Microtubules as a signal hub for axon growth in response to mechanical force
Biol Chem. 2023 Sep 8. doi: 10.1515/hsz-2023-0173. Online ahead of print.ABSTRACTMicrotubules are highly polar structures and are characterized by high anisotropy and stiffness. In neurons, they play a key role in the directional transport of vesicles and organelles. In the neuronal projections called axons, they form parallel bundles, mostly oriented with the plus-end towards the axonal termination. Their physico-chemical properties have recently attracted attention as a potential candidate in sensing, processing and transducing physical signals generated by mechanical forces. Here, we discuss the main evidence supporting...
Source: Biological Chemistry - September 7, 2023 Category: Chemistry Authors: Alessandro Falconieri Allegra Coppini Vittoria Raffa Source Type: research
Implantable Biologics for Soft Tissue Surgery Reinforcement
Surg Technol Int. 2023 Jun 30;42:sti42/1680. Online ahead of print.ABSTRACTSoft tissue reinforcement focuses on medical grafts that are designed to support and regenerate soft tissue under or near suture lines. Soft tissue is defined as areas of similarly specialized cells that function to connect, support, and surround other structures and organs of the body. These tissues include skin, subcutaneous tissue, fascia, ligaments, tendons, fibrous tissues, fat, synovial membranes, and muscle. Most of the implantable devices used for this purpose are made of collagen, the most abundant protein in mammals and a key component of ...
Source: Surgical Technology International - September 7, 2023 Category: Surgery Authors: Callie Horn Nicole Uzor Allegra Fierro Marnie Abeshouse Keval Ray John C Lantis Source Type: research
Microtubules as a signal hub for axon growth in response to mechanical force
Biol Chem. 2023 Sep 8. doi: 10.1515/hsz-2023-0173. Online ahead of print.ABSTRACTMicrotubules are highly polar structures and are characterized by high anisotropy and stiffness. In neurons, they play a key role in the directional transport of vesicles and organelles. In the neuronal projections called axons, they form parallel bundles, mostly oriented with the plus-end towards the axonal termination. Their physico-chemical properties have recently attracted attention as a potential candidate in sensing, processing and transducing physical signals generated by mechanical forces. Here, we discuss the main evidence supporting...
Source: Biological Chemistry - September 7, 2023 Category: Chemistry Authors: Alessandro Falconieri Allegra Coppini Vittoria Raffa Source Type: research
Implantable Biologics for Soft Tissue Surgery Reinforcement
Surg Technol Int. 2023 Jun 30;42:sti42/1680. Online ahead of print.ABSTRACTSoft tissue reinforcement focuses on medical grafts that are designed to support and regenerate soft tissue under or near suture lines. Soft tissue is defined as areas of similarly specialized cells that function to connect, support, and surround other structures and organs of the body. These tissues include skin, subcutaneous tissue, fascia, ligaments, tendons, fibrous tissues, fat, synovial membranes, and muscle. Most of the implantable devices used for this purpose are made of collagen, the most abundant protein in mammals and a key component of ...
Source: Surgical Technology International - September 7, 2023 Category: Surgery Authors: Callie Horn Nicole Uzor Allegra Fierro Marnie Abeshouse Keval Ray John C Lantis Source Type: research
Bioequivalence of 2 Pediatric Formulations of Fexofenadine Hydrochloride Oral Suspension
The objective of this phase 1 single-center, open-label, randomized, 2-treatment, full-replicated, 4-period, 2-sequence crossover study in healthy adult volunteers was to assess the bioequivalence of 30 mg of the new oral suspension of fexofenadine HCl (test) versus 30 mg of the marketed pediatric oral suspension of fexofenadine HCl (reference). The replicate design was based on the high intra-individual variability of fexofenadine (>30% on Cmax). The study comprised 68 randomized and treated volunteers. Plasma concentrations of fexofenadine were similar following the administration of a single dose of each formulati...
Source: Clinical Pharmacology in Drug Development - September 2, 2023 Category: Drugs & Pharmacology Authors: Clemence Rauch,
Luiz Lucio,
Beatrice Bois De Fer,
Michele Lheritier ‐Barrand Tags: Original Article Source Type: research
Measuring Motivation for COVID-19 Vaccination: An Application of the Transtheoretical Model
CONCLUSION: This study produced reliable and valid measures of TTM constructs, myths, and barriers to understand motivation to receive COVID-19 vaccination that can be used in future research.PMID:37612233 | DOI:10.1177/08901171231197899 (Source: American Journal of Health Promotion : AJHP)
Source: American Journal of Health Promotion : AJHP - August 23, 2023 Category: International Medicine & Public Health Authors: Allegra Sacco Mark L Robbins Andrea L Paiva Kathleen Monahan Hayley Lindsey Cheyenne Reyes Andrea Rusnock Source Type: research
Measuring Motivation for COVID-19 Vaccination: An Application of the Transtheoretical Model
CONCLUSION: This study produced reliable and valid measures of TTM constructs, myths, and barriers to understand motivation to receive COVID-19 vaccination that can be used in future research.PMID:37612233 | DOI:10.1177/08901171231197899 (Source: American Journal of Health Promotion : AJHP)
Source: American Journal of Health Promotion : AJHP - August 23, 2023 Category: International Medicine & Public Health Authors: Allegra Sacco Mark L Robbins Andrea L Paiva Kathleen Monahan Hayley Lindsey Cheyenne Reyes Andrea Rusnock Source Type: research
Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths
Cell Stem Cell. 2023 Aug 9:S1934-5909(23)00257-6. doi: 10.1016/j.stem.2023.07.012. Online ahead of print.ABSTRACTRNA splicing factors are recurrently mutated in clonal blood disorders, but the impact of dysregulated splicing in hematopoiesis remains unclear. To overcome technical limitations, we integrated genotyping of transcriptomes (GoT) with long-read single-cell transcriptomics and proteogenomics for single-cell profiling of transcriptomes, surface proteins, somatic mutations, and RNA splicing (GoT-Splice). We applied GoT-Splice to hematopoietic progenitors from myelodysplastic syndrome (MDS) patients with mutations i...
Source: Cell Stem Cell - August 15, 2023 Category: Stem Cells Authors: Mariela Cort és-López Paulina Chamely Allegra G Hawkins Robert F Stanley Ariel D Swett Saravanan Ganesan Tarek H Mouhieddine Xiaoguang Dai Lloyd Kluegel Celine Chen Kiran Batta Nili Furer Rahul S Vedula John Beaulaurier Alexander W Drong Scott Hickey Ne Source Type: research
