Efficacy of Single-Dose Azithromycin for Ocular Chlamydial Infection: A Longitudinal Study
In this study, four villages in Niger received a mass azithromycin distribution for trachoma. All 426 children aged 0-5 years residing in the study villages were offered conjunctival swabbing every 6 months to test for ocular Chlamydia trachomatis. Among the children infected with ocular Chlamydia before treatment, 6% (95% CI: 2-15%) tested positive for ocular Chlamydia infection 6 months later, and 15% (95% CI: 7-28%) tested positive 12 months later. The most important predictor of post-treatment ocular Chlamydia infection was pretreatment ocular Chlamydia infection (relative risk: 3.5, 95% CI: 1.3-9.4). Although the 6-mo...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Neha Pondicherry Amza Abdou Boubacar Kadri Beido Nassirou Sun Y Cotter Nicole E Varnado Travis C Porco Sheila K West Thomas M Lietman Jeremy D Keenan Source Type: research
Risk of Cardiovascular Events after Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Patients Receiving Long-Term Low-Dose Azithromycin
Am J Respir Crit Care Med. 2024 Mar 19. doi: 10.1164/rccm.202309-1699LE. Online ahead of print.NO ABSTRACTPMID:38502239 | DOI:10.1164/rccm.202309-1699LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - March 19, 2024 Category: Intensive Care Authors: Tommaso Bucci Dennis Wat Dilip Nazareth Sarah Sibley Dan Wootton Gregory Yh Lip Freddy Frost Source Type: research
Risk of Cardiovascular Events after Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Patients Receiving Long-Term Low-Dose Azithromycin
Am J Respir Crit Care Med. 2024 Mar 19. doi: 10.1164/rccm.202309-1699LE. Online ahead of print.NO ABSTRACTPMID:38502239 | DOI:10.1164/rccm.202309-1699LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - March 19, 2024 Category: Respiratory Medicine Authors: Tommaso Bucci Dennis Wat Dilip Nazareth Sarah Sibley Dan Wootton Gregory Yh Lip Freddy Frost Source Type: research
Risk of Cardiovascular Events after Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Patients Receiving Long-Term Low-Dose Azithromycin
Am J Respir Crit Care Med. 2024 Mar 19. doi: 10.1164/rccm.202309-1699LE. Online ahead of print.NO ABSTRACTPMID:38502239 | DOI:10.1164/rccm.202309-1699LE (Source: Respiratory Care)
Source: Respiratory Care - March 19, 2024 Category: Respiratory Medicine Authors: Tommaso Bucci Dennis Wat Dilip Nazareth Sarah Sibley Dan Wootton Gregory Yh Lip Freddy Frost Source Type: research
Risk of Cardiovascular Events after Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Patients Receiving Long-Term Low-Dose Azithromycin
Am J Respir Crit Care Med. 2024 Mar 19. doi: 10.1164/rccm.202309-1699LE. Online ahead of print.NO ABSTRACTPMID:38502239 | DOI:10.1164/rccm.202309-1699LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - March 19, 2024 Category: Intensive Care Authors: Tommaso Bucci Dennis Wat Dilip Nazareth Sarah Sibley Dan Wootton Gregory Yh Lip Freddy Frost Source Type: research
Antibiotic prophylaxis for leptospirosis
CONCLUSIONS: We do not know if antibiotics versus placebo or another antibiotic has little or have no effect on all-cause mortality or leptospirosis infection because the certainty of evidence is low or very low. We do not know if antibiotics versus placebo may increase the overall risk of non-serious adverse events because of very low-certainty evidence. We lack definitive rigorous data from randomised trials to support the use of antibiotics for the prophylaxis of leptospirosis infection. We lack trials reporting data on clinically relevant outcomes.PMID:38483067 | DOI:10.1002/14651858.CD014959.pub2 (Source: Cochrane Dat...
Source: Cochrane Database of Systematic Reviews - March 14, 2024 Category: General Medicine Authors: Tin Zar Win Tanaraj Perinpanathan Patrick Mukadi Chris Smith Tansy Edwards Su Myat Han Hsu Thinzar Maung David M Brett-Major Nathaniel Lee Source Type: research
Antibiotics for treatment of leptospirosis
CONCLUSIONS: As the certainty of evidence is very low, we do not know if antibiotics provide little to no effect on all-cause mortality, serious adverse events, or adverse events considered non-serious. There is a lack of definitive rigorous data from randomised trials to support the use of antibiotics for treating leptospirosis infection, and the absence of trials reporting data on clinically relevant outcomes further adds to this limitation.PMID:38483092 | DOI:10.1002/14651858.CD014960.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 14, 2024 Category: General Medicine Authors: Tin Zar Win Su Myat Han Tansy Edwards Hsu Thinzar Maung David M Brett-Major Chris Smith Nathaniel Lee Source Type: research
ERS/EBMT clinical practice guideline on treatment of pulmonary chronic graft- < em > versus < /em > -host disease in adults
Eur Respir J. 2024 Mar 14:2301727. doi: 10.1183/13993003.01727-2023. Online ahead of print.ABSTRACTChronic graft-versus-host disease (cGvHD) is a common complication after allogeneic haematopoietic stem cell transplantation, characterised by a broad disease spectrum that can affect virtually any organ. Although pulmonary cGvHD is a less common manifestation, it is of great concern due to its severity and poor prognosis. Optimal management of patients with pulmonary cGvHD is complicated and no standardised approach is available.The purpose of this joint European Respiratory Society and European Society for Blood and Marrow ...
Source: Respiratory Care - March 14, 2024 Category: Respiratory Medicine Authors: Saskia Bos John Murray Monia Marchetti Guang-Shing Cheng Anne Bergeron Daniel Wolff Clare Sander Akshay Sharma Sherif M Badawy Zinaida Peric Agnieszka Piekarska Joseph Pidala Kavita Raj Olaf Penack Samar Kulkarni Molly Beestrum Andrea Linke Matthew Rutter Source Type: research
Antibiotic prophylaxis for leptospirosis
CONCLUSIONS: We do not know if antibiotics versus placebo or another antibiotic has little or have no effect on all-cause mortality or leptospirosis infection because the certainty of evidence is low or very low. We do not know if antibiotics versus placebo may increase the overall risk of non-serious adverse events because of very low-certainty evidence. We lack definitive rigorous data from randomised trials to support the use of antibiotics for the prophylaxis of leptospirosis infection. We lack trials reporting data on clinically relevant outcomes.PMID:38483067 | PMC:PMC10938880 | DOI:10.1002/14651858.CD014959.pub2 (So...
Source: Cochrane Database of Systematic Reviews - March 14, 2024 Category: General Medicine Authors: Tin Zar Win Tanaraj Perinpanathan Patrick Mukadi Chris Smith Tansy Edwards Su Myat Han Hsu Thinzar Maung David M Brett-Major Nathaniel Lee Source Type: research
Antibiotics for treatment of leptospirosis
CONCLUSIONS: As the certainty of evidence is very low, we do not know if antibiotics provide little to no effect on all-cause mortality, serious adverse events, or adverse events considered non-serious. There is a lack of definitive rigorous data from randomised trials to support the use of antibiotics for treating leptospirosis infection, and the absence of trials reporting data on clinically relevant outcomes further adds to this limitation.PMID:38483092 | PMC:PMC10938876 | DOI:10.1002/14651858.CD014960.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 14, 2024 Category: General Medicine Authors: Tin Zar Win Su Myat Han Tansy Edwards Hsu Thinzar Maung David M Brett-Major Chris Smith Nathaniel Lee Source Type: research
Can the use of azithromycin during labour reduce the incidence of infection among puerperae and newborns? A systematic review and meta-analysis of randomized controlled trials
This systematic review and meta-analysis investigated whether the use of azithromycin during labour or caesarean section reduces the incidence of sepsis and infection among mothers and newborns. (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - March 14, 2024 Category: OBGYN Authors: Haiyan Ye, Jinlu Hu, Bo Li, Xia Yu and Xuemei Zheng Tags: Research Source Type: research
Diversity and genetic characterization of Chlamydia isolated from Siamese crocodiles (Crocodylus siamensis)
This study presents a whole-genome-based characterization of Siamese crocodile-isolated Chlamydia. The results showed that Siamese crocodile Chlamydia contained a single circular chromosome with a size of 1.22-1.23 Mbp and a plasmid with a size of 7.7-8.0 kbp. A plasmid containing eight coding sequences (CDSs) was grouped in a β lineage. A chromosome sequence had approximately 1,018-1,031 CDSs. Chlamydial factors involving virulence were documented in terms of the presence of cytotoxins and several virulence factors in the chromosomes of Siamese crocodile Chlamydia. The analysis of antimicrobial resistance genes in the Ch...
Source: Acta Tropica - March 13, 2024 Category: Infectious Diseases Authors: Somjit Chaiwattanarungruengpaisan Metawee Thongdee Nlin Arya Weena Paungpin Wanna Sirimanapong Ladawan Sariya Source Type: research
Diversity and genetic characterization of Chlamydia isolated from Siamese crocodiles (Crocodylus siamensis)
This study presents a whole-genome-based characterization of Siamese crocodile-isolated Chlamydia. The results showed that Siamese crocodile Chlamydia contained a single circular chromosome with a size of 1.22-1.23 Mbp and a plasmid with a size of 7.7-8.0 kbp. A plasmid containing eight coding sequences (CDSs) was grouped in a β lineage. A chromosome sequence had approximately 1,018-1,031 CDSs. Chlamydial factors involving virulence were documented in terms of the presence of cytotoxins and several virulence factors in the chromosomes of Siamese crocodile Chlamydia. The analysis of antimicrobial resistance genes in the Ch...
Source: Acta Tropica - March 13, 2024 Category: Infectious Diseases Authors: Somjit Chaiwattanarungruengpaisan Metawee Thongdee Nlin Arya Weena Paungpin Wanna Sirimanapong Ladawan Sariya Source Type: research
Diversity and genetic characterization of Chlamydia isolated from Siamese crocodiles (Crocodylus siamensis)
This study presents a whole-genome-based characterization of Siamese crocodile-isolated Chlamydia. The results showed that Siamese crocodile Chlamydia contained a single circular chromosome with a size of 1.22-1.23 Mbp and a plasmid with a size of 7.7-8.0 kbp. A plasmid containing eight coding sequences (CDSs) was grouped in a β lineage. A chromosome sequence had approximately 1,018-1,031 CDSs. Chlamydial factors involving virulence were documented in terms of the presence of cytotoxins and several virulence factors in the chromosomes of Siamese crocodile Chlamydia. The analysis of antimicrobial resistance genes in the Ch...
Source: Acta Tropica - March 13, 2024 Category: Infectious Diseases Authors: Somjit Chaiwattanarungruengpaisan Metawee Thongdee Nlin Arya Weena Paungpin Wanna Sirimanapong Ladawan Sariya Source Type: research
Human Campylobacter spp. infections in Italy
ConclusionCampylobacter resistance to fluoroquinolones and tetracyclines in Italy is decreasing but is still high, while macrolides retain good activity. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 12, 2024 Category: Microbiology Source Type: research
