX) from 2017 to 2022. Furthermore, traffic fatalities were evaluated for Alabama and Orange County, CA. Fentanyl positivity in DUID and traffic fatalities increased for most years in this study. In Alabama, the prevalence of fentanyl DUID cases increased 4-fold in 2022 compared to 2017. Orange County's increase from 2017 to 2022 was 14-fold. In Houston, the increase was approximately 2-fold from 2019 to 20...
Source: Journal of Forensic Sciences - July 21, 2023 Category: Forensic Medicine Authors: Curt E Harper Dani C Mata Dayong Lee Source Type: research
Alprazolam modulates persistence energy during emotion processing in first-degree relatives of individuals with schizophrenia: a network control study
Molecular Psychiatry, Published online: 23 June 2023; doi:10.1038/s41380-023-02121-zAlprazolam modulates persistence energy during emotion processing in first-degree relatives of individuals with schizophrenia: a network control study (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - June 23, 2023 Category: Psychiatry Authors: Arun S. Mahadevan Eli J. Cornblath David M. Lydon-Staley Dale Zhou Linden Parkes Bart Larsen Azeez Adebimpe Ari E. Kahn Ruben C. Gur Raquel E. Gur Theodore D. Satterthwaite Daniel H. Wolf Dani S. Bassett Source Type: research
Compounds identified in an illicit generic Xanax tablet are the result of a failed synthesis of alprazolam
J Forensic Sci. 2023 Jun 16. doi: 10.1111/1556-4029.15315. Online ahead of print.ABSTRACTUnintended compounds produced by inexperienced clandestine chemists may present a challenge in laboratories tasked with their identification. In March 2020, an anonymously submitted tablet purchased as a generic form of Xanax was analyzed by Erowid's DrugsData.org. The gas chromatography-mass spectrometry (GC-MS) results publicly released online indicated several unidentified compounds due to a lack of database references at that time. Elucidation by our group indicated the presence of several structurally related compounds that were l...
Source: Journal of Forensic Sciences - June 16, 2023 Category: Forensic Medicine Authors: Koby L Kizzire Emily Langlois Savannah Brown Source Type: research
Prescription drug dependence with and without concurrent illicit drug use: a multicenter cross-sectional survey among an addiction treatment seeking population
CONCLUSION: The study found benzodiazepine and opioid dependence in sub sample of addiction treatment seekers. The results have implications for drug policy and intervention strategies for preventing and treating drug use disorders.PMID:37324815 | PMC:PMC10267420 | DOI:10.3389/fpsyt.2023.1133606 (Source: Pain Physician)
Source: Pain Physician - June 16, 2023 Category: Anesthesiology Authors: Asma Nawaz Suzanne Nielsen Tahir Mehmood Abdullah Abdullah Ali Ahmed Waseem Ullah Ahmad Khan Source Type: research
Compounds identified in an illicit generic Xanax tablet are the result of a failed synthesis of alprazolam
J Forensic Sci. 2023 Jun 16. doi: 10.1111/1556-4029.15315. Online ahead of print.ABSTRACTUnintended compounds produced by inexperienced clandestine chemists may present a challenge in laboratories tasked with their identification. In March 2020, an anonymously submitted tablet purchased as a generic form of Xanax was analyzed by Erowid's DrugsData.org. The gas chromatography-mass spectrometry (GC-MS) results publicly released online indicated several unidentified compounds due to a lack of database references at that time. Elucidation by our group indicated the presence of several structurally related compounds that were l...
Source: Journal of Forensic Sciences - June 16, 2023 Category: Forensic Medicine Authors: Koby L Kizzire Emily Langlois Savannah Brown Source Type: research
Prescription drug dependence with and without concurrent illicit drug use: a multicenter cross-sectional survey among an addiction treatment seeking population
CONCLUSION: The study found benzodiazepine and opioid dependence in sub sample of addiction treatment seekers. The results have implications for drug policy and intervention strategies for preventing and treating drug use disorders.PMID:37324815 | PMC:PMC10267420 | DOI:10.3389/fpsyt.2023.1133606 (Source: Pain Physician)
Source: Pain Physician - June 16, 2023 Category: Anesthesiology Authors: Asma Nawaz Suzanne Nielsen Tahir Mehmood Abdullah Abdullah Ali Ahmed Waseem Ullah Ahmad Khan Source Type: research
Compounds identified in an illicit generic Xanax tablet are the result of a failed synthesis of alprazolam
J Forensic Sci. 2023 Jun 16. doi: 10.1111/1556-4029.15315. Online ahead of print.ABSTRACTUnintended compounds produced by inexperienced clandestine chemists may present a challenge in laboratories tasked with their identification. In March 2020, an anonymously submitted tablet purchased as a generic form of Xanax was analyzed by Erowid's DrugsData.org. The gas chromatography-mass spectrometry (GC-MS) results publicly released online indicated several unidentified compounds due to a lack of database references at that time. Elucidation by our group indicated the presence of several structurally related compounds that were l...
Source: Journal of Forensic Sciences - June 16, 2023 Category: Forensic Medicine Authors: Koby L Kizzire Emily Langlois Savannah Brown Source Type: research
Compounds identified in an illicit generic Xanax tablet are the result of a failed synthesis of alprazolam
J Forensic Sci. 2023 Jun 16. doi: 10.1111/1556-4029.15315. Online ahead of print.ABSTRACTUnintended compounds produced by inexperienced clandestine chemists may present a challenge in laboratories tasked with their identification. In March 2020, an anonymously submitted tablet purchased as a generic form of Xanax was analyzed by Erowid's DrugsData.org. The gas chromatography-mass spectrometry (GC-MS) results publicly released online indicated several unidentified compounds due to a lack of database references at that time. Elucidation by our group indicated the presence of several structurally related compounds that were l...
Source: Journal of Forensic Sciences - June 16, 2023 Category: Forensic Medicine Authors: Koby L Kizzire Emily Langlois Savannah Brown Source Type: research
