Macrolide antibiotics (including azithromycin) for cystic fibrosis
CONCLUSIONS: Azithromycin therapy is associated with a small but consistent improvement in respiratory function, a decreased risk of exacerbation and longer time to exacerbation at six months; but evidence for treatment efficacy beyond six months remains limited. Azithromycin appears to have a good safety profile (although a weekly dose was associated with more gastrointestinal side effects, which makes it less acceptable for long-term therapy), with a relatively minimal treatment burden for people with CF, and it is inexpensive. A wider concern may be the emergence of macrolide resistance reported in the most recent study...
Source: Cochrane Database of Systematic Reviews - February 27, 2024 Category: General Medicine Authors: Kevin W Southern Arturo Solis-Moya Dominiki Kurz Sherie Smith Source Type: research
Macrolide antibiotics (including azithromycin) for cystic fibrosis
CONCLUSIONS: Azithromycin therapy is associated with a small but consistent improvement in respiratory function, a decreased risk of exacerbation and longer time to exacerbation at six months; but evidence for treatment efficacy beyond six months remains limited. Azithromycin appears to have a good safety profile (although a weekly dose was associated with more gastrointestinal side effects, which makes it less acceptable for long-term therapy), with a relatively minimal treatment burden for people with CF, and it is inexpensive. A wider concern may be the emergence of macrolide resistance reported in the most recent study...
Source: Cochrane Database of Systematic Reviews - February 27, 2024 Category: General Medicine Authors: Kevin W Southern Arturo Solis-Moya Dominiki Kurz Sherie Smith Source Type: research
Comparison of gradient diffusion and molecular methods using Allplex ™ NG & amp;DR assay (Seegene ®) for macrolide and fluoroquinolone screening resistance in Neisseria gonorrhoeae
AbstractAntimicrobial resistance inNeisseria gonorrhoeae (NG) is increasing worldwide. Second-line treatments with macrolides or fluoroquinolones are an option for NG infections in some cases following the STI guideline recommendations. In our study, we compared the gradient diffusion test using EUCAST 2024 breakpoints with a new molecular method using the Allplex ™ NG&DR assay (Seegene®) including A2059G/C2611 mutations (23S rRNA) associated with high/moderate-level macrolide resistance and S91F mutation (gyrA) relationship with fluoroquinolone resistance in NG isolates (n = 100). We calculated the sensitivity,...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 26, 2024 Category: Microbiology Source Type: research
Azithromycin-loaded liposomes and niosomes for the treatment of skin infections: Influence of excipients and preparative methods on the functional properties
Eur J Pharm Biopharm. 2024 Feb 20:114233. doi: 10.1016/j.ejpb.2024.114233. Online ahead of print.ABSTRACTThe aim of this study was to develop azithromycin (AZT)-loaded liposomes (LP) and niosomes (NS) useful for the treatment of bacterial skin infections and acne. LP based on phosphatidylcholine from egg yolk (EPC) or from soybean lecithin (SPC), and NS composed of sorbitan monopalmitate (Span 40) or sorbitan monostearate (Span 60) were prepared through the thin film hydration (TFH) and the ethanol injection (EI) methods. The formulations were subsequently characterized for their physico-chemical and functional properties....
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 22, 2024 Category: Drugs & Pharmacology Authors: A Abruzzo R Pucci P M Abruzzo S Canaider C Parolin B Vitali F Valle M Brucale T Cerchiara B Luppi F Bigucci Source Type: research
Azithromycin-loaded liposomes and niosomes for the treatment of skin infections: Influence of excipients and preparative methods on the functional properties
Eur J Pharm Biopharm. 2024 Feb 20:114233. doi: 10.1016/j.ejpb.2024.114233. Online ahead of print.ABSTRACTThe aim of this study was to develop azithromycin (AZT)-loaded liposomes (LP) and niosomes (NS) useful for the treatment of bacterial skin infections and acne. LP based on phosphatidylcholine from egg yolk (EPC) or from soybean lecithin (SPC), and NS composed of sorbitan monopalmitate (Span 40) or sorbitan monostearate (Span 60) were prepared through the thin film hydration (TFH) and the ethanol injection (EI) methods. The formulations were subsequently characterized for their physico-chemical and functional properties....
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 22, 2024 Category: Drugs & Pharmacology Authors: A Abruzzo R Pucci P M Abruzzo S Canaider C Parolin B Vitali F Valle M Brucale T Cerchiara B Luppi F Bigucci Source Type: research
A case of late-onset organizing pneumonia following COVID-19 infection in a post-kidney transplant patient
AbstractA 50-year-old man who had undergone a living-donor kidney transplant 12 years prior for chronic renal failure due to autosomal dominant polycystic kidney disease contracted coronavirus disease 19 (COVID-19). He had a positive antigen test, mild symptoms, sore throat, and fever of 37.9 ℃. The patient was treated with molnupiravir for 5 days, and the symptoms disapp eared 5 days after onset. However, 10 days after onset, he developed a fever of approximately 37 ℃ and a non-productive cough; 27 days after onset, the patient was hospitalized for anorexia and a worsening respiratory condition. The severe acu...
Source: CEN Case Reports - February 17, 2024 Category: Urology & Nephrology Source Type: research
The effects of prenatal azithromycin exposure on offspring ovarian development at different stages, doses, and courses
Biomed Pharmacother. 2024 Feb 14;172:116246. doi: 10.1016/j.biopha.2024.116246. Online ahead of print.ABSTRACTAzithromycin, a commonly used macrolide antibiotic for treating chlamydial infections during pregnancy, has sparked investigations into its potential effects on offspring development. Despite these inquiries, there remains uncertainty about the specific impact of prenatal azithromycin exposure (PAzE) on offspring ovarian development and the precise "effect window". Pregnant mice, following clinical guidelines for azithromycin dosing, were orally administered azithromycin at different gestational stages [(gestationa...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 15, 2024 Category: Drugs & Pharmacology Authors: Yating Li Jing Huang Caiyun Ge Sen Zhu Hui Wang Yuanzhen Zhang Source Type: research
The effects of prenatal azithromycin exposure on offspring ovarian development at different stages, doses, and courses
Biomed Pharmacother. 2024 Feb 14;172:116246. doi: 10.1016/j.biopha.2024.116246. Online ahead of print.ABSTRACTAzithromycin, a commonly used macrolide antibiotic for treating chlamydial infections during pregnancy, has sparked investigations into its potential effects on offspring development. Despite these inquiries, there remains uncertainty about the specific impact of prenatal azithromycin exposure (PAzE) on offspring ovarian development and the precise "effect window". Pregnant mice, following clinical guidelines for azithromycin dosing, were orally administered azithromycin at different gestational stages [(gestationa...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 15, 2024 Category: Drugs & Pharmacology Authors: Yating Li Jing Huang Caiyun Ge Sen Zhu Hui Wang Yuanzhen Zhang Source Type: research
Identifying the Best Initial Oral Antibiotics for Adults with Community-Acquired Pneumonia: A Network Meta-Analysis
ConclusionWe observed trends toward a better clinical response and lower mortality for quinolones as empiric antibiotics for CAP, but found no conclusive evidence of any antibiotic being clearly more effective than another. More trials are needed to inform guideline recommendations on the most effective antibiotic regimens for outpatients with mild to moderate CAP. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - February 15, 2024 Category: Internal Medicine Source Type: research
Azithromycin for Prevention of Mortality in African Children
Mass administration of oral azithromycin is central to the World Health Organization (WHO) campaign to eliminate trachoma. Mass administration of azithromycin could have beneficial effects in young children due to its activity against pathogens causing pneumonia, diarrhea, and malaria, but could also have harmful effects, including generation of antimicrobial resistance. In 2009, a cluster randomized clinical trial showed that mass administration of oral azithromycin was associated with a 49% reduction in mortality in Ethiopian children aged 1 to 9 years. The subsequent Macrolides Oraux pour R éduire les Décès avec un O...
Source: JAMA - February 13, 2024 Category: General Medicine Source Type: research
Mass Azithromycin Distribution to Prevent Child Mortality
This cluster randomized placebo-controlled trial examines the efficacy of single-dose azithromycin for prevention of all-cause childhood mortality in rural Burkina Faso. (Source: JAMA)
Source: JAMA - February 13, 2024 Category: General Medicine Source Type: research
Seasonal variation in structural and functional distribution of periphyton in a macrolide antibiotics-contaminated river
Environ Pollut. 2024 Feb 9:123495. doi: 10.1016/j.envpol.2024.123495. Online ahead of print.ABSTRACTPeriphyton, a microbial assemblage of autotrophic and heterotrophic organisms, is vital to aquatic ecosystems. While exposure to macrolide antibiotics has been confirmed to reduce the biodiversity and damage the critical ecological functions in indoor microcosm bioassays, the distribution of periphyton along a macrolide antibiotic pollution gradient in a river has yet to be determined. Herein, we established the spatiotemporal distribution of five major macrolides, i.e., azithromycin (AZI), roxithromycin (ROX), erythromycin ...
Source: Environmental Pollution - February 11, 2024 Category: Environmental Health Authors: Baihuan Zhang Wenqian Yu Jiayi Liang Xiunan Yao Haotian Sun Hisato Iwata Jiahua Guo Source Type: research
Mycoplasma genitalium: Key Information for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):297-310. doi: 10.1016/j.mcna.2023.07.004. Epub 2023 Sep 14.ABSTRACTMycoplasma genitalium (MG) is an emerging sexually transmitted infection, which appears to be a cause of urethritis and cervicitis and has been associated with pelvic inflammatory disease (PID), epididymitis, proctitis, infertility, complications during pregnancy, and human immunodeficiency virus (HIV) transmission. Three Food and Drug Administration (FDA) approved tests are available. Testing should be focused to avoid inappropriate antibiotic use. The Center of Disease Control and Prevention (CDC) guidelines recommend te...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Oluyomi A Obafemi Sarah E Rowan Masayo Nishiyama Karen A Wendel Source Type: research
Selection of Antibiotics as Prophylaxis for Close Contacts of Patients with Meningococcal Disease in Areas with Ciprofloxacin Resistance - United States, 2024
MMWR Morb Mortal Wkly Rep. 2024 Feb 8;73(5):99-103. doi: 10.15585/mmwr.mm7305a2.ABSTRACTMeningococcal disease, caused by the bacterium Neisseria meningitidis, is a rare but life-threatening illness that requires prompt antibiotic treatment for patients and antibiotic prophylaxis for their close contacts. Historically, N. meningitidis isolates in the United States have been largely susceptible to the antibiotics recommended for prophylaxis, including ciprofloxacin. Since 2019, however, the number of meningococcal disease cases caused by ciprofloxacin-resistant strains has increased. Antibiotic prophylaxis with ciprofloxacin...
Source: MMWR Morb Mortal Wkl... - February 8, 2024 Category: Epidemiology Authors: Isha Berry Amy B Rubis Rebecca L Howie Shalabh Sharma Daya Marasini Henju Marjuki Samuel Crowe Lucy A McNamara Source Type: research
