< em > Mycoplasmoides genitalium < /em > Macrolide Resistance Detection is Needed in University Settings
Conclusion: Data indicate a need for molecular M. genitalium macrolide resistance determination from primary specimens in the university setting.PMID:38609142 | DOI:10.3121/cmr.2024.1871 (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - April 12, 2024 Category: General Medicine Authors: Stephen C Lavey Brittany Cassel Erik Munson Source Type: research
GSE261757 High-throughput Fitness Experiments Reveal Specific Vulnerabilities of Human-Adapted Salmonella During Stress and Infection- Barseq3 (LB, ceftriaxone, ciprofloxacin, azithromycin)
Contributors : Benjamin X Wang ; Denise M MonackSeries Type : OtherOrganism : Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 ; Salmonella enterica subsp. enterica serovar Typhi str. Ty2 ; Salmonella enterica subsp. enterica serovar Typhimurium str. D23580 ; Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74Salmonella enterica is comprised of genetically distinct “serovars”, that together provide an intriguing model for exploring the genetic basis of pathogen evolution. While the genomes of numerous Salmonella isolates with broad variations in host range and human disease manifes...
Source: GEO: Gene Expression Omnibus - April 12, 2024 Category: Genetics & Stem Cells Tags: Other Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhimurium str. D23580 Salmonella enterica subsp. enterica serovar Source Type: research
Azithromycin and moxifloxacin resistance determinants in Mycoplasma genitalium in Lleida, Spain
CONCLUSIONS: The resistance to different lines of treat ment suggests the need for a targeted therapy and the performing of a test of cure afterwards.PMID:38591493 | DOI:10.37201/req/015.2024 (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - April 9, 2024 Category: Drugs & Pharmacology Authors: L Fraile Garc ía J Aramburu Arnuelos E L ópez González A Bell és-Bellés A Mu ñoz Santa E S ánchez Báscones S Mormeneo Bayo A Bernet S ánchez I Prats S ánchez A Cumplido Portillo M Garc ía González Source Type: research
Azithromycin and moxifloxacin resistance determinants in Mycoplasma genitalium in Lleida, Spain
CONCLUSIONS: The resistance to different lines of treat ment suggests the need for a targeted therapy and the performing of a test of cure afterwards.PMID:38591493 | DOI:10.37201/req/015.2024 (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - April 9, 2024 Category: Drugs & Pharmacology Authors: L Fraile Garc ía J Aramburu Arnuelos E L ópez González A Bell és-Bellés A Mu ñoz Santa E S ánchez Báscones S Mormeneo Bayo A Bernet S ánchez I Prats S ánchez A Cumplido Portillo M Garc ía González Source Type: research
Keratin Formed Bioadhesive Ophthalmic Gel for the Bacterial Conjunctivitis Treatment
AAPS PharmSciTech. 2024 Apr 8;25(4):77. doi: 10.1208/s12249-024-02772-3.ABSTRACTKeratin has the potential to function as the gel matrix in an ophthalmic formulation for the encapsulation of the macrolide antibiotic azithromycin. The quality of this formulation was thoroughly evaluated through various analyses, such as in vitro release assessment, rheological examination, intraocular retention studies in rabbits, assessment of bacteriostatic efficacy, and safety evaluations. It is worth mentioning that the gel demonstrated shear thinning properties and exhibited characteristics of an elastic solid, thereby confirming its st...
Source: AAPS PharmSciTech - April 8, 2024 Category: Drugs & Pharmacology Authors: Mengjuan Sun Jialin Niu Yin Zhang Mengrong Wang Yan Shen Xiaolan Chen Yujuan Mao Qian Li Source Type: research
Keratin Formed Bioadhesive Ophthalmic Gel for the Bacterial Conjunctivitis Treatment
AAPS PharmSciTech. 2024 Apr 8;25(4):77. doi: 10.1208/s12249-024-02772-3.ABSTRACTKeratin has the potential to function as the gel matrix in an ophthalmic formulation for the encapsulation of the macrolide antibiotic azithromycin. The quality of this formulation was thoroughly evaluated through various analyses, such as in vitro release assessment, rheological examination, intraocular retention studies in rabbits, assessment of bacteriostatic efficacy, and safety evaluations. It is worth mentioning that the gel demonstrated shear thinning properties and exhibited characteristics of an elastic solid, thereby confirming its st...
Source: AAPS PharmSciTech - April 8, 2024 Category: Drugs & Pharmacology Authors: Mengjuan Sun Jialin Niu Yin Zhang Mengrong Wang Yan Shen Xiaolan Chen Yujuan Mao Qian Li Source Type: research
Genes, Vol. 15, Pages 470: Detection of Macrolide and/or Fluoroquinolone Resistance Genes in Mycoplasma genitalium Strains Isolated from Men in the Northwest Region of Croatia in 2018 & ndash;2023
Genes, Vol. 15, Pages 470: Detection of Macrolide and/or Fluoroquinolone Resistance Genes in Mycoplasma genitalium Strains Isolated from Men in the Northwest Region of Croatia in 2018–2023
Genes doi: 10.3390/genes15040470
Authors:
Sunčanica Ljubin-Sternak
Tomislav Meštrović
Tatjana Marijan
Maja Anušić
Sandra Šuto
Jasmina Vraneš
Mycoplasma genitalium (M. genitalium) poses a significant public health challenge due to its association with non-gonococcal urethritis (particularly in men) and antimicrobial resistance. However, despite the prevalence of M. genitalium infections and the rise in r...
Source: Genes - April 8, 2024 Category: Genetics & Stem Cells Authors: Sun čanica Ljubin-Sternak Tomislav Me štrović Tatjana Marijan Maja Anu šić Sandra Šuto Jasmina Vrane š Tags: Article Source Type: research
Antimicrobial macrozones interact with biological macromolecules via two-site binding mode of action: Fluorimetric, NMR and docking studies
Bioorg Chem. 2024 Apr 5;147:107338. doi: 10.1016/j.bioorg.2024.107338. Online ahead of print.ABSTRACTMacrozones are novel conjugates of azithromycin and thiosemicarbazones, which exhibit very good in vitro antibacterial activities against susceptible and some resistant bacterial strains thus showing a potential for further development. A combination of spectrometric (fluorimetry, STD and WaterLOGSY NMR) and molecular docking studies provided insights into atomic details of interactions between selected macrozones and biological receptors such as E. coli ribosome and bovine serum albumin. Fluorimetric measurements revealed ...
Source: Bioorganic Chemistry - April 7, 2024 Category: Chemistry Authors: Tomislav Jedna čak Ivana Mikulandra Kristina Smokrovi ć Andrea Hlou šek-Kasun Monika Kapusti ć Kristina Dela š Ivo Piantanida Marta Jurkovi ć Branimir Berto ša Klaus Zangger Predrag Novak Source Type: research
Antimicrobial macrozones interact with biological macromolecules via two-site binding mode of action: Fluorimetric, NMR and docking studies
Bioorg Chem. 2024 Apr 5;147:107338. doi: 10.1016/j.bioorg.2024.107338. Online ahead of print.ABSTRACTMacrozones are novel conjugates of azithromycin and thiosemicarbazones, which exhibit very good in vitro antibacterial activities against susceptible and some resistant bacterial strains thus showing a potential for further development. A combination of spectrometric (fluorimetry, STD and WaterLOGSY NMR) and molecular docking studies provided insights into atomic details of interactions between selected macrozones and biological receptors such as E. coli ribosome and bovine serum albumin. Fluorimetric measurements revealed ...
Source: Bioorganic Chemistry - April 7, 2024 Category: Chemistry Authors: Tomislav Jedna čak Ivana Mikulandra Kristina Smokrovi ć Andrea Hlou šek-Kasun Monika Kapusti ć Kristina Dela š Ivo Piantanida Marta Jurkovi ć Branimir Berto ša Klaus Zangger Predrag Novak Source Type: research
Azithromycin reduces bronchial wall thickening in infants with cystic fibrosis
The efficacy of azithromycin as an anti-inflammatory agent in infants with CF was investigated in the COMBAT-CF study [1]. Children with CF diagnosed by newborn screening were 1:1 randomly assigned to maintenance treatment with azithromycin or placebo from diagnosis until age of three, stratified by site. The primary outcome measure was structural airway disease as assessed on chest computed tomography scans (CTs) by the manual Perth-Rotterdam Annotated Grid Morphometric for CF (PRAGMA-CF) scoring method [2]. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 6, 2024 Category: Respiratory Medicine Authors: Yuxin Chen, Jean-Paul Charbonnier, Eleni-Rosalina Andrinopoulou, Peter D. Sly, Stephen M. Stick, Harm A.W.M. Tiddens, COMBAT-CF Study Group Source Type: research
Wuhu decoction combined with azithromycin for treatment of Mycoplasma pneumoniae pneumonia in Asian children: a systematic review and meta analysis of randomized controlled trials
Conclusion: Based on our meta-analysis findings, the combined therapy of Wuhu Decoction and azithromycin for treating pediatric Mycoplasma pneumoniae pneumonia exhibited superior overall efficacy in comparison to azithromycin monotherapy. However, in the included 22 studies, the majority of evaluated factors showed unclear bias risks, and a persistent bias risk was consistently present within one category. Moreover, due to the low quality of evidence, interpreting these results should be approached with caution. Hence, we emphasize the necessity for future high-quality, multicenter, and large-sample clinical randomized con...
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
114. Rates of reinfection for Chlamydia trachomatis in adolescents and young adults: an assessment following the CDC STI Treatment Guidelines in 2021
In 2021, the Centers for Disease Control (CDC) revised the treatment recommendation for chlamydia trachomatis from single dose azithromycin to a 7-day course of doxycycline. Given the high risk of chlamydia infection in adolescents and young adults (AYA), this study evaluated reinfection rates before and after the change in CDC treatment guidelines. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2024 Category: OBGYN Authors: Alexandra Burnett, Radhika Pandit, Aneesha Cheedalla, Yueyang Fei Source Type: research
Mesenchymal Stromal Cells as Rescue Therapy for Refractory Chronic Lung Allograft Dysfunction: Analysis of Immunoregulatory Effects In Vitro and Preliminary Data of Safety In Vivo
Purpose: Mesenchymal stromal cells (MSCs) have been reported as a promising therapy for CLAD due to their immunomodulatory and tolerogenic properties. To assess MSC immunoregulatory/anti-remodeling effects in vitro and the safety profile in vivo we: 1) assessed bone marrow-derived MSC (BMSC) activity on normal precision cut lung slices (PCLS) cultures and 2) we monthly administered 1 x 106 BMSC/Kg BW to end stage CLAD patients who had previously failed several treatment lines including azithromycin, ECP and montelukast. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Bozzini, E. Bozza, C. Bagnera, D. Briganti, K. Mucaj, G. Melloni, P. Comoli, F. Meloni Source Type: research
Ceftriaxone-Resistant Gonorrhea - China, 2022
MMWR Morb Mortal Wkly Rep. 2024 Mar 28;73(12):255-259. doi: 10.15585/mmwr.mm7312a2.ABSTRACTGonorrhea is a widespread sexually transmitted infection; in 2022, China reported 96,313 cases of gonorrhea, making it the fourth most common notifiable infectious disease in the country after viral hepatitis, pulmonary tuberculosis, and syphilis. The rise in prevalence in antimicrobial-resistant strains, particularly the international spread of ceftriaxone-resistant clones, poses a formidable challenge to gonorrhea control. The China Gonococcal Resistance Surveillance Program (China-GRSP), established in 1987 and covering 19 of 34 p...
Source: MMWR Morb Mortal Wkl... - March 28, 2024 Category: Epidemiology Authors: Xiaoyu Zhu Yue Xi Xiangdong Gong Shaochun Chen Source Type: research
Ceftriaxone-Resistant Gonorrhea - China, 2022
MMWR Morb Mortal Wkly Rep. 2024 Mar 28;73(12):255-259. doi: 10.15585/mmwr.mm7312a2.ABSTRACTGonorrhea is a widespread sexually transmitted infection; in 2022, China reported 96,313 cases of gonorrhea, making it the fourth most common notifiable infectious disease in the country after viral hepatitis, pulmonary tuberculosis, and syphilis. The rise in prevalence in antimicrobial-resistant strains, particularly the international spread of ceftriaxone-resistant clones, poses a formidable challenge to gonorrhea control. The China Gonococcal Resistance Surveillance Program (China-GRSP), established in 1987 and covering 19 of 34 p...
Source: MMWR Morb Mortal Wkl... - March 28, 2024 Category: Epidemiology Authors: Xiaoyu Zhu Yue Xi Xiangdong Gong Shaochun Chen Source Type: research
