Comparative FISH-Mapping of MC1R, ASIP, and TYRP1 in New and Old World Camelids and Association Analysis With Coat Color Phenotypes in the Dromedary (Camelus dromedarius)

This study was supported by grants from Alpaca Research Foundation (ARF) 2009–2011 and Morris Animal Foundation (MAF) D09LA-004, D14LA-005. The authors highly appreciate donations to ARF and MAF by Leslie Herzog of Herzog Alpacas. FA was supported by Qassim University, Saudi Arabia. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling Editor and reviewer PO-tW declared their involvement as co-editors in the Research Topic, and confirm the absence of any other collaboration. Supplementary Material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fgene.2019.00340/full#supplementary-material FIGURE S1 | MC1R comparative. Comparative alignment of MC1R transmembrane domain 7 amino acid sequences in diverse mammalian and vertebrate species. The p.301 position is indicated by a vertical arrow and highlighted; horizontal arrow shows the p.301R> C mutation in the dromedary. Note that Arginine is highly conserved across species, except in humans who have Histidine, which is another positively charged amino acid. FIGURE S2 | Contingency analysis output files in JMP program for the sequence variants analyzed in this study. Each output file comprises a Mosaic Plot, a Contingency Table, and Statistics Tests; N, the total number of observa...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research