Antibiotic prophylaxis for leptospirosis

CONCLUSIONS: We do not know if antibiotics versus placebo or another antibiotic has little or have no effect on all-cause mortality or leptospirosis infection because the certainty of evidence is low or very low. We do not know if antibiotics versus placebo may increase the overall risk of non-serious adverse events because of very low-certainty evidence. We lack definitive rigorous data from randomised trials to support the use of antibiotics for the prophylaxis of leptospirosis infection. We lack trials reporting data on clinically relevant outcomes.PMID:38483067 | DOI:10.1002/14651858.CD014959.pub2

Source: Cochrane Database of Systematic Reviews - March 14, 2024 Category: General Medicine Authors: Tin Zar Win Tanaraj Perinpanathan Patrick Mukadi Chris Smith Tansy Edwards Su Myat Han Hsu Thinzar Maung David M Brett-Major Nathaniel Lee Source Type: research