Arterial Leg Ulcers in the Octogenarian
Arterial leg ulcers are a debilitating sequela of chronic ischemia, and their management, particularly in the octogenarian, is an immense challenge. ALUs are frequently a manifestation of end-stage peripheral arterial disease, and their presence portends a high morbidity and mortality. Management primarily relies on restoration of flow, but in the geriatric population, interventions may carry undue risk and pathologies may not be amenable. Adjunctive therapies that improve quality of life and decrease morbidity and mortality are therefore essential, and understanding their benefits and limitations is crucial in developing ...
Source: Clinics in Geriatric Medicine - January 24, 2024 Category: Geriatrics Authors: Allegra L. Fierro, Marnie Abeshouse, Tomer Lagziel, John C. Lantis Source Type: research
Genes, Vol. 15, Pages 139: Leptin and Leptin Receptor Polymorphisms in Infants and Their Parents: Correlation with Preterm Birth
iliano Bergallo
It has been proven that single-nucleotide polymorphisms (SNPs) in LEP and LEPR genes could predispose individuals to an increased risk of pregnancy adverse outcomes (PAOs) such as recurrent pregnancy loss (RPL) and pre-eclampsia. Preterm birth (PTB) is the leading cause of infant mortality. We decided to investigate the correlation between PTB and LEP and LEPR SNPs. The study cohort included families who underwent spontaneous PTB and control samples of families who had at-term-born (≥37 weeks of gestational age) children. Swabs were performed by rubbing the sticky end for about 30 s on the gu...
Source: Genes - January 22, 2024 Category: Genetics & Stem Cells Authors: Francesco Savino Allegra Sardo Stefano Gambarino Maddalena Dini Anna Clemente Anna Pau Ilaria Galliano Massimiliano Bergallo Tags: Article Source Type: research
Medicating the coast in a metropolitan city: Enantiomeric profiles and joint probabilistic risk assessment of antidepressants and antihistamines
Environ Int. 2024 Jan 9;184:108434. doi: 10.1016/j.envint.2024.108434. Online ahead of print.ABSTRACTPharmaceuticals are receiving increasing attention as emerging contaminants in the aquatic environment. Herein, we investigated the occurrence of 11 antidepressants, 6 antihistamines and 4 metabolites in treated wastewater effluents, rivers, stormwater, and seawater in Hong Kong, with special focus on chirality. The average levels of ∑pharmaceuticals ranged from 0.525 to 1070 ng/L in all samples and the total annual mass load of target pharmaceuticals in the marine environment of Hong Kong was 756 kg/y. Antihistamines acc...
Source: Environment International - January 18, 2024 Category: Environmental Health Authors: Rongben Wu Esther Yan-Yin Sin Kai Zhang Shaopeng Xu Yuefei Ruan Yim Ling Mak Ying-Kit Yung Sunny Wai-Choi Sun Rong Yang Paul K S Lam Source Type: research
Controlling target brain regions by optimal selection of input nodes
by Karan Kabbur Hanumanthappa Manjunatha, Giorgia Baron, Danilo Benozzo, Erica Silvestri, Maurizio Corbetta, Alessandro Chiuso, Alessandra Bertoldo, Samir Suweis, Michele Allegra
The network control theory framework holds great potential to inform neurostimulation experiments aimed at inducing desired activity states in the brain. However, the current applicability of the framework is limited by inappropriate modeling of brain dynamics, and an overly ambitious focus on whole-brain activity control. In this work, we leverage recent progress in linear modeling of brain dynamics (effective connectivity) and we exploit the co...
Source: PLoS Computational Biology - January 12, 2024 Category: Biology Authors: Karan Kabbur Hanumanthappa Manjunatha Source Type: research
Safety and Efficacy of Concurrent Atezolizumab/Bevacizumab or Nivolumab Combination Therapy with Yttrium-90 Radioembolization of Advanced Unresectable Hepatocellular Carcinoma
Curr Oncol. 2023 Nov 25;30(12):10100-10110. doi: 10.3390/curroncol30120734.ABSTRACTTo evaluate the safety and efficacy of combining yttrium-90 radioembolization (Y90-RE) with immune checkpoint inhibitor therapy, consecutive advanced unresectable hepatocellular carcinoma (HCC) patients treated between 2016 and 2022 with atezolizumab/bevacizumab or nivolumab within three-months pre- and post-Y90-RE were retrospectively evaluated. Tumor response and treatment-related clinical/laboratory adverse events (AE) were assessed at 1 and 6 months, as well as differences in clinical and laboratory variables and median overall survival ...
Source: Current Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Alexander Villalobos Howard Hussein Dabbous Olivia Little Olumide Babajide Gbolahan Mehmet Akce Meghan Allegra Lilly Zachary Bercu Nima Kokabi Source Type: research
Safety and Efficacy of Concurrent Atezolizumab/Bevacizumab or Nivolumab Combination Therapy with Yttrium-90 Radioembolization of Advanced Unresectable Hepatocellular Carcinoma
Curr Oncol. 2023 Nov 25;30(12):10100-10110. doi: 10.3390/curroncol30120734.ABSTRACTTo evaluate the safety and efficacy of combining yttrium-90 radioembolization (Y90-RE) with immune checkpoint inhibitor therapy, consecutive advanced unresectable hepatocellular carcinoma (HCC) patients treated between 2016 and 2022 with atezolizumab/bevacizumab or nivolumab within three-months pre- and post-Y90-RE were retrospectively evaluated. Tumor response and treatment-related clinical/laboratory adverse events (AE) were assessed at 1 and 6 months, as well as differences in clinical and laboratory variables and median overall survival ...
Source: Current Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Alexander Villalobos Howard Hussein Dabbous Olivia Little Olumide Babajide Gbolahan Mehmet Akce Meghan Allegra Lilly Zachary Bercu Nima Kokabi Source Type: research
