Reduced Angiopoietin-Like 4 Expression in Multiple Sclerosis Lesions Facilitates Lipid Uptake by Phagocytes via Modulation of Lipoprotein-Lipase Activity

In conclusion, we provide evidence that ANGPTL4 expression is strongly reduced in reactive astrocytes in active MS lesions, which might be a protective mechanism enabling phagocytes to effectively remove myelin debris setting the stage for repair. Ethics Statement VUmc MS Centrum Amsterdam and the Netherlands Brain Bank received permission to perform autopsies for the use of tissue and for access to medical records for research purposes from the Ethical Committee of the VU University Medical Center, Amsterdam, The Netherlands. All patients and controls, or their next of kin, had given informed consent for autopsy and use of brain tissue for research purposes. Buffy coats were obtained from volunteer donors at Sanquin after written informed consent was obtained. Author Contributions AK with the help of JvH and HdV conceived the study. AK, JvH, MR, and HdV designed the experiments. AK with the help of AC performed most of the experiments. SvdP performed FACS experiments. AK with the help of JvH, MR, and HdV wrote the manuscript, which was reviewed by all authors. Funding This work was supported by the MS research foundation (MS-14-358e, AK), which had no role in study design, data collection and analyses, decision to publish, or preparation of the manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowled...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research