Gut Microbiome Diversity and Antimicrobial Resistance After a Single Dose of Oral Azithromycin in Children: A Randomized Placebo-Controlled Trial
Am J Trop Med Hyg. 2024 Jan 16;110(2):291-294. doi: 10.4269/ajtmh.23-0651. Print 2024 Feb 7.ABSTRACTMass antibiotic distribution to preschool children resulted in alterations of the gut microbiome months after distribution. This individually randomized, placebo-controlled trial evaluated changes in the gut microbiome and resistome in children aged 8 days to 59 months after one dose of oral azithromycin in Burkina Faso. A total of 450 children were randomized in a 1:1 ratio to either placebo or azithromycin. Rectal samples were collected at baseline, 2 weeks, and 6 months after randomization and subjected to DNA deep sequen...
Source: Am J Trop Med Hyg - January 16, 2024 Category: Infectious Diseases Authors: Thuy Doan Zijun Liu Ali Si é Clarisse Dah Mamadou Bountogo Mamadou Ouattara Boubacar Coulibaly Dramane Kiemde Guillaume Zonou Eric Nebie Jessica Brogdon Elodie Lebas Armin Hinterwirth Lina Zhong Cindi Chen Zhaoxia Zhou Travis Porco Benjamin F Arnold Cath Source Type: research
Gut Microbiome Diversity and Antimicrobial Resistance After a Single Dose of Oral Azithromycin in Children: A Randomized Placebo-Controlled Trial
Am J Trop Med Hyg. 2024 Jan 16;110(2):291-294. doi: 10.4269/ajtmh.23-0651. Print 2024 Feb 7.ABSTRACTMass antibiotic distribution to preschool children resulted in alterations of the gut microbiome months after distribution. This individually randomized, placebo-controlled trial evaluated changes in the gut microbiome and resistome in children aged 8 days to 59 months after one dose of oral azithromycin in Burkina Faso. A total of 450 children were randomized in a 1:1 ratio to either placebo or azithromycin. Rectal samples were collected at baseline, 2 weeks, and 6 months after randomization and subjected to DNA deep sequen...
Source: The American Journal of Tropical Medicine and Hygiene - January 16, 2024 Category: Tropical Medicine Authors: Thuy Doan Zijun Liu Ali Si é Clarisse Dah Mamadou Bountogo Mamadou Ouattara Boubacar Coulibaly Dramane Kiemde Guillaume Zonou Eric Nebie Jessica Brogdon Elodie Lebas Armin Hinterwirth Lina Zhong Cindi Chen Zhaoxia Zhou Travis Porco Benjamin F Arnold Cath Source Type: research
Azithromycin therapy in infants hospitalized for RSV bronchiolitis: airway MMP-9 levels and subsequent recurrent wheeze
Early-life RSV bronchiolitis is a significant risk factor for childhood asthma. In-vitro and in-vivo studies suggested that decreasing airway matrix metalloprotease (MMP)-9 during RSV bronchiolitis may be associated with clinical benefits. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 16, 2024 Category: Allergy & Immunology Authors: Avraham Beigelman, Charles W. Goss, Jinli Wang, Mythili Srinivasan, Jonathan Boomer, Yanjiao Zhou, Sarah Bram, Timothy J. Casper, Andrea M. Coverstone, Watcharoot Kanchongkittiphon, Cadence Kuklinski, Gregory A. Storch, Kenneth B. Schechtman, Mario Castro Source Type: research
Azithromycin therapy in infants hospitalized for respiratory syncytial virus bronchiolitis
Early life respiratory syncytial virus (RSV) bronchiolitis is a significant risk factor for childhood asthma. In vitro and in vivo studies suggested that decreasing levels of airway matrix metalloproteinase (MMP)-9 during RSV bronchiolitis may be associated with clinical benefits. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 16, 2024 Category: Allergy & Immunology Authors: Avraham Beigelman, Charles W. Goss, Jinli Wang, Mythili Srinivasan, Jonathan Boomer, Yanjiao Zhou, Sarah Bram, Timothy J. Casper, Andrea M. Coverstone, Watcharoot Kanchongkittiphon, Cadence Kuklinski, Gregory A. Storch, Kenneth B. Schechtman, Mario Castro Source Type: research
A case report of diagnosis of cat-scratch disease using metagenomic next-generation sequencing
We present the case of a middle-aged male patient who developed fever, chills, anal distension, dizziness, and muscle pain for 10 days. The patient had a documented history of cat bites 1 month prior to the onset of symptoms. Following admission, he underwent an examination to determine superficial lymphadenopathy and hypoimmunity. Additionally, he had a fever during the disease. As the patient refused a needle biopsy of lymph nodes, metagenomic next-generation sequencing (mNGS) was employed and B. henselae was detected in the peripheral blood. The patient was diagnosed with CSD and treated with a combination of azithromyc...
Source: Frontiers in cellular and infection microbiology - January 15, 2024 Category: Microbiology Source Type: research
Azithromycin preserves adult hippocampal neurogenesis and behavior in a mouse model of sepsis
Brain Behav Immun. 2024 Jan 9;117:135-148. doi: 10.1016/j.bbi.2024.01.005. Online ahead of print.ABSTRACTThe mammalian hippocampus can generate new neurons throughout life. Known as adult hippocampal neurogenesis (AHN), this process participates in learning, memory, mood regulation, and forgetting. The continuous incorporation of new neurons enhances the plasticity of the hippocampus and contributes to the cognitive reserve in aged individuals. However, the integrity of AHN is targeted by numerous pathological conditions, including neurodegenerative diseases and sustained inflammation. In this regard, the latter causes cog...
Source: Brain, Behavior, and Immunity - January 11, 2024 Category: Neurology Authors: Carla B Rodr íguez-Moreno H éctor Cañeque-Rufo Miguel Flor-Garc ía Julia Terreros-Roncal Elena P Moreno-Jim énez Noem í Pallas-Bazarra Carlo Bressa Mar Larrosa Fabio Cafini Mar ía Llorens-Martín Source Type: research
Successful treatment of glandular tularemia with azithromycin in a pregnant woman in Austria
AbstractTreatment of tularemia during pregnancy is challenging due to toxicity of standard treatment regimens. Here, we report a 31-year-old woman with glandular tularemia who was successfully treated with intravenous azithromycin. Follow-up examinations over a 6-month period showed a sustained response to treatment. She later gave birth to a healthy child. (Source: Infection)
Source: Infection - January 11, 2024 Category: Infectious Diseases Source Type: research
Full trisomy 14 in one of bichorionic biamniotic twins
We describe the case of the lethal full trisomy (T) 14 in a fetus from bichorionic biamniotic (BCBA) twin pregnancy. This is a case of a 28-year-old primigravida, with an unremarkable personal and family history, who just like her 30-year-old husband, was without consanguinity between spouses. She conceived spontaneously, without a burdened gynecological-obstetric history. By the 12th week of pregnancy, she had hyperemesis gravidarum and one episode of bleeding due to which progesterone supplementation was prescribed. Due to asymptomatic bacteriuria, she took cefuroxime axetil in the 13th week of pregnancy and azithromycin...
Source: Zeitschrift fur Geburtshilfe und Neonatologie - January 10, 2024 Category: Perinatology & Neonatology Authors: Dubravko Habek Anis Cerovac Source Type: research
Solvent-Free Method for Masking the Bitter Taste of Azithromycin Dihydrate Using Supercritical Fluid Technology
Conclusions: Overall, it has been shown herein that the supercritical fluid technology foaming method is promising in masking the bitter taste of bitter ingredients.PMID:38180038 | DOI:10.1080/03639045.2023.2298892 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - January 5, 2024 Category: Drugs & Pharmacology Authors: Hadeia Mashaqbeh Rana M Obaidat Mo'tasem M Alsmadi Source Type: research
Solvent-free method for masking the bitter taste of azithromycin dihydrate using supercritical fluid technology
CONCLUSIONS: Overall, it has been shown herein that the supercritical fluid technology foaming method is promising in masking the bitter taste of bitter ingredients.PMID:38180038 | DOI:10.1080/03639045.2023.2298892 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - January 5, 2024 Category: Drugs & Pharmacology Authors: Hadeia Mashaqbeh Rana M Obaidat Mo'tasem M Alsmadi Source Type: research
Coding Corner: Billing for Straightforward Pneumonia in a Hospitalized Patient
A 64-year-old woman with a history of heart failure with reduced ejection fraction (HFrEF) was admitted to the hospital with decompensated heart failure one day ago. On day two, the patient is still short of breath and now develops a temperature of 100.9 degrees F. You order blood cultures, urinalysis (UA), and a chest X-ray. You review the UA and personally review the chest X-ray with findings documented that reveal left lower lobe pneumonia. Complete blood count and basic metabolic panels from the same day are also reviewed. The patient’s oxygen saturation is 92% on room air.
You start intravenous ceftriaxone and oral ...
Source: The Hospitalist - January 2, 2024 Category: Hospital Management Authors: Ronda Whitaker Tags: Business of Medicine Clinical Guidelines Coding Source Type: research
Low genetic diversity of < i > Treponema pallidum < /i > ssp. < i > pertenue < /i > (TPE) isolated from patients ’ ulcers in Namatanai District of Papua New Guinea: Local human population is infected by three TPE genotypes
by Monica Medappa, Petra Posp íšilová, Maria Paula M. Madruga, Lucy N. John, Camila G. Beiras, Linda Grillová, Jan Oppelt, Arka Banerjee, Marti Vall-Mayans, Oriol Mitjà, David Šmajs
Yaws is an endemic disease caused byTreponema pallidum subsp.pertenue (TPE) that primarily affects children in rural regions of the tropics. The endemic character of yaws infections and the expected exclusive reservoir of TPE in humans opened a new opportunity to start a yaws eradication campaign. We have developed a multi-locus sequence typing (MLST) scheme for TPE isolates combining the previously published (TP0548, TP0488) and new (TP...
Source: PLoS Neglected Tropical Diseases - January 2, 2024 Category: Tropical Medicine Authors: Monica Medappa Source Type: research
