[HD-17-0002R1] Removal of the Mitochondrial Fission Factor Mff Exacerbates Neuronal Loss and Neurological Phenotypes in a Huntington ’ s Disease Mouse Model
CONCLUSIONS
Although inhibition of mitochondrial fission has been proposed as a therapeutic approach for HD, we find that removal of Mff, a mitochondrial fission factor, exacerbates the neurological phenotypes of HDR6/2 mice.Therefore, our results indicate that a deeper understanding of mitochondrial dynamics in HD is required before mitochondrial fission can be considered a therapeutic avenue for HD.
Data Availability Statement
The raw data for graphs in Figures 1-5 are available at https://figshare.com/s/584ca97ed838e5de3bde, with DOI: 10.6084/m9.figshare.6052007.
Competing Interests Statement
The authors have declared that no competing interests exist.
Funding
This work was funded by grant A-11059 from the CHDI Foundation (https://chdifoundation.org). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Source: PLOS Currents Huntington Disease - Category: Neurology Authors: dchan Source Type: research
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