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Polyamine-containing natural products: structure, bioactivity, and biosynthesis
Nat. Prod. Rep., 2024,41,525-564 DOI: 10.1039/D2NP00087C, Review ArticleQingshan Long, Wen Zhou, Haibo Zhou, Ying Tang, Wu Chen, Qingshu Liu, Xiaoying Bian Polyamine-containing natural products have been isolated from a wide range of terrestrial and marine organisms. Most of them exhibit remarkable and diverse activities with potential applications in human health and agriculture. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - April 24, 2024 Category: Chemistry Authors: Qingshan Long Source Type: research

Medium-sized peptides from microbial sources with potential for antibacterial drug development
Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D4NP00002A, Review ArticleJianwei Chen, Wei Wang, Xubin Hu, Yujie Yue, Xingyue Lu, Chenjie Wang, Bin Wei, Huawei Zhang, Hong Wang This review summarizes the medium-sized antimicrobial peptides discovered in the last three decades (1993 to the end of 2022) and highlights the novel antibacterial mechanisms as well as part of the structure –activity relationships. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - April 23, 2024 Category: Chemistry Authors: Jianwei Chen Source Type: research

Verticillins: fungal epipolythiodioxopiperazine alkaloids with chemotherapeutic potential
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Herma C. Pierre, Chiraz Soumia M. Amrine, Michael G. Doyle, Amrita Salvi, Huzefa A. Raja, Jonathan R. Chekan, Andrew C. Huntsman, James R. Fuchs, Kebin Liu, Joanna E. Burdette, Cedric J. Pearce, Nicholas H. Oberlies Verticillin A has a beautiful and complex scaffold, as noted in this image of the crystal structure. This review encapsulates both the>50 year history of verticillins and the exciting studies that have been carried out recently, offering insights and opportunities for future research. To cite this article before p...
Source: RSC - Nat. Prod. Rep. latest articles - April 17, 2024 Category: Chemistry Authors: Herma C. Pierre Source Type: research

Hot off the Press
Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D4NP90015D, Hot off the Press ArticleRobert A. Hill, Andrew Sutherland A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as eugeniinaline A fromLeuconotis eugeniifolia. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - April 15, 2024 Category: Chemistry Authors: Robert A. Hill Source Type: research

Embracing the era of antimicrobial peptides with marine organisms
Nat. Prod. Rep., 2024,41,331-346 DOI: 10.1039/D3NP00031A, Review ArticlePengyu Chen, Ting Ye, Chunyuan Li, Praveen Praveen, Zhangli Hu, Wenyi Li, Chenjing Shang The marine world is a rich reservoir for the discovery of antimicrobial peptides, namely antibiotic alternatives. The current review summarized the most recently identified AMPs, with a focus on exploiting the PTMs for mature AMP production. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - March 20, 2024 Category: Chemistry Authors: Pengyu Chen Source Type: research

Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2
Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D3NP00060E, Review ArticleSaket R. Bagde, Chu-Young Kim Structures of intact polyketide synthase modules reveal conformational rearrangements and suggest asynchronous use of reaction chambers. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - March 20, 2024 Category: Chemistry Authors: Saket R. Bagde Source Type: research

Structural, biochemical and bioinformatic analyses of nonribosomal peptide synthetase adenylation domains
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Stephanie C. Heard, Jaclyn M. Winter This review highlights the utility of using adenylation domain structural data, biochemical assays, and computational predictions for prioritizing nonribosomal peptide pathways for natural product discovery. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - March 15, 2024 Category: Chemistry Authors: Stephanie C. Heard Source Type: research

Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis
Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D3NP00067B, Review ArticleJin-Xin Zhao, Zhan-Peng Ge, Jian-Min Yue This review summarizes a total of 105 cephalotane diterpenoids, covering their isolation, structural features, biological activities, biosynthetic proposals, and completed total synthesis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - March 14, 2024 Category: Chemistry Authors: Jin-Xin Zhao Source Type: research

Bacillus subtilis as a host for natural product discovery and engineering of biosynthetic gene clusters
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Hanne Put, Hans Gerstmans, Hanne Vande Capelle, Maarten Fauvart, Jan Michiels, Joleen Masschelein This review explores the use ofBacillus as a heterologous host for natural product discovery and engineering, highlighting its unique traits, successful natural product examples and available genetic engineering tools. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - March 11, 2024 Category: Chemistry Authors: Hanne Put Source Type: research

Gold-catalyzed cyclization and cycloaddition in natural product synthesis
Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D3NP00056G, Review ArticleBoxu Lin, Tianran Liu, Tuoping Luo This review highlights a curated selection of publications utilizing homogeneous gold-catalyzed cycloaddition and cyclization reactions for the total synthesis of natural products reported from 2016 to mid-2023. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - March 8, 2024 Category: Chemistry Authors: Boxu Lin Source Type: research

Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Bichu Cheng, Qi Wang, Yi An, Fener Chen This review discusses the recent synthetic strategies for the total synthesis of galantamine, a natural medicine for the treatment of Alzheimer's disease, focusing on the construction of the key quaternary center and the asymmetric synthesis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - March 7, 2024 Category: Chemistry Authors: Bichu Cheng Source Type: research

The insect microbiome is a vast source of bioactive small molecules
Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D3NP00054K, Review ArticleCarlismari Oliveira Grundmann, Juan Guzman, Andreas Vilcinskas, M ônica Tallarico Pupo Bacteria and fungi living in symbiosis with insects have been studied over the last sixty years and found to be important sources of bioactive natural products. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - February 27, 2024 Category: Chemistry Authors: Carlismari Oliveira Grundmann Source Type: research

Opportunities and challenges of RiPP-based therapeutics
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Isabel P.-M. Pfeiffer, Maria-Paula Schr öder, Silja Mordhorst Ribosomally synthesised and post-translationally modified peptides (RiPPs) are highly promising candidates for drug discovery and development, but challenges remain. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - February 27, 2024 Category: Chemistry Authors: Isabel P.-M. Pfeiffer Source Type: research

Plant peptides – redefining an area of ribosomally synthesized and post-translationally modified peptides
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Jonathan R. Chekan, Lisa S. Mydy, Michael A. Pasquale, Roland D. Kersten Plant peptide natural products are ribosomally synthesized and post-translationally modified peptides (RiPPs). We review structure, biosynthesis, and bioactivity of plant RiPPs and define burpitides, a recent addition to plant RiPP classes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - February 27, 2024 Category: Chemistry Authors: Jonathan R. Chekan Source Type: research

Recent advances in discovery and biosynthesis of natural products from myxobacteria: an overview from 2017 to 2023
Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D3NP00062A, Review ArticleChao-Yi Wang, Jia-Qi Hu, De-Gao Wang, Yue-Zhong Li, Changsheng Wu This review presents a comprehensive overview of recent advances in the discovery methodologies, new structures, bioactivities, and unique biosynthetic logics of myxobacterial natural products reported from January 2017 to November 2023. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - February 23, 2024 Category: Chemistry Authors: Chao-Yi Wang Source Type: research