Stereotactic Body Radiation Therapy and Abiraterone Acetate for Patients Affected by Oligometastatic Castrate-Resistant Prostate Cancer: A Randomized Phase II Trial (ARTO)
CONCLUSION: The trial reached its primary end point of biochemical control and PFS, suggesting a clinical advantage for SBRT in addition to first-line AAP treatment in patients with metastatic castration-resistant prostate cancer.PMID:37733977 | DOI:10.1200/JCO.23.00985 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Giulio Francolini Andrea Gaetano Allegra Beatrice Detti Vanessa Di Cataldo Saverio Caini Alessio Bruni Gianluca Ingrosso Rolando Maria D'Angelillo Anna Rita Alitto Matteo Augugliaro Luca Triggiani Silvana Parisi Gaetano Facchini Marco Banini Gabriele Simo Source Type: research
Stereotactic Body Radiation Therapy and Abiraterone Acetate for Patients Affected by Oligometastatic Castrate-Resistant Prostate Cancer: A Randomized Phase II Trial (ARTO)
CONCLUSION: The trial reached its primary end point of biochemical control and PFS, suggesting a clinical advantage for SBRT in addition to first-line AAP treatment in patients with metastatic castration-resistant prostate cancer.PMID:37733977 | DOI:10.1200/JCO.23.00985 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Giulio Francolini Andrea Gaetano Allegra Beatrice Detti Vanessa Di Cataldo Saverio Caini Alessio Bruni Gianluca Ingrosso Rolando Maria D'Angelillo Anna Rita Alitto Matteo Augugliaro Luca Triggiani Silvana Parisi Gaetano Facchini Marco Banini Gabriele Simo Source Type: research
Acellular Fish Skin for Tissue Replacement
Surg Technol Int. 2023 Sep 20;42:sti42/1710. Online ahead of print.ABSTRACTIn modern practice, xenografts play a crucial role in wound management due to their regenerative properties. Of the various xenografts currently available on the market, acellular fish skin (AFS) grafts have emerged as a more effective alternative to existing xenografts and other standard of care (SOC) treatments for wound healing. Since AFS grafts require minimal processing, they maintain their structural integrity and natural properties, including an abundance of Omega-3 fatty acids, which is a distinctive, pro-regenerative feature. AFS grafts are...
Source: Surgical Technology International - September 20, 2023 Category: Surgery Authors: Callie Horn Allegra Fierro John C Lantis Source Type: research
Acellular Fish Skin for Tissue Replacement
Surg Technol Int. 2023 Sep 20;42:sti42/1710. doi: 10.52198/23.STI.42.WH1710. Online ahead of print.ABSTRACTIn modern practice, xenografts play a crucial role in wound management due to their regenerative properties. Of the various xenografts currently available on the market, acellular fish skin (AFS) grafts have emerged as a more effective alternative to existing xenografts and other standard of care (SOC) treatments for wound healing. Since AFS grafts require minimal processing, they maintain their structural integrity and natural properties, including an abundance of Omega-3 fatty acids, which is a distinctive, pro-rege...
Source: Surgical Technology International - September 20, 2023 Category: Surgery Authors: Callie Horn Allegra Fierro John C Lantis Source Type: research
P-glycoprotein mechanical functional analysis using in silico molecular modeling: Pharmacokinetic variability according to ABCB1 c.2677G & gt; T/A genetic polymorphisms
Int J Biol Macromol. 2023 Sep 6:126777. doi: 10.1016/j.ijbiomac.2023.126777. Online ahead of print.ABSTRACTP-glycoprotein (P-gp) is a widely membrane-expressed multi-drug transporter. It is unclear whether the pharmacokinetic diversity of P-gp substrates is highly dependent on ABCB1 polymorphisms encoding P-gp. The purpose of this study is to analyze the mechanistic function of P-gp through in silico molecular modeling and to approach the resolution of controversy over pharmacokinetic differences according to ABCB1 polymorphisms. P-gp conformations of apo, ligand-docked, and outward-facing states can be modeled based on st...
Source: International Journal of Biological Macromolecules - September 8, 2023 Category: Biochemistry Authors: Seung-Hyun Jeong Ji-Hun Jang Yong-Bok Lee Source Type: research
P-glycoprotein mechanical functional analysis using in silico molecular modeling: Pharmacokinetic variability according to ABCB1 c.2677G & gt; T/A genetic polymorphisms
Int J Biol Macromol. 2023 Sep 6:126777. doi: 10.1016/j.ijbiomac.2023.126777. Online ahead of print.ABSTRACTP-glycoprotein (P-gp) is a widely membrane-expressed multi-drug transporter. It is unclear whether the pharmacokinetic diversity of P-gp substrates is highly dependent on ABCB1 polymorphisms encoding P-gp. The purpose of this study is to analyze the mechanistic function of P-gp through in silico molecular modeling and to approach the resolution of controversy over pharmacokinetic differences according to ABCB1 polymorphisms. P-gp conformations of apo, ligand-docked, and outward-facing states can be modeled based on st...
Source: International Journal of Biological Macromolecules - September 8, 2023 Category: Biochemistry Authors: Seung-Hyun Jeong Ji-Hun Jang Yong-Bok Lee Source Type: research
Microtubules as a signal hub for axon growth in response to mechanical force
Biol Chem. 2023 Sep 8. doi: 10.1515/hsz-2023-0173. Online ahead of print.ABSTRACTMicrotubules are highly polar structures and are characterized by high anisotropy and stiffness. In neurons, they play a key role in the directional transport of vesicles and organelles. In the neuronal projections called axons, they form parallel bundles, mostly oriented with the plus-end towards the axonal termination. Their physico-chemical properties have recently attracted attention as a potential candidate in sensing, processing and transducing physical signals generated by mechanical forces. Here, we discuss the main evidence supporting...
Source: Biological Chemistry - September 7, 2023 Category: Chemistry Authors: Alessandro Falconieri Allegra Coppini Vittoria Raffa Source Type: research
Implantable Biologics for Soft Tissue Surgery Reinforcement
Surg Technol Int. 2023 Jun 30;42:sti42/1680. Online ahead of print.ABSTRACTSoft tissue reinforcement focuses on medical grafts that are designed to support and regenerate soft tissue under or near suture lines. Soft tissue is defined as areas of similarly specialized cells that function to connect, support, and surround other structures and organs of the body. These tissues include skin, subcutaneous tissue, fascia, ligaments, tendons, fibrous tissues, fat, synovial membranes, and muscle. Most of the implantable devices used for this purpose are made of collagen, the most abundant protein in mammals and a key component of ...
Source: Surgical Technology International - September 7, 2023 Category: Surgery Authors: Callie Horn Nicole Uzor Allegra Fierro Marnie Abeshouse Keval Ray John C Lantis Source Type: research
