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Structure, properties of gossypol and its derivatives —from physiological activities to drug discovery and drug design
Nat. Prod. Rep., 2022, Advance Article DOI: 10.1039/D1NP00080B, Review ArticleYanxia Liu, Lulu Wang, Lin Zhao, Yagang Zhang Gossypol is a polyphenolic compound isolated from cottonseed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - May 19, 2022 Category: Chemistry Authors: Yanxia Liu Source Type: research

Harmonizing biosynthesis with post-ingestive modifications to understand the ecological functions of plant natural products
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Jiancai Li, Ian T. Baldwin, Dapeng Li The post-ingestive modifications in herbivores are essential to the function of plant specialized metabolites. Here, we highlight recent advances and discuss the prospects of functional study to plant natural products. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - May 16, 2022 Category: Chemistry Authors: Jiancai Li Source Type: research

Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Russell J. Cox Current understanding of iterative highly programmed Type 1 PKS that control starter unit selection, chain length, methylation pattern, and stereochemistry. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - May 11, 2022 Category: Chemistry Authors: Russell J. Cox Source Type: research

Silybin and its congeners: from traditional medicine to molecular effects
Nat. Prod. Rep., 2022, Advance Article DOI: 10.1039/D2NP00013J, Review ArticleVladim ír Křen, Kateřina Valentová Recent developments in chemistry, biosynthesis, analytical methods, and transformations of flavonolignans from silymarin are presented. Their pharmacology, biological activities, SAR and safety with special attention to the chirality are discussed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - May 5, 2022 Category: Chemistry Authors: Vladim ír Křen Source Type: research

Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi
Nat. Prod. Rep., 2022, Advance Article DOI: 10.1039/D1NP00067E, Review ArticleSusanne H. Kirsch, F. P. Jake Haeckl, Rolf M üller Bacterial RNA polymerase is an attractive target for the development of antibacterial therapeutics. We review the mode of action of approved compounds and highlight additional emerging target sites inhibited primarily by microbial natural products. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - May 4, 2022 Category: Chemistry Authors: Susanne H. Kirsch Source Type: research

The ins and outs of transporters at plasma membrane and tonoplast in plant specialized metabolism
Nat. Prod. Rep., 2022, Advance Article DOI: 10.1039/D2NP00016D, Review ArticleBarbara Ann Halkier, Deyang Xu This review focuses on biochemistry of recently identified transporters of plant specialized metabolites at the plasma membrane and tonoplast. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - April 28, 2022 Category: Chemistry Authors: Barbara Ann Halkier Source Type: research

Chemical synthesis in competition with global genome mining and heterologous expression for the preparation of dimeric indole-derived 2,5-dioxopiperazines
Nat. Prod. Rep., 2022, Advance Article DOI: 10.1039/D2NP00006G, Review ArticlePatricia Garc ía-Domínguez, Andrea Areal, Rosana Alvarez, Angel R. de Lera Natural products chemists addressing global genome mining and heterologous expression, purification and structural determination, and the synthetic campaigns conspire to generate dimeric tryptophan-derived dioxopiperazines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - April 26, 2022 Category: Chemistry Authors: Patricia Garc ía-Domínguez Source Type: research

Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Ryan Limbocker, Silvia Errico, Denise Barbut, Tuomas P. J. Knowles, Michele Vendruscolo, Fabrizio Chiti, Michael Zasloff The natural products squalamine and trodusquemine are promising potential therapeutics against Alzheimer's, Parkinson's, and other neurodegenerative diseases for their ability to modulate protein aggregation processes and target protein misfolded oligomers that are toxic to neurons. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - April 20, 2022 Category: Chemistry Authors: Ryan Limbocker Source Type: research

Plant biosynthetic gene clusters in the context of metabolic evolution
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Samuel J. Smit, Benjamin R. Lichman A significant subset of plant specialised metabolism genes are arranged in biosynthetic gene clusters. Here, we review these clusters and discuss their possible roles within the context of genome dynamics and metabolic evolution. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - April 20, 2022 Category: Chemistry Authors: Samuel J. Smit Source Type: research

The phosphate ester group in secondary metabolites
Nat. Prod. Rep., 2022, Advance Article DOI: 10.1039/D1NP00078K, Review ArticleFranco Della-Felice, Aloisio de Andrade Bartolomeu, Ronaldo Aloise Pilli The structural, biological, and pharmacological profiles of phosphorylated secondary metabolites is presented. An overview of the phosphorylation methodologies employed in their total syntheses is also included. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - April 14, 2022 Category: Chemistry Authors: Franco Della-Felice Source Type: research

Strychnine and its mono- and dimeric analogues: a pharmaco-chemical perspective
Nat. Prod. Rep., 2022, Advance Article DOI: 10.1039/D1NP00079A, Review ArticleDarius P. Zlotos, Yasmine M. Mandour, Anders A. Jensen Since its isolation in 1818, strychnine has attracted the attention of chemists and pharmacologists. Here, we discuss structures, syntheses, metabolic transformations, and pharmacological actions of the alkaloid and its mono- and dimeric analogues. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - April 5, 2022 Category: Chemistry Authors: Darius P. Zlotos Source Type: research

Hot off the Press
Nat. Prod. Rep., 2022, Advance Article DOI: 10.1039/D2NP90011D, Hot off the Press ArticleRobert A. Hill, Andrew Sutherland A personal selection of 32 recent papers is presented, covering various aspects of current developments in bioorganic chemistry and novel natural products, such as daphnepapytone A fromDaphne papyracea. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - April 1, 2022 Category: Chemistry Authors: Robert A. Hill Source Type: research

Chemoenzymatic approaches to plant natural product inspired compounds
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Rebecca Roddan, Eve M. Carter, Benjamin Thair, Helen C. Hailes Chemoenzymatic routes to plant natural products and analogues are described, highlighting the advantages of incorporating biocatalysis into synthetic strategies. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - March 28, 2022 Category: Chemistry Authors: Rebecca Roddan Source Type: research

Fruity, sticky, stinky, spicy, bitter, addictive, and deadly: evolutionary signatures of metabolic complexity in the Solanaceae
Nat. Prod. Rep., 2022, Advance Article DOI: 10.1039/D2NP00003B, Review ArticlePaul D. Fiesel, Hannah M. Parks, Robert L. Last, Cornelius S. Barry This review focuses on the biosynthesis and evolution of specialized metabolism in the Solanaceae (Nightshade) family. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - March 24, 2022 Category: Chemistry Authors: Paul D. Fiesel Source Type: research

Structure, synthesis, biosynthesis, and activity of the characteristic compounds from Ginkgo biloba L.
Nat. Prod. Rep., 2022,39,474-511 DOI: 10.1039/D1NP00026H, Review ArticleXin-Guang Liu, Xu Lu, Wen Gao, Ping Li, Hua Yang Ginkgo biloba L. is one of the most distinctive plants to have emerged on earth and has no close living relatives. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - March 23, 2022 Category: Chemistry Authors: Xin-Guang Liu Source Type: research