Human Campylobacter spp. infections in Italy
ConclusionCampylobacter resistance to fluoroquinolones and tetracyclines in Italy is decreasing but is still high, while macrolides retain good activity. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 12, 2024 Category: Microbiology Source Type: research
Antimicrobial susceptibilities of < em > Neisseria gonorrhoeae < /em > in Canada, 2021
CONCLUSION: The spread of antimicrobial-resistant gonorrhea is a significant public health concern. The continued regional and national surveillance of antimicrobial resistance in N. gonorrhoeae is essential in ensuring effective treatment therapies are recommended.PMID:38463902 | PMC:PMC10919915 | DOI:10.14745/ccdr.v49i09a05 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 11, 2024 Category: Infectious Diseases Authors: Pamela Sawatzky Brigitte Lefebvre Mathew Diggle Linda Hoang Jason Wong Samir Patel Paul Van Caessele Jessica Minion Richard Garceau Sarah Jeffrey David Haldane Lillian Lourenco Genevieve Gravel Michael Mulvey Irene Martin Source Type: research
Antimicrobial susceptibilities of < em > Neisseria gonorrhoeae < /em > in Canada, 2021
CONCLUSION: The spread of antimicrobial-resistant gonorrhea is a significant public health concern. The continued regional and national surveillance of antimicrobial resistance in N. gonorrhoeae is essential in ensuring effective treatment therapies are recommended.PMID:38463902 | PMC:PMC10919915 | DOI:10.14745/ccdr.v49i09a05 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 11, 2024 Category: Infectious Diseases Authors: Pamela Sawatzky Brigitte Lefebvre Mathew Diggle Linda Hoang Jason Wong Samir Patel Paul Van Caessele Jessica Minion Richard Garceau Sarah Jeffrey David Haldane Lillian Lourenco Genevieve Gravel Michael Mulvey Irene Martin Source Type: research
Mycobacterial spindle cell pseudotumor of the spinal cord: Case report and literature review
We report the first description of spinal cord mycobacterial spindle cell pseudotumor. A patient with newly diagnosed advanced HIV presented with recent-onset bilateral leg weakness and was found to have a hypermetabolic spinal cord mass on structural and molecular imaging. Biopsy and cultures from blood and cerebrospinal fluid confirmed spindle cell pseudotumor due to Mycobacterium avium-intracellulare. Despite control of HIV and initial reduction in pseudotumor volume on antiretrovirals and antimycobacterials (azithromycin, ethambutol, rifampin/rifabutin), he ultimately experienced progressive leg weakness due to pseudot...
Source: Journal of Neuroimmunology - March 11, 2024 Category: Allergy & Immunology Authors: Michael Tran Duong, Adam Ungemach, Faizan Malik, Melissa T. Duong, Noah Wasserman, Kumarasen Cooper, Austin R. Pantel, Jessica O'Neil, Zsofia Szep Source Type: research
Late-Onset Diffuse Lung Disease in an 8-Year-Old Girl
Chest. 2024 Mar;165(3):e71-e74. doi: 10.1016/j.chest.2023.08.005.ABSTRACTAn 8-year-old girl presented with a 34-day history of cough, fatigue, and impaired exercise tolerance. She experienced cyanosis on exertion but denied fever, hemoptysis, hematuria, or seizures. Her perinatal and family histories were unremarkable, and she had no history of exposure to TB. A chest radiogram from a local clinic showed diffuse pulmonary lesions. Tuberculin skin test, interferon-γ release assay, and HIV antibody test results were all negative. Immunoglobulin levels and lymphocyte subsets were normal. The patient did not respond to IV azi...
Source: Chest - March 9, 2024 Category: Respiratory Medicine Authors: Huiying Wang Yu Tang Yuelin Shen Source Type: research
‘Failure at every level’: How science sleuths exposed massive ethics violations at a famed French institute
With six studies published in the 2010s, French microbiologist Didier Raoult added to his already vast publication record. He and his colleagues conducted a wide range of investigations into infectious diseases and their treatments. They took stool samples from patients on long-term antibiotic treatment, looking for alterations in their gut microbiome. They swabbed the throats of pilgrims leaving France for Mecca, searching for evidence of a bacterium that causes brain abscesses. And they studied samples of heart valves and blood clots from patients with heart inflammation to refine tests for the bacteria that cause the co...
Source: Science of Aging Knowledge Environment - March 7, 2024 Category: Geriatrics Source Type: research
In vivo screening for toxicity-modulating drug interactions identifies antagonism that protects against ototoxicity in zebrafish
Introduction: Ototoxicity is a debilitating side effect of over 150 medications with diverse mechanisms of action, many of which could be taken concurrently to treat multiple conditions. Approaches for preclinical evaluation of drug-drug interactions that might impact ototoxicity would facilitate design of safer multi-drug regimens and mitigate unsafe polypharmacy by flagging combinations that potentially cause adverse interactions for monitoring. They may also identify protective agents that antagonize ototoxic injury.Methods: To address this need, we have developed a novel workflow that we call Parallelized Evaluation of...
Source: Frontiers in Pharmacology - March 7, 2024 Category: Drugs & Pharmacology Source Type: research
Management of Acne in Pregnancy
AbstractAcne is one of the most common dermatological conditions to affect women of childbearing age, so it is important to consider the safety of long-term acne treatments on women who could become pregnant. In this review article, we clarify what management options are available to treat acne during pregnancy. Topical treatments, typically first-line for acne, such as azelaic acid, clindamycin, erythromycin, metronidazole, benzoyl peroxide, salicylic acid, dapsone, and retinoids, were reviewed. Systemic treatments, such as zinc supplements, cephalexin, cefadroxil, amoxicillin, azithromycin, erythromycin, and corticostero...
Source: American Journal of Clinical Dermatology - March 7, 2024 Category: Dermatology Source Type: research
Efficacy of doxycycline therapy for macrolide-resistant Mycoplasma pneumoniae pneumonia in children at different periods
ConclusionsChildren receiving early oral doxycycline had a shorter duration of fever and hospitalization in macrolide-resistantMycoplasma pneumoniae patients. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 5, 2024 Category: Pediatrics Source Type: research
Prevalence and determinants of antibiotics self-medication among indigenous people of Bangladesh: a cross-sectional study
Conclusion
Male gender, family income, place of residence and knowledge of antibiotics were the significant predictors of antibiotic self-medication. Hence, it is important to streamline awareness-raising campaigns at the community level to mitigate the practice of SMA in indigenous people and ultimately address the devastating effects of Antimicrobial resistance (AMR) in Bangladesh. (Source: BMJ Open)
Source: BMJ Open - March 5, 2024 Category: General Medicine Authors: Mannan, A., Chakma, K., Dewan, G., Saha, A., Chy, N. U. H. A., Mehedi, H. M. H., Hossain, A., Wnaiza, J., Ahsan, M. T., Rana, M. M., Alam, N. Tags: Open access, Epidemiology Source Type: research
Azithromycin induced asthma remission in adults with persistent uncontrolled asthma: a secondary analysis of a randomised, double-blind, placebo-controlled trial
Chest. 2024 Feb 29:S0012-3692(24)00284-8. doi: 10.1016/j.chest.2024.02.048. Online ahead of print.ABSTRACTBACKGROUND: Asthma remission is a potential treatment goal.RESEARCH QUESTION: Does adding azithromycin to standard therapy in patients with persistent uncontrolled asthma induce remission compared to placebo?STUDY DESIGN AND METHODS: This secondary analysis used data from the AMAZES clinical trial - a double-blind placebo-controlled trial that evaluated the safety and efficacy of azithromycin on asthma exacerbations. The primary remission definition (referred to as clinical remission) was zero exacerbations and zero or...
Source: Chest - March 2, 2024 Category: Respiratory Medicine Authors: Dennis Thomas Vanessa M McDonald Sean Stevens Melissa Baraket Sandra Hodge Alan James Christine Jenkins Guy B Marks Matthew Peters Paul Reynolds John W Upham Ian A Yang Peter G Gibson Source Type: research
Antibiotic resistance and virulence genes profile of Non typhodial Salmonella species isolated from poultry enteritis in India
AbstractSalmonella species (spp) is the most important gastrointestinal pathogen present ubiquitously. Non typhoidal Salmonella (NTS) is commonly associated with gastroenteritis in humans. Layer birds once get infection with NTS, can become persistently infected withSalmonella Typhimurium and intermittently shed the bacteria. It results in a high risk of potential exposure of eggs to the bacteria. The current study was conducted to determine the serotype diversity, presence of virulence genes, antibiotic resistance pattern, and genes of NTS from poultry enteritis. Out of 151 intestinal swabs from poultry total 118 NTS w...
Source: Tropical Animal Health and Production - March 2, 2024 Category: Veterinary Research Source Type: research
Synthesis and characterization of nanocomposite based polymeric membrane (PES/PVP/GO-TiO < sub > 2 < /sub > ) and performance evaluation for the removal of various antibiotics (amoxicillin, azithromycin & amp; ciprofloxacin) from aqueous solution
This study presents an innovative approach through the fabrication and evaluation of a Polyethersulfone (PES) membrane adorned with GO-TiO2 nanocomposites. The objective is to enhance the removal efficiency of various antibiotics, addressing the challenge of emerging organic compounds (EOCs) in water systems. The nanocomposite membranes, synthesized via the phase inversion method, incorporate hydrophilic agents, specifically GO-TiO2 nanocomposites and Polyvinylpyrrolidone (PVP). The resultant membranes underwent comprehensive characterization employing AFM, EDS, tensile strength testing, water contact angle measurements, a...
Source: Chemosphere - March 1, 2024 Category: Chemistry Authors: Rohit Goyat Joginder Singh Ahmad Umar Yajvinder Saharan Ahmed A Ibrahim Sheikh Akbar Sotirios Baskoutas Source Type: research
Synthesis and characterization of nanocomposite based polymeric membrane (PES/PVP/GO-TiO < sub > 2 < /sub > ) and performance evaluation for the removal of various antibiotics (amoxicillin, azithromycin & amp; ciprofloxacin) from aqueous solution
This study presents an innovative approach through the fabrication and evaluation of a Polyethersulfone (PES) membrane adorned with GO-TiO2 nanocomposites. The objective is to enhance the removal efficiency of various antibiotics, addressing the challenge of emerging organic compounds (EOCs) in water systems. The nanocomposite membranes, synthesized via the phase inversion method, incorporate hydrophilic agents, specifically GO-TiO2 nanocomposites and Polyvinylpyrrolidone (PVP). The resultant membranes underwent comprehensive characterization employing AFM, EDS, tensile strength testing, water contact angle measurements, a...
Source: Chemosphere - March 1, 2024 Category: Chemistry Authors: Rohit Goyat Joginder Singh Ahmad Umar Yajvinder Saharan Ahmed A Ibrahim Sheikh Akbar Sotirios Baskoutas Source Type: research
Synthesis and characterization of nanocomposite based polymeric membrane (PES/PVP/GO-TiO < sub > 2 < /sub > ) and performance evaluation for the removal of various antibiotics (amoxicillin, azithromycin & amp; ciprofloxacin) from aqueous solution
This study presents an innovative approach through the fabrication and evaluation of a Polyethersulfone (PES) membrane adorned with GO-TiO2 nanocomposites. The objective is to enhance the removal efficiency of various antibiotics, addressing the challenge of emerging organic compounds (EOCs) in water systems. The nanocomposite membranes, synthesized via the phase inversion method, incorporate hydrophilic agents, specifically GO-TiO2 nanocomposites and Polyvinylpyrrolidone (PVP). The resultant membranes underwent comprehensive characterization employing AFM, EDS, tensile strength testing, water contact angle measurements, a...
Source: Chemosphere - March 1, 2024 Category: Chemistry Authors: Rohit Goyat Joginder Singh Ahmad Umar Yajvinder Saharan Ahmed A Ibrahim Sheikh Akbar Sotirios Baskoutas Source Type: research
