GSE245932 ribosome frofiling with or without 16 mg/L azithromycin treated in pseudomonas aeruginosa UCBPP-PA14
Contributors : Congjuan Xu ; Huan Ren ; Weihui Wu ; Xiaolei PanSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Pseudomonas aeruginosaAzithromycin binds to the nascent peptide exit tunnel (NPET) close to the peptidyltransferase center (PTC) of the ribosome, which obstructs the NPET and subsequently induces ribosome stalling and depletion of intracellular pools of tRNAs. To understand the mechanism through which azithromycin represses the transcription of mutation promoting genes, we utilized ribosome profiling to analyze azithromycin caused redistribution of ribosomes on the cellular m...
Source: GEO: Gene Expression Omnibus - January 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Pseudomonas aeruginosa Source Type: research
76 Multi-Country Trial of Intrapartum Oral Azithromycin: Cultures of Neonatal Infections
An intrapartum oral dose of azithromycin (AZI) reduced maternal but not neonatal/fetal death or sepsis. Herein, we compare the frequency of neonatal cultures, organisms and antimicrobial resistance from neonatal infections by AZI vs. placebo groups. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Alan T. Tita Tags: Oral Concurrent Session 8 - Labor & Delivery Source Type: research
65 Prophylactic Antibiotics after Cesarean Trial (PACT): A Randomized Control Trial
A trial of postoperative antibiotics as prophylaxis for post-cesarean surgical site infections (SSI) noted a benefit in obese patients with ruptured membranes. However, this was before pre-incision extended antibiotic prophylaxis with adjunctive azithromycin. We sought to assess if 48-hour post-cesarean antibiotics reduce infectious morbidity in the era of extended pre-operative prophylaxis. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Brett Goldman, Nicholas Spencer, Maggie Kuhlmann, Mollie McDonnold, George R. Saade, Antonio F. Saad Tags: Oral Concurrent Session 7 - Clinical Obstetrics & Postpartum Source Type: research
54 Azithromycin to Reduce Maternal Infections in Planned Vaginal Birth: Secondary Analysis of the A-PLUS Trial
The intrapartum azithromycin trial (A-PLUS Trial) showed a reduction in maternal sepsis or death mainly driven by sepsis. To test the hypothesis that a single oral dose of intrapartum 2g azithromycin (AZI) in women in labor planning a vaginal delivery reduces the incidence of any maternal infection (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Waldemar Carlo, Alan T. Tita, Elizabeth M. McClure Tags: Oral Concurrent Session 5 - Medical & Surgical Complications Source Type: research
4 Cost-effectiveness of Azithromycin for the Prevention of Maternal Sepsis or Death in Planned Vaginal Births
Maternal sepsis is one of the top three causes of maternal death globally. In a multi-country randomized trial performed by the National Institute of Child Health and Human Development ’s Global Network for Women’s and Children’s Health Research, a single oral dose of azithromycin significantly reduced the risk of maternal sepsis or death in low- and middle-income countries (LMICs). To support policymakers considering recommendations regarding intrapartum azithromycin in LMI Cs, we estimate the cost per case of maternal sepsis or death averted, and the incremental cost of the intervention after accounting for cost-sa...
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Jackie Patterson, Simon Neuwahl, Janet Moore, Elizabeth M. McClure, Waldemar Carlo, Melissa Buserman, Alan T. Tita Tags: Oral Plenary Session I and Late-Breaking Source Type: research
164 Adjunctive azithromycin for unscheduled cesarean delivery complicated by intraamniotic infection
Adjunctive azithromycin at the time of unscheduled cesarean delivery (CD) reduces postoperative infection. Patients with intraamniotic infection (IAI) were excluded in the original trial. We sought to determine if azithromycin is associated with reduced postoperative infection in this population. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Taylor S. Freret, Kaitlyn E. James, Alexander Melamed, Mark A. Clapp, Malavika Prabhu Source Type: research
394 Azithromycin Dose and PPROM Treatment (ADAPT): a randomized controlled Phase I trial
Azithromycin clears from plasma quickly and concentrates in local tissue which is why daily dosing is not always needed. However, 1g one time dose of azithromycin may not maintain local (amniotic fluid) drug concentrations above minimum inhibitory concentrations (MIC50) for common genitourinary pathogens (50-200ng/ml). We aim to compare the pharmacokinetics of one time vs daily dosing of azithromycin in the setting of preterm prelabor rupture of membranes (PPROM). (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Rupsa C. Boelig, Gagan Kaushal, Ankit Rochani, Walter Kraft Source Type: research
649 Intrapartum oral azithromycin to prevent maternal postpartum hemorrhage
A single oral dose of azithromycin (AZI) given during labor in women planning a vaginal delivery reduced maternal infections including sepsis and the effect was stronger in Africa than Asia. Since maternal infection contributes to labor dysfunction and postpartum hemorrhage (PPH), we evaluated the association between AZI and PPH. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Alan T. Tita Source Type: research
970 The effectiveness of a CD bundle with vaginal preparation, Cefazolin and Azithromycin in reducing infections
Recent data suggest that vaginal preparation and adjunctive macrolide administration reduce the risk of infectious morbidity in non-elective cesarean deliveries (CD). We aimed to evaluate the effectiveness of a CD bundle including preoperative vaginal preparation, Cefazolin and Azithromycin administration, as compared to Cefazoline alone, in reducing post-operative infections in CD performed in the second stage of labor. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Gal Cohen, Hanoch Schreiber, Yakin Amer, Hila Shalev-Ram, or Eliner, Tal Biron-Shental, Michal Kovo Source Type: research
1019 Multi-country trial of intrapartum oral azithromycin: cultures of maternal infections
An intrapartum oral dose of azithromycin (AZI) reduced maternal death or sepsis (by WHO clinical criteria). Herein, we compare the frequency of cultures, organisms and antimicrobial resistance from maternal infections by AZI vs. placebo groups. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Alan T. Tita Source Type: research
Vibrio species: development of EUCAST susceptibility testing methods and MIC and zone diameter distributions on which to determine clinical breakpoints
ConclusionsWe demonstrated the validity of using standard BMD and EUCAST disc diffusion methodology for AST of fiveVibrio spp., and generated suitable data to allow EUCAST to determine clinical MIC and zone diameter breakpoints for five pathogenicVibrio spp., including both non-toxigenic and toxigenicV. cholerae. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - December 30, 2023 Category: Microbiology Source Type: research
Effects of azithromycin exposure during pregnancy at different stages, doses and courses on testicular development in fetal mice
Biomed Pharmacother. 2023 Dec 27;170:116063. doi: 10.1016/j.biopha.2023.116063. Online ahead of print.ABSTRACTAzithromycin is a commonly used antibiotic during pregnancy, but some studies have suggested its potential developmental toxicity. Currently, the effects and mechanisms of prenatal azithromycin exposure (PAzE) on fetal testicular development are still unclear. The effects of prenatal exposure to the same drug on fetal testicular development could vary depending on different stages, doses, and courses. Hence, in this study, based on clinical medication characteristics, Kunming mice was administered intragastrically ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 28, 2023 Category: Drugs & Pharmacology Authors: Ziyu Kong Lu Zhu Yi Liu Yi Liu Guanghui Chen Tao Jiang Hui Wang Source Type: research
Antibiotic sensitivity of environmental Legionella pneumophila strains isolated in Poland
CONCLUSIONS: The lowest biocidal concentration was found for levofloxacin, the highest for tetracycline. The highest MIC50 and MIC90 values were found for tetracycline and the lowest for rifampicin. The highest biocidal values were found for azithromycin and the lowest for tetracycline.PMID:38153060 | DOI:10.26444/aaem/167934 (Source: Annals of Agricultural and Environmental Medicine : AAEM)
Source: Annals of Agricultural and Environmental Medicine : AAEM - December 28, 2023 Category: Environmental Health Authors: Iwona G ładysz Agnieszka Sikora Ma łgorzata Wójtowicz-Bobin Adam Szepeluk Renata Matuszewska Marta Bartosik Jan Kazimierz Karczewski Source Type: research
Effects of azithromycin exposure during pregnancy at different stages, doses and courses on testicular development in fetal mice
Biomed Pharmacother. 2023 Dec 27;170:116063. doi: 10.1016/j.biopha.2023.116063. Online ahead of print.ABSTRACTAzithromycin is a commonly used antibiotic during pregnancy, but some studies have suggested its potential developmental toxicity. Currently, the effects and mechanisms of prenatal azithromycin exposure (PAzE) on fetal testicular development are still unclear. The effects of prenatal exposure to the same drug on fetal testicular development could vary depending on different stages, doses, and courses. Hence, in this study, based on clinical medication characteristics, Kunming mice was administered intragastrically ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 28, 2023 Category: Drugs & Pharmacology Authors: Ziyu Kong Lu Zhu Yi Liu Yi Liu Guanghui Chen Tao Jiang Hui Wang Source Type: research
Antibiotic sensitivity of environmental Legionella pneumophila strains isolated in Poland
CONCLUSIONS: The lowest biocidal concentration was found for levofloxacin, the highest for tetracycline. The highest MIC50 and MIC90 values were found for tetracycline and the lowest for rifampicin. The highest biocidal values were found for azithromycin and the lowest for tetracycline.PMID:38153060 | DOI:10.26444/aaem/167934 (Source: Annals of Agricultural and Environmental Medicine : AAEM)
Source: Annals of Agricultural and Environmental Medicine : AAEM - December 28, 2023 Category: Environmental Health Authors: Iwona G ładysz Agnieszka Sikora Ma łgorzata Wójtowicz-Bobin Adam Szepeluk Renata Matuszewska Marta Bartosik Jan Kazimierz Karczewski Source Type: research
