Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit (Oryctolagus cuniculus) Hair Follicle Cycle by RNA Sequencing

Conclusion In summary, this study established a rabbit HF synchronization model and investigated the lncRNA, circRNA, miRNA, and mRNA expression profiles by transcriptome analysis of samples collected at different stages of the HF cycle. GO and KEGG pathway enrichment analyses were carried out to identify candidate ncRNAs and mRNAs involved in the regulation of the HF cycle. In addition, ceRNA networks were constructed, which may be active during the HF cycle. These results provide a basis for an improved understanding of the mechanisms underlying the HF cycle. Data Availability The datasets generated for this study can be found in The lncRNA-seq, miRNA-seq, and circRNA-seq data were deposited in the SRA of the NCBI, The lncRNA-seq, miRNA-seq, and circRNA-seq data were deposited in the Short Read Archive (SRA) of the National Center for Biotechnology Information (NCBI) under the bioproject numbers PRJNA479733, PRJNA495446, and PRJNA495449. Ethics Statement The experimental procedures in this study were approved by the Animal Care and Use Committee of Yangzhou University. Author Contributions BZ was responsible for the collection and analysis of results and wrote the manuscript. YC, SH, NY, andMWwere responsible for construction of hair follicle synchronization model. ML, JL, and YX carried out of the experiments. BZ andXWdesigned the study and finalized the manuscript. All authors read and approved the final manuscript. Funding This work was supported by the Modern A...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research