Astrocytes in preoptic area regulate acute nociception-induced hypothermia through adenosine receptors
CONCLUSION: Our results elucidate the interplay between acute nociception and thermoregulation, specifically highlighting POA astrocyte activation. This enriches our understanding of physiological responses to painful stimuli and contributes to the analysis of the anatomical basis involved in the process.PMID:38715251 | DOI:10.1111/cns.14726 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 8, 2024 Category: Neuroscience Authors: Junke Jia Ting Chen Chang Chen Tengxiao Si Chenyi Gao Yuanyuan Fang Jiahui Sun Jie Wang Zongze Zhang Source Type: research
Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury
CONCLUSIONS: ADORA3 antagonist alleviates chronic ischemic WMI by modulating myelin clearance of microglia, which may be a potential therapeutic target for the treatment of VaD.PMID:38715283 | DOI:10.1111/cns.14742 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 8, 2024 Category: Neuroscience Authors: Yuhao Xu Limoran Tang Chao Zhou Liang Sun Yujie Hu Zhi Zhang Shengnan Xia Xinyu Bao Haiyan Yang Yun Xu Source Type: research
Baicalin and baicalein from Scutellaria baicalensis Georgi alleviate aberrant neuronal suppression mediated by GABA from reactive astrocytes
CONCLUSIONS: In summary, baicalin and baicalein isolated from S. baicalensis reduce astrocyte reactivity and alleviate aberrant tonic inhibition of hippocampal neurons during neuroinflammation.PMID:38715318 | DOI:10.1111/cns.14740 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 8, 2024 Category: Neuroscience Authors: Juyeong Cho Eun-Bin Hong Young-Sik Kim Jungbin Song Yeon Ha Ju Hyunjin Kim Hyowon Lee Hocheol Kim Min-Ho Nam Source Type: research
Histone deacetylase as emerging pharmacological therapeutic target for neuropathic pain: From epigenetic to selective drugs
CONCLUSIONS: Abnormally elevated HDACs promote neuronal excitability and neuroinflammation by epigenetically modulating pivotal gene expression in neuronal and immune cells, contributing to peripheral and central sensitization in the progression of neuropathic pain, and HDACi showed significant efficacy and great potential for alleviating neuropathic pain.PMID:38715326 | DOI:10.1111/cns.14745 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 8, 2024 Category: Neuroscience Authors: Wencui Zhang Bo Jiao Shangchen Yu Caixia Zhang Kaiwen Zhang Baowen Liu Xianwei Zhang Source Type: research
Advanced tumor electric fields therapy: A review of innovative research and development and prospect of application in glioblastoma
CONCLUSION: Tumor electric fields therapy is an effective and highly promising treatment modality for GBM. The full therapeutic potential of TEFT can be exploited by combined with other innovative technologies and treatments.PMID:38715344 | DOI:10.1111/cns.14720 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 8, 2024 Category: Neuroscience Authors: Jinxin Lan Yuyang Liu Junyi Chen Hongyu Liu Yaping Feng Jialin Liu Ling Chen Source Type: research
Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives
CNS Neurosci Ther. 2024 May;30(5):e14715. doi: 10.1111/cns.14715.ABSTRACTGliomas are the most common primary tumors of the central nervous system, with glioblastoma multiforme (GBM) having the highest incidence, and their therapeutic efficacy depends primarily on the extent of surgical resection and the efficacy of postoperative chemotherapy. The role of the intracranial blood-brain barrier and the occurrence of the drug-resistant gene O6-methylguanine-DNA methyltransferase have greatly limited the efficacy of chemotherapeutic agents in patients with GBM and made it difficult to achieve the expected clinical response. In r...
Source: CNS Neuroscience and Therapeutics - May 6, 2024 Category: Neuroscience Authors: Jiyuan Liu Fan Yang Jinqu Hu Xiuchun Zhang Source Type: research
Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives
CNS Neurosci Ther. 2024 May;30(5):e14715. doi: 10.1111/cns.14715.ABSTRACTGliomas are the most common primary tumors of the central nervous system, with glioblastoma multiforme (GBM) having the highest incidence, and their therapeutic efficacy depends primarily on the extent of surgical resection and the efficacy of postoperative chemotherapy. The role of the intracranial blood-brain barrier and the occurrence of the drug-resistant gene O6-methylguanine-DNA methyltransferase have greatly limited the efficacy of chemotherapeutic agents in patients with GBM and made it difficult to achieve the expected clinical response. In r...
Source: CNS Neuroscience and Therapeutics - May 6, 2024 Category: Neuroscience Authors: Jiyuan Liu Fan Yang Jinqu Hu Xiuchun Zhang Source Type: research
Identification of the circRNA-miRNA-mRNA network for treating methamphetamine-induced relapse and behavioral sensitization with cannabidiol
CONCLUSIONS: This study constructed the ceRNAs network for the first time, revealing the potential mechanism of CBD in treating METH-induced CPP reinstatement and behavioral sensitization, thus advancing the application of CBD in METH use disorders.PMID:38702929 | PMC:PMC11069028 | DOI:10.1111/cns.14737 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Liu Liu Chan Wang Haowei Wang Lin Miao Tong Xie Yunqing Tian Xiaodong Li Yizhen Huang Xiaofeng Zeng Bofeng Zhu Source Type: research
Plasma exosomes impair microglial degradation of α-synuclein through V-ATPase subunit V1G1
CONCLUSION: Pathogenic protein accumulation is a key feature of PD, and compromised V-type ATPase dysfunction might participate in PD pathogenesis. Moreover, V1G1 overexpression protects against neuronal toxicity in an MPTP-based PD mouse model, which may provide opportunities to develop novel therapeutic interventions for PD treatment.PMID:38702933 | PMC:PMC11069054 | DOI:10.1111/cns.14738 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Yunna Li Yiming Wang Liang Kou Sijia Yin Xiaosa Chi Yadi Sun Jiawei Wu Zongjie Jin Qiulu Zhou Wenkai Zou Tao Wang Yun Xia Source Type: research
Correlation between desynchrony of hippocampal neural activity and hyperlocomotion in the model mice of schizophrenia and therapeutic effects of aripiprazole
CONCLUSIONS: These results suggest that the disruption of neural coordination may underly the neuropathological mechanism for hyperlocomotion of SZ.PMID:38702935 | PMC:PMC11069053 | DOI:10.1111/cns.14739 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Xueru Wang Zijie Li Shihui Kuai Xuejiao Wang Jingyu Chen Yanping Yang Ling Qin Source Type: research
Integrated analysis of single cell-RNA sequencing and Mendelian randomization identifies lactate dehydrogenase B as a target of melatonin in ischemic stroke
CONCLUSION: Our study identifies LDHB as a novel biomarker for ischemic stroke via combining the sc RNA-seq and MR analysis.PMID:38702940 | PMC:PMC11069049 | DOI:10.1111/cns.14741 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Fei Shi Guiyun Zhang Jinshi Li Liang Shu Cong Yu Dabin Ren Yisong Zhang Ping Zheng Source Type: research
Identification of the circRNA-miRNA-mRNA network for treating methamphetamine-induced relapse and behavioral sensitization with cannabidiol
CONCLUSIONS: This study constructed the ceRNAs network for the first time, revealing the potential mechanism of CBD in treating METH-induced CPP reinstatement and behavioral sensitization, thus advancing the application of CBD in METH use disorders.PMID:38702929 | DOI:10.1111/cns.14737 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Liu Liu Chan Wang Haowei Wang Lin Miao Tong Xie Yunqing Tian Xiaodong Li Yizhen Huang Xiaofeng Zeng Bofeng Zhu Source Type: research
Plasma exosomes impair microglial degradation of α-synuclein through V-ATPase subunit V1G1
CONCLUSION: Pathogenic protein accumulation is a key feature of PD, and compromised V-type ATPase dysfunction might participate in PD pathogenesis. Moreover, V1G1 overexpression protects against neuronal toxicity in an MPTP-based PD mouse model, which may provide opportunities to develop novel therapeutic interventions for PD treatment.PMID:38702933 | DOI:10.1111/cns.14738 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Yunna Li Yiming Wang Liang Kou Sijia Yin Xiaosa Chi Yadi Sun Jiawei Wu Zongjie Jin Qiulu Zhou Wenkai Zou Tao Wang Yun Xia Source Type: research
Correlation between desynchrony of hippocampal neural activity and hyperlocomotion in the model mice of schizophrenia and therapeutic effects of aripiprazole
CONCLUSIONS: These results suggest that the disruption of neural coordination may underly the neuropathological mechanism for hyperlocomotion of SZ.PMID:38702935 | DOI:10.1111/cns.14739 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Xueru Wang Zijie Li Shihui Kuai Xuejiao Wang Jingyu Chen Yanping Yang Ling Qin Source Type: research
Integrated analysis of single cell-RNA sequencing and Mendelian randomization identifies lactate dehydrogenase B as a target of melatonin in ischemic stroke
CONCLUSION: Our study identifies LDHB as a novel biomarker for ischemic stroke via combining the sc RNA-seq and MR analysis.PMID:38702940 | DOI:10.1111/cns.14741 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Fei Shi Guiyun Zhang Jinshi Li Liang Shu Cong Yu Dabin Ren Yisong Zhang Ping Zheng Source Type: research
