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Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri
Nat. Prod. Rep., 2023,40,237-274 DOI: 10.1039/D1NP00074H, Review ArticleXinhui Wang, Scott A. Jarmusch, Jens C. Frisvad, Thomas O. Larsen Aspergilli are biosynthetically ‘talented’ micro-organisms and therefore the natural products community has continually been interested in the wealth of biosynthetic gene clusters (BGCs) encoding numerous secondary metabolites related to these fungi. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - February 22, 2023 Category: Chemistry Authors: Xinhui Wang Source Type: research

Tailoring enzyme strategies and functional groups in biosynthetic pathways
Nat. Prod. Rep., 2023,40,326-386 DOI: 10.1039/D2NP00048B, Review ArticleChristopher T. Walsh Secondary metabolites are assembled by drawing off and committing some of the flux of primary metabolic building blocks to sets of enzymes that tailor the maturing scaffold. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - February 22, 2023 Category: Chemistry Authors: Christopher T. Walsh Source Type: research

Streptomyces cell-free systems for natural product discovery and engineering
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Simon J. Moore, Hung-En Lai, Jian Li, Paul S. Freemont Streptomyces cell-free gene expression (CFE) systems for natural product discovery. The CFE system simply requires DNA, a cell-extract, amino acids, and a metabolite solution to study transcription, translation, and biosynthesis in a single reaction. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - February 22, 2023 Category: Chemistry Authors: Simon J. Moore Source Type: research

Discovery, bioactivity and biosynthesis of fungal piperazines
Nat. Prod. Rep., 2023,40,387-411 DOI: 10.1039/D2NP00070A, Review ArticleRui Wang, Andrew M. Piggott, Yit-Heng Chooi, Hang Li Fungi are prolific producers of piperazine alkaloids, with more than 90 examples isolated to date. This review summarises the current knowledge of the discovery, classification, bioactivity and biosynthesis of fungal piperazines up to July of 2022. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - February 22, 2023 Category: Chemistry Authors: Rui Wang Source Type: research

Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?
Nat. Prod. Rep., 2023, Advance Article DOI: 10.1039/D2NP00085G, HighlightDarren C. Holland, Anthony R. Carroll Limited screening focus has led to most marine derived indole alkaloids (MIA) being inactive. However, computational comparisons with indole drugs suggest MIAs will be active in new disease relevant targets if a screening focus shift is adopted. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - February 15, 2023 Category: Chemistry Authors: Darren C. Holland Source Type: research

Marine natural products
Nat. Prod. Rep., 2023, Advance Article DOI: 10.1039/D2NP00083K, Review ArticleAnthony R. Carroll, Brent R. Copp, Rohan A. Davis, Robert A. Keyzers, Mich èle R. Prinsep A comprehensive review of 1425 new MNPs including a novel cyanobacterial cyclodepsipeptide, gatorbulin-1, that targets a 7th tubulin binding site. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - February 14, 2023 Category: Chemistry Authors: Anthony R. Carroll Source Type: research

Hot off the Press
Nat. Prod. Rep., 2023, Advance Article DOI: 10.1039/D3NP90007J, Hot off the Press ArticleRobert A. Hill, Andrew Sutherland A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products, such as euphylonoid A fromEuphorbia hylonoma. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - February 9, 2023 Category: Chemistry Authors: Robert A. Hill Source Type: research

Dynamic environmental interactions shaped by vegetative plant volatiles
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Roc ío Escobar-Bravo, Po-An Lin, Jamie M. Waterman, Matthias Erb Vegetative plant volatiles influence their environment, andvice versa. We review these dynamic interactions and identify frameworks that can help to explain volatile emission patterns and their biological functions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - February 2, 2023 Category: Chemistry Authors: Roc ío Escobar-Bravo Source Type: research

Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids
Nat. Prod. Rep., 2023, Advance Article DOI: 10.1039/D2NP00052K, Review ArticleMinghui Fan, Liangbang Zou, Kaidi Tian, Guoqing Chen, Kai Cheng, Yong Li This review presents the structural diversity of 73 stemmadenine and related alkaloids, as well as their biological activities, and fully describes the biosynthetic proposal for stemmadenine and the successful synthetic approaches. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - February 2, 2023 Category: Chemistry Authors: Minghui Fan Source Type: research

Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Russell J. Cox Current understanding of iterative highly programmed Type 1 PKS that control starter unit selection, chain length, methylation pattern, and stereochemistry. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - January 25, 2023 Category: Chemistry Authors: Russell J. Cox Source Type: research

Engineering fungal terpene biosynthesis
Nat. Prod. Rep., 2023,40,28-45 DOI: 10.1039/D2NP00020B, Review ArticleZhiyong Yin, Jeroen S. Dickschat This review summarises recent research on metobolic engineering approaches towards terpenes, including work to investigate unknown pathways and to improve accessibility of known compounds. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - January 25, 2023 Category: Chemistry Authors: Zhiyong Yin Source Type: research

Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis
Nat. Prod. Rep., 2023,40,46-61 DOI: 10.1039/D2NP00014H, Review ArticleTakayoshi Awakawa, Takahiro Mori, Richiro Ushimaru, Ikuro Abe The α-ketoglutarate dependent oxygenases catalyze remarkable chemistries in polyketide-derived fungal meroterpenoid biosynthesis. This review summarizes recent progress in the structure-based engineering of these enzymes. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - January 25, 2023 Category: Chemistry Authors: Takayoshi Awakawa Source Type: research

Engineering the biosynthesis of fungal nonribosomal peptides
Nat. Prod. Rep., 2023,40,62-88 DOI: 10.1039/D2NP00036A, Review ArticleLiwen Zhang, Chen Wang, Kang Chen, Weimao Zhong, Yuquan Xu, Istv án Molnár Fungal nonribosomal peptides (NRPs) and the related polyketide –nonribosomal peptide hybrid products (PK–NRPs) are a prolific source of bioactive compounds, some of which have been developed into essential drugs. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - January 25, 2023 Category: Chemistry Authors: Liwen Zhang Source Type: research

Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining
Nat. Prod. Rep., 2023,40,89-127 DOI: 10.1039/D2NP00050D, Review ArticleChen-Yu Chiang, Masao Ohashi, Yi Tang Heterologous expression of biosynthetic gene clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways, bottom-up investigation of biosynthetic enzymes, and engineered biosynthesis of new natural product variants. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - January 25, 2023 Category: Chemistry Authors: Chen-Yu Chiang Source Type: research

Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Katherine Williams, Agnieszka J. Szwalbe, Kate M. J. de Mattos-Shipley, Andy M. Bailey, Russell J. Cox, Christine L. Willis We review studies from early isolation and elucidation to recent bioinformatics andin vitro work regarding the biosynthesis of maleidrides. These are dimeric anhydrides, made from monomers coupled in various modes leading to structural diversity. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Nat. Prod. Rep. latest articles)
Source: RSC - Nat. Prod. Rep. latest articles - January 25, 2023 Category: Chemistry Authors: Katherine Williams Source Type: research