Unravelling < i > Chlamydia trachomatis < /i > diversity in Amhara, Ethiopia: MLVA- < i > ompA < /i > sequencing as a molecular typing tool for trachoma
by Anna J. Harte, Ehsan Ghasemian, Harry Pickering, Joanna Houghton, Ambahun Chernet, Eshetu Sata, Gizachew Yismaw, Taye Zeru, Zerihun Tadesse, E. Kelly Callahan, Scott D. Nash, Martin Holland
Trachoma is the leading infectious cause of blindness worldwide and is now largely confined to around 40 low- and middle-income countries. It is caused byChlamydia trachomatis (Ct), a contagious intracellular bacterium. The World Health Organization recommends mass drug administration (MDA) with azithromycin for treatment and control of ocular Ct infections, alongside improving facial cleanliness and environmental conditions to redu...
Source: PLoS Neglected Tropical Diseases - April 25, 2024 Category: Tropical Medicine Authors: Anna J. Harte Source Type: research
Streptococcal Pharyngitis: Rapid Evidence Review
Am Fam Physician. 2024 Apr;109(4):343-349.ABSTRACTGroup A beta-hemolytic streptococcal pharyngitis is a common infection responsible for more than 6 million office visits in the United States annually. Only 10% of adults seeking care for a sore throat have group A beta-hemolytic streptococcal pharyngitis; however, 60% or more are prescribed antibiotics. Guidelines recommend using clinical decision rules to assess the risk of group A beta-hemolytic streptococcal infection, followed by rapid antigen testing if a diagnosis is unclear, before prescribing antibiotics. Fever, tonsillar exudate, cervical lymphadenitis, and patien...
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Jennifer L Hamilton Leon McCrea Ii Source Type: research
Increasing azithromycin resistance in patients with enteric fever: Cause for concern
Trop Doct. 2024 Apr 22:494755241247082. doi: 10.1177/00494755241247082. Online ahead of print.NO ABSTRACTPMID:38646775 | DOI:10.1177/00494755241247082 (Source: Tropical Doctor)
Source: Tropical Doctor - April 22, 2024 Category: Tropical Medicine Authors: Vijay Alexander John Titus George Jackwin Sam Paul Source Type: research
High cure rates of Mycoplasma genitalium following empiric treatment with azithromycin alongside frequent detection of macrolide resistance in Austria
ConclusionsMycoplasma genitalium was readily detected in this Austrian observational study, affected predominantly MSM and often presented as asymptomatic disease. We observed a worryingly high prevalence of AZM resistance mutations; however, empiric AZM treatment cleared twice as many MG infections as expected. (Source: Infection)
Source: Infection - April 22, 2024 Category: Infectious Diseases Source Type: research
Neonatal anthropometric indicators of infant growth and mortality in Burkina Faso
CONCLUSIONS: Interventions for identifying infants at highest risk of mortality and growth failure should consider WAZ as part of their screening protocol.PMID:38639113 | DOI:10.1017/S1368980024000880 (Source: Public Health Nutrition)
Source: Public Health Nutrition - April 19, 2024 Category: International Medicine & Public Health Authors: Mamadou Bountogo Ali Si é Alphonse Zakane Guillaume Compaor é Thierry Ou édraogo Elodie Lebas Kieran S O'Brien Thomas M Lietman Catherine E Oldenburg Source Type: research
Fragmentation characteristics-based nontargeted screening method of exogenous chemical residues in animal-derived foods using reversed-phase and hydrophilic interaction liquid chromatography-high-resolution mass spectrometry
In this study, first, fragmentation characteristics of 51 classes of exogenous chemical residues were summarized based on experimental mass spectra of standards in reversed-phase and hydrophilic interaction liquid chromatography-high-resolution mass spectrometry (MS) and mass spectra from the MassBank of North America (MoNA) library. According to the proportion of fragmentation characteristics to the total number of chemical residues in each class, four screening levels were defined to classify 51 classes of chemical residues. Then, a nontargeted screening method was developed based on the fragmentation characteristics. Th...
Source: Talanta - April 19, 2024 Category: Chemistry Authors: Wenying Liang Tiantian Chen Yujie Zhang Xin Lu Xinyu Liu Chunxia Zhao Guowang Xu Source Type: research
Short-term azithromycin use is associated with QTc interval prolongation in children with cystic fibrosis
CONCLUSION: Short-term use of azithromycin prophylaxis in pediatric patients with mild CF slightly increased the QTc interval in the first and third months of follow-up. Nevertheless, all QTc interval changes fell within the safety zone. Notably, 1 month of follow-up treatment should be performed to check for any alteration in the QTc interval. If increased QTc interval duration is not detected in the first month, azithromycin prophylaxis can be safely prescribed.PMID:38637249 | DOI:10.1016/j.arcped.2024.02.004 (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - April 18, 2024 Category: Pediatrics Authors: As ım Enhoş Hazar Do ğuş Kus Can Yilmaz Yozgat Erkan Cak ır Hakan Yazan Ahmet Berk Erol Ufuk Erenberk Yilmaz Yozgat Source Type: research
Minimum inhibitory concentrations of Neisseria gonorrhoeae strains in clients of the Amsterdam sexual health clinic with a Dutch versus an international sexual network
Conclusions
For three cephalosporin antibiotics, we found Ng strains with slightly higher MICs in clients with partner(s) from Europe or Latin America and the Caribbean. International travel might contribute to the spread of Ng with lower susceptibility. More understanding of the emergence of AMR Ng is needed. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Teker, B., Schim van der Loeff, M., Hoornenborg, E., Boyd, A., Reedijk, S., van Dam, A., Jongen, V. W., de Vries, H. Tags: Original research Source Type: research
Predominance of multidrug-resistant < i > Salmonella < /i > Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar
ConclusionsWe report a high rate of MDR and low-level ciprofloxacin resistantS. Typhi circulating in Zanzibar, belonging to genotype 4.3.1.1, which is widespread in Southeast Asia and African countries and associated with low-level ciprofloxacin resistance. Few therapeutic options are available for treatment of typhoid fever in the study setting. Surveillance of the prevalence, spread and antimicrobial susceptibility ofS. Typhi can guide treatment and control efforts. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 17, 2024 Category: Tropical Medicine Authors: Annette Onken Source Type: research
A novel mutation in hERG gene associated with azithromycin-induced acquired long QT syndrome
CONCLUSIONS: These findings suggest that hERG gene mutations might be involved in the genetic susceptibility mechanism underlying acquired LQTS induced by azithromycin.PMID:38625436 | DOI:10.1007/s11033-024-09421-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 16, 2024 Category: Molecular Biology Authors: Yun-Jiu Cheng Yang Wu Hui-Qiang Wei Yi-Jian Liao Li-Ping Qu Yue-Han Pan Li-Juan Liu Wen-Tao Bi Source Type: research
Efficacy and safety of antibiotics for treatment of leptospirosis: a systematic review and network meta-analysis
ConclusionsFindings recommend that leptospirosis patients be treated with antibiotics, which significantly reduced the leptospirosis defervescence time. Cephalosporins, doxycycline, and penicillin are suggested, and azithromycin may be a suitable alternative for drug-resistant cases.Systematic review registrationPROSPERO CRD42022354938. (Source: Systematic Reviews)
Source: Systematic Reviews - April 16, 2024 Category: International Medicine & Public Health Source Type: research
Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower Respiratory Tract Infection
ConclusionsIn this large prospective study in the US primary and urgent care setting, antibiotics had no measurable impact on the severity or duration of cough due to acute LRTI. Patients had unrealistic expectations regarding the duration of LRTI and the effect of antibiotics which should be the target of antibiotic stewardship efforts. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - April 15, 2024 Category: Internal Medicine Source Type: research
< em > Mycoplasmoides genitalium < /em > Macrolide Resistance Detection is Needed in University Settings
Conclusion: Data indicate a need for molecular M. genitalium macrolide resistance determination from primary specimens in the university setting.PMID:38609142 | DOI:10.3121/cmr.2024.1871 (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - April 12, 2024 Category: General Medicine Authors: Stephen C Lavey Brittany Cassel Erik Munson Source Type: research
< em > Mycoplasmoides genitalium < /em > Macrolide Resistance Detection is Needed in University Settings
Conclusion: Data indicate a need for molecular M. genitalium macrolide resistance determination from primary specimens in the university setting.PMID:38609142 | DOI:10.3121/cmr.2024.1871 (Source: Clin Med Res)
Source: Clin Med Res - April 12, 2024 Category: Research Authors: Stephen C Lavey Brittany Cassel Erik Munson Source Type: research
