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Cheminformatic analysis of natural product-based drugs and chemical probes
Nat. Prod. Rep., 2022,39,20-32 DOI: 10.1039/D1NP00039J, HighlightSamantha Stone, David J. Newman, Steven L. Colletti, Derek S. Tan Cheminformatic analyses illustrate that drugs from natural product-based and synthetic origins have distinctive structural and physicochemical features. These drugs also cluster by biosynthetic origin and, to some extent, by therapeutic class. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - January 27, 2022 Category: Chemistry Authors: Samantha Stone Source Type: research

Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products
Nat. Prod. Rep., 2022,39,139-162 DOI: 10.1039/D1NP00017A, Review ArticleBo Gao, Bo Yang, Xudong Feng, Chun Li Nitrogen heterocyclic natural products (NHNPs) are primary or secondary metabolites containing nitrogen heterocyclic (N-heterocyclic) skeletons. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - January 27, 2022 Category: Chemistry Authors: Bo Gao Source Type: research

Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Rory F. Little, Christian Hertweck This review covers the mechanisms of chain release in polyketide and non-ribosomal peptide biosynthesis. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - January 27, 2022 Category: Chemistry Authors: Rory F. Little Source Type: research

Correction: Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Rory F. Little, Christian Hertweck The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - January 27, 2022 Category: Chemistry Authors: Rory F. Little Source Type: research

How different are marine microbial natural products compared to their terrestrial counterparts?
Nat. Prod. Rep., 2022,39,7-19 DOI: 10.1039/D1NP00051A, HighlightTanja M. Voser, Max D. Campbell, Anthony R. Carroll Cheminformatics analysis shows that most marine microbial natural products are like terrestrial microbial natural products. New methods to access novel marine microbial chemistry are needed. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - January 27, 2022 Category: Chemistry Authors: Tanja M. Voser Source Type: research

From solo to duet, intersections of natural product assembly with self-resistance
Nat. Prod. Rep., 2022, Advance Article DOI: 10.1039/D1NP00064K, HighlightLinrui Wu, Qian Zhang, Zixin Deng, Yi Yu It has become a ‘received wisdom’ that there are universal links between natural product (NP) self-resistance and biosynthesis, which needs interpretation. This review highlights evidence of intersection between NP self-resistance and biosynthesis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - January 16, 2022 Category: Chemistry Authors: Linrui Wu Source Type: research

Anthracyclines: biosynthesis, engineering and clinical applications
Nat. Prod. Rep., 2022, Advance Article DOI: 10.1039/D1NP00059D, Review ArticleMandy B. Hulst, Thadee Grocholski, Jacques J. C. Neefjes, Gilles P. van Wezel, Mikko Mets ä-Ketelä Anthracyclines are important anticancer drugs. We discuss recent insights into the biosynthetic pathways and bioactivities of anthracyclines, and evaluate the discovery and engineering of effective derivatives with less severe side effects. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - December 24, 2021 Category: Chemistry Authors: Mandy B. Hulst Source Type: research

Synthesis of rearranged indole diterpenes of the paxilline type
Nat. Prod. Rep., 2022, Advance Article DOI: 10.1039/D1NP00062D, Review ArticleDevon J. Schatz, Eric J. Kuenstner, David T. George, Sergey V. Pronin Paxilline indole diterpenes have fascinated chemists for the past several decades. This review highlights the diversity of strategies and tactics that have been employed in the corresponding area of organic synthesis, from inception to the present. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - December 21, 2021 Category: Chemistry Authors: Devon J. Schatz Source Type: research

Challenges and opportunities for cheat therapy in the control of bacterial infections
Nat. Prod. Rep., 2022, Advance Article DOI: 10.1039/D1NP00053E, Review ArticleJames Gurney, Camille Simonet, Kristofer Wollein Waldetoft, Sam P. Brown Bacterial pathogens can be highly social, communicating and cooperating within multi-cellular groups to make us sick. Manipulating these behaviors might have therapeutic benefits. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - December 16, 2021 Category: Chemistry Authors: James Gurney Source Type: research

Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Andre G. Tempone, Pauline Pieper, Samanta E. T. Borborema, Fernanda Thevenard, Joao Henrique G. Lago, Simon L. Croft, Edward A. Anderson This Review discusses the isolation and bioactivity of marine alkaloids against protozoan parasite diseases, and chemical syntheses that enable the further development of these scaffolds as drug leads. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - December 15, 2021 Category: Chemistry Authors: Andre G. Tempone Source Type: research

Skipped dienes in natural product synthesis
Nat. Prod. Rep., 2021,38,2187-2213 DOI: 10.1039/D1NP00012H, Review ArticleGreg Petruncio, Zachary Shellnutt, Synah Elahi-Mohassel, Suman Alishetty, Mikell Paige The 1,4-diene motif, also known as a skipped diene, is widespread across various classes of natural products including alkaloids, fatty acids, terpenoids, and polyketides as part of either the finalized structure or a biosynthetic intermediate. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - December 15, 2021 Category: Chemistry Authors: Greg Petruncio Source Type: research

Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Vincent Courdavault, Sarah E. O'Connor, Michael K. Jensen, Nicolas Papon The recent achievements in the transfer of biosynthetic pathways of plant natural products in heterologous organisms offer new perspectives towards the supply of these compounds through metabolic engineering approaches. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - December 15, 2021 Category: Chemistry Authors: Vincent Courdavault Source Type: research

Naturally occurring prenylated chalcones from plants: structural diversity, distribution, activities and biosynthesis
Nat. Prod. Rep., 2021,38,2236-2260 DOI: 10.1039/D0NP00083C, Review ArticleKang Zhou, Song Yang, Shu-Ming Li This review covers the literature until July 2020 on structures, biological activities, distribution and biosynthesis of prenylated chalcones in plants. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - December 15, 2021 Category: Chemistry Authors: Kang Zhou Source Type: research

Site-directed mutagenesis and substrate compatibility to reveal the structure –function relationships of plant oxidosqualene cyclases
Nat. Prod. Rep., 2021,38,2261-2275 DOI: 10.1039/D1NP00015B, Review ArticleKuan Chen, Meng Zhang, Min Ye, Xue Qiao Site-directed mutagenesis and substrate promiscuity of plant OSCs were summarized to understand the cyclization mechanism. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - December 15, 2021 Category: Chemistry Authors: Kuan Chen Source Type: research

The chromodepsins – chemistry, biology and biosynthesis of a selective Gq inhibitor natural product family
Nat. Prod. Rep., 2021,38,2276-2292 DOI: 10.1039/D1NP00005E, Review ArticleCornelia Hermes, Gabriele M. K önig, Max Crüsemann This review summarizes research on the chromodepsins, a small natural product family inhibiting Gq proteins, including their discovery, mode of action, biosynthesis, ecology, total synthesis, pharmacological and therapeutic use. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - December 15, 2021 Category: Chemistry Authors: Cornelia Hermes Source Type: research