Exploring the Therapeutic Potential of < em > Ganoderma lucidum < /em > in Cancer
J Clin Med. 2024 Feb 18;13(4):1153. doi: 10.3390/jcm13041153.ABSTRACTTriterpenoids, such as ganoderic acid, and polysaccharides, including β-D-glucans, α-D-glucans, and α-D-mannans, are the main secondary metabolites of the medicinal fungus Ganoderma lucidum. There is evidence of the effects of ganoderic acid in hematological malignancies, whose mechanisms involve the stimulation of immune response, the macrophage-like differentiation, the activation of MAP-K pathway, an IL3-dependent cytotoxic action, the induction of cytoprotective autophagy, and the induction of apoptosis. In fact, this compound has been tested in tw...
Source: Clinical Lymphoma and Myeloma - February 24, 2024 Category: Cancer & Oncology Authors: Gabriella Cancemi Santino Caserta Sebastiano Gangemi Giovanni Pioggia Alessandro Allegra Source Type: research
Selective CDK7 inhibition suppresses cell cycle progression and MYC signaling while enhancing apoptosis in therapy-resistant estrogen receptor positive breast cancer
CONCLUSIONS: Taken together, these findings support the clinical investigation of selective CDK7 inhibition combined with ET to overcome treatment resistance in ER+ BC. In addition, our study highlights the potential of increased MYC activity and intact P53 as predictors for sensitivity to CDK7 inhibitor-based treatments.PMID:38381406 | DOI:10.1158/1078-0432.CCR-23-2975 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - February 21, 2024 Category: Cancer & Oncology Authors: Cristina Guarducci Agostina Nardone Douglas Russo Zsuzsanna Nagy Capucine Heraud Albert Grinshpun Qi Zhang Allegra Freelander Matthew Joseph Leventhal Avery Feit Gabriella Cohen Feit Ariel Feiglin Weihan Liu Francisco Hermida-Prado Nikolas Kesten Wen Ma C Source Type: research
Selective CDK7 inhibition suppresses cell cycle progression and MYC signaling while enhancing apoptosis in therapy-resistant estrogen receptor positive breast cancer
CONCLUSIONS: Taken together, these findings support the clinical investigation of selective CDK7 inhibition combined with ET to overcome treatment resistance in ER+ BC. In addition, our study highlights the potential of increased MYC activity and intact P53 as predictors for sensitivity to CDK7 inhibitor-based treatments.PMID:38381406 | DOI:10.1158/1078-0432.CCR-23-2975 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - February 21, 2024 Category: Cancer & Oncology Authors: Cristina Guarducci Agostina Nardone Douglas Russo Zsuzsanna Nagy Capucine Heraud Albert Grinshpun Qi Zhang Allegra Freelander Matthew Joseph Leventhal Avery Feit Gabriella Cohen Feit Ariel Feiglin Weihan Liu Francisco Hermida-Prado Nikolas Kesten Wen Ma C Source Type: research
Selective CDK7 inhibition suppresses cell cycle progression and MYC signaling while enhancing apoptosis in therapy-resistant estrogen receptor positive breast cancer
CONCLUSIONS: Taken together, these findings support the clinical investigation of selective CDK7 inhibition combined with ET to overcome treatment resistance in ER+ BC. In addition, our study highlights the potential of increased MYC activity and intact P53 as predictors for sensitivity to CDK7 inhibitor-based treatments.PMID:38381406 | DOI:10.1158/1078-0432.CCR-23-2975 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - February 21, 2024 Category: Cancer & Oncology Authors: Cristina Guarducci Agostina Nardone Douglas Russo Zsuzsanna Nagy Capucine Heraud Albert Grinshpun Qi Zhang Allegra Freelander Matthew Joseph Leventhal Avery Feit Gabriella Cohen Feit Ariel Feiglin Weihan Liu Francisco Hermida-Prado Nikolas Kesten Wen Ma C Source Type: research
Selective CDK7 inhibition suppresses cell cycle progression and MYC signaling while enhancing apoptosis in therapy-resistant estrogen receptor positive breast cancer
CONCLUSIONS: Taken together, these findings support the clinical investigation of selective CDK7 inhibition combined with ET to overcome treatment resistance in ER+ BC. In addition, our study highlights the potential of increased MYC activity and intact P53 as predictors for sensitivity to CDK7 inhibitor-based treatments.PMID:38381406 | DOI:10.1158/1078-0432.CCR-23-2975 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - February 21, 2024 Category: Cancer & Oncology Authors: Cristina Guarducci Agostina Nardone Douglas Russo Zsuzsanna Nagy Capucine Heraud Albert Grinshpun Qi Zhang Allegra Freelander Matthew Joseph Leventhal Avery Feit Gabriella Cohen Feit Ariel Feiglin Weihan Liu Francisco Hermida-Prado Nikolas Kesten Wen Ma C Source Type: research
An Evaluation of Wet Granulation Process Selection for API Prone to Polymorphic Form Conversion in the Presence of Moisture and Heat
ConclusionThe drying process is a critical factor in anhydrous form conservation. FBG and FBD yielded better preservation of the initial anhydrous forms. HSG could be an acceptable granulation method for API susceptible to hydrate formation if the API solubility is low. Selecting an FBG+FBD process minimizes API hydrate formation and preserves the original anhydrous form. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - February 21, 2024 Category: Drugs & Pharmacology Source Type: research
Integration of National Health Insurance claims data and animal models reveals fexofenadine as a promising repurposed drug for Parkinson ’s disease
Parkinson ’s disease (PD) is a common and costly progressive neurodegenerative disease of unclear etiology. A disease-modifying approach that can directly stop or slow its progression remains a major unmet need... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - February 21, 2024 Category: Neurology Authors: Jae-Bong Kim, Yujeong Kim, Soo-Jeong Kim, Tae ‑Young Ha, Dong-Kyu Kim, Dong Won Kim, Minyoung So, Seung Ho Kim, Hyun Goo Woo, Dukyong Yoon and Sang Myun Park Tags: Research Source Type: research
An Evaluation of Wet Granulation Process Selection for API Prone to Polymorphic Form Conversion in the Presence of Moisture and Heat
ConclusionThe drying process is a critical factor in anhydrous form conservation. FBG and FBD yielded better preservation of the initial anhydrous forms. HSG could be an acceptable granulation method for API susceptible to hydrate formation if the API solubility is low. Selecting an FBG+FBD process minimizes API hydrate formation and preserves the original anhydrous form. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - February 21, 2024 Category: Drugs & Pharmacology Source Type: research
Influenza-like illness surveillance may underestimate the incidence of respiratory syncytial virus in adult outpatients
In adults, respiratory syncytial virus (RSV) is a common cause of acute respiratory infections (ARIs) and is associated with a significant burden [1]. Two adult RSV vaccines have recently been authorized [2]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 15, 2024 Category: Infectious Diseases Authors: Alexander Domnich, Andrea Orsi, Matilde Ogliastro, Allegra Ferrari, Bianca Bruzzone, Donatella Panatto, Giancarlo Icardi Tags: Short Communication Source Type: research
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Giovanni Andrea Vitale, Christian Geibel, Vidit Minda, Mingxun Wang, Allegra T. Aron, Daniel Petras In this review we discuss emerging functional metabolomics strategies and their potential use to reveal mechanistic insights in large-scale natural product discovery studies. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - February 14, 2024 Category: Chemistry Authors: Giovanni Andrea Vitale Source Type: research
Adenomyosis and infertility: a possible glimmer of light in the dark
(Source: Fertility and Sterility)
Source: Fertility and Sterility - February 11, 2024 Category: Reproduction Medicine Authors: Adolfo Allegra, Angelo Marino Tags: Reflections Source Type: research
Children's representation of specialized skilled movements: The cases of snowboarding and aikido
This article investigates children's graphic representation of two complex motor skills, snowboarding and aikido, from the perspective of drawing flexibility research. In particular, the role of working memory capacity in the development of drawing flexibility is examined. A total of 127 children in the age range 5.7-11.9 years were shown short videos of snowboarding and aikido and were required to make drawings of them. In addition, participants were administered Goodenough's Draw-a-man Test (that measures the ability to draw detail and proportion in the human figure) and two working memory tests (the Mr. Cucumber test an...
Source: Memory and Cognition - February 9, 2024 Category: Neuroscience Authors: Allegra Sosic Sabrina Panesi Sergio Morra Source Type: research
Multicentric Study on Oncological Outcomes and Prognostic Factors of Open Partial Horizontal Laryngectomies
Conclusions: OPHLs represent an excellent alternative to TL considering the characteristics of the tumor and the general conditions of the patient.PMID:38321705 | DOI:10.1177/01455613231225906 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - February 7, 2024 Category: ENT & OMF Authors: Eugenia Allegra Maria Rita Bianco Domenico Michele Modica Alfio Azzolina Elio Privitera Daniele Latella Federico Occhiuzzi Mario Galfano Vincenzo Saita Source Type: research
Fexofenadine-loaded chitosan coated solid lipid nanoparticles (SLNs): A potential oral therapy for ulcerative colitis
Eur J Pharm Biopharm. 2024 Feb 2:114205. doi: 10.1016/j.ejpb.2024.114205. Online ahead of print.ABSTRACTThe targeting and mucoadhesive features of chitosan (CS)-linked solid lipid nanoparticles (SLNs) were exploited to efficiently deliver fexofenadine (FEX) into the colon, forming a novel and potential oral therapeutic option for ulcerative colitis (UC) treatment. Different FEX-CS-SLNs with varied molecular weights of CS were prepared and optimized. Optimized FEX-CS-SLNs exhibited 229 ± 6.08 nm nanometric size, 36.3 ± 3.18 mV zeta potential, 64.9 % EE, and a controlled release profile. FTIR, DSC, and TEM confirmed good d...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 4, 2024 Category: Drugs & Pharmacology Authors: Walaa A El-Dakroury Moataz B Zewail Gihan F Asaad Heba M I Abdallah Marwa E Shabana Abdelrahman R Said Ahmed S Doghish Hadeer A Azab Dalia H Amer Ahmed E Hassan Alaa S Sayed Ghada M Samra Al-Aliaa M Sallam Source Type: research
105. “There's Preconceived Notions about What I'm Experiencing”: Experiences of Racial and Gender Discrimination in Sexual Healthcare Settings Among Transgender and Nonbinary Young Adults of Color
Transgender and nonbinary Black, Indigenous, and other People of Color (BIPOC) face significant inequities in accessing sexual healthcare. The sexual healthcare experiences of BIPOC transgender and nonbinary young adults (YA), however, have received less attention and therefore remain poorly understood. Guided by intersectionality theory, this qualitative study explored how BIPOC transgender and nonbinary YA experience and resist racial and gender discrimination in sexual healthcare settings. (Source: Journal of Adolescent Health)
Source: Journal of Adolescent Health - January 30, 2024 Category: Child Development Authors: Candice Mazon, Christian Badillo Badillo, Frinny Polanco Walters, Allegra R. Gordon Source Type: research
